LOCUS       NM_006167               3278 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens NK3 homeobox 1 (NKX3-1), transcript variant 1, mRNA.
ACCESSION   NM_006167
VERSION     NM_006167.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3278)
  AUTHORS   Mehreen,A., Manjee,K.G., Paralkar,D., Paner,G.P. and Lan,T.
  TITLE     NKX3.1 Expression in Non-Prostatic Tumors and Characterizing its
            Expression in Esophageal/Gastroesophageal Adenocarcinoma
  JOURNAL   Adv Anat Pathol 31 (3), 202-205 (2024)
   PUBMED   38525603
  REMARK    GeneRIF: NKX3.1 Expression in Non-Prostatic Tumors and
            Characterizing its Expression in Esophageal/Gastroesophageal
            Adenocarcinoma.
            Review article
REFERENCE   2  (bases 1 to 3278)
  AUTHORS   Bae,A.N., Kim,J., Park,J.H., Lee,J.H. and Choi,E.
  TITLE     Comprehensive Analysis of NKX3.2 in Liver Hepatocellular Carcinoma
            by Bigdata
  JOURNAL   Medicina (Kaunas) 59 (10), 1782 (2023)
   PUBMED   37893500
  REMARK    GeneRIF: Comprehensive Analysis of NKX3.2 in Liver Hepatocellular
            Carcinoma by Bigdata.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3278)
  AUTHORS   Matsuda,C., Ishii,K., Nakagawa,Y., Shirai,T., Sasaki,T.,
            Hirokawa,Y.S., Iguchi,K. and Watanabe,M.
  TITLE     Fibroblast-derived exosomal microRNA regulates NKX3-1 expression in
            androgen-sensitive, androgen receptor-dependent prostate cancer
            cells
  JOURNAL   J Cell Biochem 124 (8), 1135-1144 (2023)
   PUBMED   37334663
  REMARK    GeneRIF: Fibroblast-derived exosomal microRNA regulates NKX3-1
            expression in androgen-sensitive, androgen receptor-dependent
            prostate cancer cells.
REFERENCE   4  (bases 1 to 3278)
  AUTHORS   Patel,S., Wald,A.I., Bastaki,J.M., Chiosea,S.I., Singhi,A.D. and
            Seethala,R.R.
  TITLE     NKX3.1 Expression and Molecular Characterization of Secretory
            Myoepithelial Carcinoma (SMCA): Advancing the Case for a Salivary
            Mucous Acinar Phenotype
  JOURNAL   Head Neck Pathol 17 (2), 467-478 (2023)
   PUBMED   36746884
  REMARK    GeneRIF: NKX3.1 Expression and Molecular Characterization of
            Secretory Myoepithelial Carcinoma (SMCA): Advancing the Case for a
            Salivary Mucous Acinar Phenotype.
REFERENCE   5  (bases 1 to 3278)
  AUTHORS   Korkmaz,K.S., Korkmaz,C.G., Ragnhildstveit,E., Kizildag,S.,
            Pretlow,T.G. and Saatcioglu,F.
  TITLE     Full-length cDNA sequence and genomic organization of human NKX3A -
            alternative forms and regulation by both androgens and estrogens
  JOURNAL   Gene 260 (1-2), 25-36 (2000)
   PUBMED   11137288
REFERENCE   6  (bases 1 to 3278)
  AUTHORS   Carson,J.A., Fillmore,R.A., Schwartz,R.J. and Zimmer,W.E.
  TITLE     The smooth muscle gamma-actin gene promoter is a molecular target
            for the mouse bagpipe homologue, mNkx3-1, and serum response factor
  JOURNAL   J Biol Chem 275 (50), 39061-39072 (2000)
   PUBMED   10993896
REFERENCE   7  (bases 1 to 3278)
  AUTHORS   Choi,C.Y., Kim,Y.H., Kwon,H.J. and Kim,Y.
  TITLE     The homeodomain protein NK-3 recruits Groucho and a histone
            deacetylase complex to repress transcription
  JOURNAL   J Biol Chem 274 (47), 33194-33197 (1999)
   PUBMED   10559189
REFERENCE   8  (bases 1 to 3278)
  AUTHORS   Prescott,J.L., Blok,L. and Tindall,D.J.
  TITLE     Isolation and androgen regulation of the human homeobox cDNA,
            NKX3.1
  JOURNAL   Prostate 35 (1), 71-80 (1998)
   PUBMED   9537602
REFERENCE   9  (bases 1 to 3278)
  AUTHORS   Voeller,H.J., Augustus,M., Madike,V., Bova,G.S., Carter,K.C. and
            Gelmann,E.P.
  TITLE     Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21,
            is not mutated in human prostate cancers
  JOURNAL   Cancer Res 57 (20), 4455-4459 (1997)
   PUBMED   9377551
  REMARK    Erratum:[Cancer Res 1997 Dec 15;57(24):5613]
REFERENCE   10 (bases 1 to 3278)
  AUTHORS   He,W.W., Sciavolino,P.J., Wing,J., Augustus,M., Hudson,P.,
            Meissner,P.S., Curtis,R.T., Shell,B.K., Bostwick,D.G.,
            Tindall,D.J., Gelmann,E.P., Abate-Shen,C. and Carter,K.C.
  TITLE     A novel human prostate-specific, androgen-regulated homeobox gene
            (NKX3.1) that maps to 8p21, a region frequently deleted in prostate
            cancer
  JOURNAL   Genomics 43 (1), 69-77 (1997)
   PUBMED   9226374
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012574.7, AF247704.1 and
            AC051642.5.
            
            On Nov 22, 2018 this sequence version replaced NM_006167.3.
            
            Summary: This gene encodes a homeobox-containing transcription
            factor. This transcription factor functions as a negative regulator
            of epithelial cell growth in prostate tissue. Aberrant expression
            of this gene is associated with prostate tumor progression.
            Alternate splicing results in multiple transcript variants of this
            gene. [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF247704.1, SRR3476690.395662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380871.5/ ENSP00000370253.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC012574.7         13040-13040         c
            2-498               AF247704.1         1-497
            499-3278            AC051642.5         236-3015
FEATURES             Location/Qualifiers
     source          1..3278
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..3278
                     /gene="NKX3-1"
                     /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A"
                     /note="NK3 homeobox 1"
                     /db_xref="GeneID:4824"
                     /db_xref="HGNC:HGNC:7838"
                     /db_xref="MIM:602041"
     exon            1..335
                     /gene="NKX3-1"
                     /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..754
                     /gene="NKX3-1"
                     /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A"
                     /note="isoform 1 is encoded by transcript variant 1; NK
                     homeobox, family 3, A; homeobox protein Nkx-3.1; homeobox
                     protein NK-3 homolog A; NK3 transcription factor homolog
                     A; NK3 transcription factor related, locus 1"
                     /codon_start=1
                     /product="homeobox protein Nkx-3.1 isoform 1"
                     /protein_id="NP_006158.2"
                     /db_xref="CCDS:CCDS6042.1"
                     /db_xref="GeneID:4824"
                     /db_xref="HGNC:HGNC:7838"
                     /db_xref="MIM:602041"
                     /translation="MLRVPEPRPGEAKAEGAAPPTPSKPLTSFLIQDILRDGAQRQGG
                     RTSSQRQRDPEPEPEPEPEGGRSRAGAQNDQLSTGPRAAPEEAETLAETEPERHLGSY
                     LLDSENTSGALPRLPQTPKQPQKRSRAAFSHTQVIELERKFSHQKYLSAPERAHLAKN
                     LKLTETQVKIWFQNRRYKTKRKQLSSELGDLEKHSSLPALKEEAFSRASLVSVYNSYP
                     YYPYLYCVGSWSPAFW"
     exon            336..3278
                     /gene="NKX3-1"
                     /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3253..3258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKX3-1"
                     /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A"
                     /note="hexamer: AATAAA"
     polyA_site      3278
                     /gene="NKX3-1"
                     /gene_synonym="BAPX2; NKX3; NKX3.1; NKX3A"
                     /note="major polyA site"
ORIGIN      
        1 agcggtgcgg gccgggcggg tgcattcagg ccaaggcggg gccgccggga tgctcagggt
       61 tccggagccg cggcccgggg aggcgaaagc ggagggggcc gcgccgccga ccccgtccaa
      121 gccgctcacg tccttcctca tccaggacat cctgcgggac ggcgcgcagc ggcaaggcgg
      181 ccgcacgagc agccagagac agcgcgaccc ggagccggag ccagagccag agccagaggg
      241 aggacgcagc cgcgccgggg cgcagaacga ccagctgagc accgggcccc gcgccgcgcc
      301 ggaggaggcc gagacgctgg cagagaccga gccagaaagg cacttggggt cttatctgtt
      361 ggactctgaa aacacttcag gcgcccttcc aaggcttccc caaaccccta agcagccgca
      421 gaagcgctcc cgagctgcct tctcccacac tcaggtgatc gagttggaga ggaagttcag
      481 ccatcagaag tacctgtcgg cccctgaacg ggcccacctg gccaagaacc tcaagctcac
      541 ggagacccaa gtgaagatat ggttccagaa cagacgctat aagactaagc gaaagcagct
      601 ctcctcggag ctgggagact tggagaagca ctcctctttg ccggccctga aagaggaggc
      661 cttctcccgg gcctccctgg tctccgtgta taacagctat ccttactacc catacctgta
      721 ctgcgtgggc agctggagcc cagctttttg gtaatgccag ctcaggtgac aaccattatg
      781 atcaaaaact gccttcccca gggtgtctct atgaaaagca caaggggcca aggtcaggga
      841 gcaagaggtg tgcacaccaa agctattgga gatttgcgtg gaaatctcag attcttcact
      901 ggtgagacaa tgaaacaaca gagacagtga aagttttaat acctaagtca ttcctccagt
      961 gcatactgta ggtcattttt tttgcttctg gctacctgtt tgaaggggag agagggaaaa
     1021 tcaagtggta ttttccagca ctttgtatga ttttggatga gttgtacacc caaggattct
     1081 gttctgcaac tccatcctcc tgtgtcactg aatatcaact ctgaaagagc aaacctaaca
     1141 ggagaaagga caaccaggat gaggatgtca ccaactgaat taaacttaag tccagaagcc
     1201 tcctgttggc cttggaatat ggccaaggct ctctctgtcc ctgtaaaaga gaggggcaaa
     1261 tagagagtct ccaagagaac gccctcatgc tcagcacata tttgcatggg agggggagat
     1321 gggtgggagg agatgaaaat atcagctttt cttattcctt tttattcctt ttaaaatggt
     1381 atgccaactt aagtatttac agggtggccc aaatagaaca agatgcactc gctgtgattt
     1441 taagacaagc tgtataaaca gaactccact gcaagagggg gggccgggcc aggagaatct
     1501 ccgcttgtcc aagacagggg cctaaggagg gtctccacac tgctgctagg ggctgttgca
     1561 tttttttatt agtagaaagt ggaaaggcct cttctcaact tttttccctt gggctggaga
     1621 atttagaatc agaagtttcc tggagttttc aggctatcat atatactgta tcctgaaagg
     1681 caacataatt cttccttccc tccttttaaa attttgtgtt cctttttgca gcaattactc
     1741 actaaagggc ttcattttag tccagatttt tagtctggct gcacctaact tatgcctcgc
     1801 ttatttagcc cgagatctgg tctttttttt tttttttttt tttttttttc cgtctcccca
     1861 aagctttatc tgtcttgact ttttaaaaaa gtttgggggc agattctgaa ttggctaaaa
     1921 gacatgcatt tttaaaacta gcaactctta tttctttcct ttaaaaatac atagcattaa
     1981 atcccaaatc ctatttaaag acctgacagc ttgagaaggt cactactgca tttataggac
     2041 cttctggtgg ttctgctgtt acgtttgaag tctgacaatc cttgagaatc tttgcatgca
     2101 gaggaggtaa gaggtattgg attttcacag aggaagaaca cagcgcagaa tgaagggcca
     2161 ggcttactga gctgtccagt ggagggctca tgggtgggac atggaaaaga aggcagccta
     2221 ggccctgggg agcccagtcc actgagcaag caagggactg agtgagcctt ttgcaggaaa
     2281 aggctaagaa aaaggaaaac cattctaaaa cacaacaaga aactgtccaa atgctttggg
     2341 aactgtgttt attgcctata atgggtcccc aaaatgggta acctagactt cagagagaat
     2401 gagcagagag caaaggagaa atctggctgt ccttccattt tcattctgtt atctcaggtg
     2461 agctggtaga ggggagacat tagaaaaaaa tgaaacaaca aaacaattac taatgaggta
     2521 cgctgaggcc tgggagtctc ttgactccac tacttaattc cgtttagtga gaaacctttc
     2581 aattttcttt tattagaagg gccagcttac tgttggtggc aaaattgcca acataagtta
     2641 atagaaagtt ggccaatttc accccatttt ctgtggtttg ggctccacat tgcaatgttc
     2701 aatgccacgt gctgctgaca ccgaccggag tactagccag cacaaaaggc agggtagcct
     2761 gaattgcttt ctgctcttta catttctttt aaaataagca tttagtgctc agtccctact
     2821 gagtactctt tctctcccct cctctgaatt taattctttc aacttgcaat ttgcaaggat
     2881 tacacatttc actgtgatgt atattgtgtt gcaaaaaaaa aaaaaaagtg tctttgttta
     2941 aaattacttg gtttgtgaat ccatcttgct ttttccccat tggaactagt cattaaccca
     3001 tctctgaact ggtagaaaaa catctgaaga gctagtctat cagcatctga caggtgaatt
     3061 ggatggttct cagaaccatt tcacccagac agcctgtttc tatcctgttt aataaattag
     3121 tttgggttct ctacatgcat aacaaaccct gctccaatct gtcacataaa agtctgtgac
     3181 ttgaagttta gtcagcaccc ccaccaaact ttatttttct atgtgttttt tgcaacatat
     3241 gagtgttttg aaaataaagt acccatgtct ttattaga
//
