LOCUS       NM_001290079            1347 bp    mRNA    linear   PRI 03-JUN-2024
DEFINITION  Homo sapiens NK1 homeobox 1 (NKX1-1), mRNA.
ACCESSION   NM_001290079
VERSION     NM_001290079.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Simon,R., Britsch,S. and Bergemann,A.
  TITLE     Ablation of Sax2 gene expression prevents diet-induced obesity
  JOURNAL   FEBS J 278 (2), 371-382 (2011)
   PUBMED   21126319
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Simon,R., Lufkin,T. and Bergemann,A.D.
  TITLE     Homeobox gene Sax2 deficiency causes an imbalance in energy
            homeostasis
  JOURNAL   Dev Dyn 236 (10), 2792-2799 (2007)
   PUBMED   17879320
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Stanfel,M.N., Moses,K.A., Schwartz,R.J. and Zimmer,W.E.
  TITLE     Regulation of organ development by the NKX-homeodomain factors: an
            NKX code
  JOURNAL   Cell Mol Biol (Noisy-le-grand) Suppl 51, OL785-OL799 (2005)
   PUBMED   16405855
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1347)
  AUTHORS   Simon,R. and Lufkin,T.
  TITLE     Postnatal lethality in mice lacking the Sax2 homeobox gene
            homologous to Drosophila S59/slouch: evidence for positive and
            negative autoregulation
  JOURNAL   Mol Cell Biol 23 (24), 9046-9060 (2003)
   PUBMED   14645517
REFERENCE   5  (bases 1 to 1347)
  AUTHORS   Moretti,P., Simmons,P., Thomas,P., Haylock,D., Rathjen,P., Vadas,M.
            and D'Andrea,R.
  TITLE     Identification of homeobox genes expressed in human haemopoietic
            progenitor cells
  JOURNAL   Gene 144 (2), 213-219 (1994)
   PUBMED   7518789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC118281.4.
            
            Summary: This gene encodes a transcription factor that belongs to
            NKX family of homeodomain-containing proteins which are critical
            regulators of organ development. In mice, the orthologous gene is
            expressed predominantly in the brainstem, in the vicinity of
            serotonergic neurons, and is required for the coordinated crosstalk
            of factors involved in the maintenance of energy homeostasis. Mice
            with a knockout of the orthologous gene lack subcutaneous fat and
            intra-abdominal epididymal and mesenteric white adipose tissue two
            weeks after birth, and die within three weeks after birth.
            [provided by RefSeq, Jul 2017].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000422806.2/ ENSP00000407978.2
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AC118281.4         33309-33771         c
            464-1347            AC118281.4         30261-31144         c
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..1347
                     /gene="NKX1-1"
                     /gene_synonym="HSPX153; NKX-1.1; SAX2"
                     /note="NK1 homeobox 1"
                     /db_xref="GeneID:54729"
                     /db_xref="HGNC:HGNC:24975"
                     /db_xref="MIM:617869"
     CDS             1..1347
                     /gene="NKX1-1"
                     /gene_synonym="HSPX153; NKX-1.1; SAX2"
                     /note="HPX-153 homeobox; homeobox protein 153; homeobox
                     protein SAX-2; NK1 transcription factor related, locus 1"
                     /codon_start=1
                     /product="NK1 transcription factor-related protein 1"
                     /protein_id="NP_001277008.1"
                     /db_xref="CCDS:CCDS93464.1"
                     /db_xref="GeneID:54729"
                     /db_xref="HGNC:HGNC:24975"
                     /db_xref="MIM:617869"
                     /translation="MSASGPEAPGDIPALPPPPQPGSGPAPPAPAAAAQEAMDGRAEL
                     PAFPRAGAPPLAASDTVPAAPEGAGAARPAAPLRPTSFSVLDILDPNKFNSRRRRCVL
                     LGPVAPAACAPCASAPCAPAPAASGRPPRAEELERRALAGAGGVGAAGAEPPNAGDPF
                     KAGEAETNDTNGYSSGGGGHSPSADSGDEVPDDEDDDEDEAPETEAARGAEEARGGGG
                     GLGARGSGCQGAAETDASPGATVDEAAAPGPRENSPVAQGPPGGAAAPGGAGTTPQGT
                     ATAAKPKRKRTGSDSKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLS
                     LTETQVKIWFQNRRTKWKKQNPGADTSAPTGGGGGPGPGAGPGTGLPGGLSPLSPSPP
                     MGAPLGMHGPAGYPAHGPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPAFYAPHL"
     exon            1..463
                     /gene="NKX1-1"
                     /gene_synonym="HSPX153; NKX-1.1; SAX2"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1347
                     /gene="NKX1-1"
                     /gene_synonym="HSPX153; NKX-1.1; SAX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagcgcta gcggccccga ggctcctggg gacattcccg cgctaccgcc gcctccccag
       61 ccaggttcgg ggcccgcacc gcccgctccc gccgccgctg cccaggaagc tatggacggg
      121 cgcgccgagc tgccggcctt tccccgcgct ggagccccgc cgctcgcggc cagcgacact
      181 gtgcctgcgg cgcccgaggg ggctggagcg gcccggcccg cagcgcccct gcgccccacc
      241 tccttctcgg tactggacat cctggacccc aacaagttca acagcaggag gcgtcgttgc
      301 gtgctgctgg gcccagtggc tcccgctgcg tgcgcccctt gcgcttcggc cccatgcgcc
      361 cctgcacccg ccgcctcggg acgcccgcca cgcgcggagg agctggagcg ccgcgccctc
      421 gccggcgccg ggggagtcgg agccgccgga gctgagccgc cgaacgccgg cgaccccttc
      481 aaggcagggg aggccgagac caacgacacc aacggctaca gcagcggcgg cggcggccac
      541 agcccgagcg cggacagcgg ggacgaggtt cccgacgacg aggacgacga cgaggacgaa
      601 gcgcccgaga cggaggcggc gcgaggcgcg gaggaggcgc ggggaggcgg cggcggcctc
      661 ggggcccgcg ggtcgggttg ccagggcgcg gctgagaccg acgcgtcccc cggagccacc
      721 gtcgacgagg cagcggcccc cggaccccgc gagaactcgc ccgttgccca gggcccaccg
      781 ggaggtgcag cggcgccggg gggcgcgggg accaccccgc agggcacggc gacggcggcg
      841 aagcccaagc ggaagcgcac ggggtccgac tccaagtccg ggaagccgcg gcgagcgcgc
      901 accgccttca cctacgagca gctcgtggcg ctggagaaca agttcaaggc cacgcgctac
      961 ctgtcggtgt gcgagcgcct caacctggcg ctgtcgctca gcctcaccga gacgcaggtg
     1021 aagatctggt tccagaaccg ccgaaccaag tggaagaagc agaacccggg cgccgacacc
     1081 agcgctccga ccggcggcgg gggcggaccg ggaccggggg ccgggcctgg cacggggctg
     1141 cccggcggcc tcagcccgct cagcccctcg ccgcccatgg gcgccccgct cggcatgcac
     1201 ggcccggccg ggtacccggc gcacggcccc ggaggcctgg tgtgcgccgc gcagctgccg
     1261 ttcctgtcga gcccggcggt gctctcgccc ttcgtgctgg gctcgcagac ctacggggcg
     1321 cccgccttct acgcgccgca cctctga
//
