LOCUS       NM_014360               1843 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NK2 homeobox 8 (NKX2-8), mRNA.
ACCESSION   NM_014360
VERSION     NM_014360.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Zhou,Z., Xiong,L., Wu,Z., Jiang,L., Li,Y., Li,Z., Peng,Y., Ning,K.,
            Zou,X., Liu,Z., Wang,J., Li,Z., Zhou,F., Liu,Z., Zhang,Z. and Yu,C.
  TITLE     Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma
            via transcriptional repression of MDR1
  JOURNAL   Cell Death Dis 13 (5), 492 (2022)
   PUBMED   35610207
  REMARK    GeneRIF: Nkx2.8 promotes chemosensitivity in bladder urothelial
            carcinoma via transcriptional repression of MDR1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1843)
  AUTHORS   Zhu,J., Wu,G., Song,L., Cao,L., Tan,Z., Tang,M., Li,Z., Shi,D.,
            Zhang,S. and Li,J.
  TITLE     NKX2-8 deletion-induced reprogramming of fatty acid metabolism
            confers chemoresistance in epithelial ovarian cancer
  JOURNAL   EBioMedicine 43, 238-252 (2019)
   PUBMED   31047858
  REMARK    GeneRIF: Our results demonstrate that NKX2-8 deletion-reprogrammed
            FA metabolism contributes to chemoresistance and Perhexiline might
            serve as a potential tailored treatment for patients with
            NKX2-8-deleted EOC.
REFERENCE   3  (bases 1 to 1843)
  AUTHORS   Yu,C., Liu,Z., Chen,Q., Li,Y., Jiang,L., Zhang,Z. and Zhou,F.
  TITLE     Nkx2.8 Inhibits Epithelial-Mesenchymal Transition in Bladder
            Urothelial Carcinoma via Transcriptional Repression of Twist1
  JOURNAL   Cancer Res 78 (5), 1241-1252 (2018)
   PUBMED   29311157
  REMARK    GeneRIF: Low NKX2-8 expression is associated with Bladder
            Urothelial Carcinoma.
REFERENCE   4  (bases 1 to 1843)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 1843)
  AUTHORS   Kim,M., Park,Y.K., Kang,T.W., Lee,S.H., Rhee,Y.H., Park,J.L.,
            Kim,H.J., Lee,D., Lee,D., Kim,S.Y. and Kim,Y.S.
  TITLE     Dynamic changes in DNA methylation and hydroxymethylation when hES
            cells undergo differentiation toward a neuronal lineage
  JOURNAL   Hum Mol Genet 23 (3), 657-667 (2014)
   PUBMED   24087792
REFERENCE   6  (bases 1 to 1843)
  AUTHORS   Hagihara,A., Miyamoto,K., Furuta,J., Hiraoka,N., Wakazono,K.,
            Seki,S., Fukushima,S., Tsao,M.S., Sugimura,T. and Ushijima,T.
  TITLE     Identification of 27 5' CpG islands aberrantly methylated and 13
            genes silenced in human pancreatic cancers
  JOURNAL   Oncogene 23 (53), 8705-8710 (2004)
   PUBMED   15467763
REFERENCE   7  (bases 1 to 1843)
  AUTHORS   Hamamoto,R., Furukawa,Y., Morita,M., Iimura,Y., Silva,F.P., Li,M.,
            Yagyu,R. and Nakamura,Y.
  TITLE     SMYD3 encodes a histone methyltransferase involved in the
            proliferation of cancer cells
  JOURNAL   Nat Cell Biol 6 (8), 731-740 (2004)
   PUBMED   15235609
REFERENCE   8  (bases 1 to 1843)
  AUTHORS   Kajiyama,Y., Tian,J. and Locker,J.
  TITLE     Regulation of alpha-fetoprotein expression by Nkx2.8
  JOURNAL   Mol Cell Biol 22 (17), 6122-6130 (2002)
   PUBMED   12167706
  REMARK    GeneRIF: A murine Nkx2.8 was isolated from the Hepal-6 cell line
            and showed oligonucleotide binding competitive with fetoprotein
            transcription factor.
REFERENCE   9  (bases 1 to 1843)
  AUTHORS   Santagati,F., Gerber,J.K., Blusch,J.H., Kokubu,C., Peters,H.,
            Adamski,J., Werner,T., Balling,R. and Imai,K.
  TITLE     Comparative analysis of the genomic organization of Pax9 and its
            conserved physical association with Nkx2-9 in the human, mouse, and
            pufferfish genomes
  JOURNAL   Mamm Genome 12 (3), 232-237 (2001)
   PUBMED   11252173
REFERENCE   10 (bases 1 to 1843)
  AUTHORS   Apergis,G.A., Crawford,N., Ghosh,D., Steppan,C.M., Vorachek,W.R.,
            Wen,P. and Locker,J.
  TITLE     A novel nk-2-related transcription factor associated with human
            fetal liver and hepatocellular carcinoma
  JOURNAL   J Biol Chem 273 (5), 2917-2925 (1998)
   PUBMED   9446603
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA438523.1, AK313537.1,
            BC041090.1 and AL079303.3.
            
            On May 17, 2019 this sequence version replaced NM_014360.3.
            
            Summary: The protein encoded by this gene is a homeobox-containing
            developmental regulator associated with liver development. The
            encoded protein binds to the alpha-fetoprotein (AFP) gene promoter
            and increases the expression of AFP. This gene is overexpressed in
            some lung cancers and is linked to poor patient survival, possibly
            due to its resistance to cisplatin. This gene is aberrantly
            methylated in pancreatic cancer, deleted in squamous cell lung
            carcinomas, and acts as a tumor suppressor in esophageal cancer.
            Mutations in this gene may also be a cause of neural tube defects.
            [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041090.1, AF000295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258829.6/ ENSP00000258829.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA438523.1         1-7
            8-33                AK313537.1         1-26
            34-1836             BC041090.1         1-1803
            1837-1843           AL079303.3         17620-17626         c
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.3"
     gene            1..1843
                     /gene="NKX2-8"
                     /gene_synonym="Nkx2-9; NKX2.8; NKX2H"
                     /note="NK2 homeobox 8"
                     /db_xref="GeneID:26257"
                     /db_xref="HGNC:HGNC:16364"
                     /db_xref="MIM:603245"
     exon            1..382
                     /gene="NKX2-8"
                     /gene_synonym="Nkx2-9; NKX2.8; NKX2H"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..945
                     /gene="NKX2-8"
                     /gene_synonym="Nkx2-9; NKX2.8; NKX2H"
                     /note="NK-2 homolog 8; homeobox protein NK-2 homolog H;
                     NK2 transcription factor related, locus 8"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.8"
                     /protein_id="NP_055175.2"
                     /db_xref="CCDS:CCDS9660.1"
                     /db_xref="GeneID:26257"
                     /db_xref="HGNC:HGNC:16364"
                     /db_xref="MIM:603245"
                     /translation="MATSGRLSFTVRSLLDLPEQDAQHLPRREPEPRAPQPDPCAAWL
                     DSERGHYPSSDESSLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERR
                     FRQQRYLSAPEREQLASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELH
                     AAPGLLRRVVVPVLVRDGQPCGGGGGGEVGTAAAQEKCGAPPAAACPLPGYPAFGPGS
                     ALGLFPAYQHLASPALVSWNW"
     exon            383..1843
                     /gene="NKX2-8"
                     /gene_synonym="Nkx2-9; NKX2.8; NKX2H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKX2-8"
                     /gene_synonym="Nkx2-9; NKX2.8; NKX2H"
                     /note="hexamer: AATAGA"
     polyA_site      1268
                     /gene="NKX2-8"
                     /gene_synonym="Nkx2-9; NKX2.8; NKX2H"
                     /note="major polyA site"
ORIGIN      
        1 agtgctcatt caggtactta acaccctgga gacccggacc tcggctttca aagcggcctg
       61 ggtgggaaga gctgtttata taaacagaga ttccgctgta aatgcgctaa tatcccggct
      121 gccagcgcat ggcgagcgcc tcccacgccc atccgtagga gcggcgtccc ggccgcccct
      181 ccgttcccag cctgccctgc ccccgcctcc ttcccctcct cggccatggc cacctctgga
      241 cgcctgagct tcaccgtgcg cagccttcta gatttacccg agcaggacgc gcaacacctg
      301 ccgaggcggg agccagaacc acgcgccccc cagcccgacc cctgcgccgc ctggctggat
      361 tcggagcgcg gccactaccc ttcctcggac gagagcagcc tggagaccag cccgccagac
      421 tcgtcgcagc ggccgtccgc taggcccgcg tctccgggct cggacgccga gaaaaggaag
      481 aagcggcggg tgctattctc caaggcgcag acgctggagt tggagcggcg cttccggcag
      541 cagcggtacc tgtctgcgcc cgagcgcgag cagctggcga gcctgcttcg cctcacgccc
      601 acgcaggtca agatctggtt ccagaatcat cgctacaagc tgaagcgcgc tcgcgctcca
      661 ggggcggcgg agtcgcctga cctggcagca tccgccgagc tgcacgccgc gcccggcctg
      721 ctgcgtcgcg tggtggtgcc ggtgcttgtt cgcgacgggc agccgtgcgg cggcggcggc
      781 ggtggcgagg tgggaaccgc cgcggcccag gagaagtgcg gcgcccctcc agccgccgcc
      841 tgccctctgc cgggctaccc tgccttcggt cccggctcgg cgcttggcct cttccccgcc
      901 taccagcact tagcatcccc cgccctggtc tcctggaact ggtgaggccg cagggcggca
      961 cctggggcta ccctcgactt tggagcgcgc tctgcgattg gagcagggcc ggagccgaac
     1021 gcctggaacg ctctccgtcc gcctccctgc agccccatct ccttgggcgc cagggtccct
     1081 ggcgcgccct catcagccgt cgcgcaagca cacacgaggg acgtgtgcca gagccccctc
     1141 cctcaccttc cctccaccgc cagccccaga gttagatttt atgcttgggc cttatttgta
     1201 tatttttaaa tagcgatttg tataggaagc aagttatttt tttaaaaaat agagtatttt
     1261 tcctcgtagt tcgagaataa aatgtgtggg gttgggtccc ctgcgcgcct gcggggaacg
     1321 taggcgggag tcgtgccccc cagaccggtg ttcgcatcgc tggctcgccc cttgactggc
     1381 taagtggggc ccggccccag ctggatcgaa gggcgggttg cagtcccgac acggctttag
     1441 gaagatacct gggggatgga ggggtggtga tgtcagggtt gggcgcggga agaaaaggag
     1501 aggaggaagc tgaggcaact ttgggattct tgtcagcggg aggcgtcact ggccccagag
     1561 tgactccgac tctccgctgg gctcccagag ctgctggcgt ttcgaatacc gaaaagtcaa
     1621 ccctgtggac cacgacaggg cagaaggagt ttctccggag atgagccggc gaggccaggt
     1681 gcggggcgcg ctgcaccgga gcagcccagg ccgggccgca agctgtttcc agagtgcagg
     1741 agccaagtgc tcggggaccc tttgaaaagt gcctggggac ctgaagagca ccggggaatt
     1801 tgtaacccct atttaagcct gcaagtgcct aagttagctg tga
//
