LOCUS       NM_001394894            3427 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens NLR family pyrin domain containing 11 (NLRP11),
            transcript variant 8, mRNA.
ACCESSION   NM_001394894
VERSION     NM_001394894.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3427)
  AUTHORS   Rojas-Lopez,M., Gil-Marques,M.L., Kharbanda,V., Zajac,A.S.,
            Miller,K.A., Wood,T.E., Hachey,A.C., Egger,K.T. and Goldberg,M.B.
  TITLE     NLRP11 is a pattern recognition receptor for bacterial
            lipopolysaccharide in the cytosol of human macrophages
  JOURNAL   Sci Immunol 8 (85), eabo4767 (2023)
   PUBMED   37478192
  REMARK    GeneRIF: NLRP11 is a pattern recognition receptor for bacterial
            lipopolysaccharide in the cytosol of human macrophages.
REFERENCE   2  (bases 1 to 3427)
  AUTHORS   Ozel,I., Akkaya,I., Oylumlu,E., Uzel,G. and Ciraci,C.
  TITLE     Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4+ T
            Helper Cell Responses
  JOURNAL   J Immunol Res 2020, 1421795 (2020)
   PUBMED   32832566
  REMARK    GeneRIF: Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses
            Human CD4(+) T Helper Cell Responses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3427)
  AUTHORS   Ellwanger,K., Becker,E., Kienes,I., Sowa,A., Postma,Y., Cardona
            Gloria,Y., Weber,A.N.R. and Kufer,T.A.
  TITLE     The NLR family pyrin domain-containing 11 protein contributes to
            the regulation of inflammatory signaling
  JOURNAL   J Biol Chem 293 (8), 2701-2710 (2018)
   PUBMED   29301940
  REMARK    GeneRIF: Data suggest that NLRP11 plays novel role in myeloid cells
            and B-lymphocytes (where NLRP11 expression is high); expression of
            NLRP11 in both tumor and non-tumor cell lines down-regulates
            NFkappaB and interferon type I signaling responses.
REFERENCE   4  (bases 1 to 3427)
  AUTHORS   Qin,Y., Su,Z., Wu,Y., Wu,C., Jin,S., Xie,W., Jiang,W., Zhou,R. and
            Cui,J.
  TITLE     NLRP11 disrupts MAVS signalosome to inhibit type I interferon
            signaling and virus-induced apoptosis
  JOURNAL   EMBO Rep 18 (12), 2160-2171 (2017)
   PUBMED   29097393
  REMARK    GeneRIF: Using MAVS as a platform, NLRP11 degrades TRAF6 to
            attenuate the production of type I IFNs as well as virus-induced
            apoptosis. Our findings reveal the regulatory role of NLRP11 in
            antiviral immunity by disrupting MAVS signalosome.
REFERENCE   5  (bases 1 to 3427)
  CONSRTM   GENDEP Investigators; MARS Investigators; STAR*D Investigators
  TITLE     Common genetic variation and antidepressant efficacy in major
            depressive disorder: a meta-analysis of three genome-wide
            pharmacogenetic studies
  JOURNAL   Am J Psychiatry 170 (2), 207-217 (2013)
   PUBMED   23377640
REFERENCE   6  (bases 1 to 3427)
  AUTHORS   Baranzini,S.E., Wang,J., Gibson,R.A., Galwey,N., Naegelin,Y.,
            Barkhof,F., Radue,E.W., Lindberg,R.L., Uitdehaag,B.M.,
            Johnson,M.R., Angelakopoulou,A., Hall,L., Richardson,J.C.,
            Prinjha,R.K., Gass,A., Geurts,J.J., Kragt,J., Sombekke,M.,
            Vrenken,H., Qualley,P., Lincoln,R.R., Gomez,R., Caillier,S.J.,
            George,M.F., Mousavi,H., Guerrero,R., Okuda,D.T., Cree,B.A.,
            Green,A.J., Waubant,E., Goodin,D.S., Pelletier,D., Matthews,P.M.,
            Hauser,S.L., Kappos,L., Polman,C.H. and Oksenberg,J.R.
  TITLE     Genome-wide association analysis of susceptibility and clinical
            phenotype in multiple sclerosis
  JOURNAL   Hum Mol Genet 18 (4), 767-778 (2009)
   PUBMED   19010793
REFERENCE   7  (bases 1 to 3427)
  AUTHORS   Dowds,T.A., Masumoto,J., Chen,F.F., Ogura,Y., Inohara,N. and
            Nunez,G.
  TITLE     Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial
            Mediterranean fever gene product
  JOURNAL   Biochem Biophys Res Commun 302 (3), 575-580 (2003)
   PUBMED   12615073
REFERENCE   8  (bases 1 to 3427)
  AUTHORS   Tschopp,J., Martinon,F. and Burns,K.
  TITLE     NALPs: a novel protein family involved in inflammation
  JOURNAL   Nat Rev Mol Cell Biol 4 (2), 95-104 (2003)
   PUBMED   12563287
  REMARK    Review article
REFERENCE   9  (bases 1 to 3427)
  AUTHORS   Grenier,J.M., Wang,L., Manji,G.A., Huang,W.J., Al-Garawi,A.,
            Kelly,R., Carlson,A., Merriam,S., Lora,J.M., Briskin,M.,
            DiStefano,P.S. and Bertin,J.
  TITLE     Functional screening of five PYPAF family members identifies PYPAF5
            as a novel regulator of NF-kappaB and caspase-1
  JOURNAL   FEBS Lett 530 (1-3), 73-78 (2002)
   PUBMED   12387869
REFERENCE   10 (bases 1 to 3427)
  AUTHORS   Wang,L., Manji,G.A., Grenier,J.M., Al-Garawi,A., Merriam,S.,
            Lora,J.M., Geddes,B.J., Briskin,M., DiStefano,P.S. and Bertin,J.
  TITLE     PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates
            activation of NF-kappa B and caspase-1-dependent cytokine
            processing
  JOURNAL   J Biol Chem 277 (33), 29874-29880 (2002)
   PUBMED   12019269
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012310.5 and AC008749.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 10, 2021 this sequence version replaced NM_001394894.1.
            
            Summary: This gene is a member of the the NOD-like receptor protein
            (NLRP) gene family and encodes a protein with an N-terminal pyrin
            death (PYD) domain and nucleoside triphosphate hydrolase (NACHT)
            domain and a C-terminal leucine-rich repeats (LRR) region. This
            gene has been shown to regulate caspases in the proinflammatory
            signal transduction pathway and, based on studies of other members
            of the NLRP gene family with similar domain structure, is predicted
            to form part of the multiprotein inflammasome complex. Alternative
            splicing produces multiple transcript variants encoding distince
            isoforms. [provided by RefSeq, May 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034730.1, AY168967.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000589093.6/ ENSP00000466285.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC012310.5         24377-24413         c
            38-370              AC012310.5         10318-10650         c
            371-1940            AC012310.5         1183-2752           c
            1941-2102           AC008749.6         113951-114112       c
            2103-2270           AC008749.6         107670-107837       c
            2271-2441           AC008749.6         102178-102348       c
            2442-2612           AC008749.6         98399-98569         c
            2613-2783           AC008749.6         95327-95497         c
            2784-2954           AC008749.6         94905-95075         c
            2955-3427           AC008749.6         91497-91969         c
FEATURES             Location/Qualifiers
     source          1..3427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42-q13.43"
     gene            1..3427
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /note="NLR family pyrin domain containing 11"
                     /db_xref="GeneID:204801"
                     /db_xref="HGNC:HGNC:22945"
                     /db_xref="MIM:609664"
     exon            1..37
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            38..370
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..3201
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /note="isoform 1 is encoded by transcript variant 8;
                     NACHT, leucine rich repeat and PYD containing 11;
                     nucleotide-binding oligomerization domain, leucine rich
                     repeat and pyrin domain containing 11; NACHT, LRR and PYD
                     domains-containing protein 11; PYRIN-containing APAF1-like
                     protein 6; PAAD- and NACHT-containing protein 10B;
                     PAAD-and NACHT domain-containing protein 10;
                     nucleotide-binding oligomerization domain protein 17"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 11
                     isoform 1"
                     /protein_id="NP_001381823.1"
                     /db_xref="CCDS:CCDS12935.1"
                     /db_xref="GeneID:204801"
                     /db_xref="HGNC:HGNC:22945"
                     /db_xref="MIM:609664"
                     /translation="MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPL
                     IQMTKEELANVLPISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRR
                     KFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKT
                     IVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADIL
                     SDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLIS
                     SRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVG
                     LCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLG
                     LLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIH
                     LNVQEFCTAIAFLMAVPNYLIPSGSREYKEKREQYSDFNQVFTFIFGLLNANRRKILE
                     TSFGYQLPMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALM
                     EVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWRE
                     ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLL
                     KALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIAS
                     LLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRV
                     LLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVI
                     ATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLT
                     TNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKER
                     KPSLIFLSETWSLKEGREIGVTPASQPGSIIPNSNLDYMFFKFPRMSAAMRTSNTASR
                     QPL"
     exon            371..1940
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2102
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2270
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2441
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2612
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..2783
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2954
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3427
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /note="hexamer: GATAAA"
     polyA_site      3427
                     /gene="NLRP11"
                     /gene_synonym="CLR19.6; NALP11; NOD17; PAN10; PYPAF6;
                     PYPAF7"
                     /note="major polyA site"
ORIGIN      
        1 gctttcgacc agccaaggag acctggtggc agggttgatc tcatatttct tgtgcctcaa
       61 aatcccttct ctgaagtctg ccttccctgg agaagcaaga tggcagaatc ggattctact
      121 gactttgacc tgctgtggta tctagagaat ctcagtgaca aggaatttca gagttttaag
      181 aagtatctgg cacgcaagat tcttgatttc aaactgccac agtttccact gatacagatg
      241 acaaaagaag aactggctaa cgtgttgcca atctcttatg agggacagta tatatggaat
      301 atgctcttca gcatattttc aatgatgcgt aaggaagatc tttgtaggaa gatcattggc
      361 agacgaaacc gcaatcagga ggcatgcaaa gctgtcatga ggagaaaatt catgctgcaa
      421 tgggaaagtc acacttttgg aaaatttcat tataaatttt ttcgtgacgt ttcgtcagat
      481 gtgttctaca tacttcaatt agcctatgat tctaccagct attattcagc aaacaatctc
      541 aatgtgttcc tgatgggaga gagagcatct ggaaaaacta ttgttataaa tctggctgtg
      601 ttgaggtgga tcaagggtga gatgtggcag aacatgatct cgtacgtcgt tcacctcact
      661 gctcacgaaa taaaccagat gaccaacagc agcttggctg agctaatcgc caaggactgg
      721 cctgacggcc aggctcccat tgcagacatc ctgtctgatc ccaagaaact ccttttcatc
      781 ctcgaggact tggacaacat aagattcgag ttaaatgtca atgaaagtgc tttgtgtagt
      841 aacagcaccc agaaagttcc cattccagtt ctcctggtca gtttgctgaa gagaaaaatg
      901 gctccaggct gctggttcct catctcctca aggcccacac gtgggaataa tgtaaaaacg
      961 ttcttgaaag aggtagattg ctgcacgacc ttgcagctgt cgaatgggaa gagggagata
     1021 tattttaact ctttctttaa agaccgccag agggcgtcgg cagccctcca gcttgtacat
     1081 gaggatgaaa tactcgtggg tctgtgccga gtcgccatct tatgctggat cacgtgtact
     1141 gtcctgaagc ggcagatgga caaggggcgt gacttccagc tctgctgcca aacacccact
     1201 gatctacatg cccactttct tgctgatgcg ttgacatcag aggctggact tactgccaat
     1261 cagtatcacc taggtctcct aaaacgtctg tgtttgctgg ctgcaggagg actgtttctg
     1321 agcaccctga atttcagtgg tgaagacctc agatgtgttg ggtttactga ggctgatgtc
     1381 tctgtgttgc aggccgcgaa tattcttttg ccgagcaaca ctcataaaga ccgttacaag
     1441 ttcatacact tgaacgtcca ggagttttgt acagccattg catttctgat ggcagtaccc
     1501 aactatctga tcccctcagg cagcagagag tataaagaga agagagaaca atactctgac
     1561 tttaatcaag tgtttacttt catttttggt cttctaaatg caaacaggag aaagattctt
     1621 gagacatcct ttggatacca gctaccgatg gtagacagct tcaagtggta ctcggtggga
     1681 tacatgaaac atttggaccg tgacccggaa aagttgacgc accatatgcc tttgttttac
     1741 tgtctctatg agaatcggga agaagaattt gtgaagacga ttgtggatgc tctcatggag
     1801 gttacagttt accttcaatc agacaaggat atgatggtct cattatactg tctggattac
     1861 tgctgtcacc tgaggacact taagttgagt gttcagcgca tctttcaaaa caaagagcca
     1921 cttataaggc caactgctag tcaaatgaag agccttgtct actggagaga gatctgctct
     1981 cttttttata caatggagag cctccgggag ctgcatatct ttgacaatga ccttaatggt
     2041 atttcagaaa ggattctgtc taaagccctg gagcattcta gctgtaaact tcgcacactc
     2101 aagttgtcct atgtctcgac tgcttctggt tttgaagact tactcaaggc tttggctcgt
     2161 aatcggagcc tgacatacct gagtatcaac tgtacgtcca tttccctaaa tatgttttca
     2221 cttctgcatg acatcctgca cgagcccaca tgccaaataa gtcatctgag cttgatgaaa
     2281 tgtgatttgc gagccagcga atgtgaagaa atcgcctctc tcctcatcag tggcgggagt
     2341 ctgagaaaac tgaccttatc cagcaatccg ctgaggagcg acgggatgaa catactgtgt
     2401 gatgccttgc ttcatcccaa ctgcactctt atatcactgg tgttagtctt ctgctgtctc
     2461 actgaaaatt gctgcagcgc ccttggaaga gtgcttctgt tcagcccaac tctaagacaa
     2521 ctagacctgt gtgtgaatcg cttaaaaaat tacggagtgt tgcatgtgac gtttcccttg
     2581 ctgtttccaa cctgtcagtt agaggagctt catctgtctg gctgtttctt tagcagcgat
     2641 atctgtcaat atattgccat agttattgct actaatgaaa aactgaggag cctggagatt
     2701 gggagcaaca aaatagaaga tgcaggaatg cagctgctat gtggtggttt gagacatccc
     2761 aactgcatgt tggtgaatat tgggctagaa gagtgcatgt taaccagtgc ctgctgtcga
     2821 tctcttgcct ctgttcttac caccaacaaa acactagaaa gactcaactt gcttcaaaat
     2881 cacttgggca atgatggagt tgcaaaactt cttgagagct tgatcagccc agattgtgta
     2941 cttaaggtag ttgggcttcc attaactggc ctgaacacac aaacccagca gttgctgatg
     3001 actgtaaagg aaagaaaacc cagtttgatc tttctgtctg aaacttggtc tttaaaggaa
     3061 ggcagagaaa ttggtgtgac acctgcttct cagccaggtt caataatacc taattctaat
     3121 ttggattaca tgtttttcaa atttcccaga atgtctgcag ccatgagaac gtcaaataca
     3181 gcatctaggc aacccctttg atcatgttgt acgtaaacag tatttattat aaattactac
     3241 cgtgactggg atgcaagaga attaggacta taattttcct atttgatgtg tgtgtgtgtg
     3301 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgaccttgat ccagtcaacc acttcaaatt
     3361 cctacactgt ctcaagagta ttaaaaggat tatatgaagt aataaaggat aaaatgcatt
     3421 ggaaaaa
//
