LOCUS       NM_001384950            6781 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens NLR family CARD domain containing 5 (NLRC5),
            transcript variant 3, mRNA.
ACCESSION   NM_001384950 XM_005256193
VERSION     NM_001384950.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6781)
  AUTHORS   Guo,L., Wang,M., Zhao,W., Guo,M., Qian,T., Peng,F., Cao,G., Yu,S.
            and Liu,D.
  TITLE     CircATXN7 regulates the proliferation and invasion of esophageal
            cancer cells through miR-4319/NLRC5
  JOURNAL   Cell Signal 122, 111341 (2024)
   PUBMED   39121974
  REMARK    GeneRIF: CircATXN7 regulates the proliferation and invasion of
            esophageal cancer cells through miR-4319/NLRC5.
REFERENCE   2  (bases 1 to 6781)
  AUTHORS   Adcox,H.E., Hunt,J.R., Allen,P.E., Siff,T.E., Rodino,K.G.,
            Ottens,A.K. and Carlyon,J.A.
  TITLE     Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention
            and degradation to inhibit MHC class I expression
  JOURNAL   Nat Commun 15 (1), 8069 (2024)
   PUBMED   39277599
  REMARK    GeneRIF: Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic
            retention and degradation to inhibit MHC class I expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6781)
  AUTHORS   Guo,B., Zhu,H., Xiao,C., Zhang,J., Liu,X., Fang,Y., Wei,B.,
            Zhang,J., Cao,Y. and Zhan,L.
  TITLE     NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response
  JOURNAL   BMC Med 22 (1), 351 (2024)
   PUBMED   39218863
  REMARK    GeneRIF: NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6781)
  AUTHORS   Ling,L., Chen,J., Zhan,L., Fu,J., He,R., Wang,W., Wei,B., Ma,X. and
            Cao,Y.
  TITLE     NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling
            pathway in cervical cancer
  JOURNAL   Sci Rep 14 (1), 15353 (2024)
   PUBMED   38961101
  REMARK    GeneRIF: NLRC5 promotes tumorigenesis by regulating the PI3K/AKT
            signaling pathway in cervical cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6781)
  AUTHORS   Zhu,B., Ouda,R., An,N., Tanaka,T. and Kobayashi,K.S.
  TITLE     The balance between nuclear import and export of NLRC5 regulates
            MHC class I transactivation
  JOURNAL   J Biol Chem 300 (5), 107205 (2024)
   PUBMED   38519032
  REMARK    GeneRIF: The balance between nuclear import and export of NLRC5
            regulates MHC class I transactivation.
REFERENCE   6  (bases 1 to 6781)
  AUTHORS   Neerincx,A., Lautz,K., Menning,M., Kremmer,E., Zigrino,P.,
            Hosel,M., Buning,H., Schwarzenbacher,R. and Kufer,T.A.
  TITLE     A role for the human nucleotide-binding domain, leucine-rich
            repeat-containing family member NLRC5 in antiviral responses
  JOURNAL   J Biol Chem 285 (34), 26223-26232 (2010)
   PUBMED   20538593
  REMARK    GeneRIF: function for NLRC5 in anti-viral innate immune responses
REFERENCE   7  (bases 1 to 6781)
  AUTHORS   Benko,S., Magalhaes,J.G., Philpott,D.J. and Girardin,S.E.
  TITLE     NLRC5 limits the activation of inflammatory pathways
  JOURNAL   J Immunol 185 (3), 1681-1691 (2010)
   PUBMED   20610642
  REMARK    GeneRIF: NLRC5 is identified and characterized as a key regulator
            of proinflammatory pathways in immune cells.
REFERENCE   8  (bases 1 to 6781)
  AUTHORS   Cui,J., Zhu,L., Xia,X., Wang,H.Y., Legras,X., Hong,J., Ji,J.,
            Shen,P., Zheng,S., Chen,Z.J. and Wang,R.F.
  TITLE     NLRC5 negatively regulates the NF-kappaB and type I interferon
            signaling pathways
  JOURNAL   Cell 141 (3), 483-496 (2010)
   PUBMED   20434986
  REMARK    GeneRIF: Study identifies NLRC5 as a negative regulator that blocks
            two central components of the NF-kappaB and type I interferon
            signaling pathways and suggest an important role for NLRC5 in
            homeostatic control of innate immunity.
REFERENCE   9  (bases 1 to 6781)
  AUTHORS   Kuenzel,S., Till,A., Winkler,M., Hasler,R., Lipinski,S., Jung,S.,
            Grotzinger,J., Fickenscher,H., Schreiber,S. and Rosenstiel,P.
  TITLE     The nucleotide-binding oligomerization domain-like receptor NLRC5
            is involved in IFN-dependent antiviral immune responses
  JOURNAL   J Immunol 184 (4), 1990-2000 (2010)
   PUBMED   20061403
  REMARK    GeneRIF: NLRC5 may represent a molecular switch of interferon
            (IFN)-gamma activation sequence and IFN-specific response element
            signaling pathways contributing to antiviral defense mechanisms.
REFERENCE   10 (bases 1 to 6781)
  AUTHORS   Dowds,T.A., Masumoto,J., Chen,F.F., Ogura,Y., Inohara,N. and
            Nunez,G.
  TITLE     Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial
            Mediterranean fever gene product
  JOURNAL   Biochem Biophys Res Commun 302 (3), 575-580 (2003)
   PUBMED   12615073
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023825.8 and AC009090.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 1, 2020 this sequence version replaced XM_005256193.2.
            
            Summary: This gene encodes a member of the caspase recruitment
            domain-containing NLR family. This gene plays a role in cytokine
            response and antiviral immunity through its inhibition of
            NF-kappa-B activation and negative regulation of type I interferon
            signaling pathways. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (3), as well as variant 1, encodes
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3108318.1,
                                           SRR18074968.2896205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000688547.1/ ENSP00000509992.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC023825.8         189593-189653       c
            62-176              AC023825.8         162022-162136       c
            177-483             AC023825.8         158203-158509       c
            484-543             AC023825.8         156895-156954       c
            544-612             AC023825.8         155357-155425       c
            613-2263            AC023825.8         152192-153842       c
            2264-2347           AC023825.8         151055-151138       c
            2348-2431           AC023825.8         150825-150908       c
            2432-2515           AC023825.8         149354-149437       c
            2516-2605           AC023825.8         149126-149215       c
            2606-2665           AC023825.8         147747-147806       c
            2666-2731           AC023825.8         145541-145606       c
            2732-2815           AC023825.8         144959-145042       c
            2816-2899           AC023825.8         143027-143110       c
            2900-2989           AC023825.8         141926-142015       c
            2990-3058           AC023825.8         139361-139429       c
            3059-3127           AC023825.8         138492-138560       c
            3128-3217           AC023825.8         137636-137725       c
            3218-3301           AC023825.8         137145-137228       c
            3302-3391           AC023825.8         135606-135695       c
            3392-3436           AC023825.8         133718-133762       c
            3437-3526           AC023825.8         132569-132658       c
            3527-3610           AC023825.8         131582-131665       c
            3611-3694           AC023825.8         127589-127672       c
            3695-3784           AC023825.8         124370-124459       c
            3785-3847           AC023825.8         124116-124178       c
            3848-3934           AC023825.8         123691-123777       c
            3935-4018           AC023825.8         121062-121145       c
            4019-4108           AC023825.8         120149-120238       c
            4109-4174           AC023825.8         119678-119743       c
            4175-4258           AC023825.8         117679-117762       c
            4259-4342           AC023825.8         117509-117592       c
            4343-4429           AC023825.8         113912-113998       c
            4430-4510           AC023825.8         112596-112676       c
            4511-4594           AC023825.8         111740-111823       c
            4595-4687           AC023825.8         111382-111474       c
            4688-4771           AC009090.12        193659-193742       c
            4772-4855           AC009090.12        192960-193043       c
            4856-4939           AC009090.12        188895-188978       c
            4940-5023           AC009090.12        186676-186759       c
            5024-5107           AC009090.12        186199-186282       c
            5108-5191           AC009090.12        185776-185859       c
            5192-5269           AC009090.12        185558-185635       c
            5270-5353           AC009090.12        184445-184528       c
            5354-5425           AC009090.12        184286-184357       c
            5426-5509           AC009090.12        183949-184032       c
            5510-5593           AC009090.12        182397-182480       c
            5594-5677           AC009090.12        181968-182051       c
            5678-6781           AC009090.12        180058-181161       c
FEATURES             Location/Qualifiers
     source          1..6781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     gene            1..6781
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /note="NLR family CARD domain containing 5"
                     /db_xref="GeneID:84166"
                     /db_xref="HGNC:HGNC:29933"
                     /db_xref="MIM:613537"
     exon            1..61
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            62..176
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            177..483
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..5789
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /note="isoform 1 is encoded by transcript variant 3;
                     nucleotide-binding oligomerization domains 27; NOD-like
                     receptor C5; nucleotide-binding oligomerization domain,
                     leucine rich repeat and CARD domain containing 5;
                     caterpiller protein 16.1; nucleotide-binding
                     oligomerization domain protein 4"
                     /codon_start=1
                     /product="protein NLRC5 isoform 1"
                     /protein_id="NP_001371879.1"
                     /db_xref="CCDS:CCDS10773.1"
                     /db_xref="GeneID:84166"
                     /db_xref="HGNC:HGNC:29933"
                     /db_xref="MIM:613537"
                     /translation="MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSR
                     NETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTS
                     QLGAEGKSQPESQLHHGLKRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYR
                     SQIPGSGQPHAFHQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVN
                     KGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSEL
                     LFDLYLSPESDHDTVFQYLEKNADQVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNG
                     TLLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE
                     LQTNGRLRSLCAVPALCQVACLCLHHLLPDHAPGQSVALLPNMTQLYMQMVLALSPPG
                     HLPTSSLLDLGEVALRGLETGKVIFYAKDIAPPLIAFGATHSLLTSFCVCTGPGHQQT
                     GYAFTHLSLQEFLAALHLMASPKVNKDTLTQYVTLHSRWVQRTKARLGLSDHLPTFLA
                     GLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLKKLATRKLTGPKVVELCHCVDETQE
                     PELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEHREAPIHLDFDGCPLEPHCPEAL
                     VGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPL
                     CPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCP
                     TVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQV
                     HDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAG
                     VHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSEL
                     PLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPG
                     LGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWAT
                     GSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEF
                     LSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHA
                     TLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRC
                     LLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSR
                     EDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRP
                     AGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPE
                     AVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLS
                     ELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWML
                     KRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEE
                     LDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELM
                     LGCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAEN
                     NLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEA
                     AAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQ
                     HLKSQEPRLDFAFFDNQPQAPWGT"
     exon            484..543
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            544..612
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            613..2263
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2347
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2431
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2515
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2605
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2606..2665
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2731
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2815
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2899
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2989
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3058
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3059..3127
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3217
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3301
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3391
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3436
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3526
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3527..3610
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3611..3694
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3695..3784
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3847
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3848..3934
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            3935..4018
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4108
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4109..4174
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4175..4258
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4342
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4429
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4430..4510
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4594
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4595..4687
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..4771
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4772..4855
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4856..4939
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            4940..5023
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5024..5107
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5108..5191
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5192..5269
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5270..5353
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5354..5425
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5426..5509
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5510..5593
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5594..5677
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            5678..6781
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6761..6766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /note="hexamer: AATAAA"
     polyA_site      6781
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /note="major polyA site"
ORIGIN      
        1 agtttcgtgc agagcgcgga ggagccgcga gcgctgaggg tgagtgccgg gagctctgag
       61 ggagtctgca ctatggaaac aacctgtcaa tccagctcaa ggcacacata gcccagacac
      121 ccatgagacc ctctccgtgg ggaccctaga gcacctatca tgaacgagga gaccaaggct
      181 ggctcctcat ggaccccgtt ggcctccagc tcggcaacaa gaacctgtgg agctgtcttg
      241 tgaggctgct caccaaagac ccagaatggc tgaacgccaa gatgaagttc ttcctcccca
      301 acacggacct ggattccagg aacgagacct tggaccctga acagagagtc atcctgcaac
      361 tcaacaagct gcatgtccag ggttcggaca cctggcagtc tttcattcat tgtgtgtgca
      421 tgcagctgga ggtgcctctg gacctggagg tgctgctgct gagtactttt ggctatgatg
      481 atgggttcac cagccagctg ggagctgagg ggaaaagcca acctgaatct cagctccacc
      541 atggcctgaa gcgcccacat cagagctgtg ggtcctcacc ccgccggaag cagtgcaaga
      601 agcagcagct agagttggcc aagaagtacc tgcagctcct gcggacctct gcccagcagc
      661 gctacaggag ccaaatccct gggtcagggc agccccacgc cttccaccag gtctatgtcc
      721 ctccaatcct gcgccgggcc acagcatcct tagacactcc ggagggggcc attatggggg
      781 acgtcaaggt ggaagatggt gctgacgtga gcatctcgga cctcttcaac accagggtta
      841 acaagggccc gagggtgacc gtgcttttgg ggaaggctgg catgggcaag accacgctgg
      901 cccaccggct ctgccagaag tgggcagagg gccatctgaa ctgtttccag gccctgttcc
      961 tttttgaatt ccgccagctc aacttgatca cgaggttcct gacaccgtcc gagctccttt
     1021 ttgatctgta cctgagccct gaatcggacc acgacactgt cttccagtac ctggagaaga
     1081 acgctgacca agtcctgctg atctttgatg ggctagatga ggccctccag cctatgggtc
     1141 ctgatggccc aggcccagtc ctcacccttt tctcccatct ctgcaatggg accctcctgc
     1201 ctggctgccg ggtgatggct acctcccgtc cagggaagct gcctgcctgc ctgcctgcag
     1261 aggcagccat ggtccacatg ttgggctttg atgggccacg ggtggaagaa tatgtgaatc
     1321 acttcttcag cgcccagcca tcgcgggagg gggccctggt ggagttacag acaaatggac
     1381 gtctccgaag cctgtgtgcg gtgcccgcac tgtgccaagt cgcctgtctc tgcctccacc
     1441 atctgcttcc tgaccacgcc ccaggccagt ctgtggccct cctgcccaac atgactcagc
     1501 tctatatgca gatggtgctc gccctcagcc cccctgggca cttgcccacc tcgtccctac
     1561 tggacctggg ggaggtggcc ctgaggggcc tggagacagg gaaggttatc ttctatgcaa
     1621 aagatattgc tccacccttg atagcttttg gggccactca cagcctgctg acttccttct
     1681 gcgtctgcac aggccctggg caccagcaga caggctatgc tttcacccac ctcagcctgc
     1741 aggagtttct tgctgccctg cacctgatgg ccagccccaa ggtgaacaaa gacacactta
     1801 cccagtatgt taccctccat tcccgctggg tacagcggac caaagctaga ctgggcctct
     1861 cagaccacct ccccaccttc ctggcgggcc tggcatcctg cacctgccgc cccttcctta
     1921 gccacctggc gcagggcaat gaggactgtg tgggtgccaa gcaggctgct gtagtgcagg
     1981 tgttgaagaa gttggccacc cgcaagctca cagggccaaa ggttgtagag ctgtgtcact
     2041 gtgtggatga gacacaggag cctgagctgg ccagtctcac cgcacaaagc ctcccctatc
     2101 aactgccctt ccacaatttc ccactgacct gcaccgacct ggccaccctg accaacatcc
     2161 tagagcacag ggaggccccc atccacctgg attttgatgg ctgtcccctg gagccccact
     2221 gccctgaggc tctggtaggc tgtgggcaga tagagaatct cagctttaag agcaggaagt
     2281 gtggggatgc ctttgcagaa gccctctcca ggagcttgcc gacaatgggg aggctgcaga
     2341 tgctggggtt agcaggaagt aaaatcactg cccgaggcat cagccacctg gtgaaagctt
     2401 tgcctctctg tccacagctg aaagaagtca gttttcggga caaccagctc agtgaccagg
     2461 tggtgctgaa cattgtggag gttctccctc acctaccacg gctccggaag cttgacctga
     2521 gcagcaacag catctgcgtg tcaaccctac tctgcttggc aagggtggca gtcacgtgtc
     2581 ctaccgtcag gatgcttcag gccagggagg cggacctcat cttccttctt tccccgccca
     2641 cagagacaac tgcagagcta caaagagctc cagacctgca ggaaagtgac ggccagagga
     2701 aaggggctca gagcagaagc ttgacgctca ggctgcagaa gtgtcagctc caggtccacg
     2761 atgcggaggc cctcatagcc ctgctccagg aaggccctca cctggaggaa gtggacctct
     2821 cagggaacca gctggaagat gaaggctgtc ggctgatggc agaggctgca tcccagctgc
     2881 acatcgccag gaagctggac ctcagtaaca acgggctttc tgtggccggg gtgcattgtg
     2941 tgctgagggc cgtgagtgcg tgctggaccc tggcagagct gcacatcagc ctgcagcaca
     3001 aaactgtgat cttcatgttt gcccaggagc cagaggagca gaaggggccc caggagaggg
     3061 ctgcatttct tgacagcctc atgctccaga tgccctctga gctgcctctg agctcccgaa
     3121 ggatgaggct gacacattgt ggcctccaag aaaagcacct agagcagctc tgcaaggctc
     3181 tgggaggaag ctgccacctc ggtcacctcc acctcgactt ctcaggcaat gctctggggg
     3241 atgaaggtgc agcccggctg gctcagctgc tcccagggct gggagctctg cagtccttga
     3301 acctcagtga gaacggtttg tccctggatg ccgtgttggg tttggttcgg tgcttctcca
     3361 ctctgcagtg gctcttccgc ttggacatca gctttgaaag ccaacacatc ctcctgagag
     3421 gggacaagac aagcagggat atgtgggcca ctggatcttt gccagacttc ccagctgcag
     3481 ccaagttctt agggttccgt cagcgctgca tccccaggag cctctgcctc agtgagtgtc
     3541 ctctggagcc cccaagcctc acccgcctct gtgccactct gaaggactgc ccgggacccc
     3601 tggaactgca attgtcctgt gagttcctga gtgaccagag cctggagact ctactggact
     3661 gcttacctca actccctcag ctgagcctgc tgcagctgag ccagacggga ctgtccccga
     3721 aaagcccctt cctgctggcc aacaccttaa gcctgtgtcc acgggttaaa aaggtggatc
     3781 tcaggtccct gcaccatgca actttgcact tcagatccaa cgaggaggag gaaggcgtgt
     3841 gctgtggcag gttcacaggc tgcagcctca gccaggagca cgtagagtca ctctgctggt
     3901 tgctgagcaa gtgtaaagac ctcagccagg tggatctctc agcaaacctg ctgggcgaca
     3961 gcggactcag atgccttctg gaatgtctgc cgcaggtgcc catctccggt ttgcttgatc
     4021 tgagtcacaa cagcatttct caggaaagtg ccctgtacct gctggagaca ctgccctcct
     4081 gcccacgtgt ccgggaggcc tcagtgaacc tgggctctga gcagagcttc cggattcact
     4141 tctccagaga ggaccaggct gggaagacac tcaggctaag tgagtgcagc ttccggccag
     4201 agcacgtgtc caggctggcc accggcttga gcaagtccct gcagctgacg gagctcacgc
     4261 tgacccagtg ctgcctgggc cagaagcagc tggccatcct cctgagcttg gtggggcgac
     4321 ccgcagggct gttcagcctc agggtgcagg agccgtgggc ggacagagcc agggttctct
     4381 ccctgttaga agtctgcgcc caggcctcag gcagtgtcac tgaaatcagc atctccgaga
     4441 cccagcagca gctctgtgtc cagctggaat ttcctcgcca ggaagagaat ccagaagctg
     4501 tggcactcag gttggctcac tgtgaccttg gagcccacca cagccttctt gtcgggcagc
     4561 tgatggagac atgtgccagg ctgcagcagc tcagcttgtc tcaggttaac ctctgtgagg
     4621 acgatgatgc cagttccctg ctgctgcaga gcctcctgct gtccctctct gagctgaaga
     4681 catttcggct gacctccagc tgtgtgagca ccgagggcct cgcccacctg gcatctggtc
     4741 tgggccactg ccaccacttg gaggagctgg acttgtctaa caatcaattt gatgaggagg
     4801 gcaccaaggc gctgatgagg gcccttgagg ggaaatggat gctaaagagg ctggacctca
     4861 gtcaccttct gctgaacagc tccaccttgg ccttgcttac tcacagacta agccagatga
     4921 cctgcctgca gagcctcaga ctgaacagga acagtatcgg tgatgtcggt tgctgccacc
     4981 tttctgaggc tctcagggct gccaccagcc tagaggagct ggacttgagc cacaaccaga
     5041 ttggagacgc tggtgtccag cacttagcta ccatcctgcc tgggctgcca gagctcagga
     5101 agatagacct ctcagggaat agcatcagct cagccggggg agtgcagttg gcagagtctc
     5161 tcgttctttg caggcgcctg gaggagttga tgcttggctg caatgccctg ggggatccca
     5221 cagccctggg gctggctcag gagctgcccc agcacctgag ggtcctacac ctaccattca
     5281 gccatctggg cccaggtggg gccctgagcc tggcccaggc cctggatgga tccccccatt
     5341 tggaagagat cagcttggcg gaaaacaacc tggctggagg ggtcctgcgt ttctgtatgg
     5401 agctcccgct gctcagacag atagacctgg tttcctgtaa gattgacaac cagactgcca
     5461 agctcctcac ctccagcttc acgagctgcc ctgccctgga agtaatcttg ctgtcctgga
     5521 atctcctcgg ggatgaggca gctgccgagc tggcccaggt gctgccgcag atgggccggc
     5581 tgaagagagt ggacctggag aagaatcaga tcacagcttt gggggcctgg ctcctggctg
     5641 aaggactggc ccaggggtct agcatccaag tcatccgcct ctggaataac cccattccct
     5701 gcgacatggc ccagcacctg aagagccagg agcccaggct ggactttgcc ttctttgaca
     5761 accagcccca ggccccttgg ggtacttgat ggccccctca agacctttgg aatccagcca
     5821 agtgatgcac ccaaatgatc cacctttcgc ccactgggat aattgactca ggaaagaaga
     5881 gcctcggcag ggcgctctgc actccaccca ggaggaagga tacgtgtgtc ctgctgcagt
     5941 cctcagggag aacttttttg ggaaccagga gctgggtctg gacaaaggag taccctgcat
     6001 tacgtgggat atgtgtgatc aattggggac atgcgacaca caatgagggt gtcatgacaa
     6061 tgcatgacac gtacggttat atgtggcagt gtgacccctt gacatgtggc gttacatgaa
     6121 agtcagtgtg gcacgtgttc tgtggcatgg gtgctggcat cccaagtagc aggatacatg
     6181 attgttggtc tatatatgac acatgacaaa tgtccatgtc acaggactca tggctggcca
     6241 gatgacctca ggctggccca agatctaatt tattaatttt taaagcaaat acatatttat
     6301 agattgtgtg tatggagcag ctaagtcagg aaaagtcttc cgcccgagct gggaggggag
     6361 agtgtccatg cactgaccag tccaggggct caagggccag ggctctggaa caagccaggg
     6421 actcagccat taagtcccct cctgcctcaa tcctcagcct acccatctat aaacttgatg
     6481 actcctccct tacttacata ctagcttcca aggacaggtg gaggtagggc cagcctggcg
     6541 ggagtggaga agcccagtct gtcctatgta agggacaaag ccaggtctaa tggtactggg
     6601 tagggggcac tgccaagaca ataagctagg ctactgggtc cagctactac tttggtggga
     6661 ttcaggtgag tctccatgca cttcacatgt tacccagtgt tcttgttact tccaaggaga
     6721 accaagaatg gctctgtcac actcgaagcc aggcttgatc aataaacaca atggtattcc
     6781 a
//
