LOCUS       NM_178844               6413 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens NLR family CARD domain containing 3 (NLRC3),
            transcript variant 1, mRNA.
ACCESSION   NM_178844
VERSION     NM_178844.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6413)
  AUTHORS   Maimaitiaili,N., Zeng,Y., Ju,P., Zhakeer,G., E,G., Yao,H., Shi,Y.,
            Zhai,M., Zhuang,J., Peng,W., Zhuoga,D. and Yu,Q.
  TITLE     NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension
            development via IKK/NF-kappaB p65/HIF-1alpha pathway
  JOURNAL   Exp Cell Res 431 (2), 113755 (2023)
   PUBMED   37586455
  REMARK    GeneRIF: NLRC3 deficiency promotes hypoxia-induced pulmonary
            hypertension development via IKK/NF-kappaB p65/HIF-1alpha pathway.
            Review article
REFERENCE   2  (bases 1 to 6413)
  AUTHORS   He,X. and Zhou,H.
  TITLE     Decoding the IBD paradox: A triadic interplay between REG3,
            enterococci, and NOD2
  JOURNAL   Cell Host Microbe 31 (9), 1425-1427 (2023)
   PUBMED   37708849
  REMARK    GeneRIF: Decoding the IBD paradox: A triadic interplay between
            REG3, enterococci, and NOD2.
REFERENCE   3  (bases 1 to 6413)
  AUTHORS   Zhuo,Y., Li,X. and Feng,W.
  TITLE     NLRC3 is a potential prognostic biomarker that is correlated with
            immune cell infiltration in lung adenocarcinoma
  JOURNAL   Sci Rep 13 (1), 2923 (2023)
   PUBMED   36808166
  REMARK    GeneRIF: NLRC3 is a potential prognostic biomarker that is
            correlated with immune cell infiltration in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6413)
  AUTHORS   Lyu,Y., Han,M., Ma,R., Wu,X. and Liu,R.
  TITLE     [Knockdown of NLRC3 promotes proliferation and invasion of human
            colon cancer cells]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 37 (9), 769-774 (2021)
   PUBMED   34533122
  REMARK    GeneRIF: [Knockdown of NLRC3 promotes proliferation and invasion of
            human colon cancer cells].
REFERENCE   5  (bases 1 to 6413)
  AUTHORS   Kang,J.H., Li,M.J., Luan,P.P., Jiang,D.K., Chen,Y.W., Xu,X., Yu,Q.,
            Xu,Y.W., Su,Q., Peng,W.H. and Jian,W.X.
  TITLE     NLRC3 silencing accelerates the invasion of hepatocellular
            carcinoma cell via IL-6/JAK2/STAT3 pathway activation
  JOURNAL   Cell Biol Int 44 (10), 2053-2064 (2020)
   PUBMED   32584509
  REMARK    GeneRIF: NLRC3 silencing accelerates the invasion of hepatocellular
            carcinoma cell via IL-6/JAK2/STAT3 pathway activation.
REFERENCE   6  (bases 1 to 6413)
  AUTHORS   Schneider,M., Zimmermann,A.G., Roberts,R.A., Zhang,L.,
            Swanson,K.V., Wen,H., Davis,B.K., Allen,I.C., Holl,E.K., Ye,Z.,
            Rahman,A.H., Conti,B.J., Eitas,T.K., Koller,B.H. and Ting,J.P.
  TITLE     The innate immune sensor NLRC3 attenuates Toll-like receptor
            signaling via modification of the signaling adaptor TRAF6 and
            transcription factor NF-kappaB
  JOURNAL   Nat Immunol 13 (9), 823-831 (2012)
   PUBMED   22863753
  REMARK    GeneRIF: NLRC3 inhibited Toll-like receptor (TLR)-dependent
            activation of the transcription factor NF-kappaB by interacting
            with the TLR signaling adaptor TRAF6
REFERENCE   7  (bases 1 to 6413)
  AUTHORS   Ling,A., Soares,F., Croitoru,D.O., Tattoli,I., Carneiro,L.A.,
            Boniotto,M., Benko,S., Philpott,D.J. and Girardin,S.E.
  TITLE     Post-transcriptional inhibition of luciferase reporter assays by
            the Nod-like receptor proteins NLRX1 and NLRC3
  JOURNAL   J Biol Chem 287 (34), 28705-28716 (2012)
   PUBMED   22718770
  REMARK    GeneRIF: Post-transcriptional inhibition of luciferase reporter
            assays by the Nod-like receptor proteins NLRX1 and NLRC3.
REFERENCE   8  (bases 1 to 6413)
  AUTHORS   Moore,C.B., Medina,M.A., van Deventer,H.W., O'Connor,B.P.,
            Cameron,S., Taxman,D.J., Maile,R., Ting,J.P. and Cairns,B.A.
  TITLE     Downregulation of immune signaling genes in patients with large
            surface burn injury
  JOURNAL   J Burn Care Res 28 (6), 879-887 (2007)
   PUBMED   17925653
REFERENCE   9  (bases 1 to 6413)
  AUTHORS   Conti,B.J., Davis,B.K., Zhang,J., O'connor,W. Jr., Williams,K.L.
            and Ting,J.P.
  TITLE     CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that
            negatively regulates T cell function
  JOURNAL   J Biol Chem 280 (18), 18375-18385 (2005)
   PUBMED   15705585
  REMARK    GeneRIF: This report describes the first cloning and
            characterization of a novel CATERPILLER gene, CLR16.2 that is
            located on human chromosome 16. The protein encoded by this gene
            has a typical NBD-LRR configuration.
REFERENCE   10 (bases 1 to 6413)
  AUTHORS   Inohara,N. and Nunez,G.
  TITLE     NODs: intracellular proteins involved in inflammation and apoptosis
  JOURNAL   Nat Rev Immunol 3 (5), 371-382 (2003)
   PUBMED   12766759
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK090476.1, AY601811.1,
            FJ889357.1, AK090431.1, BC027864.1 and AW271824.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_178844.3.
            
            Summary: This gene encodes a NOD-like receptor family member. The
            encoded protein is a cytosolic regulator of innate immunity. This
            protein directly interacts with stimulator of interferon genes
            (STING), to prevent its proper trafficking, resulting in disruption
            of STING-dependent activation of the innate immune response.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY601811.1, SRR14038193.1298738.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359128.10/ ENSP00000352039.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK090476.1         2-13
            13-423              AY601811.1         1-411
            424-3621            FJ889357.1         1-3198
            3622-4845           AK090431.1         3818-5041
            4846-5599           BC027864.1         55-808
            5600-5600           AW271824.1         23-23
            5601-6413           BC027864.1         810-1622
FEATURES             Location/Qualifiers
     source          1..6413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..6413
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /note="NLR family CARD domain containing 3"
                     /db_xref="GeneID:197358"
                     /db_xref="HGNC:HGNC:29889"
                     /db_xref="MIM:615648"
     exon            1..255
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            256..337
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            338..399
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..601
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             424..3621
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /note="NOD-like receptor C3; nucleotide-binding
                     oligomerization domain, leucine rich repeat and CARD
                     domain containing 3; CARD15-like protein; caterpiller
                     protein 16.2; NACHT, LRR and CARD domains-containing
                     protein 3"
                     /codon_start=1
                     /product="NLR family CARD domain-containing protein 3"
                     /protein_id="NP_849172.2"
                     /db_xref="CCDS:CCDS73817.1"
                     /db_xref="GeneID:197358"
                     /db_xref="HGNC:HGNC:29889"
                     /db_xref="MIM:615648"
                     /translation="MRKQEVRTGREAGQGHGTGSPAEQVKALMDLLAGKGSQGSQAPQ
                     ALDRTPDAPLGPCSNDSRIQRHRKALLSKVGGGPELGGPWHRLASLLLVEGLTDLQLR
                     EHDFTQVEATRGGGHPARTVALDRLFLPLSRVSVPPRVSITIGVAGMGKTTLVRHFVR
                     LWAHGQVGKDFSLVLPLTFRDLNTHEKLCADRLICSVFPHVGEPSLAVAVPARALLIL
                     DGLDECRTPLDFSNTVACTDPKKEIPVDHLITNIIRGNLFPEVSIWITSRPSASGQIP
                     GGLVDRMTEIRGFNEEEIKVCLEQMFPEDQALLGWMLSQVQADRALYLMCTVPAFCRL
                     TGMALGHLWRSRTGPQDAELWPPRTLCELYSWYFRMALSGEGQEKGKASPRIEQVAHG
                     GRKMVGTLGRLAFHGLLKKKYVFYEQDMKAFGVDLALLQGAPCSCFLQREETLASSVA
                     YCFTHLSLQEFVAAAYYYGASRRAIFDLFTESGVSWPRLGFLTHFRSAAQRAMQAEDG
                     RLDVFLRFLSGLLSPRVNALLAGSLLAQGEHQAYRTQVAELLQGCLRPDAAVCARAIN
                     VLHCLHELQHTELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSL
                     SQGVLQSLLPQLLYCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKG
                     AKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGAR
                     SMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKAL
                     AEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAH
                     ALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQAL
                     QLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAV
                     NRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNH
                     RLQHINLQGNHIGDSGARMISEAIKTNAPTCTVEM"
     exon            602..2351
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2438
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2522
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2606
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2690
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2774
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2858
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2942
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3026
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3110
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3194
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3278
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3362
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3446
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..3530
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3531..6413
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6390..6395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /note="hexamer: AATAAA"
     polyA_site      6413
                     /gene="NLRC3"
                     /gene_synonym="CLR16.2; NOD3"
                     /note="major polyA site"
ORIGIN      
        1 ggagccacag ggacagccgg tgggctcggt ggggctgcag aaggtcgggg ctgcactgct
       61 ctcggccccc acacggttgg ttggttggcg tggtaagtgc cctgatccct ggtcctgaga
      121 actcaggctg gcacagggat tcccagggca tctaccacca cgcagctgga gcagggctga
      181 gcccaggagc atggagatgg acgcccccag gccccccagt cttgctgtcc ctggagcagc
      241 atcgaggccc gggagaactg tggacaacgg aaggctgagc cccatccatt gagttcctgg
      301 ggccccactg gaggggctgc tgtggccagg gtgcacggtc acaaatgaag acaccaaggc
      361 gcagagaggt gactcagcct gccctcagtc acctatctgc tcctggaggt gatccccgac
      421 tccatgagga agcaagaggt gcggacgggc agggaggccg gccagggcca cggtacgggc
      481 tccccagccg agcaggtgaa agccctcatg gatctgctgg ctgggaaggg cagtcaaggc
      541 tcccaggccc cgcaggccct ggataggaca ccggatgccc cgctggggcc ctgcagcaat
      601 gactcaagga tacagaggca ccgcaaggcc ctgctgagca aggtgggagg tggcccggag
      661 ctgggcggac cctggcacag gctggcctcc ctcctgctgg tggagggcct gacggacctg
      721 cagctgaggg aacacgactt cacacaggtg gaggccaccc gcgggggcgg gcaccccgcc
      781 aggaccgtcg ccctggaccg gctcttcctg cctctctccc gggtgtctgt cccaccccgg
      841 gtctccatca ctatcggggt ggccggcatg ggcaagacca ccctggtgag gcacttcgtc
      901 cgcctctggg cccatgggca ggtcggcaag gacttctcgc tggtgctgcc tctgaccttc
      961 cgggatctca acacccacga gaagctgtgt gccgaccgac tcatctgctc ggtcttcccg
     1021 cacgtcgggg agcccagcct ggcggtggca gtcccagcca gggccctcct gatcctggac
     1081 ggcttggatg agtgcaggac gcctctggac ttctccaaca ccgtggcctg cacggaccca
     1141 aagaaggaga tcccggtgga ccacctgatc accaacatca tccgtggcaa cctctttccg
     1201 gaagtttcca tctggatcac ctcccgtccc agtgcatctg gccagatccc agggggcctg
     1261 gtggaccgga tgacggagat ccggggcttt aacgaggagg agatcaaggt gtgtttggag
     1321 cagatgttcc ccgaggacca ggcccttctg ggctggatgc tgagccaagt gcaggctgac
     1381 agggccctgt acctgatgtg caccgtccca gccttctgca ggctcacggg gatggcgcta
     1441 ggccacctgt ggcgcagcag gacggggccc caggatgcag agctgtggcc cccgaggacc
     1501 ctgtgcgagc tctactcatg gtactttagg atggccctca gcggggaggg gcaggagaag
     1561 ggcaaggcaa gccctcgcat cgagcaggtg gcccatggtg gccgcaagat ggtggggaca
     1621 ttgggccgtc tggccttcca tgggctgctc aagaagaaat acgtgtttta cgagcaagac
     1681 atgaaggcgt ttggtgtaga cctcgctctg ctgcagggcg ccccgtgcag ctgcttcctg
     1741 cagagagagg agacgttggc atcgtcagtg gcctactgct tcacccacct gtccctgcag
     1801 gagtttgtgg cagccgcgta ttactatggc gcatccagga gggccatctt cgacctcttc
     1861 actgagagcg gcgtatcctg gcccaggctg ggcttcctca cgcatttcag gagcgcagcc
     1921 cagcgggcca tgcaggcaga ggacgggagg ctggacgtgt tcctgcgctt cctctccggc
     1981 ctcttgtctc cgagggtcaa tgccctcctg gccggctccc tgctggccca aggcgagcac
     2041 caggcctacc ggacccaggt ggctgagctc ctgcagggct gcctgcgccc cgatgccgca
     2101 gtctgtgcac gggccatcaa cgtgttgcac tgcctgcatg agctgcagca caccgagctg
     2161 gcccgcagcg tggaggaggc catggagagc ggggccctgg ccaggctgac tggtcccgcg
     2221 caccgcgctg ccctggccta cctcctgcag gtgtccgacg cctgtgccca ggaggccaac
     2281 ctgtccctga gcctcagcca gggcgtcctt cagagcctgc tgccccagct gctctactgc
     2341 cggaagctca ggctggacac caaccagttc caggaccccg tgatggagct gctgggcagc
     2401 gtgctgagtg ggaaggactg tcgcattcag aagatcagct tggcggagaa ccagatcagt
     2461 aacaaagggg ccaaagctct ggccagatcc ctcttggtca acagaagtct gacctctctg
     2521 gacctccgcg gtaactccat tggaccacaa ggggccaagg cgctggcaga cgctttgaag
     2581 atcaaccgca ccctgacctc cctgagcctc cagggcaaca ccgttaggga tgatggtgcc
     2641 aggtccatgg ctgaggcctt ggcctccaac cggaccctct ccatgctgca cctgcagaag
     2701 aacagcatcg ggcccatggg agcccagcgg atggcagatg ccttgaagca gaacaggagt
     2761 ctgaaagagc tcatgttctc cagtaatagt attggtgatg gaggtgccaa ggccctggct
     2821 gaggccctga aggtgaacca gggcctggag agcctggacc tgcagagcaa ttccatcagt
     2881 gacgcaggag tggcagcact gatgggggcc ctctgcacca accagaccct cctcagcctc
     2941 agccttcgag aaaactccat cagtcccgag ggagcccagg ccatcgctca tgccctctgc
     3001 gccaacagca ccctgaagaa cctggacctg acagccaacc tcctccacga ccagggtgcc
     3061 cgggccatcg cagtggcagt gagagaaaac cgcaccctca cctcccttca cctgcagtgg
     3121 aacttcatcc aggccggcgc tgcccaggcc ctgggacaag cactacagct caacaggagc
     3181 ctcaccagct tagatttaca ggagaacgcc atcggggatg acggagcgtg tgcggtggcc
     3241 cgtgcactga aggtcaacac agccctcact gctctctatc tccaggtggc ctcaattggt
     3301 gcttcaggcg cccaggtgct aggggaagcc ttggctgtga acagaacctt ggagattctc
     3361 gacttaagag gaaatgccat tggggtggct ggagccaaag ccctggcaaa tgctctgaag
     3421 gtaaactcaa gtctccggag actcaatctt caagagaatt ctctggggat ggacggggcg
     3481 atatgcattg ccacagcact gtctggaaac cacaggctcc agcatatcaa tctccaggga
     3541 aaccacattg gggactccgg ggccaggatg atctcagagg ccatcaagac aaatgctccc
     3601 acgtgcactg ttgaaatgtg atcctggtgg acggatcagg agaatgggca gatgctcagc
     3661 tggaagcttt tgaacagaaa ggccgacttc tggggggcct gtctgggagc tgggaacgct
     3721 gcttgctcag cacgagagcc gggctctgca gggaggaagg agaggtgctg ccggaggagg
     3781 tcgtgagctc ctcttctgct gcaggagtgg tccaggcagg gggtgacggg tactctgtta
     3841 tggcacagag aagggagggg ccacccccaa gggactaggg gccaaaggcc tgaaagctga
     3901 gcagtacagg aggctggttc cagctttaca ccctgaggac ttcatgtgtc cccaaccttt
     3961 aaaaatgttt attactgccc ctttccactc acctggttaa aaatcatccc atgctctgag
     4021 atgagctgcc acctcaagcc cgtgaggagc atccgtttgg taggggtaac agaggggacc
     4081 cttctttatc ttctcaagaa gaagatttca gggtatcatc cttacagaca tgaaaaagct
     4141 atgggaaaat tgtgaagata aatgaaagtt ttaattctag gattctggaa acagagacag
     4201 taagagttct ccaaggattt tgcctttttt gtttgttttt gagatggagt ctcgctcttg
     4261 tcgcccaggc tggagtgcag tggcacgatc tcagctccct gcaacctccg cctcccgggt
     4321 tcatgtgatt ctcctgcctc agcctcccca gtagctggga atacaggcac ccgccaccat
     4381 gcccggctaa tttttgtagt tttagtagag acggggtttc atcatgttgg ccaggctggt
     4441 ctcgaactcc tgacctcagg tgatccatca gcctgggcct cccaaagtac tgggattaca
     4501 ggcatgagcc accacacctg gccccatttt ttatttatta caaaatcaaa gacatgggtg
     4561 atgcctggca catgttgtct ggagtctggc acactggtta tcaatagcac attcagtgta
     4621 ttcagtgatg tcattcttta tttatttttg agacagaatc tgtcacccag gctggagtgc
     4681 agtggcatga tctcagctca ctgtaggctc tacctcatgg gttccagtga ttctcctgcc
     4741 tcggcctccc aagtagttgg gtctacaggc acgcaccacc acacccagct aatttttgta
     4801 tttttagtag agatggggtt tcaccatgtt gatcaggctg gtctttaact cctgacctca
     4861 agtgatccac ccacctcagc ctcccaaagt gctgggatta caggtgtgag ccactgcacc
     4921 tggcagtgat gtcattcctt actaggcttc caaagccact gctgtggcca cagcttccat
     4981 ggagacaggc aagctgagcc tctatgtggc accaattcct gcagctgttt gtgttggagg
     5041 gaaaaaaatc caaatggaca tcaacagctt tcatcaacta aataaccaca gaaaatattt
     5101 atgaagacta taaagcaatg attacttttg aattggaaag gaatcactat tatttgaaat
     5161 gtttcttcaa aagtgagcat ccggacagga accatcatgg atgctgaggc catggatgaa
     5221 ggcctactcg ggaagatgat atccttgcag tctcaaaacg gcaccccaca aaggtgatat
     5281 cctaatttac aaagggaaaa aggtacctta atctgaaatc tggcaaatgc agcctcaaca
     5341 gaagtgacag aattgaacat cgccaataat gggacacaca gacatcacat gcccccagtc
     5401 tgatgcacca cggagtcgtc tctgatgtat tcttgtcaaa aaatgtttgc ctgattctaa
     5461 tcatgaaaga acaattagaa aaaatccaaa ttgacagata ttctgcagaa taaatggcct
     5521 gacctcatca aaaacatcaa tgtcatgaaa aacacaaaac attgcagata gcgtgaaatt
     5581 aaagattaca gagatataat ttaatgcaag atctctgact ggatcctaga ctgcaggaaa
     5641 aagtctgcta taaagaacat ttggatcact tgtagtagct gggaaataaa acaaaacatt
     5701 atttgtaaaa ggggggaaat ctgaacatgg gtcttgcagt atttatgaca gtttttgcgg
     5761 ggcagagatt tctagattga cagctgtttt agtactttca aggtgatgct ctgtctgctg
     5821 gtttgcattg tttctgtctg agttaagaga ctggcagaac acagagttgc agtagccaaa
     5881 cactggagaa agctgggccc tacagaaacc taacgctgaa gaaacctcag gagccaaact
     5941 ggtggagaaa acaaagagtc ctccctctct cccttttcaa ataatgatca tacatcttca
     6001 agctgtctga aatggttaag gagttcagtc tgtcgtcagg cacacaccag agccagctag
     6061 cccacacaga ccccatcaga gcaaaacaga caagagaatt taattcatat ccacatagaa
     6121 aggacttcta ggtaggaggt agacccttta gctcccttcc aattaaagga gtccccaatt
     6181 ctggcacctg agagtcccct gggtctaaca gctatgatat ttatgtagtg tgttgcttac
     6241 ctaaatgaat acaatttcct tccagacacg tgacactgat attaaagtgc taatgagagg
     6301 gatctatttc ttcttgtacg ctaaaagaga aacagcagtt cagatttccc atcagaagtc
     6361 cgaggacttt gttcttgata actactacca ataaaaattg agtatttgaa aaa
//
