LOCUS       NM_001365588            7194 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens neuroligin 4 Y-linked (NLGN4Y), transcript variant 8,
            mRNA.
ACCESSION   NM_001365588 XM_011531425
VERSION     NM_001365588.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7194)
  AUTHORS   Nguyen,T.A., Wu,K., Pandey,S., Lehr,A.W., Li,Y., Bemben,M.A.,
            Badger,J.D. 2nd, Lauzon,J.L., Wang,T., Zaghloul,K.A., Thurm,A.,
            Jain,M., Lu,W. and Roche,K.W.
  TITLE     A Cluster of Autism-Associated Variants on X-Linked NLGN4X
            Functionally Resemble NLGN4Y
  JOURNAL   Neuron 106 (5), 759-768 (2020)
   PUBMED   32243781
  REMARK    GeneRIF: A Cluster of Autism-Associated Variants on X-Linked NLGN4X
            Functionally Resemble NLGN4Y.
REFERENCE   2  (bases 1 to 7194)
  AUTHORS   Bogaert,A.F., Skorska,M.N., Wang,C., Gabrie,J., MacNeil,A.J.,
            Hoffarth,M.R., VanderLaan,D.P., Zucker,K.J. and Blanchard,R.
  TITLE     Male homosexuality and maternal immune responsivity to the Y-linked
            protein NLGN4Y
  JOURNAL   Proc Natl Acad Sci U S A 115 (2), 302-306 (2018)
   PUBMED   29229842
  REMARK    GeneRIF: Results suggest an association between a maternal immune
            response to neuroligin 4 Y-linked (NLGN4Y) and subsequent sexual
            orientation in male offspring.
            Erratum:[Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2212767119.
            doi: 10.1073/pnas.2212767119.. PMID: 35981140]
REFERENCE   3  (bases 1 to 7194)
  AUTHORS   Gong,Y., Wang,L., Chippada-Venkata,U., Dai,X., Oh,W.K. and Zhu,J.
  TITLE     Constructing Bayesian networks by integrating gene expression and
            copy number data identifies NLGN4Y as a novel regulator of prostate
            cancer progression
  JOURNAL   Oncotarget 7 (42), 68688-68707 (2016)
   PUBMED   27626693
  REMARK    GeneRIF: Results suggest that NLGN4Y is an important negative
            regulator in prostate cancer progression.
REFERENCE   4  (bases 1 to 7194)
  AUTHORS   Ross,J.L., Tartaglia,N., Merry,D.E., Dalva,M. and Zinn,A.R.
  TITLE     Behavioral phenotypes in males with XYY and possible role of
            increased NLGN4Y expression in autism features
  JOURNAL   Genes Brain Behav 14 (2), 137-144 (2015)
   PUBMED   25558953
  REMARK    GeneRIF: Expression of NLGN4Y, a gene that may be involved in
            synaptic function, is increased in boys with XYY
REFERENCE   5  (bases 1 to 7194)
  AUTHORS   Dinamarca,M.C., Weinstein,D., Monasterio,O. and Inestrosa,N.C.
  TITLE     The synaptic protein neuroligin-1 interacts with the amyloid
            beta-peptide. Is there a role in Alzheimer's disease?
  JOURNAL   Biochemistry 50 (38), 8127-8137 (2011)
   PUBMED   21838267
REFERENCE   6  (bases 1 to 7194)
  AUTHORS   Yamakawa,H., Oyama,S., Mitsuhashi,H., Sasagawa,N., Uchino,S.,
            Kohsaka,S. and Ishiura,S.
  TITLE     Neuroligins 3 and 4X interact with syntrophin-gamma2, and the
            interactions are affected by autism-related mutations
  JOURNAL   Biochem Biophys Res Commun 355 (1), 41-46 (2007)
   PUBMED   17292328
REFERENCE   7  (bases 1 to 7194)
  AUTHORS   Ylisaukko-oja,T., Rehnstrom,K., Auranen,M., Vanhala,R., Alen,R.,
            Kempas,E., Ellonen,P., Turunen,J.A., Makkonen,I., Riikonen,R.,
            Nieminen-von Wendt,T., von Wendt,L., Peltonen,L. and Jarvela,I.
  TITLE     Analysis of four neuroligin genes as candidates for autism
  JOURNAL   Eur J Hum Genet 13 (12), 1285-1292 (2005)
   PUBMED   16077734
  REMARK    GeneRIF: Neuroligin mutations most probably represent rare causes
            of autism; it is unlikely that the allelic variants in any of these
            genes would be major risk factors for autism.
REFERENCE   8  (bases 1 to 7194)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   9  (bases 1 to 7194)
  AUTHORS   Jamain,S., Quach,H., Betancur,C., Rastam,M., Colineaux,C.,
            Gillberg,I.C., Soderstrom,H., Giros,B., Leboyer,M., Gillberg,C. and
            Bourgeron,T.
  CONSRTM   Paris Autism Research International Sibpair Study
  TITLE     Mutations of the X-linked genes encoding neuroligins NLGN3 and
            NLGN4 are associated with autism
  JOURNAL   Nat Genet 34 (1), 27-29 (2003)
   PUBMED   12669065
REFERENCE   10 (bases 1 to 7194)
  AUTHORS   Cantallops,I. and Cline,H.T.
  TITLE     Synapse formation: if it looks like a duck and quacks like a duck
            ...
  JOURNAL   Curr Biol 10 (17), R620-R623 (2000)
   PUBMED   10996085
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010726.4, AC010979.3,
            AC010879.2 and AC011903.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 5, 2018 this sequence version replaced XM_011531425.2.
            
            Summary: This gene encodes a type I membrane protein that belongs
            to the family of neuroligins, which are cell adhesion molecules
            present at the postsynaptic side of the synapse, and may be
            essential for the formation of functional synapses. Alternatively
            spliced transcript variants have been found for this gene.[provided
            by RefSeq, Mar 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.174867.1,
                                           SRR1803616.230736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684976.1/ ENSP00000510011.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC010726.4         163939-164118
            181-763             AC010979.3         85095-85677
            764-823             AC010879.2         73351-73410
            824-976             AC010879.2         77009-77161
            977-1162            AC010879.2         178080-178265
            1163-1952           AC011903.4         3901-4690
            1953-7194           AC011903.4         14584-19825
FEATURES             Location/Qualifiers
     source          1..7194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.221"
     gene            1..7194
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /note="neuroligin 4 Y-linked"
                     /db_xref="GeneID:22829"
                     /db_xref="HGNC:HGNC:15529"
                     /db_xref="MIM:400028"
     exon            1..180
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /inference="alignment:Splign:2.1.0"
     exon            181..763
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2802
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 8; alternative HNL4Y"
                     /codon_start=1
                     /product="neuroligin-4, Y-linked isoform 4 precursor"
                     /protein_id="NP_001352517.1"
                     /db_xref="CCDS:CCDS94714.1"
                     /db_xref="GeneID:22829"
                     /db_xref="HGNC:HGNC:15529"
                     /db_xref="MIM:400028"
                     /translation="MLRPQGLLWLPLLFTSVCVMLNSNVLLWITALAIKFTLIDSQAQ
                     YPVVNTNYGKIQGLRTPLPSEILGPVEQYLGVPYASPPTGERRFQPPESPSSWTGIRN
                     ATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIYVPMEDGTN
                     IKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIV
                     ITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAG
                     ASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLDTTDM
                     VECLKNKNYKELIQQTITPATYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVN
                     QGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADK
                     ENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSA
                     HGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF
                     IHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNLNEIF
                     QYVSTTTKVPPPDMTSFPYGTRRSPAKIWPTTKRPAITPANNPKHSKDPHKTGPEDTT
                     VLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHETHRHPSPQRNTTND
                     ITHIQNEEIMSLQMKQLEHDHECESLQAHDTLRLTCPPDYTLTLRRSPDDIPFMTPNT
                     ITMIPNTLMGMQPLHTFKTFSGGQNSTNLPHGHSTTRV"
     exon            764..823
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /inference="alignment:Splign:2.1.0"
     exon            824..976
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1162
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1952
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..7194
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5470..5475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /note="hexamer: AATAAA"
     polyA_site      5510
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /note="major polyA site"
     regulatory      6461..6466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /note="hexamer: ATTAAA"
     polyA_site      6485
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
     regulatory      7178..7183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
                     /note="hexamer: AATATA"
     polyA_site      7194
                     /gene="NLGN4Y"
                     /gene_synonym="HNL4Y"
ORIGIN      
        1 acagtcggag gcggcagaga cggtggcggg tgagctaggg gctgtgagac gaagcaggga
       61 gagagtgaac ttcagccccg tcccctcccc actgccacgg ctggggcaac ccaacccgcg
      121 cctgaagcgg cttggcttga cctgcggaag cgcgggccgg gatggcgtgg ggagagggag
      181 gttgcattgg agttttcgaa agacttatct ttctgcaggc tcgcctctga gctttgtctc
      241 cttggagcca cctcacttag acagcttcgg atgtggatgc agatttgaac catgttgcgt
      301 ccccagggac tgctatggct ccctttgttg ttcacctctg tctgtgtcat gttaaactcc
      361 aatgttcttc tgtggataac tgctcttgcc atcaagttca ccctcattga cagccaagca
      421 cagtatccag ttgtcaacac aaattatggt aaaatccagg gcctaagaac accattaccc
      481 agtgagatct tgggtccagt ggagcagtac ttaggggtcc cctatgcctc acccccaact
      541 ggagagaggc ggtttcagcc accagaatcc ccatcctcct ggactggcat ccgaaatgct
      601 actcagtttt ctgctgtgtg cccccagcac ctggatgaaa gattcttatt gcatgacatg
      661 ctgcccatct ggtttaccac cagtttggat actttgatga cctatgttca agatcaaaat
      721 gaagactgcc tttacttaaa catctatgtg cccatggaag atggaaccaa cataaagaga
      781 aatgcagacg atataaccag taatgaccat ggtgaagata aagatattca tgaacagaac
      841 agtaagaagc ctgttatggt ctatatccat gggggatctt acatggaggg aaccggtaac
      901 atgattgatg gcagcatttt ggccagctat gggaacgtca tcgttatcac cattaactac
      961 cgtctgggaa tactagggtt tttaagtacc ggtgaccagg cagcaaaagg caactatggg
     1021 ctcctggatc agattcaagc actgaggtgg attgaggaga atgtcggagc ctttggcggg
     1081 gaccccaaga gagtgactat ctttggctcg ggggctgggg cctcctgtgt cagcctgttg
     1141 accctgtccc actactcaga aggtctcttc cagaaggcca tcattcagag cggcactgcc
     1201 ctgtccagct gggcagtgaa ctaccagccg gccaagtaca ctcggatatt ggcagacaag
     1261 gtcggctgca acatgctgga caccacggac atggtagaat gtctgaagaa caagaactac
     1321 aaggagctca tccagcagac catcaccccg gccacctacc acatagcctt tgggccggtg
     1381 atcgacggcg acgtcatccc agacgacccc cagatcctga tggagcaagg cgagttcctc
     1441 aactacgaca tcatgctggg cgtcaaccaa ggggaaggcc tgaagttcgt ggacggcatc
     1501 gtggataacg aggacggtgt gacgcccaac gactttgact tctccgtgtc caacttcgtg
     1561 gacaaccttt acggctaccc tgaagggaaa gacactttgc gggagactat caagttcatg
     1621 tacacagact gggccgataa ggaaaacccg gagacgcggc ggaaaaccct ggtggctctc
     1681 tttactgacc atcagtgggt ggcccccgcc gtggccaccg ccgacctgca cgcgcagtac
     1741 ggctccccca cctacttcta tgccttctat catcactgcc aaagcgaaat gaagcccagc
     1801 tgggcagatt cggcccatgg cgatgaagtc ccctatgtct tcggcatccc catgatcggt
     1861 cccacagagc tcttcagttg taatttctcc aagaacgacg tcatgctcag tgccgtggtg
     1921 atgacctact ggacgaactt cgccaaaact ggtgatccaa accaaccagt tcctcaggat
     1981 accaagttca ttcatacaaa acccaatcgc tttgaagaag tggcctggtc caagtataat
     2041 cccaaagacc agctctatct gcatattggc ttgaaaccca gagtgagaga tcactaccgg
     2101 gcaacgaaag tggctttctg gttggaattg gttcctcatt tgcacaactt gaacgagata
     2161 ttccagtatg tttcaacaac cacaaaggtt cctccaccag acatgacatc atttccctat
     2221 ggcacccggc gatctcccgc caagatatgg ccaaccacca aacgcccagc aatcactcct
     2281 gccaacaatc ccaaacactc taaggaccct cacaaaacag ggcccgagga cacaactgtc
     2341 ctcattgaaa ccaaacgaga ttattccacc gaattaagtg tcaccattgc cgtcggggcg
     2401 tcgctcctct tcctcaacat cttagccttt gcggcgctgt actacaaaaa ggacaagagg
     2461 cgccatgaga ctcacaggca ccccagtccc cagagaaaca ccacaaatga tatcactcac
     2521 atccagaacg aagagatcat gtctctgcag atgaagcagc tggaacacga tcacgagtgt
     2581 gagtcgctgc aggcacacga cacgctgagg ctcacctgcc ctccagacta caccctcacg
     2641 ctgcgccggt cgccggatga catcccattt atgacgccaa acaccatcac catgattcca
     2701 aacacattga tggggatgca gcctttacac acttttaaaa ccttcagtgg aggacaaaac
     2761 agtacaaatt taccccacgg acattccacc actagagtat agcttttccc tatttcccct
     2821 cctatccctc tgcccctact gctcagcaat gtaaaagaga caaataagga gaaagaaaat
     2881 ctccaaacca ggaatgtttt tgtgccactg actttagata aaaatgcaaa agggcagtca
     2941 tcctgtccca gcagaccctt ctcattggca ttttccagta ttgtgagatc aatttctgac
     3001 catatgaaat gtgaaaagta tatgtttctg ttacaatact gctttaagat ctaaaccatg
     3061 ccaacagatg tttcgtgtga ctaggacatc accatttcaa ggaactgtgt gtttccaaca
     3121 tcatggtagc agcacacact tccaaagctc agccagggac acttaatatt ttttaattac
     3181 aatggaaatt taaacatttt tatgtgggct acacaatgga tggctcttct taagtgaaga
     3241 aagactctat aggcttttac acagcacatg aagcagtaat ccagaaagaa ggaaatgcag
     3301 aattttatta tcaaagtaag cgaattgact gtgcagaaaa attgtagggt tctgtggaag
     3361 gaggtattct gccagcctga actatattta agaaactttg taaaaaataa aaatgtatat
     3421 agctgtgagc tcaaacaaaa actgcagaca aacaaaaaag agaaaagctt ttatttgtgt
     3481 tttcagtttg aaagaacttt tagcaaggtt gtgctttcaa acacatatta gtcctaccac
     3541 cttagttcct ctacagcaaa agaggctttt cttcttaatt acatgtaaac aaagacatgg
     3601 gattttctga cgtaagattt tcatttgtag gaatatgtga tgtcaaatgg aagactcaga
     3661 agttttgtgt ggcctatttc tccctgtcag gttgcacaga tgcatgtaga gcattcttag
     3721 gagaccattg ttttagaaaa ctttgatttg tacatgttag ttttcatgaa attgcaacac
     3781 agagataggt cctaaaagtg gaatgtattt aaaacttgtt gaattagaca cacacacaca
     3841 gacacacaca aagaatcagc agagaaaaca aaatacaagt cctgttctgt agttcttgcc
     3901 ctttgaatat atttgggaag agttgcttcc tatttcagga ccctgccaaa aaagaagaaa
     3961 gcttgccttt ggtggggcta tgccccttgg agtaaataca gctctgtgtt ccctagcagc
     4021 tgccggagga tttggctgat gaagtacctg ctcagcttag ctaatcagat taaaggaaga
     4081 catgtatgtc ttttgtttaa gcacctagtc ccttatgtat cagtaaacag gtttttaaaa
     4141 atcttttatg tcatttatag gataaaacat atgcttgtct gaaaatatca ccttttgtgg
     4201 atttatctga tcaccaaata ataaatatta agaagaatgg gggaaaaagg atagaatatt
     4261 aaaactgctt tgcataggtt tttggggaaa ttaggatatc ttcactgaca agacactgaa
     4321 tggaatttat tcacccattt taaattggtt acttggggat cagagatttg tctctccaac
     4381 agcttgtggt tttcttatta ctcattttca ggaaagtttg tagtattaca aggcagaagg
     4441 aaacacagta gcaatggttg ctctatattt tgtctttcaa agattactgc attaccaaga
     4501 aacagtagcc aaagatgttt gaagatcatg tcccttagct gcattgtggg ttattctaga
     4561 aatccaatgt taaatgcctc tactaaagtg gggattcccc ataaaaattg tccagctacc
     4621 tgactctttt gcaataacaa ctttgattac tgaatccata cactcaaact atagtgatat
     4681 atcagtgttt gggagtgacc tctagaaaaa agaaaactgt ttttagaaat acataaaatc
     4741 acttccaaat cctgttgctt atgttgggtt aaatttgaaa gcaattctct atatataaat
     4801 atgtgaaata ttatgatctg aacttagcac acatgaagca acatttcttt gctacacaga
     4861 ggtgtcttgg aaagatttca ttcccaattc atttttcata gatctataat caggcaattt
     4921 ctgcaagcaa tgtatgaccc cacctgagca accacaaata ggctctccat gaaactgcaa
     4981 aggaactgat gtgtggcatc catgctggtt ttgtctgtct ataatatgaa ttcaagtatc
     5041 tgttcatatt tccaattgtc tcctgctagc aatatgtgcc acaacatgac agtcttgtga
     5101 catcttaagg aaaagaagag ttcctgttaa atgaatagct ttagctttta caggggatta
     5161 tgattaaaag tgatttagta catcttacat gatatctcat ttctacgtga aaagaagtta
     5221 tagaatcttc atagagttcc atgagaaaaa tatacttgct atttatagaa aacgagaaaa
     5281 aagaaaaaaa tgagaaacaa gtaagaaaaa atcctttcct aggcttttcc ttgatcttca
     5341 gaggcacaca gggtttaatg gttccttagg ttattatttt gaggttttgt tctttctttt
     5401 gccttaagta atgacagaag atatatatgg ccagacacat atgtataaac ttttcagcag
     5461 cattttaata ataaaatatc acactatttt ctaatgcttt gtacaaacaa ttatgcatct
     5521 gttctttctt ggtaggtgga atattttatt tacttttgcc attctttgaa tgcctttttc
     5581 tttgtaaatg ctacatggta gctctcacat aggctacaaa tggataaata catttggtaa
     5641 tgggatggtt tctttagctt tggccagctg cacagttgag gaggctctgc tggcctgatt
     5701 ttggaaaacc aagccctgtt tggtgaagct cctgagatga cactgcctga aaatgagtat
     5761 ttggttgtgt tatttctacc actgttcatt cttgtgtctc tgtgttttga tttgtgttca
     5821 acaaactgat gccttaatgg tttcaaatag aaagccttag gtgagtaaac cttctagtga
     5881 cagtaagaaa ttctactgaa tgaaactcca gaggcagaaa atcattgtca ttccaatggg
     5941 agctcaattg tcaattcctt cctgtgcatt cagccatcac gaacttattt cacattcaca
     6001 gtagctctaa ggggcaggca cctgcattac tcccctttca taatggaaga tgttctgact
     6061 ttgaaacatg cccccttgga caggaaaatt tgatggataa caggatagca tatcctcata
     6121 tcccaatctt tcaccaagaa gttatacagc aaacacttgt aagtcaaggt cttgcatgat
     6181 aatctttgct aagtagcaag taaagaaata tagcaaggac ccagactctt tggaatatgt
     6241 gaactaaatc cttcagatgt tgttggcctc aatcatgttg tgaaggcaca caggagaata
     6301 catacacaca catatgcata tatgtatata tgtacatgta tgtgtacatt atatatgagt
     6361 atacatgtac ctatcctata tatgtatgta tgtatagagt cacagactgc ataatgtttt
     6421 ggacaaatat agatcacata tatgatgata gtgtcttgag attaaaatac catgttttta
     6481 ttgtaccttt tcagtgttca gatatgttta gacaaacaaa tgcttatcat tgtgttacag
     6541 ttgcctaagg tcttctctcc agtcacatgc tgtacaggtt tgtagactgg aagaactagg
     6601 ctataccata gagcctaggt gtgctatagg ctacacatcg gttttgtgta agtatactac
     6661 atgatgtttg cacaatgatg aaattgccta acgaaacttt tctcagaaac ctattgatac
     6721 atgactgtgt atgtttacat tatatatact gtatatgcac acatgcatat atgcatatat
     6781 atgttataca tttacatatg tacatggata tcacatactt taaattcctg aagatgtcat
     6841 tttcattaaa tacatatgca cacacactca taaacacaca cagactcata tatacacaca
     6901 aatctataac acatttgtgc tcacatatac attcctctgt gtgtgtgtgt gtattacatt
     6961 actgcttttt atctgtgaaa tcacattctg cagtttcatt tactgtgatc aactatgatc
     7021 taaaaatata tgagtacttc aataagatat tttgaaagaa accacattca cataacattt
     7081 atgacattat aattgttcta ttttattagc tattgttcat ctcttactcc atctacttta
     7141 taaattaagc ttcataataa gtgtgtatat ttaataaaat atatagtata taaa
//
