LOCUS       NM_001417890            3799 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens NFKB repressing factor (NKRF), transcript variant 2,
            mRNA.
ACCESSION   NM_001417890 NM_017544
VERSION     NM_001417890.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3799)
  AUTHORS   Liu,Y., Yang,J., Weng,D. and Xie,Y.
  TITLE     A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-beta
            Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma
            Cells
  JOURNAL   Int J Mol Sci 25 (7), 3576 (2024)
   PUBMED   38612387
  REMARK    GeneRIF: A1CF Binding to the p65 Interaction Site on NKRF Decreased
            IFN-beta Expression and p65 Phosphorylation (Ser536) in Renal
            Carcinoma Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3799)
  AUTHORS   Wang,H., Lian,X., Wang,K. and Wang,S.
  TITLE     WWP2 binds to NKRF, enhances the NF-kappaB signaling, and promotes
            malignant phenotypes of acute myeloid leukemia cells
  JOURNAL   Biochem Cell Biol 102 (1), 85-95 (2024)
   PUBMED   37921219
  REMARK    GeneRIF: WWP2 binds to NKRF, enhances the NF-kappaB signaling, and
            promotes malignant phenotypes of acute myeloid leukemia cells.
REFERENCE   3  (bases 1 to 3799)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   4  (bases 1 to 3799)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3799)
  AUTHORS   Li,J., Guo,M., Tian,X., Wang,X., Yang,X., Wu,P., Liu,C., Xiao,Z.,
            Qu,Y., Yin,Y., Wang,C., Zhang,Y., Zhu,Z., Liu,Z., Peng,C., Zhu,T.
            and Liang,Q.
  TITLE     Virus-Host Interactome and Proteomic Survey Reveal Potential
            Virulence Factors Influencing SARS-CoV-2 Pathogenesis
  JOURNAL   Med 2 (1), 99-112 (2021)
   PUBMED   32838362
REFERENCE   6  (bases 1 to 3799)
  AUTHORS   Jianfeng,D., Feng,J., Chaoneng,J., Zhongzhou,Z., Shaohua,G.,
            Qihan,W., Liu,W., Gang,Y., Yi,X. and Mao,Y.
  TITLE     Cloning of the correct full length cDNA of NF-kappaB-repressing
            factor
  JOURNAL   Mol Cells 16 (3), 397-401 (2003)
   PUBMED   14744032
  REMARK    GeneRIF: cDNA is 3247 bp long, contains three exons and maps to
            human chromosome Xq24. NRF is widely expressed in human tissues.
REFERENCE   7  (bases 1 to 3799)
  AUTHORS   Feng,X., Guo,Z., Nourbakhsh,M., Hauser,H., Ganster,R., Shao,L. and
            Geller,D.A.
  TITLE     Identification of a negative response element in the human
            inducible nitric-oxide synthase (hiNOS) promoter: The role of
            NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS
            gene
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14212-14217 (2002)
   PUBMED   12381793
  REMARK    GeneRIF: role of NF-kappa B-repressing factor (NRF) in basal
            repression of the hiNOS gene
REFERENCE   8  (bases 1 to 3799)
  AUTHORS   Nourbakhsh,M. and Hauser,H.
  TITLE     Constitutive silencing of IFN-beta promoter is mediated by NRF
            (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB
  JOURNAL   EMBO J 18 (22), 6415-6425 (1999)
   PUBMED   10562553
REFERENCE   9  (bases 1 to 3799)
  AUTHORS   Nourbakhsh,M. and Hauser,H.
  TITLE     The transcriptional silencer protein NRF: a repressor of NF-kappa B
            enhancers
  JOURNAL   Immunobiology 198 (1-3), 65-72 (1997)
   PUBMED   9442378
REFERENCE   10 (bases 1 to 3799)
  AUTHORS   Frattini,A., Faranda,S., Bagnasco,L., Patrosso,C., Nulli,P.,
            Zucchi,I. and Vezzoni,P.
  TITLE     Identification of a new member (ZNF183) of the Ring finger gene
            family in Xq24-25
  JOURNAL   Gene 192 (2), 291-298 (1997)
   PUBMED   9224902
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004913.2 and NTIA01000131.1.
            
            On Mar 13, 2023 this sequence version replaced NM_017544.5.
            
            Summary: This gene encodes a transcriptional repressor that
            interacts with specific negative regulatory elements to mediate
            transcriptional repression of certain nuclear factor kappa B
            responsive genes. The protein localizes predominantly to the
            nucleolus with a small fraction found in the nucleoplasm and
            cytoplasm. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.32234.1,
                                           SRR11853566.30022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000710306.2/ ENSP00000518188.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AC004913.2         44712-45178         c
            468-476             NTIA01000131.1     432536-432544
            477-695             AC004913.2         44485-44703         c
            696-826             AC004913.2         31137-31267         c
            827-3799            AC004913.2         27091-30063         c
FEATURES             Location/Qualifiers
     source          1..3799
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..3799
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /note="NFKB repressing factor"
                     /db_xref="GeneID:55922"
                     /db_xref="HGNC:HGNC:19374"
                     /db_xref="MIM:300440"
     exon            1..695
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             430..2784
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /note="transcription factor NRF"
                     /codon_start=1
                     /product="NF-kappa-B-repressing factor"
                     /protein_id="NP_001404819.1"
                     /db_xref="GeneID:55922"
                     /db_xref="HGNC:HGNC:19374"
                     /db_xref="MIM:300440"
                     /translation="MAGGRLLLGGDFLSPPPLPPLPPPPLPPLPPPPPEPVLEQWRYS
                     HESDWQWALRRSFICRHLHSYPGAALDQLLALSAAWTNHVFLGCRYSPRLMEKILQMA
                     EGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASS
                     SKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTK
                     DQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIW
                     KNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGY
                     ACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVC
                     QIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNS
                     ASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQP
                     TYPSVKSSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYER
                     MTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDV
                     ISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKR
                     EGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLK
                     SKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN"
     exon            696..826
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /inference="alignment:Splign:2.1.0"
     exon            827..3799
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3135..3140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /note="hexamer: AATAAA"
     polyA_site      3158
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
     regulatory      3772..3777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /note="hexamer: AATAAA"
     polyA_site      3799
                     /gene="NKRF"
                     /gene_synonym="ITBA4; NRF"
                     /note="major polyA site"
ORIGIN      
        1 ctcacaaccc cggacggcac gcgggtaggt aggctagaac ctagaggagg ggagcagagc
       61 gtgctggggt cttttatcgc tctccgcgca gtgcgtgggt ctgcggatcc gtggaggtgc
      121 ggagcctgac tcggcctccc cggctcgcgc gtgagtgcgg cggaagccct tctgctcctc
      181 cacgagttag aggagtgtag gggacgtgca tcccagtgtc gggacgcgag ctcgtgctcc
      241 tcttttcctc ctaacggtgg cccccacgca cacactccag tccccccgag agttgatctt
      301 ctcccctcag cgcgcccctc cttacccggc ccctcccacc ggccccccgt ttccgcccgc
      361 ttgctagctg cctagctcgc ggtccgtagt cggcttcgtc cctggggtcc ctgcttgggg
      421 gcggagaaga tggctggagg acgtctgctg ttggggggcg acttcctgtc gccgccgccg
      481 ctgccccccc tcccgccgcc gccgctgccg cccctcccgc cgcccccgcc cgagccagtg
      541 ctggagcagt ggcgctatag ccacgaaagt gactggcagt gggctctgcg gcgcagcttc
      601 atctgtcggc acctgcacag ctatcccggg gctgccctcg accagctcct cgcgctctcc
      661 gccgcctgga ccaaccacgt cttcctgggc tgcaggtaca gcccacgctt gatggaaaaa
      721 attctccaaa tggctgaagg tattgatatt ggggagatgc cttcatatga tctggtgctg
      781 tccaaacctt ccaaaggtca aaaacgccac ctctcaacat gtgatggtca aaatcctcct
      841 aaaaagcaag ccggttccaa attccatgcg agacctcgtt ttgagcctgt acattttgta
      901 gctagtagtt caaaagatga aagacaggaa gatccttatg gccctcaaac aaaagaggta
      961 aatgaacaaa cacattttgc cagcatgcca agagacatct accaagatta tactcaagac
     1021 tctttcagta tacaagatgg gaattctcag tattgtgatt catcaggatt cattctcaca
     1081 aaagaccagc ctgtaacagc caacatgtat tttgacagtg ggaaccctgc cccaagcacc
     1141 acatcacagc aggcaaactc tcagtcaact cctgagcctt caccatcaca gacatttccc
     1201 gagtctgtgg tagccgagaa gcagtatttt attgaaaaat taacggcgac aatctggaag
     1261 aacctttcta atccagaaat gacttctgga tctgataaaa ttaattatac atatatgtta
     1321 actcgttgta ttcaggcgtg taagacaaat cctgagtata tatatgctcc tttaaaggaa
     1381 attcctcctg ccgacatccc caaaaataaa aaacttctaa ctgatggcta tgcttgtgaa
     1441 gttagatgcc aaaatatcta cttaactaca ggttatgctg gcagcaagaa tgggtccagg
     1501 gatcgagcta cagagctagc tgtaaaactc ttgcagaaac gtattgaagt tagagttgtc
     1561 cggcggaaat tcaagcatac atttggagag gacctcgtgg tgtgtcagat tggcatgtcc
     1621 tcctatgaat ttcctccagc tctgaagcca ccagaagacc tggtggtgct gggtaaagat
     1681 gcttccgggc agccaatttt taatgcttct gccaaacact ggaccaattt tgtcattaca
     1741 gaaaatgcaa atgatgcaat tggtatcctt aacaattctg cctcattcaa caagatgtca
     1801 attgaataca aatatgagat gatgccaaat cgcacatggc gttgtcgagt gtttttacaa
     1861 gatcactgct tagctgaagg ttatggaacc aagaaaacaa gtaaacatgc agctgccgac
     1921 gaggctttga aaattcttca aaaaacacag cccacttatc catctgtcaa aagttcacaa
     1981 tgccatacag gctcttcacc cagaggatct ggaaagaaga aagatataaa ggatcttgta
     2041 gtttatgaga attcttcaaa tcccgtgtgc acgctgaacg acacagctca gtttaaccga
     2101 atgacagttg agtatgtcta tgaaaggatg acaggcctcc gctggaaatg caaagtgatt
     2161 ctagagagtg aagtaattgc agaagcagtt ggggtgaaga aaactgtcaa atatgaagct
     2221 gctggggaag ctgtgaaaac cctcaaaaag acccagccaa ctgtcattaa caacttgaag
     2281 aaaggagctg ttgaagatgt gatttcaaga aatgaaattc agggccgctc agcagaggag
     2341 gcttacaaac agcaaatcaa agaagataat attggaaatc agctgctgag aaagatgggt
     2401 tggactggtg gtggtttagg taaatctggt gagggcatac gggagcctat ctcagtgaaa
     2461 gagcagcata agcgggaagg gcttggtctg gatgtagaga gggtgaataa aattgccaag
     2521 agagatattg aacagatcat cagaaactac gcccgctccg agagccacac agatttgact
     2581 ttctctagag agctgactaa tgatgaacgg aagcaaatac atcagattgc ccagaagtat
     2641 ggtcttaaga gtaagtctca tggggtgggc catgataggt acctagtggt aggtagaaaa
     2701 agacggaagg aagacctact agatcagctc aaacaggaag gccaagtggg ccattacgag
     2761 cttgttatgc ctcaagcaaa ttgagatctt actaatttat tttgtaaatg cctaatgagg
     2821 cagatttttg aattaaagaa atgctacatg ttccggttgc agagtatatt cataagatgt
     2881 ctcaccttgt tcatttcaca tagtggttta ttagatattg gaacctaaag aattctgtcc
     2941 acttgtatta gcttaatcca gcagatgata ttgtgcagtt actgtttgtg tctttgatat
     3001 tgctgtgtcc ctcagatttt agtagtttga caagcaagaa cacatatcca aatggaattt
     3061 taccctgaga aattatcatt ttaaagggca tagcacagca atctgcaaca atatgtaaag
     3121 ttgatattga ctacaataaa aatccagtct taattccaga tttactgaaa atgtcagatc
     3181 attttgtatt aatctatttt catctttgtg tgaagccagt tatagaatgt ttgacaataa
     3241 attgtgctgt acacgtaaat gtccttacca actaaatgat gtaaaacttt cttaaagtaa
     3301 ttttagtgtt catttattta taacttctac catgtgattt ccagactatt ggaagtgatt
     3361 tactgtatct tgtgatatat gggttttaac aaattctagt cttcacgctg agagagcact
     3421 acttgagaga gcagttgaaa gtttcaaaaa ctttggttca atctgaagaa aggaagcttg
     3481 aactgtttgt tcttggtgcc ttgcagagag actcacagca actctccatt atagctttca
     3541 cacggtttgg atgtgcagca catccaaggc aaccacagct gtggtagagc ttggtaaaag
     3601 actgaagata cattggtgct ttgatgaaaa ggtcagttgg ctggtccctc tctcaaaaag
     3661 cttattaagc ctgaaaagcc aactttgtaa catatttaaa actgctattt tcgcttattt
     3721 ctggaatgta aaaaaaaaaa atgtataaaa agaattagtg tatgcttcct gaataaaaag
     3781 gagccaaagt tgatcagaa
//
