LOCUS       NM_016231               3526 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens nemo like kinase (NLK), mRNA.
ACCESSION   NM_016231
VERSION     NM_016231.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3526)
  AUTHORS   Singh,A.K., Thacker,G., Upadhyay,V., Mishra,M., Sharma,A.,
            Sethi,A., Chowdhury,S., Siddiqui,S., Verma,S.P., Pandey,A.,
            Bhatt,M.L.B. and Trivedi,A.K.
  TITLE     Nemo-like kinase blocks myeloid differentiation by targeting tumor
            suppressor C/EBPalpha in AML
  JOURNAL   FEBS J 291 (20), 4539-4557 (2024)
   PUBMED   39110129
  REMARK    GeneRIF: Nemo-like kinase blocks myeloid differentiation by
            targeting tumor suppressor C/EBPalpha in AML.
REFERENCE   2  (bases 1 to 3526)
  AUTHORS   Tejwani,L., Jung,Y., Kokubu,H., Sowmithra,S., Ni,L., Lee,C.,
            Sanders,B., Lee,P.J., Xiang,Y., Luttik,K., Soriano,A., Yoon,J.,
            Park,J., Ro,H.H., Ju,H., Liao,C., Tieze,S.M., Rigo,F.,
            Jafar-Nejad,P. and Lim,J.
  TITLE     Reduction of nemo-like kinase increases lysosome biogenesis and
            ameliorates TDP-43-related neurodegeneration
  JOURNAL   J Clin Invest 133 (16), e138207 (2023)
   PUBMED   37384409
  REMARK    GeneRIF: Reduction of nemo-like kinase increases lysosome
            biogenesis and ameliorates TDP-43-related neurodegeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3526)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3526)
  AUTHORS   Wilkes,M.C., Siva,K., Chen,J., Varetti,G., Youn,M.Y., Chae,H.,
            Ek,F., Olsson,R., Lundback,T., Dever,D.P., Nishimura,T., Narla,A.,
            Glader,B., Nakauchi,H., Porteus,M.H., Repellin,C.E., Gazda,H.T.,
            Lin,S., Serrano,M., Flygare,J. and Sakamoto,K.M.
  TITLE     Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
  JOURNAL   Nat Commun 11 (1), 3344 (2020)
   PUBMED   32620751
  REMARK    GeneRIF: Diamond Blackfan anemia is mediated by hyperactive
            Nemo-like kinase.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3526)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3526)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Ray,S., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human retina for the NEIBank
            Project: retbindin, an abundant, novel retinal cDNA and alternative
            splicing of other retina-preferred gene transcripts
  JOURNAL   Mol Vis 8, 196-204 (2002)
   PUBMED   12107411
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3526)
  AUTHORS   Kortenjann,M., Wehrle,C., Nehls,M.C. and Boehm,T.
  TITLE     Only one nemo-like kinase gene homologue in invertebrate and
            mammalian genomes
  JOURNAL   Gene 278 (1-2), 161-165 (2001)
   PUBMED   11707333
REFERENCE   8  (bases 1 to 3526)
  AUTHORS   Kehrer-Sawatzki,H., Moschgath,E., Maier,C., Legius,E., Elgar,G. and
            Krone,W.
  TITLE     Characterization of the Fugu rubripes NLK and FN5 genes flanking
            the NF1 (Neurofibromatosis type 1) gene in the 5' direction and
            mapping of the human counterparts
  JOURNAL   Gene 251 (1), 63-71 (2000)
   PUBMED   10863097
REFERENCE   9  (bases 1 to 3526)
  AUTHORS   Brott,B.K., Pinsky,B.A. and Erikson,R.L.
  TITLE     Nlk is a murine protein kinase related to Erk/MAP kinases and
            localized in the nucleus
  JOURNAL   Proc Natl Acad Sci U S A 95 (3), 963-968 (1998)
   PUBMED   9448268
REFERENCE   10 (bases 1 to 3526)
  AUTHORS   Volorio,S., Simon,G., Repetto,M., Cucciardi,M., Banfi,S.,
            Borsani,G., Ballabio,A. and Zollo,M.
  TITLE     Sequencing analysis of forty-eight human image cDNA clones similar
            to Drosophila mutant protein
  JOURNAL   DNA Seq 9 (5-6), 307-315 (1998)
   PUBMED   10524757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090287.9, DA224552.1, AK024686.1, U69562.1, DA573077.1,
            BQ636970.1, BM723604.1 and AL036279.2.
            
            On Nov 22, 2018 this sequence version replaced NM_016231.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064663.1, SRR1803617.172398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407008.8/ ENSP00000384625.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC090287.9         87540-87675
            137-682             DA224552.1         13-558
            683-844             AK024686.1         330-491
            845-1661            U69562.1           392-1208            c
            1662-2041           U69562.1           11-390              c
            2042-2526           DA573077.1         237-721
            2527-2880           BQ636970.1         281-634
            2881-3419           BM723604.1         174-712
            3420-3526           AL036279.2         15-121              c
FEATURES             Location/Qualifiers
     source          1..3526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3526
                     /gene="NLK"
                     /note="nemo like kinase"
                     /db_xref="GeneID:51701"
                     /db_xref="HGNC:HGNC:29858"
                     /db_xref="MIM:609476"
     exon            1..655
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1781
                     /gene="NLK"
                     /EC_number="2.7.11.24"
                     /codon_start=1
                     /product="serine/threonine-protein kinase NLK"
                     /protein_id="NP_057315.3"
                     /db_xref="CCDS:CCDS11224.2"
                     /db_xref="GeneID:51701"
                     /db_xref="HGNC:HGNC:29858"
                     /db_xref="MIM:609476"
                     /translation="MSLCGARANAKMMAAYNGGTSAAAAGHHHHHHHHLPHLPPPHLH
                     HHHHPQHHLHPGSAAAVHPVQQHTSSAAAAAAAAAAAAAMLNPGQQQPYFPSPAPGQA
                     PGPAAAAPAQVQAAAAATVKAHHHQHSHHPQQQLDIEPDRPIGYGAFGVVWSVTDPRD
                     GKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDYFEEIYVV
                     TELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNC
                     VLKICDFGLARVEELDESRHMTQEVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAEL
                     LGRRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTL
                     SSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYLDEGRLRYHTCMCKCCFSTSTGRV
                     YTSDFEPVTNPKFDDTFEKNLSSVRQVKEIIHQFILEQQKGNRVPLCINPQSAAFKSF
                     ISSTVAQPSEMPPSPLVWE"
     exon            656..785
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            786..841
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            842..948
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1034
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1244
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1346
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1433
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1632
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1726
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..3526
                     /gene="NLK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3505..3510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLK"
                     /note="hexamer: ATTAAA"
     polyA_site      3526
                     /gene="NLK"
                     /note="major polyA site"
ORIGIN      
        1 cttttggcaa cccacaccct tccacacacg ctcaccccaa aattaaacac caagatcctc
       61 taacttgttt ggattgactg atgaagacat aaagctctat gttttttgag gtggagtgag
      121 tggtttttct tcatttttaa atggccaaat gacagcttga cccagtttgc tttccaatca
      181 aagggcattt attttgaatg tctctttgtg gcgcaagagc caacgcaaaa atgatggcgg
      241 cttacaatgg cggtacatct gcagcagcag caggtcacca ccaccaccat caccaccacc
      301 ttccacacct ccctcctcct cacctgcacc accaccacca ccctcaacac catcttcatc
      361 cggggtcggc tgccgctgta caccctgtac agcagcacac ctcttcggca gctgcggcag
      421 ccgcagcagc ggctgcagct gcagccatgt taaaccctgg gcaacaacag ccatatttcc
      481 catcaccggc accggggcag gctcctggac cagctgcagc agccccagct caggtacagg
      541 ctgccgcagc tgctacagtt aaggcgcacc atcatcagca ctcgcatcat ccacagcagc
      601 agctggatat tgagccggat agacctattg gatatggagc ctttggtgtt gtctggtcag
      661 taacagatcc aagagatgga aagagagtag cgctcaaaaa gatgcccaac gtcttccaga
      721 atctggtctc ttgcaaaagg gtcttccggg aattgaagat gttgtgtttt tttaagcatg
      781 ataatgtact ctctgccctt gacatactcc aacctccaca cattgactat tttgaagaaa
      841 tatatgttgt cacagaattg atgcagagtg acctacataa aattatcgtc tctcctcaac
      901 cactcagctc agatcatgtc aaagtttttc tttatcagat tttgcgaggt ttgaaatatc
      961 tccattcagc tggcatttta catcgagaca ttaagccagg gaatctcctt gtgaacagca
     1021 actgtgttct aaagatttgt gattttggat tggccagagt ggaagaatta gatgaatccc
     1081 gtcatatgac tcaggaagtt gttactcagt attatcgggc tccagaaatc ctgatgggca
     1141 gccgtcatta cagcaatgct attgacatct ggtctgtggg atgtatcttt gcagaactac
     1201 taggacgaag aatattgttt caggcacaga gtcccattca gcagttggat ttgatcacgg
     1261 atctgttggg cacaccatca ctggaagcaa tgaggacagc ttgtgaaggc gctaaggcac
     1321 atatactcag gggtcctcat aaacagccat ctcttcctgt actctatacc ctgtctagcc
     1381 aggctacaca tgaagctgtt catctccttt gcaggatgtt ggtctttgat ccatccaaaa
     1441 gaatatccgc taaggatgcc ttagcccacc cctacctaga tgaagggcga ctacgatatc
     1501 acacatgtat gtgtaaatgt tgcttttcca cctccactgg aagagtttat accagtgact
     1561 ttgagcctgt caccaatccc aaatttgatg acactttcga gaagaacctc agttctgtcc
     1621 gacaggttaa agaaattatt catcagttca ttttggaaca gcagaaagga aacagagtgc
     1681 ctctctgcat caaccctcag tctgctgctt ttaagagctt tattagttcc actgttgctc
     1741 agccatctga gatgccccca tctcctctgg tgtgggagtg atggtggaag ataatgtact
     1801 actgaagatg taatgtagct ttccactgga gtctgggatt tgcaattctg gaggttaatc
     1861 atgcttgtac tgtaatttta ctaatgaagt tttaaattaa caaccactac ttgtatgata
     1921 tgaataatat ttagaaatgt tactagactt ttaatcttgt aaagtggttg tgcttttaga
     1981 agaaaaatat tttacccaga gttgcacatg ttttatgaat ttagtgcagc tgttatggct
     2041 cacctcagaa caaaagagaa ttgaaccaaa tttgggagtt tggggtttta tgttttgttt
     2101 ttcttttcta aaatgaagtg agattgttca cacacacaca cacacacaca cacacacaca
     2161 aacacaaagg acagtcatac attttgatat ttgagccatt cctaaagatt tggggttttc
     2221 taaaactaaa gaatctagga accttgcctg cgaccaatca tggagccacg tgagctgatc
     2281 gtggctgcac ctggggggag ggtagggagg aggggcatgc cacctaatga tcaagcccta
     2341 taattagctt ctcattagag ccgtgatggt gatgtgtgct gtctaaaatc caatgttgtg
     2401 ggtagagaga atgagtttgt gactaggaga gactaaactt ttgttttcct tacccagtat
     2461 aaatatatat atatatattt aatctatttt tattagaagt ttttctgctc tttcttacat
     2521 aaaagaaccc caagcatgca tctttcatgt gtgtaaataa ttcatttctg ggctaatttc
     2581 aaaagaatcc caatattgct gtatagaaag agaactagct tgcacatttt aggtctgtga
     2641 aattttgtga gacttttcct gcactggaca gtaaaaaaat aataaaagac aaaaacaaat
     2701 ttaaaaaaaa atttaagcca caaaaaaagg cacataggga attatgtcaa atgtgtttgt
     2761 gtccttaggc aaagctgtgg gagtcttgaa atgtcacagt agtaaataac ttattacttt
     2821 ttgacaagtt ctttttttct gttggaacac tgaattcttc tgtgcatatg tacatatgaa
     2881 tacaaatcga aggcctctac ctcctggagt tatacaactt ggcttgttta cctccacatg
     2941 ctgatgatga ctattttttt tttttgagtt cagtgtggag acttgaaact tgaatgtccc
     3001 ttccaacttt tatattaaaa ataaaaagac aagaaaattg aagatcattt ttcacctgta
     3061 caaggaatac taatggatcg tcttaaaatt ggtctaggaa aaaaccttgg tgtgtgttat
     3121 ggacaattaa ctgttaaagt tattgtaagt tatctgtatt tagcagagta ttttcaactt
     3181 gagtgatctg agctgaattt gaagactatt aataagttat gtttggaagt tttaacttca
     3241 atgaagtaat tatttgctgt gaaagaaaca aacattgaat tactaaacaa agatggtgca
     3301 atatctttgt ttttttttta tgaggctcct gagaatcaac ccaactgaag catttcaatt
     3361 cacttgaatg agaaacgtgt ttagtatcaa aagagcccaa gaagacactg gtgtgaaagg
     3421 tacaatctca gaggttggtc aattaccgtg gcacactttc tggtcacttt gtacaatgta
     3481 gatttgaagt acagtggtga aaacattaaa tgtgacattt gaaaaa
//
