LOCUS       NM_005385               7265 bp    mRNA    linear   PRI 25-APR-2024
DEFINITION  Homo sapiens natural killer cell triggering receptor (NKTR),
            transcript variant 1, mRNA.
ACCESSION   NM_005385
VERSION     NM_005385.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7265)
  AUTHORS   Davis,T.L., Walker,J.R., Campagna-Slater,V., Finerty,P.J.,
            Paramanathan,R., Bernstein,G., MacKenzie,F., Tempel,W., Ouyang,H.,
            Lee,W.H., Eisenmesser,E.Z. and Dhe-Paganon,S.
  TITLE     Structural and biochemical characterization of the human
            cyclophilin family of peptidyl-prolyl isomerases
  JOURNAL   PLoS Biol 8 (7), e1000439 (2010)
   PUBMED   20676357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7265)
  AUTHORS   Sakashita,E., Tatsumi,S., Werner,D., Endo,H. and Mayeda,A.
  TITLE     Human RNPS1 and its associated factors: a versatile alternative
            pre-mRNA splicing regulator in vivo
  JOURNAL   Mol Cell Biol 24 (3), 1174-1187 (2004)
   PUBMED   14729963
  REMARK    Erratum:[Mol Cell Biol. 2004 Apr;24(7):3068]
REFERENCE   3  (bases 1 to 7265)
  AUTHORS   Chambers,C.A., Gallinger,S., Anderson,S.K., Giardina,S.,
            Ortaldo,J.R., Hozumi,N. and Roder,J.
  TITLE     Expression of the NK-TR gene is required for NK-like activity in
            human T cells
  JOURNAL   J Immunol 152 (6), 2669-2674 (1994)
   PUBMED   8144875
REFERENCE   4  (bases 1 to 7265)
  AUTHORS   Rinfret,A. and Anderson,S.K.
  TITLE     IL-2 regulates the expression of the NK-TR gene via an alternate
            RNA splicing mechanism
  JOURNAL   Mol Immunol 30 (14), 1307-1313 (1993)
   PUBMED   8413330
REFERENCE   5  (bases 1 to 7265)
  AUTHORS   Young,H.A., Jenkins,N.A., Copeland,N.G., Simek,S., Lerman,M.I.,
            Zbar,B., Glenn,G., Ortaldo,J.R. and Anderson,S.K.
  TITLE     Localization of a novel natural killer triggering receptor locus to
            human chromosome 3p23-p21 and mouse chromosome 9
  JOURNAL   Genomics 16 (2), 548-549 (1993)
   PUBMED   8314596
REFERENCE   6  (bases 1 to 7265)
  AUTHORS   Anderson,S.K., Gallinger,S., Roder,J., Frey,J., Young,H.A. and
            Ortaldo,J.R.
  TITLE     A cyclophilin-related protein involved in the function of natural
            killer cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (2), 542-546 (1993)
   PUBMED   8421688
REFERENCE   7  (bases 1 to 7265)
  AUTHORS   Frey,J.L., Bino,T., Kantor,R.R., Segal,D.M., Giardina,S.L.,
            Roder,J., Anderson,S. and Ortaldo,J.R.
  TITLE     Mechanism of target cell recognition by natural killer cells:
            characterization of a novel triggering molecule restricted to CD3-
            large granular lymphocytes
  JOURNAL   J Exp Med 174 (6), 1527-1536 (1991)
   PUBMED   1720812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L04288.2 and AA493639.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005385.3.
            
            Summary: This gene encodes a membrane-anchored protein with a
            hydrophobic amino terminal domain and a cyclophilin-like PPIase
            domain. It is present on the surface of natural killer cells and
            facilitates their binding to targets. Its expression is regulated
            by IL2 activation of the cells. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice junction compared to variant 3. The resulting isoform (a)
            has the same N- and C-termini but is 1 aa shorter compared to
            isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.125357.1, L04288.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000232978.13/ ENSP00000232978.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7065              L04288.2           73-7137
            7066-7265           AA493639.1         141-340
FEATURES             Location/Qualifiers
     source          1..7265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..7265
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /note="natural killer cell triggering receptor"
                     /db_xref="GeneID:4820"
                     /db_xref="HGNC:HGNC:7833"
                     /db_xref="MIM:161565"
     exon            1..93
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            94..174
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..4505
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /EC_number="5.2.1.8"
                     /note="isoform a is encoded by transcript variant 1;
                     natural killer triggering receptor; NK-tumor recognition
                     protein; natural-killer cells cyclophilin-related protein;
                     NK-TR protein; natural killer-tumor recognition sequence;
                     PPIase; rotamase; peptidyl-prolyl cis-trans isomerase
                     NKTR"
                     /codon_start=1
                     /product="NK-tumor recognition protein isoform a"
                     /protein_id="NP_005376.2"
                     /db_xref="CCDS:CCDS2702.1"
                     /db_xref="GeneID:4820"
                     /db_xref="HGNC:HGNC:7833"
                     /db_xref="MIM:161565"
                     /translation="MGAQDRPQCHFDIEINREPVGRIMFQLFSDICPKTCKNFLCLCS
                     GEKGLGKTTGKKLCYKGSTFHRVVKNFMIQGGDFSEGNGKGGESIYGGYFKDENFILK
                     HDRAFLLSMANRGKHTNGSQFFITTKPAPHLDGVHVVFGLVISGFEVIEQIENLKTDA
                     ASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEH
                     ERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSERSDTNEKRSVDSSAK
                     REKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIK
                     GRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEKWSKGDKLSDP
                     CSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRR
                     HKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSKSDKDVQ
                     SSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRASKS
                     PRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPPPSRWKPGQK
                     PWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYS
                     DRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSR
                     SSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKY
                     SESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHS
                     KKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEA
                     TSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRG
                     KPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEI
                     DDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSK
                     LSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEICTPDRSSPAKVEETS
                     PLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVGKQDSSSASLASA
                     GESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGL
                     RIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSK
                     SETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYK
                     SHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSC
                     RSYGSDSESDRSYSHHRSPSESSRYS"
     exon            175..249
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            250..357
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            358..402
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            403..490
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            491..520
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            521..666
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            667..889
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1045
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1133
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1279
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..4162
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4258
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            4259..4315
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            4316..4417
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     exon            4418..7265
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7248..7253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /note="hexamer: AATATA"
     polyA_site      7265
                     /gene="NKTR"
                     /gene_synonym="CypNK; p104"
                     /note="major polyA site"
ORIGIN      
        1 gacggcgttc cgttagcggc gttggggttt ggctgcagtg gcagtgcttt ctcttctgct
       61 cacggggacc cgctcaggct ggaggccagc cagctcttgc cgccacctcg gtcgcgatgg
      121 gggcgcagga ccggccgcag tgccacttcg acatcgagat caaccgggag ccggttggtc
      181 gcattatgtt tcagctcttc tcagacatat gtccaaaaac atgcaaaaac ttcctttgct
      241 tgtgctcagg agagaaaggc cttgggaaaa caactgggaa gaagttatgt tataaaggtt
      301 ctacgttcca tcgtgtggtt aaaaacttta tgattcaggg tggggacttc agtgaaggta
      361 atggaaaagg tggagaatca atttatggtg gatattttaa agatgaaaac tttattctca
      421 aacatgacag agcgttcctt ttatcaatgg caaatcgagg gaaacatacc aatggttccc
      481 agtttttcat taccacaaag cctgctccac acctggatgg ggtgcatgta gtctttggac
      541 tggttatttc tggttttgaa gtaatcgaac aaattgaaaa tctgaagacc gatgctgcaa
      601 gcagaccata tgcagatgtg cgagttattg actgtggagt acttgccaca aaatcaataa
      661 aagatgtttt tgagaaaaaa aggaagaaac caactcattc agaaggctcg gattcctctt
      721 ccaattcctc ctcttcttca gaatcatctt cagaaagtga acttgaacat gagagaagca
      781 gaaggaggaa acataagagg aggccaaaag ttaaacgttc taaaaagagg cgaaaggaag
      841 caagcagttc agaagagcca aggaataaac atgcaatgaa cccaaaaggt cactctgaga
      901 ggagtgatac caatgaaaaa aggtcagttg attccagtgc taaaagggaa aaacctgtgg
      961 tccgcccaga agagattcct ccagtgcctg agaaccgatt tttactgaga agagatatgc
     1021 ctgttgttac tgcagaacct gaaccgaaga ttcctgatgt tgcacccatt gtaagtgatc
     1081 agaaaccatc tgtatcaaag tctggacgga agattaaagg aaggggcaca attcgctatc
     1141 acacacctcc aagatcaaga tcctgttctg agtcagatga tgatgacagc agtgaaactc
     1201 ctcctcactg gaaagaggaa atgcagagat taagagcata tagaccacct agtggagaaa
     1261 aatggagtaa aggagataag ttaagtgacc cctgttcaag ccgatgggat gaaagaagct
     1321 tgtctcagag atccagatca tggtcctata atggatatta ttcagacctt agtacagcaa
     1381 gacactctgg ccaccataaa aaacgcagaa aagaaaaaaa ggttaagcat aaaaagaaag
     1441 ggaaaaagca gaaacactgc agaagacaca aacaaacaaa gaagagaagg attcttatac
     1501 cgtctgacat agaatcctca aaatcttcca ctcgaagaat gaaatcctct tgtgatagag
     1561 aaaggagttc tcgttcttcc tcattgtcat ctcatcactc atcaaagaga gactggtcta
     1621 aatctgataa ggatgtccag agctctttaa cccattccag cagagactca tacagatcaa
     1681 aatctcactc acagtcttat tctagaggaa gctcaagatc aaggactgcg tcaaagtcct
     1741 catcacattc tcgaagtaga tcaaagtcca gatctagttc caagtctggg caccgaaaga
     1801 gagcatcaaa atcaccaaga aaaacagctt ctcagttaag tgaaaataaa ccagttaaaa
     1861 cagaaccttt aagagcaacc atggcacaaa atgaaaatgt agtagtacaa ccagttgtag
     1921 cagaaaatat tcctgtaata ccactgagtg acagtccccc cccttcaaga tggaagcctg
     1981 gacagaaacc ttggaagccc tcttatgagc gaattcagga aatgaaagct aaaacaaccc
     2041 atttgctacc catccaaagc acttacagtt tagcaaatat taaagagact ggtagctcat
     2101 catcctacca taaaagagaa aaaaattcgg aaagtgatca gagcacttat tcaaaataca
     2161 gtgatagaag ttcagaaagc tcaccaaggt caaggagcag atcttctagg agtagatctt
     2221 attccagatc atatacaaga tcacgtagtc tagctagttc acattcaagg tctaggtctc
     2281 catcatctag atctcattca cgaaataaat acagtgatca ttcacagtgt agtagatcat
     2341 cttcatatac ttctattagc agtgatgatg gaaggcgagc taagaggaga cttagatcca
     2401 gtgggaaaaa aaatagcgtt tcacataaaa agcatagcag cagctctgaa aagacacttc
     2461 acagtaaata tgtcaaaggt agagacaggt cttcatgtgt gagaaagtat agcgagagca
     2521 gatcatcttt agattattct tcagacagtg agcagtcaag tgttcaggcc acacagtcag
     2581 cccaggaaaa agagaagcag ggccaaatgg aaagaacaca taataaacaa gaaaaaaaca
     2641 gaggtgaaga aaaatccaag tctgaacggg aatgccctca ttcaaaaaaa agaactttga
     2701 aagagaatct ttctgatcac cttagaaatg gcagtaagcc caaaaggaag aattatgctg
     2761 gtagtaaatg ggactctgag tcaaattcag aacgagatgt cactaaaaac agtaaaaatg
     2821 actcccatcc atcctctgac aaggaagaag gtgaggccac atccgattct gaatcagagg
     2881 ttagtgaaat tcacatcaaa gtcaaaccca caaccaagtc gtccacaaat acttcactgc
     2941 ctgatgataa tggtgcttgg aaatcaagca aacagcgcac atcaacttct gactctgagg
     3001 ggtcctgttc caattcggaa aacaataggg gaaagccaca aaagcacaaa catgggtcaa
     3061 aggaaaatct taaaagagaa cacaccaaaa aagtgaaaga gaaattgaaa gggaaaaaag
     3121 acaaaaagca taaggctcca aaacgaaagc aagcatttca ctggcagcct ccactagaat
     3181 ttggtgaaga ggaggaggag gagattgatg acaagcaagt tactcaggaa tcaaaagaga
     3241 aaaaagtttc tgaaaacaat gaaaccataa aagataatat tctaaaaact gagaaatcca
     3301 gtgaagagga cctttcaggt aaacatgata cagtgactgt ttcatcagat cttgatcagt
     3361 ttactaaaga tgatagtaaa ctcagtattt ctcccacagc tttaaatact gaggaaaatg
     3421 tggcctgttt acaaaacatt cagcacgttg aagaaagtgt tcccaatgga gtggaagatg
     3481 tgcttcaaac agatgacaac atggagatct gcactcctga taggagttcc ccagcaaaag
     3541 tagaggagac ttcccctcta ggaaatgcac ggcttgatac cccagatata aacattgttt
     3601 tgaagcagga tatggcaacg gaacatcctc aagcagaggt agtaaaacag gaaagcagca
     3661 tgtccgaaag taaagtgttg ggtgaagtgg ggaaacagga cagcagctct gctagcttgg
     3721 ctagtgctgg agaaagtacc gggaagaagg aggtggctga gaagagccag atcaacctca
     3781 ttgataagaa atggaagccc ctgcaaggtg tggggaacct ggcagcacct aatgctgcca
     3841 catccagtgc tgtggaagtt aaggtgttga ccactgtgcc tgaaatgaaa ccacaaggct
     3901 tgagaataga aattaaaagc aaaaataaag ttcggcctgg gtctctcttt gatgaagtaa
     3961 gaaagacagc acgcttaaac cgtagaccaa gaaatcagga gagttcaagt gatgagcaga
     4021 cgcctagtcg ggatgatgat agccagtcca ggagtccaag tagatctcga agtaaatctg
     4081 aaaccaaatc aagacacaga acaaggtctg tctcctatag tcactcaaga agtcgatcga
     4141 gaagttccac atcatcttat cgatcaagaa gctactctag aagtcggagc agaggatggt
     4201 acagcagagg ccgaaccaga agccggagca gttcctaccg gagttacaaa agtcacagga
     4261 cgtccagcag gagcagatcc aggagcagct catatgatcc ccacagtcga tccaggtcct
     4321 acacctacga tagctactat agcaggagtc ggagtcgaag tagaagccag agaagtgaca
     4381 gttaccaccg aggcagaagt tataatcggc ggtccaggag ttgtagatct tatggctctg
     4441 acagtgaaag tgaccgaagt tactctcatc accggagccc cagtgagagc agcagataca
     4501 gttgaaaacg tccggataca aattatatct tatttgtaaa tatctggcaa cttagcttaa
     4561 gaaatgtaat gacagtctgt tgttctattt caatatcaga ggtgaatttc aaaaatagac
     4621 acttcttaat tgttactggt tcatttacat gtggggagaa gaatttaaaa tacagatatg
     4681 tctcctaaaa atatttttat gccacatttt acagtagcca actatggaaa tgaatttcat
     4741 tttcttgaat caagaaatcg tgaaatttat ctatgtataa tttgcaatat tattttaagt
     4801 ctatttcact ctatcttacg tatcccttag aatacagatt ctttttgcct gtttttccag
     4861 ttttagcata tatgctgcca agcatagaac tgtgaaggag aactgttaaa ggcggccaaa
     4921 tatttatata ctgattacat agagtcttgt acatatgtgc tctaaaaaca aaccacccag
     4981 aattgatact gttggtaacc aggagtataa ggcagtggct ctggggttct taattcattc
     5041 ctaacttctt tgatacttca caggattagg aaagtggtca tcatacatcc cacacagtct
     5101 gtattacttc aggcttgtgg gcaaggttag gaagaatcaa tcagccttaa ctataaatac
     5161 ctgcactgtc tctgaggact tactatttta tgttcttttt aatcaatacc gatcagaagt
     5221 ttaggttata aaaacaattc tacttcatgc tttggtgctt ggtaattttt ggtgcgtctt
     5281 taagcattac tcttatatat catatattaa aataccataa aaatgaaatt cagacaaaat
     5341 cactggcacc aaaaatggtt tattctgagc tgtcttcact ttgactattt ggggggcttc
     5401 tctcaagtac agatgtgggt tggggtcccc tggagcaggc aggattggca gtaagagata
     5461 ttggccactc aagtctactg tgtgtgtgtg cctctggaag agtgaagaat ggacttcaaa
     5521 agtaacatca aaaatctaac tgccaccatc ctggagacat tttgcagggc tttcctttca
     5581 agtctttcaa gtacaggata ttaccacaac agcagctgaa ctgttgtaac cagcatgttt
     5641 ttcctatttc cactgtgacc tgcagctgac tcaaagcctt gcgtgacctg acccaggtgc
     5701 aagagacagg ggaagaggga tagagggtat agcataaatt acatattttc atggctttgg
     5761 gtggttcctc caaaaataat tggacctgta aaaactagtg tgtgtgtgtg tgtgtgtgtg
     5821 tgtgtgtgtg tggttttttt ttttaatctt tactttgaat ttgttcccca agtgtactta
     5881 atcaccttag tgccagttta atccagttat gcagaagaaa ttcatattgg ttgcctgatg
     5941 tagagctcag caccacccta ccacaggcct tgtctggtgt atttgggaag tggaaaagag
     6001 ccctcagttg gagggagctg acaacccttg gtggagggag ggtgcccttg aatgtattaa
     6061 aactatcacc caaagaaggt atgaaaacag ggtaaggtgg tcagttgttt gccaggtcaa
     6121 tagacagaaa gtacattaga aaacaggact taggccaaac aaacaatact ggatactgaa
     6181 tacaaaacag tatgatttat attaaaggtt tccaaaggtt gcctgcaaag gagaatatta
     6241 ctactagtca gcaggaaaaa aatgcattca gaacccaagc agaaactgcc aaatgtaatt
     6301 aggttaagaa aagttaccct tgggcagtgt attagttttc tattgctgtg tgacaaatta
     6361 ccccaaattt agcagtttaa aaaacaatac ccatagcagt tctgtagctc atgagtctgg
     6421 cacagtgtgg ctggattctc tgctcagggt cttaaaggct gaaataaggg ttggcaggac
     6481 aacattcctt catggaggct ctggggaaga atctgcttct aagttcattc aggttgttgg
     6541 cggaattcag ttctttgctg gctctcagct ggaggcccct ctctcacctc aaggctgcct
     6601 gcattccttc ttatgtggtc ccctccagct tcaaaccagc cttcctgctc tttctcatgc
     6661 ttcatatctc tctcccgtcc tcctgtttta ggggcatatg attagctcaa gcccacagat
     6721 atattttaag gttgattgtg cgatagaaca taattgcagg agtactgtct catctcatca
     6781 tattcacggg ttctggagat tagctcattg aaagtgggag gggcattttc aaattctgcc
     6841 taccacaggc aataactgcc catctcagct gtaggtggaa tttttaccca gaaaagatag
     6901 gccctagaag cctcatttct tttctccatg gaaaaggaca gccctctgct gcagcgttca
     6961 acttgtgtgt ttactgacag agtgaactac agaaatagct tttcttccta aaggggattg
     7021 ttctacattt tgaagttatt ttttaataaa attgaattat gttgtgtatt gtgcttctta
     7081 ataggaaatg cattattgga ctgtttttgt aacatcctgt ttattgcaaa tagctagtat
     7141 cgttcaaaaa ctgtataaaa tacttttgta catattagca atgtctaatt tgtatacact
     7201 tcagttaaat ttccctaaaa cttgaaaggg gaccttgtag aaattaaaat atatacttag
     7261 tctaa
//
