LOCUS       NP_001371879            1866 aa            linear   PRI 30-APR-2025
DEFINITION  protein NLRC5 isoform 1 [Homo sapiens].
ACCESSION   NP_001371879 XP_005256250
VERSION     NP_001371879.1
DBSOURCE    REFSEQ: accession NM_001384950.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1866)
  AUTHORS   Guo,L., Wang,M., Zhao,W., Guo,M., Qian,T., Peng,F., Cao,G., Yu,S.
            and Liu,D.
  TITLE     CircATXN7 regulates the proliferation and invasion of esophageal
            cancer cells through miR-4319/NLRC5
  JOURNAL   Cell Signal 122, 111341 (2024)
   PUBMED   39121974
  REMARK    GeneRIF: CircATXN7 regulates the proliferation and invasion of
            esophageal cancer cells through miR-4319/NLRC5.
REFERENCE   2  (residues 1 to 1866)
  AUTHORS   Adcox,H.E., Hunt,J.R., Allen,P.E., Siff,T.E., Rodino,K.G.,
            Ottens,A.K. and Carlyon,J.A.
  TITLE     Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention
            and degradation to inhibit MHC class I expression
  JOURNAL   Nat Commun 15 (1), 8069 (2024)
   PUBMED   39277599
  REMARK    GeneRIF: Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic
            retention and degradation to inhibit MHC class I expression.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1866)
  AUTHORS   Guo,B., Zhu,H., Xiao,C., Zhang,J., Liu,X., Fang,Y., Wei,B.,
            Zhang,J., Cao,Y. and Zhan,L.
  TITLE     NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response
  JOURNAL   BMC Med 22 (1), 351 (2024)
   PUBMED   39218863
  REMARK    GeneRIF: NLRC5 exerts anti-endometriosis effects through inhibiting
            ERbeta-mediated inflammatory response.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1866)
  AUTHORS   Ling,L., Chen,J., Zhan,L., Fu,J., He,R., Wang,W., Wei,B., Ma,X. and
            Cao,Y.
  TITLE     NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling
            pathway in cervical cancer
  JOURNAL   Sci Rep 14 (1), 15353 (2024)
   PUBMED   38961101
  REMARK    GeneRIF: NLRC5 promotes tumorigenesis by regulating the PI3K/AKT
            signaling pathway in cervical cancer.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1866)
  AUTHORS   Zhu,B., Ouda,R., An,N., Tanaka,T. and Kobayashi,K.S.
  TITLE     The balance between nuclear import and export of NLRC5 regulates
            MHC class I transactivation
  JOURNAL   J Biol Chem 300 (5), 107205 (2024)
   PUBMED   38519032
  REMARK    GeneRIF: The balance between nuclear import and export of NLRC5
            regulates MHC class I transactivation.
REFERENCE   6  (residues 1 to 1866)
  AUTHORS   Neerincx,A., Lautz,K., Menning,M., Kremmer,E., Zigrino,P.,
            Hosel,M., Buning,H., Schwarzenbacher,R. and Kufer,T.A.
  TITLE     A role for the human nucleotide-binding domain, leucine-rich
            repeat-containing family member NLRC5 in antiviral responses
  JOURNAL   J Biol Chem 285 (34), 26223-26232 (2010)
   PUBMED   20538593
  REMARK    GeneRIF: function for NLRC5 in anti-viral innate immune responses
REFERENCE   7  (residues 1 to 1866)
  AUTHORS   Benko,S., Magalhaes,J.G., Philpott,D.J. and Girardin,S.E.
  TITLE     NLRC5 limits the activation of inflammatory pathways
  JOURNAL   J Immunol 185 (3), 1681-1691 (2010)
   PUBMED   20610642
  REMARK    GeneRIF: NLRC5 is identified and characterized as a key regulator
            of proinflammatory pathways in immune cells.
REFERENCE   8  (residues 1 to 1866)
  AUTHORS   Cui,J., Zhu,L., Xia,X., Wang,H.Y., Legras,X., Hong,J., Ji,J.,
            Shen,P., Zheng,S., Chen,Z.J. and Wang,R.F.
  TITLE     NLRC5 negatively regulates the NF-kappaB and type I interferon
            signaling pathways
  JOURNAL   Cell 141 (3), 483-496 (2010)
   PUBMED   20434986
  REMARK    GeneRIF: Study identifies NLRC5 as a negative regulator that blocks
            two central components of the NF-kappaB and type I interferon
            signaling pathways and suggest an important role for NLRC5 in
            homeostatic control of innate immunity.
REFERENCE   9  (residues 1 to 1866)
  AUTHORS   Kuenzel,S., Till,A., Winkler,M., Hasler,R., Lipinski,S., Jung,S.,
            Grotzinger,J., Fickenscher,H., Schreiber,S. and Rosenstiel,P.
  TITLE     The nucleotide-binding oligomerization domain-like receptor NLRC5
            is involved in IFN-dependent antiviral immune responses
  JOURNAL   J Immunol 184 (4), 1990-2000 (2010)
   PUBMED   20061403
  REMARK    GeneRIF: NLRC5 may represent a molecular switch of interferon
            (IFN)-gamma activation sequence and IFN-specific response element
            signaling pathways contributing to antiviral defense mechanisms.
REFERENCE   10 (residues 1 to 1866)
  AUTHORS   Dowds,T.A., Masumoto,J., Chen,F.F., Ogura,Y., Inohara,N. and
            Nunez,G.
  TITLE     Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial
            Mediterranean fever gene product
  JOURNAL   Biochem Biophys Res Commun 302 (3), 575-580 (2003)
   PUBMED   12615073
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023825.8 and AC009090.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 1, 2020 this sequence version replaced XP_005256250.1.
            
            Summary: This gene encodes a member of the caspase recruitment
            domain-containing NLR family. This gene plays a role in cytokine
            response and antiviral immunity through its inhibition of
            NF-kappa-B activation and negative regulation of type I interferon
            signaling pathways. [provided by RefSeq, Oct 2011].
            
            Transcript Variant: This variant (3), as well as variant 1, encodes
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3108318.1,
                                           SRR18074968.2896205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000688547.1/ ENSP00000509992.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1866
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q13"
     Protein         1..1866
                     /product="protein NLRC5 isoform 1"
                     /note="nucleotide-binding oligomerization domains 27;
                     NOD-like receptor C5; nucleotide-binding oligomerization
                     domain, leucine rich repeat and CARD domain containing 5;
                     caterpiller protein 16.1; nucleotide-binding
                     oligomerization domain protein 4"
                     /calculated_mol_wt=204465
     Region          1..95
                     /region_name="Atypical_Card"
                     /note="Atypical caspase recruitment domain; pfam18461"
                     /db_xref="CDD:436519"
     Region          105..135
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          173..>530
                     /region_name="NACHT"
                     /note="Predicted NTPase, NACHT family domain [Signal
                     transduction mechanisms]; COG5635"
                     /db_xref="CDD:444362"
     Region          222..383
                     /region_name="NACHT"
                     /note="NACHT domain; pfam05729"
                     /db_xref="CDD:428606"
     Region          514..628
                     /region_name="NLRC4_HD2"
                     /note="NLRC4 helical domain HD2; pfam17776"
                     /db_xref="CDD:465499"
     Region          599..622
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          <649..>782
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          713..737
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          716..743
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          741..765
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          744..771
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          751..1069
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          769..792
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          772..799
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          800..826
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          830..871
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          869..892
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          872..899
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          897..921
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          930..953
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          976..1000
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1004..1026
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1009..1307
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1031..1058
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Site            order(1040..1041,1144,1172,1252,1277,1279,1305)
                     /site_type="other"
                     /note="Substrate binding site [chemical binding]"
                     /db_xref="CDD:238064"
     Region          1138..1161
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1162..1184
                     /region_name="LRR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1242..1265
                     /region_name="LRR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1272..1294
                     /region_name="LRR 14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1442..1667
                     /region_name="PPP1R42"
                     /note="protein phosphatase 1 regulatory subunit 42;
                     cl42388"
                     /db_xref="CDD:455733"
     Region          1462..1488
                     /region_name="LRR 15"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1465..1495
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1493..1516
                     /region_name="LRR 16"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1496..1523
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1521..1544
                     /region_name="LRR 17"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1524..1545
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1546..1579
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1554..1577
                     /region_name="LRR 18"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          <1556..1851
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          1578..1600
                     /region_name="LRR 19"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1580..1607
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1605..1628
                     /region_name="LRR 20"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1608..1635
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1633..1656
                     /region_name="LRR 21"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1636..1663
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1661..1684
                     /region_name="LRR 22"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1664..1688
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1687..1714
                     /region_name="LRR 23"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1690..1717
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1715..1739
                     /region_name="LRR 24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1718..1741
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1741..1762
                     /region_name="LRR 25"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1742..1769
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1770..1789
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          1795..1818
                     /region_name="LRR 26"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86WI3.3)"
     Region          1798..1825
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     CDS             1..1866
                     /gene="NLRC5"
                     /gene_synonym="CLR16.1; NOD27; NOD4"
                     /coded_by="NM_001384950.1:189..5789"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS10773.1"
                     /db_xref="GeneID:84166"
                     /db_xref="HGNC:HGNC:29933"
                     /db_xref="MIM:613537"
ORIGIN      
        1 mdpvglqlgn knlwsclvrl ltkdpewlna kmkfflpntd ldsrnetldp eqrvilqlnk
       61 lhvqgsdtwq sfihcvcmql evpldlevll lstfgyddgf tsqlgaegks qpesqlhhgl
      121 krphqscgss prrkqckkqq lelakkylql lrtsaqqryr sqipgsgqph afhqvyvppi
      181 lrratasldt pegaimgdvk vedgadvsis dlfntrvnkg prvtvllgka gmgkttlahr
      241 lcqkwaeghl ncfqalflfe frqlnlitrf ltpsellfdl ylspesdhdt vfqyleknad
      301 qvllifdgld ealqpmgpdg pgpvltlfsh lcngtllpgc rvmatsrpgk lpaclpaeaa
      361 mvhmlgfdgp rveeyvnhff saqpsregal velqtngrlr slcavpalcq vaclclhhll
      421 pdhapgqsva llpnmtqlym qmvlalsppg hlptsslldl gevalrglet gkvifyakdi
      481 appliafgat hslltsfcvc tgpghqqtgy afthlslqef laalhlmasp kvnkdtltqy
      541 vtlhsrwvqr tkarlglsdh lptflaglas ctcrpflshl aqgnedcvga kqaavvqvlk
      601 klatrkltgp kvvelchcvd etqepelasl taqslpyqlp fhnfpltctd latltnileh
      661 reapihldfd gcplephcpe alvgcgqien lsfksrkcgd afaealsrsl ptmgrlqmlg
      721 lagskitarg ishlvkalpl cpqlkevsfr dnqlsdqvvl nivevlphlp rlrkldlssn
      781 sicvstllcl arvavtcptv rmlqareadl ifllspptet taelqrapdl qesdgqrkga
      841 qsrsltlrlq kcqlqvhdae aliallqegp hleevdlsgn qledegcrlm aeaasqlhia
      901 rkldlsnngl svagvhcvlr avsacwtlae lhislqhktv ifmfaqepee qkgpqeraaf
      961 ldslmlqmps elplssrrmr lthcglqekh leqlckalgg schlghlhld fsgnalgdeg
     1021 aarlaqllpg lgalqslnls englsldavl glvrcfstlq wlfrldisfe sqhillrgdk
     1081 tsrdmwatgs lpdfpaaakf lgfrqrcipr slclsecple ppsltrlcat lkdcpgplel
     1141 qlsceflsdq sletlldclp qlpqlsllql sqtglspksp fllantlslc prvkkvdlrs
     1201 lhhatlhfrs neeeegvccg rftgcslsqe hveslcwlls kckdlsqvdl sanllgdsgl
     1261 rclleclpqv pisglldlsh nsisqesaly lletlpscpr vreasvnlgs eqsfrihfsr
     1321 edqagktlrl secsfrpehv srlatglsks lqlteltltq cclgqkqlai llslvgrpag
     1381 lfslrvqepw adrarvlsll evcaqasgsv teisisetqq qlcvqlefpr qeenpeaval
     1441 rlahcdlgah hsllvgqlme tcarlqqlsl sqvnlceddd asslllqsll lslselktfr
     1501 ltsscvsteg lahlasglgh chhleeldls nnqfdeegtk almralegkw mlkrldlshl
     1561 llnsstlall thrlsqmtcl qslrlnrnsi gdvgcchlse alraatslee ldlshnqigd
     1621 agvqhlatil pglpelrkid lsgnsissag gvqlaeslvl crrleelmlg cnalgdptal
     1681 glaqelpqhl rvlhlpfshl gpggalslaq aldgsphlee islaennlag gvlrfcmelp
     1741 llrqidlvsc kidnqtakll tssftscpal evillswnll gdeaaaelaq vlpqmgrlkr
     1801 vdleknqita lgawllaegl aqgssiqvir lwnnpipcdm aqhlksqepr ldfaffdnqp
     1861 qapwgt
//
