LOCUS       NM_020795               4980 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens neuroligin 2 (NLGN2), mRNA.
ACCESSION   NM_020795
VERSION     NM_020795.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4980)
  AUTHORS   Zhang,Z., Hou,M., Ou,H., Wang,D., Li,Z., Zhang,H. and Lu,J.
  TITLE     Expression and structural analysis of human neuroligin 2 and
            neuroligin 3 implicated in autism spectrum disorders
  JOURNAL   Front Endocrinol (Lausanne) 13, 1067529 (2022)
   PUBMED   36479216
  REMARK    GeneRIF: Expression and structural analysis of human neuroligin 2
            and neuroligin 3 implicated in autism spectrum disorders.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4980)
  AUTHORS   Schafer,J., Forster,L., Mey,I., Papadopoulos,T., Brose,N. and
            Steinem,C.
  TITLE     Neuroligin-2 dependent conformational activation of collybistin
            reconstituted in supported hybrid membranes
  JOURNAL   J Biol Chem 295 (52), 18604-18613 (2020)
   PUBMED   33127642
  REMARK    GeneRIF: Neuroligin-2 dependent conformational activation of
            collybistin reconstituted in supported hybrid membranes.
REFERENCE   3  (bases 1 to 4980)
  AUTHORS   Ali,H., Marth,L. and Krueger-Burg,D.
  TITLE     Neuroligin-2 as a central organizer of inhibitory synapses in
            health and disease
  JOURNAL   Sci Signal 13 (663) (2020)
   PUBMED   33443230
  REMARK    GeneRIF: Neuroligin-2 as a central organizer of inhibitory synapses
            in health and disease.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4980)
  AUTHORS   Heshmati,M., Aleyasin,H., Menard,C., Christoffel,D.J.,
            Flanigan,M.E., Pfau,M.L., Hodes,G.E., Lepack,A.E., Bicks,L.K.,
            Takahashi,A., Chandra,R., Turecki,G., Lobo,M.K., Maze,I.,
            Golden,S.A. and Russo,S.J.
  TITLE     Cell-type-specific role for nucleus accumbens neuroligin-2 in
            depression and stress susceptibility
  JOURNAL   Proc Natl Acad Sci U S A 115 (5), 1111-1116 (2018)
   PUBMED   29339486
  REMARK    GeneRIF: nucleus accumbens neuroligin-2 has a role in depression
            and stress susceptibility
REFERENCE   5  (bases 1 to 4980)
  AUTHORS   Gangwar,S.P., Zhong,X., Seshadrinathan,S., Chen,H., Machius,M. and
            Rudenko,G.
  TITLE     Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin
            Trans-synaptic Bridges
  JOURNAL   Neuron 94 (6), 1132-1141 (2017)
   PUBMED   28641112
  REMARK    GeneRIF: MDGAs regulate the formation of neuroligin-neurexin
            trans-synaptic bridges by sterically blocking access of neurexins
            to neuroligins.
REFERENCE   6  (bases 1 to 4980)
  AUTHORS   Scheiffele,P., Fan,J., Choih,J., Fetter,R. and Serafini,T.
  TITLE     Neuroligin expressed in nonneuronal cells triggers presynaptic
            development in contacting axons
  JOURNAL   Cell 101 (6), 657-669 (2000)
   PUBMED   10892652
REFERENCE   7  (bases 1 to 4980)
  AUTHORS   Philibert,R.A., Winfield,S.L., Sandhu,H.K., Martin,B.M. and
            Ginns,E.I.
  TITLE     The structure and expression of the human neuroligin-3 gene
  JOURNAL   Gene 246 (1-2), 303-310 (2000)
   PUBMED   10767552
REFERENCE   8  (bases 1 to 4980)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   9  (bases 1 to 4980)
  AUTHORS   Irie,M., Hata,Y., Takeuchi,M., Ichtchenko,K., Toyoda,A., Hirao,K.,
            Takai,Y., Rosahl,T.W. and Sudhof,T.C.
  TITLE     Binding of neuroligins to PSD-95
  JOURNAL   Science 277 (5331), 1511-1515 (1997)
   PUBMED   9278515
REFERENCE   10 (bases 1 to 4980)
  AUTHORS   Ichtchenko,K., Nguyen,T. and Sudhof,T.C.
  TITLE     Structures, alternative splicing, and neurexin binding of multiple
            neuroligins
  JOURNAL   J Biol Chem 271 (5), 2676-2682 (1996)
   PUBMED   8576240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113189.11, AF376802.1,
            BM800364.1, DR763679.1, EL949788.1, AA447769.1 and AI613237.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020795.3.
            
            Summary: This gene encodes a member of a family of neuronal cell
            surface proteins. Members of this family may act as splice
            site-specific ligands for beta-neurexins and may be involved in the
            formation and remodeling of central nervous system synapses.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF376802.1, SRR9304719.239650.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302926.7/ ENSP00000305288.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC113189.11        57928-58265
            339-848             AF376802.1         1-510
            849-849             AC113189.11        58776-58776
            850-1376            AF376802.1         512-1038
            1377-1377           AC113189.11        65160-65160
            1378-3131           AF376802.1         1040-2793
            3132-3677           BM800364.1         118-663
            3678-4240           DR763679.1         65-627
            4241-4854           EL949788.1         10-623
            4855-4875           AA447769.1         108-128             c
            4876-4980           AI613237.1         2-106               c
FEATURES             Location/Qualifiers
     source          1..4980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..4980
                     /gene="NLGN2"
                     /note="neuroligin 2"
                     /db_xref="GeneID:57555"
                     /db_xref="HGNC:HGNC:14290"
                     /db_xref="MIM:606479"
     exon            1..868
                     /gene="NLGN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             412..2919
                     /gene="NLGN2"
                     /codon_start=1
                     /product="neuroligin-2 precursor"
                     /protein_id="NP_065846.1"
                     /db_xref="CCDS:CCDS11103.1"
                     /db_xref="GeneID:57555"
                     /db_xref="HGNC:HGNC:14290"
                     /db_xref="MIM:606479"
                     /translation="MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVV
                     NTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL
                     PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRD
                     EATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGV
                     LGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLIL
                     SHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPS
                     RELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVE
                     DSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKT
                     LLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVF
                     GVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE
                     EVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPP
                     YATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAV
                     GASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEE
                     ELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPP
                     PPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV"
     exon            869..919
                     /gene="NLGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1069
                     /gene="NLGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1255
                     /gene="NLGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1448
                     /gene="NLGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..2045
                     /gene="NLGN2"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..4980
                     /gene="NLGN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4963..4968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NLGN2"
                     /note="hexamer: TATAAA"
     polyA_site      4980
                     /gene="NLGN2"
                     /note="major polyA site"
ORIGIN      
        1 gcaacttggt ctgaattcca ggtcactaac cacttgtctc ttctgtttcc ccattccttt
       61 ctgtctgccc catccaattt cccttgccct cttccacctc tgtatttttc tgtctgtccg
      121 tctgtctgta tcctgcctcc ctgcccctct cgctccaccc cccgcaggtc gggcctgcct
      181 tcaccttctc ccatttcctt ccccttcccc accccgtgcc ccctccatgg agaggaacag
      241 accccttctc tgtccagtct aacccaggtc cctccccaac cccctcctcc ctcctttccc
      301 cccgcccctc ctccctcctg gggcgagggg ggcctccctc cctctccccc ccttctctct
      361 ctctccgagg ggggggggtc ccagggaggg agggggggtc ccccgatcag catgtggctc
      421 ctggcgctgt gtctggtggg gctggcgggg gctcaacgcg ggggaggggg tcccggcggc
      481 ggcgccccgg gcggccccgg cctgggcctc ggcagcctcg gcgaggagcg cttcccggtg
      541 gtgaacacgg cctacgggcg agtgcgcggt gtgcggcgcg agctcaacaa cgagatcctg
      601 ggccccgtcg tgcagttctt gggcgtgccc tacgccacgc cgcccctggg cgcccgccgc
      661 ttccagccgc ctgaggcgcc cgcctcgtgg cccggcgtgc gcaacgccac caccctgccg
      721 cccgcctgcc cgcagaacct gcacggggcg ctgcccgcca tcatgctgcc tgtgtggttc
      781 accgacaact tggaggcggc cgccacctac gtgcagaacc agagcgagga ctgcctgtac
      841 ctcaacctct acgtgcccac cgaggacggt ccgctcacaa aaaaacgtga cgaggcgacg
      901 ctcaatccgc cagacacaga tatccgtgac cctgggaaga agcctgtgat gctgtttctc
      961 catggcggct cctacatgga ggggaccgga aacatgttcg atggctcagt cctggctgcc
     1021 tatggcaacg tcattgtagc cacgctcaac taccgtcttg gggtgctcgg ttttctcagc
     1081 accggggacc aggctgcaaa aggcaactat gggctcctgg accagatcca ggccctgcgc
     1141 tggctcagtg aaaacatcgc ccactttggg ggcgaccccg agcgtatcac catctttggt
     1201 tccggggcag gggcctcctg cgtcaacctt ctgatcctct cccaccattc agaagggctg
     1261 ttccagaagg ccatcgccca gagtggcacc gccatttcca gctggtctgt caactaccag
     1321 ccgctcaagt acacgcggct gctggcagcc aaggtgggct gtgaccgaga ggacagcgct
     1381 gaagctgtgg agtgtctgcg ccggaagccc tcccgggagc tggtggacca ggacgtgcag
     1441 cctgcccgct accacatcgc ctttgggccc gtggtggatg gcgacgtggt ccccgatgac
     1501 cctgagatcc tcatgcagca gggagaattc ctcaactacg acatgctcat cggcgtcaac
     1561 cagggagagg gcctcaagtt cgtggaggac tctgcagaga gcgaggacgg tgtgtctgcc
     1621 agcgcctttg acttcactgt ctccaacttt gtggacaacc tgtatggcta cccggaaggc
     1681 aaggatgtgc ttcgggagac catcaagttt atgtacacag actgggccga ccgggacaat
     1741 ggcgaaatgc gccgcaaaac cctgctggcg ctctttactg accaccaatg ggtggcacca
     1801 gctgtggcca ctgccaagct gcacgccgac taccagtctc ccgtctactt ttacaccttc
     1861 taccaccact gccaggcgga gggccggcct gagtgggcag atgcggcgca cggggatgaa
     1921 ctgccctatg tctttggcgt gcccatggtg ggtgccaccg acctcttccc ctgtaacttc
     1981 tccaagaatg acgtcatgct cagtgccgtg gtcatgacct actggaccaa cttcgccaag
     2041 actggggacc ccaaccagcc ggtgccgcag gataccaagt tcatccacac caagcccaat
     2101 cgcttcgagg aggtggtgtg gagcaaattc aacagcaagg agaagcagta tctgcacata
     2161 ggcctgaagc cacgcgtgcg tgacaactac cgcgccaaca aggtggcctt ctggctggag
     2221 ctcgtgcccc acctgcacaa cctgcacacg gagctcttca ccaccaccac gcgcctgcct
     2281 ccctacgcca cgcgctggcc gcctcgtccc cccgctggcg ccccgggcac acgccggccc
     2341 ccgccgcctg ccaccctgcc tcccgagccc gagcccgagc ccggcccaag ggcctatgac
     2401 cgcttccccg gggactcacg ggactactcc acggagctga gcgtcaccgt ggccgtgggt
     2461 gcctccctcc tcttcctcaa catcctggcc tttgctgccc tctactacaa gcgggaccgg
     2521 cggcaggagc tgcggtgcag gcggcttagc ccacctggcg gctcaggctc tggcgtgcct
     2581 ggtgggggcc ccctgctccc cgccgcgggc cgtgagctgc caccagagga ggagctggtg
     2641 tcactgcagc tgaagcgggg tggtggcgtc ggggcggacc ctgccgaggc tctgcgccct
     2701 gcctgcccgc ccgactacac cctggccctg cgccgggcac cggacgatgt gcctctcttg
     2761 gcccccgggg ccctgaccct gctgcccagt ggcctggggc caccgccacc cccaccgccc
     2821 ccctcccttc atcccttcgg gcccttcccc ccgccccctc ccaccgccac cagccacaac
     2881 aacacgctac cccaccccca ctccaccact cgggtatagg gggtgggtgg ggaggccctc
     2941 ctccccggcc ctccctggcc cggccactcc gaaggcaggg aggaggactt ggcaactggc
     3001 ttttctcctg tggagtcgtc acacgccatc cagcagcgct aaggtggaca tgggattcct
     3061 ccctgcgatg cgtgtctttc ccacgcagag aagcccagtc tcttctctgg atctgggcct
     3121 ttgaacaact ggggggcgtt ttctcccccc cattgggaca ccagtcttcg gtgtgtggaa
     3181 tgtggtattt tcccgcgtgg aggtgtgctt tctcacaacg gggtgtgttt tcccatgtgc
     3241 agggtgaggt ttttttttgc caccctggac acatgttggc cccctcaaag aatttctgtg
     3301 gggatttgta ccccagaatc ctgttccccc atcccttctc ccacctcctc ccctctccct
     3361 ccccctggag accctggaag tggtgtgttc acatacagtg acccttggcc accagaccac
     3421 agaggatgga gcctgggaag cagcgaggaa atcacagccc cctcgcccct gcctcccttg
     3481 cccctacccc ggcgaagcat gttccccccg acgcccccct tggcacaagt cagatgaagc
     3541 acgttctgcc ggggaggccc tcaccttcca gagaggacag acacagattt cctgctgggg
     3601 gagggaggag tccacgcatc ctgatgctgc ctggaagctt attttcccgt ggccaggacg
     3661 catttctctg agtggaaaca ggttcttgca tgtggatgtg tgtttcccca ggcagacggc
     3721 ccctctcttc ccagcacttc cctgcctccc ccaggcctca ggcccagcac ccagttcctc
     3781 ctcacatggc aggtgagcac agacttctag ttggcaggag ctgaggaggg tgaacaaacc
     3841 ccgagggagg cccggccctt gctcccgagt tggggggagg gggtgtggca acgtgccccc
     3901 cgcagaggcc acgcatgttt gaccaaagcc ctcattgtgg tccgaggaca gccttttccc
     3961 caggcctcag agcattgctc atccgtgcca aactgggtag gtggatttga gcggaaagac
     4021 tcccaaaatg tgccaagaat ttcccagtcc caggcagggc aggggaaact aagggcaagc
     4081 aggatacagg gcgagggatg tggcaggtga gggggctccc gcctgtgccc cttctcctca
     4141 ccatgtctcc cccaccctgc ctcagttctc cgttcccctt catctccgtc cccctctttg
     4201 aagctgtccc catctcagtg tcagaccagc cttctcctca gctgaccacc ctcctctgac
     4261 ccacgccccc tccttgtctg aaagaaagga gccttgaatg gtggagggag gcagtgggga
     4321 gaaaggtctc accggacagg ttgggagaat gaggtcagcg gtgctgggga acagatggag
     4381 ggggcagtgg ggacagggct tgggcagaca ccagcaggaa taatttgaaa tgtgtgaggt
     4441 gactccccgg agggccttgg gcttgggcat ttgggaaaag aatgatgtct ggaagggctt
     4501 aagggacaca gtggacgagg ggagagtcct catctgctgg cattttgtgg ggtgttagtg
     4561 ccaaacttga ataggggctg gggtgctgtc ttccactgac acccaaatcc agaatccctg
     4621 gtcttgagtc cccagaactt tgcctcttga ctgtcccttc tcttcctacc tccatccatg
     4681 gaaaattagt tattttctga tcctttcccc tgcctggtct agctcctctc caaacagcca
     4741 tgccctccaa atgctagaga cctgggccct gaaccctgta gacagatgcc ctcagaattg
     4801 gggcatggga ggggggctgg gggaccccat gattcagcca cggactccaa tgcccagctc
     4861 ctctccccaa aacaatcccg acaatccctt atccctaccc caaccctttg cggctctgta
     4921 cacattttta aacctggcaa aagatgaaga gaatattgta aatataaaag tttaactgtt
//
