LOCUS       NM_001391958            4322 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens NLR family pyrin domain containing 10 (NLRP10),
            transcript variant 1, mRNA.
ACCESSION   NM_001391958 XM_011520043
VERSION     NM_001391958.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4322)
  AUTHORS   Cho,Y., Cao,Z., Luo,X., Tian,J.J., Hukkanen,R.R., Hussien,R.,
            Cancilla,B., Chowdhury,P., Li,F., Ma,S., LaGory,E.L., Schroeder,M.,
            Dusenberry,A., Marshall,L., Hawkins,J., van Lookeren Campagne,M.
            and Zhou,Y.
  TITLE     NLRP10 maintains epidermal homeostasis by promoting keratinocyte
            survival and P63-dependent differentiation and barrier function
  JOURNAL   Cell Death Dis 15 (10), 759 (2024)
   PUBMED   39424623
  REMARK    GeneRIF: NLRP10 maintains epidermal homeostasis by promoting
            keratinocyte survival and P63-dependent differentiation and barrier
            function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4322)
  AUTHORS   Yi,X., Song,Y., Xu,J., Wang,L., Liu,L., Huang,D. and Zhang,L.
  TITLE     NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome
            activation via ROS/MAPK/NF-kappaB signaling in human periodontal
            ligament cells
  JOURNAL   Odontology 112 (1), 100-111 (2024)
   PUBMED   37043073
  REMARK    GeneRIF: NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome
            activation via ROS/MAPK/NF-kappaB signaling in human periodontal
            ligament cells.
REFERENCE   3  (bases 1 to 4322)
  AUTHORS   Kutsuwada,Y., Yokota,K., Yoshida,K., Tsuda,H., Watanabe,K.,
            Matsumoto,A. and Iwamoto,S.
  TITLE     Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the
            axillary microbiome in a Japanese population
  JOURNAL   J Dermatol Sci 105 (2), 98-104 (2022)
   PUBMED   35078690
  REMARK    GeneRIF: Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with
            the axillary microbiome in a Japanese population.
REFERENCE   4  (bases 1 to 4322)
  AUTHORS   Mirza,N., Sowa,A.S., Lautz,K. and Kufer,T.A.
  TITLE     NLRP10 Affects the Stability of Abin-1 To Control Inflammatory
            Responses
  JOURNAL   J Immunol 202 (1), 218-227 (2019)
   PUBMED   30510071
  REMARK    GeneRIF: this study shows that NLRP10 affects the stability of
            Abin-1 to control inflammatory responses
REFERENCE   5  (bases 1 to 4322)
  AUTHORS   Kaur,G., Bagam,P., Pinkston,R., Singh,D.P. and Batra,S.
  TITLE     Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms
  JOURNAL   Toxicology 398-399, 52-67 (2018)
   PUBMED   29501574
  REMARK    GeneRIF: Authors observed an important role of NLRP10 in cytokine
            and chemokine production as well as expression of NF-kappaB and
            MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549
            cell culture with recombinant IL-17A (rIL-17A) during NLRP10
            knockdown rescued CSE-induced inflammatory responses.
REFERENCE   6  (bases 1 to 4322)
  AUTHORS   Ha,H.J., Kim,D.S. and Hahn,Y.
  TITLE     A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after
            the human-chimpanzee divergence
  JOURNAL   Biochem Genet 47 (9-10), 665-670 (2009)
   PUBMED   19544093
  REMARK    GeneRIF: The structural modification of the NLRP10 gene might have
            played a role in development or enhancement of human-specific
            traits during evolution.
REFERENCE   7  (bases 1 to 4322)
  AUTHORS   Kinoshita,T., Wang,Y., Hasegawa,M., Imamura,R. and Suda,T.
  TITLE     PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback
            regulator of caspase-1-dependent interleukin-1beta secretion
  JOURNAL   J Biol Chem 280 (23), 21720-21725 (2005)
   PUBMED   15817483
  REMARK    GeneRIF: PYPAF3 is a feedback regulator of interleukin-1beta
            secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute
            an anti-inflammatory subgroup of PYRIN-containing apoptotic
            protease-activating factor-1-like proteins
REFERENCE   8  (bases 1 to 4322)
  AUTHORS   Wang,Y., Hasegawa,M., Imamura,R., Kinoshita,T., Kondo,C., Konaka,K.
            and Suda,T.
  TITLE     PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and
            caspase-1
  JOURNAL   Int Immunol 16 (6), 777-786 (2004)
   PUBMED   15096476
  REMARK    GeneRIF: PYNOD is a novel regulator of apoptosis and inflammation.
REFERENCE   9  (bases 1 to 4322)
  AUTHORS   Inohara,N. and Nunez,G.
  TITLE     NODs: intracellular proteins involved in inflammation and apoptosis
  JOURNAL   Nat Rev Immunol 3 (5), 371-382 (2003)
   PUBMED   12766759
  REMARK    Review article
REFERENCE   10 (bases 1 to 4322)
  AUTHORS   Tschopp,J., Martinon,F. and Burns,K.
  TITLE     NALPs: a novel protein family involved in inflammation
  JOURNAL   Nat Rev Mol Cell Biol 4 (2), 95-104 (2003)
   PUBMED   12563287
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC044810.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 22, 2021 this sequence version replaced XM_011520043.3.
            
            Summary: Members of the NALP protein family typically contain a
            NACHT domain, a NACHT-associated domain (NAD), a C-terminal
            leucine-rich repeat (LRR) region, and an N-terminal pyrin domain
            (PYD). The protein encoded by this gene belongs to the NALP protein
            family despite lacking the LRR region. This protein likely plays a
            regulatory role in the innate immune system. The protein belongs to
            the signal-induced multiprotein complex, the inflammasome, that
            activates the pro-inflammatory caspases, caspase-1 and caspase-5.
            Other experiments indicate that this gene acts as a multifunctional
            negative regulator of inflammation and apoptosis. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4183635.1,
                                           SRR14038195.1161954.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000691676.1/ ENSP00000509542.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               AC044810.7         186114-186315       c
            203-536             AC044810.7         184075-184408       c
            537-4322            AC044810.7         178405-182190       c
FEATURES             Location/Qualifiers
     source          1..4322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4322
                     /gene="NLRP10"
                     /gene_synonym="CLR11.1; NALP10; NOD8; PAN5; PYNOD"
                     /note="NLR family pyrin domain containing 10"
                     /db_xref="GeneID:338322"
                     /db_xref="HGNC:HGNC:21464"
                     /db_xref="MIM:609662"
     exon            1..202
                     /gene="NLRP10"
                     /gene_synonym="CLR11.1; NALP10; NOD8; PAN5; PYNOD"
                     /inference="alignment:Splign:2.1.0"
     exon            203..536
                     /gene="NLRP10"
                     /gene_synonym="CLR11.1; NALP10; NOD8; PAN5; PYNOD"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..2215
                     /gene="NLRP10"
                     /gene_synonym="CLR11.1; NALP10; NOD8; PAN5; PYNOD"
                     /note="NACHT, leucine rich repeat and PYD containing 10;
                     nucleotide-binding oligomerization domain, leucine rich
                     repeat and pyrin domain containing 10; nucleotide-binding
                     oligomerization domain protein 8"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein
                     10"
                     /protein_id="NP_001378887.1"
                     /db_xref="CCDS:CCDS7784.1"
                     /db_xref="GeneID:338322"
                     /db_xref="HGNC:HGNC:21464"
                     /db_xref="MIM:609662"
                     /translation="MAMAKARKPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPL
                     ARGELEGLIPVDLAELLISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVY
                     REHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGE
                     KPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESK
                     LEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHL
                     LIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQA
                     DRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTF
                     LPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSN
                     DYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGND
                     EMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDLEFS
                     LYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQSQNLFSVKSSLSHGPKEEQKCPSVHGQ
                     KEGKDNIAGTQKEASTGKGRGTEETPKNTYI"
     exon            537..4322
                     /gene="NLRP10"
                     /gene_synonym="CLR11.1; NALP10; NOD8; PAN5; PYNOD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4299..4304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLRP10"
                     /gene_synonym="CLR11.1; NALP10; NOD8; PAN5; PYNOD"
                     /note="hexamer: AATAAA"
     polyA_site      4322
                     /gene="NLRP10"
                     /gene_synonym="CLR11.1; NALP10; NOD8; PAN5; PYNOD"
                     /note="major polyA site"
ORIGIN      
        1 gtagctggta ggtaccagca ccaccaaaca gaagtgaact agtgagtatg ggctaagaga
       61 gcccaaactt ggacctgtag agctgtcgga ccaggaaagg ggatctgttt cgtctcagtc
      121 cccaggcttt gcttactggg ctcctggatc agggagctga gttctcgctg cctcacctcc
      181 agctccccaa gtctgaactg tggtcactgg tcttctggtc tggacttgat ccttccccca
      241 gatcaccatg gccatggcca aggccagaaa gccccgggag gcattgctct gggccttgag
      301 tgaccttgag gagaacgatt tcaagaagtt aaagttctac ttacgggata tgaccctgtc
      361 tgagggccag cccccactgg ccagagggga gttggagggc ctgattccgg tggacctggc
      421 agaattactg atttcaaagt atggagaaaa ggaggctgtg aaagttgtcc tcaagggctt
      481 gaaggtcatg aacctgttgg aacttgtgga ccagctcagc catatttgtc tgcatgatta
      541 cagagaagta taccgagagc atgtgcgctg cctagaggaa tggcaggaag caggagtcaa
      601 tggcagatac aaccaggtgc tcctggtggc caagcccagc tcagagagcc cagaatcact
      661 tgcctgcccc ttcccggagc aggagctgga gtctgtcacg gtggaggctc tatttgattc
      721 aggggaaaag ccctcactgg ccccatcctt agttgtgcta caggggtcgg ctggcactgg
      781 aaagacaact ctcgccagaa aaatggtgtt ggactgggcc accggtactc tgtacccagg
      841 ccggtttgat tatgtctttt atgtaagctg caaagaagtg gtcctgctgc tggagagcaa
      901 actggagcag ctccttttct ggtgctgcgg ggacaatcaa gcccctgtca cagagattct
      961 gaggcagcca gagcggctcc tgttcatcct ggatggcttt gatgagctgc agaggccctt
     1021 tgaagaaaag ttgaagaaga ggggtttgag tcccaaggag agcctgctgc accttctaat
     1081 taggagacat acactcccca cgtgctccct tctcatcacc acccggcccc tggctttgag
     1141 gaatctggag cccttgctga aacaagcacg tcatgtccat atcctaggct tctctgagga
     1201 ggagagggcg aggtacttca gctcctattt cacggatgag aagcaagctg accgtgcctt
     1261 cgacattgta cagaaaaatg acattctcta caaagcgtgt caggttccag gcatttgctg
     1321 ggtggtctgc tcctggctgc aggggcagat ggagagaggc aaagttgtct tagagacacc
     1381 tagaaacagc actgacatct tcatggctta cgtctccacc tttctgccgc ccgatgatga
     1441 tgggggctgc tccgagcttt cccggcacag ggtcctgagg agtctgtgct ccctagcagc
     1501 tgaagggatt cagcaccaga ggttcctatt tgaagaagct gagctcagga aacataattt
     1561 agatggcccc aggcttgccg ctttcctgag tagtaacgac taccaattgg gacttgccat
     1621 caagaagttc tacagcttcc gccacatcag cttccaggac ttttttcatg ccatgtctta
     1681 cctggtgaaa gaggaccaaa gccggctggg gaaggagtcc cgcagagaag tgcaaaggct
     1741 gctggaggta aaggagcagg aagggaatga tgagatgacc ctcactatgc agtttttact
     1801 ggacatctcg aaaaaagaca gcttctcgaa cttggagctc aagttctgct tcagaatttc
     1861 tccctgttta gcgcaggatc tgaagcattt taaagaacag atggaatcta tgaagcacaa
     1921 caggacctgg gatttggaat tctccctgta tgaagctaaa ataaagaatc tggtaaaagg
     1981 tattcagatg aacaatgtat cattcaagat aaaacattca aatgaaaaga aatcacagag
     2041 ccagaattta ttttctgtca aaagcagctt gagtcatgga cctaaggagg agcaaaaatg
     2101 tccttctgtc catggacaga aggagggcaa agataatata gcaggaacac aaaaggaagc
     2161 ttctactgga aaaggcagag ggacagagga aacaccaaaa aatacttaca tataaaccta
     2221 attaaatatg tacaagatct ctatgaggaa aatgacaaca ctctgaggaa agaaatcaaa
     2281 gaagctgtaa atgaatggga agattttcca tgttcatgaa tagaaagact caatattgtt
     2341 aagatgttag ttttccccag tttgatctgt agattcaatg caatcccaat caagatccca
     2401 gcaaataact ttgtggacat tgataagatg attctaatgt ttatgtgcaa aggcaaaaga
     2461 ctcagaatag ccaataaaat attgaagaag aacaaagttg gaggagtgct gctatccaac
     2521 ttcttcctac tataaagcta cagtaatcaa gacagtatgg tattgttaaa ataatagaga
     2581 aatcagtgga gtagaataga gaaccagaaa caaacctaca caaaaatggt caattgatct
     2641 tagacaaagg agcaaaagca atttaatgga gaaagtttac tcttttcaac aaatggtgct
     2701 gaaataactg gacatccaca tgtaaaaaaa tgaatctaga tgtaaaatac aaaagtacta
     2761 atataaactg ctagaagata atataggaga aaatctaggt gaccttgggt ttggcgatga
     2821 ctttttagat ataacagcaa aagcatgaat cattaaaaaa agaattagtt ggcttcatga
     2881 aaattaaaaa cttatgctct gtgaaagaca ctgttaagag aatgaaaaga taagccaaag
     2941 actgggagaa aatatttgca aacacatatc tgataaaaga cttgggtaaa aaaaaataca
     3001 aatagctctt aaaactcaat aataagtaaa gagtctactt aaaaagtgag taggaggccc
     3061 aggctggtgg atcacgaggt caagagaccg agaccatcct ggccaatgtg gtgaaacccc
     3121 gtctttacta aaaatacgaa agttagccgg gcgtggtggt gcacacctgt agtcccagct
     3181 actcaggagg ctgaggcagg agaattgctt gaatctggga ggcggaggtt gcagtgagct
     3241 gagatcgcac cactgcactc cagcctggca acagagtgag actctgcctc aaaaaaaaaa
     3301 aggtgagtaa aaagattgga acagacagct tattaaagaa gatacacaga tggcaaataa
     3361 atatttgaaa agacgctcaa cttcatatgt cattagggaa ttgcaaacta aaaccacaat
     3421 aagataccat gacacccctg ttagaatggc taacatccca aatcctggca acactaaatg
     3481 cttgttagga tgtggagtag tgggagcctt attcattgct ggtcagaatg caaaatggta
     3541 cagccacttt gaaagacagt ttggcagttt cttacaaagc taaacatagt tttactatat
     3601 gtaagatcta gcaattatgc tcctagatat taacccaagt gagttggaaa cttatgtcca
     3661 cataaaaacc tgcacatgaa tatttatagc agctttattc gtaattgccc aaatttggaa
     3721 gcaaccaaga tgtccttcaa taggtgatgg ataagcaaac tgtgatacat ccacataatg
     3781 taatagtatt cagtgataaa aataaatgag caattaagac atgaaaagat atggagaagc
     3841 cttaaatgca actactaagt gaaagaagtc agtctgaaaa ggctacatac tgtgtaattc
     3901 caaatatatg ctcttatgaa aaatgaaaaa ctatggagac aattaaaaat cagtggttgt
     3961 caggggttca aggagagtca gggagagata accaggtgga ggcacaggca ctttaggata
     4021 gtaaaactat tctgtgtgat attataatga tggagtcatg acataaattt ttcaaaacgc
     4081 atagagctgt acaatacaaa gagtgaatcc taatgtaaac tgtgccttgt agttaataat
     4141 agtgtatcaa aattggttca tcaatgatca caaatgtgtc acactaatgc aagatgttaa
     4201 taagagaaac tttgtgaggg ggtggtggtg gtggagaggg tatataggaa ctttctgtat
     4261 ttaaaaaaag ttttattgaa gtataattag tttaatacaa taaactgtgc atatttaata
     4321 ta
//
