LOCUS       NP_660328                364 aa            linear   PRI 27-APR-2025
DEFINITION  homeobox protein Nkx-2.3 [Homo sapiens].
ACCESSION   NP_660328
VERSION     NP_660328.2
DBSOURCE    REFSEQ: accession NM_145285.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Gabris,F., Kajtar,B., Kellermayer,Z. and Balogh,P.
  TITLE     Quantitative Analysis of NKX2-3 Expression in Human Colon: An
            Immunohistochemical Study
  JOURNAL   J Histochem Cytochem 72 (1), 11-23 (2024)
   PUBMED   38063211
  REMARK    GeneRIF: Quantitative Analysis of NKX2-3 Expression in Human Colon:
            An Immunohistochemical Study.
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Hu,M., Chen,N., Chen,M., Chen,F., Lu,Y., Xu,Y., Yang,L., Zeng,H.,
            Shen,M., Chen,X., Chen,S., Wang,F., Wang,S. and Wang,J.
  TITLE     Transcription factor Nkx2-3 maintains the self-renewal of
            hematopoietic stem cells by regulating mitophagy
  JOURNAL   Leukemia 37 (6), 1361-1374 (2023)
   PUBMED   37095209
  REMARK    GeneRIF: Transcription factor Nkx2-3 maintains the self-renewal of
            hematopoietic stem cells by regulating mitophagy.
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Nagel,S., Pommerenke,C., Meyer,C. and MacLeod,R.A.F.
  TITLE     NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate
            Megakaryocytic-Erythroid Cell Differentiation in AML
  JOURNAL   Int J Mol Sci 22 (21), 11434 (2021)
   PUBMED   34768865
  REMARK    GeneRIF: NKL Homeobox Genes NKX2-3 and NKX2-4 Deregulate
            Megakaryocytic-Erythroid Cell Differentiation in AML.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Liu,C., Wu,W., Xu,M., Mi,J., Xu,L. and Wang,R.
  TITLE     Development and Validation of an Autophagy-Related Signature for
            Head and Neck Squamous Cell Carcinoma
  JOURNAL   Biomed Res Int 2021, 1028158 (2021)
   PUBMED   34423028
  REMARK    GeneRIF: Development and Validation of an Autophagy-Related
            Signature for Head and Neck Squamous Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Burlet,B., Ramla,S., Fournier,C., Abrey-Recalde,M.J., Sauter,C.,
            Chretien,M.L., Rossi,C., Duffourd,Y., Ragot,S., Buriller,C.,
            Tournier,B., Chapusot,C., Nadal,N., Racine,J., Guy,J., Bailly,F.,
            Martin,L., Casasnovas,O., Bastie,J.N., Caillot,D., Albuisson,J.,
            Broccardo,C., Thieblemont,C., Delva,L., Maynadie,M., Aucagne,R. and
            Callanan,M.B.
  TITLE     Identification of novel, clonally stable, somatic mutations
            targeting transcription factors PAX5 and NKX2-3, the epigenetic
            regulator LRIF1, and BRAF in a case of atypical B-cell chronic
            lymphocytic leukemia harboring a t(14;18)(q32;q21)
  JOURNAL   Cold Spring Harb Mol Case Stud 7 (1), a005934 (2021)
   PUBMED   33608382
  REMARK    GeneRIF: Identification of novel, clonally stable, somatic
            mutations targeting transcription factors PAX5 and NKX2-3, the
            epigenetic regulator LRIF1, and BRAF in a case of atypical B-cell
            chronic lymphocytic leukemia harboring a t(14;18)(q32;q21).
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Parkes,M., Barrett,J.C., Prescott,N.J., Tremelling,M.,
            Anderson,C.A., Fisher,S.A., Roberts,R.G., Nimmo,E.R.,
            Cummings,F.R., Soars,D., Drummond,H., Lees,C.W., Khawaja,S.A.,
            Bagnall,R., Burke,D.A., Todhunter,C.E., Ahmad,T., Onnie,C.M.,
            McArdle,W., Strachan,D., Bethel,G., Bryan,C., Lewis,C.M.,
            Deloukas,P., Forbes,A., Sanderson,J., Jewell,D.P., Satsangi,J.,
            Mansfield,J.C., Cardon,L. and Mathew,C.G.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Sequence variants in the autophagy gene IRGM and multiple other
            replicating loci contribute to Crohn's disease susceptibility
  JOURNAL   Nat Genet 39 (7), 830-832 (2007)
   PUBMED   17554261
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (residues 1 to 364)
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study of 14,000 cases of seven common
            diseases and 3,000 shared controls
  JOURNAL   Nature 447 (7145), 661-678 (2007)
   PUBMED   17554300
REFERENCE   8  (residues 1 to 364)
  AUTHORS   Biben,C., Wang,C.C. and Harvey,R.P.
  TITLE     NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is
            required for salivary gland and tooth morphogenesis
  JOURNAL   Int J Dev Biol 46 (4), 415-422 (2002)
   PUBMED   12141427
REFERENCE   9  (residues 1 to 364)
  AUTHORS   Phiel,C.J., Gabbeta,V., Parsons,L.M., Rothblat,D., Harvey,R.P. and
            McHugh,K.M.
  TITLE     Differential binding of an SRF/NK-2/MEF2 transcription factor
            complex in normal versus neoplastic smooth muscle tissues
  JOURNAL   J Biol Chem 276 (37), 34637-34650 (2001)
   PUBMED   11457859
REFERENCE   10 (residues 1 to 364)
  AUTHORS   Harvey,R.P.
  TITLE     NK-2 homeobox genes and heart development
  JOURNAL   Dev Biol 178 (2), 203-216 (1996)
   PUBMED   8812123
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI764885.1, BC025788.1 and
            AL353719.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 9, 2007 this sequence version replaced NP_660328.1.
            
            Summary: This gene encodes a homeodomain-containing transcription
            factor. The encoded protein is a member of the NKX family of
            homeodomain transcription factors. Studies of similar proteins in
            mouse and rat have indicated a potential role in cellular
            differentiation.[provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA935495.1, AK300856.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344586.9/ ENSP00000342828.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     Protein         1..364
                     /product="homeobox protein Nkx-2.3"
                     /note="homeobox protein NK-2 homolog C; NK2 transcription
                     factor related, locus 3"
                     /calculated_mol_wt=38275
     Region          132..153
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8TAU0.2)"
     Region          149..205
                     /region_name="Homeodomain"
                     /note="pfam00046"
                     /db_xref="CDD:459649"
     CDS             1..364
                     /gene="NKX2-3"
                     /gene_synonym="CSX3; NK2.3; NKX2.3; NKX2C; NKX4-3"
                     /coded_by="NM_145285.3:191..1285"
                     /db_xref="CCDS:CCDS41558.1"
                     /db_xref="GeneID:159296"
                     /db_xref="HGNC:HGNC:7836"
                     /db_xref="MIM:606727"
ORIGIN      
        1 mmlpspvtst pfsvkdilnl eqqhqhfhga hlqadlehhf hsapcmlaaa egtqfsdgge
       61 edeedegekl sylnslaaad ghgdsglcpq gyvhtvlrds csepkeheee pevvrdrsqk
      121 scqlkkslet agdckaaees erpkprsrrk prvlfsqaqv felerrfkqq rylsapereh
      181 lasslkltst qvkiwfqnrr ykckrqrqdk slelgahapp ppprrvavpv lvrdgkpcvt
      241 psaqaygapy svgasaysyn sfpaygygns aaaaaaaaaa aaaaaaysss ygcaypaggg
      301 gggggtsaat tamqpacsaa gggpfvnvsn lggfgsggsa qplhqgtaag aacaqgtlqg
      361 iraw
//
