LOCUS       NM_198478               4822 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens NTPase KAP family P-loop domain containing 1 (NKPD1),
            mRNA.
ACCESSION   NM_198478 NM_001131067 XM_011526802 XM_209152
VERSION     NM_198478.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4822)
  AUTHORS   Amin,N., Belonogova,N.M., Jovanova,O., Brouwer,R.W., van
            Rooij,J.G., van den Hout,M.C., Svishcheva,G.R., Kraaij,R.,
            Zorkoltseva,I.V., Kirichenko,A.V., Hofman,A., Uitterlinden,A.G.,
            van IJcken,W.F., Tiemeier,H., Axenovich,T.I. and van Duijn,C.M.
  TITLE     Nonsynonymous Variation in NKPD1 Increases Depressive Symptoms in
            European Populations
  JOURNAL   Biol Psychiatry 81 (8), 702-707 (2017)
   PUBMED   27745872
  REMARK    GeneRIF: Study suggests that nonsynonymous variation in the gene
            NKPD1 affects depressive symptoms in the general population.
REFERENCE   2  (bases 1 to 4822)
  AUTHORS   Pinto,C.S., Jinnah,H.A., Shirley,T.L., Nyhan,W.L. and Seifert,R.
  TITLE     Altered membrane NTPase activity in Lesch-Nyhan disease
            fibroblasts: comparison with HPRT knockout mice and HPRT-deficient
            cell lines
  JOURNAL   J Neurochem 93 (6), 1579-1586 (2005)
   PUBMED   15935074
  REMARK    GeneRIF: altered membrane NTPase activity is a biochemical hallmark
            of HPRT deficiency, but species and cell-type differences have to
            be considered
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005757.1.
            
            On or before May 6, 2021 this sequence version replaced
            XM_011526802.2, NM_198478.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. This representation lacks full-length support in
            human; it is supported by partial human transcript data and by
            homologous transcript alignments from mouse GeneID:69547.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145893,
                              SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000686631.1/ ENSP00000509174.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC005757.1         25543-25600         c
            59-220              AC005757.1         24678-24839         c
            221-658             AC005757.1         23281-23718         c
            659-790             AC005757.1         20403-20534         c
            791-4822            AC005757.1         14362-18393         c
FEATURES             Location/Qualifiers
     source          1..4822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..4822
                     /gene="NKPD1"
                     /note="NTPase KAP family P-loop domain containing 1"
                     /db_xref="GeneID:284353"
                     /db_xref="HGNC:HGNC:24739"
     exon            1..58
                     /gene="NKPD1"
                     /inference="alignment:Splign:2.1.0"
     exon            59..220
                     /gene="NKPD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2628
                     /gene="NKPD1"
                     /codon_start=1
                     /product="NTPase KAP family P-loop domain-containing
                     protein 1"
                     /protein_id="NP_940880.3"
                     /db_xref="GeneID:284353"
                     /db_xref="HGNC:HGNC:24739"
                     /translation="MHKHYKVHFAKDAQSPNGHYFWDPELGHRKGCCHQWRQDSAALR
                     AHGPCRPSPQSHWQLAYHSHQVGGSGWRRGLLPSVLQQQRQPQSQPSPPSPLRQRLCP
                     IHEAQKGLPATSTVPKEPASAPQAPTLPTTAPAMARSGPALPSAAGVLLKPSEPTDAR
                     PLPAPAACGSFTAYSSDILTEDDVYCSCLAKTLCHVPVPVTVGFYAPFGCRLHMMLDK
                     ITALMQQEAAQRESEELQHVQWRPRAVSGWGVPQLLWYLVFLQPIITEVHLRRRNVQF
                     LFIRFSAWQYAGTDKLWAGLVTTLCEGIRRHYGALPFSVYSVLGNKPATRQDCCQSEW
                     HCRRRVCLGLLALLAALGLGVGLLYLSLGGHALGHGSPSGSLLKVFGGAATTLSGSGL
                     LMAVYSVGKHLFVSQRKKIERLVSREKFGSQLGFMCEVKKEVELLTDFLCFLEIYQRR
                     RLRVVLEVTGLDTCYPERVVGVLNAINTLLSDSHAPFIFILVVDPSILAACLESAGNM
                     KGTADNGYLFLNRTVTLPFSVPIMGRRTKLQFLHDAVQSRDDLLYREMTRKPWLPGDA
                     GGESAQLLAVQAQAGTERGQGRIDDEAARRIQEALFCLHDERDCLYEYVPDNVVSMRR
                     IVNTVPITVRLLQQQQQQGDFGGPTPRQAVAWVVLANQWPCRLSWALQCLEDRQQTGG
                     APEGRARLWDVFRDNSRELHTMTKALQNVLDLDGDPELFERFLGADFPFTVAEAQSLL
                     RCTVNLDHSIRRRMGLIRAVSALKPPSPPKSPTRDTPHAAHRANSASRAPPSGRASGQ
                     AGEGHHTGDLAHRGKLWPVACALFRPGQSSPGGP"
     exon            221..658
                     /gene="NKPD1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..790
                     /gene="NKPD1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..4822
                     /gene="NKPD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2863..2868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKPD1"
                     /note="hexamer: AATAAA"
     polyA_site      2889
                     /gene="NKPD1"
                     /note="major polyA site"
     regulatory      4144..4149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKPD1"
                     /note="hexamer: AATAAA"
     polyA_site      4184
                     /gene="NKPD1"
                     /note="major polyA site"
     regulatory      4292..4297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKPD1"
                     /note="hexamer: AATAAA"
     polyA_site      4312
                     /gene="NKPD1"
     regulatory      4794..4799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKPD1"
                     /note="hexamer: AATAAA"
     polyA_site      4822
                     /gene="NKPD1"
ORIGIN      
        1 gggctggtgt ggcagctgct cgtggggcag gcagctgggg ccgtgaggcc accgtcagag
       61 gctacgccaa gcctgtgtgc tccctcctgc ctcaggagca ggcccccagc acccagctgc
      121 ccggctgcca tgcacaaaca ttacaaagtc cacttcgcca aggatgccca gagccccaac
      181 gggcactact tctgggaccc agagttgggg caccgaaaag gatgctgtca tcagtggcgc
      241 caggactcag cggccctccg agcccatggg ccctgtcggc cttcccccca atcacactgg
      301 cagctggcct accacagcca ccaagtgggt ggcagtggct ggcgccgggg cctcctgccc
      361 tccgtcctgc agcagcagcg gcagccccag tcccagccct cacctcccag ccccctgcgg
      421 cagcggctct gccccattca cgaagcccag aaggggctgc ctgcaacctc cactgtcccc
      481 aaggaacctg ccagcgcccc tcaggcgccc accttaccca ccacggcacc agccatggcc
      541 aggagtggcc cagctctacc ctccgcggct ggcgtcctcc tgaagcccag cgagcccact
      601 gatgcccggc ccctgcccgc cccagcggcc tgtggctcct tcactgccta cagctccgac
      661 atcctgacag aggatgacgt ctactgcagc tgcctggcca agacactctg ccacgtgccg
      721 gtccctgtga ccgtgggttt ctatgcccct ttcggctgcc gcctgcacat gatgctggac
      781 aagatcacgg cgctgatgca gcaggaggcc gcgcagcgcg agagcgagga gctgcagcac
      841 gtgcagtggc ggccgcgtgc cgtgagcggc tggggcgtcc cgcagctact gtggtacctg
      901 gtgttcctgc agcccatcat caccgaggtg cacctgcggc gcaggaacgt gcagttcctt
      961 ttcatccgct ttagcgcctg gcagtacgcg ggcaccgaca agctgtgggc cggcctggtg
     1021 accacgttgt gcgagggcat ccgccgccac tatggcgcac tgcccttcag cgtgtactcg
     1081 gtgctgggca acaagccggc caccaggcag gactgctgcc agagcgagtg gcattgtcgg
     1141 cgccgcgtgt gcctggggct gctggcgctg ctggcggcgc tgggcctggg tgtggggctg
     1201 ctctacttgt cactgggcgg ccacgcgctg ggccacggca gcccgagcgg cagcctgctc
     1261 aaggtgtttg gcggcgcggc caccacactg tcgggctcgg ggctgctcat ggccgtgtac
     1321 tcggtgggca agcacctgtt cgtaagccag cgcaagaaga tcgagcggct ggtgtcgcgt
     1381 gaaaagttcg gcagccagct gggtttcatg tgcgaggtga agaaggaggt ggagctgctc
     1441 accgacttcc tgtgcttcct ggagatctac cagcggcgca ggctgcgcgt ggtgctggag
     1501 gtcaccgggc tggacacgtg ctacccggag cgcgtggtgg gcgtgctcaa cgccatcaac
     1561 acgctgctgt ccgacagcca cgcgcccttc atcttcatcc tggtcgtgga ccccagcatc
     1621 ctggccgcgt gcctagagag cgcgggcaac atgaagggca cggccgataa cggctacctc
     1681 ttcctcaacc gcactgtcac gctgcccttc tctgtgccca ttatgggccg ccgcaccaag
     1741 ctgcagttcc tgcacgatgc ggtgcagagc cgcgacgacc tgttgtaccg cgagatgacg
     1801 cgcaagccgt ggctgccggg ggacgccggg ggcgagagcg cgcagctgct ggcggtgcag
     1861 gcgcaggcgg ggacggagcg cgggcagggc cgcatcgacg acgaggcggc gcggcgaatc
     1921 caggaggcgc tcttctgcct tcacgacgag cgcgactgcc tctacgagta cgtgcccgac
     1981 aacgtggtgt ccatgcggcg catcgtcaac accgtgccca tcaccgtgcg cctgctgcag
     2041 cagcagcagc agcaggggga ctttgggggc cccacgccgc gccaggcggt ggcgtgggtg
     2101 gtgctcgcca accagtggcc gtgccgcctg agctgggcgc tgcagtgcct ggaggaccgg
     2161 cagcagaccg ggggcgcgcc cgagggccgc gcgcgcctct gggacgtttt ccgcgacaac
     2221 agccgcgagc tgcacaccat gaccaaggcg ttgcagaacg tgctcgacct ggacggcgac
     2281 cccgagctct tcgagcgctt cctgggcgcc gacttcccct tcaccgtggc cgaggcgcag
     2341 agcctgctgc gctgcacggt caacctggac cactccatcc gccggcgcat gggtctcatc
     2401 cgagccgtca gcgcgctcaa gccgcccagc ccgcccaagt cccctacccg cgataccccc
     2461 cacgctgccc accgggccaa cagcgcctcc agggcgcccc cgtcgggccg tgcctcaggg
     2521 caagccggcg aaggccacca cactggggac ttggcccaca ggggcaagct atggccggtg
     2581 gcctgtgcgc tcttccgtcc agggcaatcc agcccaggtg ggccttaaat ggaggacttg
     2641 gcgggcagca ggaggcaagg gttcctccat ctgcccagat gggagaatag ggggctggac
     2701 tggggccgca acccagggtc cgaatgagcc ctgtgaggcc cacaccccca ggtgaacctg
     2761 agccagagcc gtggacatag cttccaagga gtgcggccac aagccggtgc cagcatgaga
     2821 gcaggcacag aaggaccagt gaggaagtca gggtatacat gcaataaatg gaggtgttga
     2881 gagcccggag ttgctctccg catcctgatc tgaccaggga ccaggcctgc cccgtcctgc
     2941 cacagggcct gccccatcct gctaagccca cttactcctc tgcaccatgc tggcctcctc
     3001 atctggcatc tctgtggcag gagaggctgc gggggtggtg ggtgaggctg cagagatgac
     3061 aggtggatgg gccaggttga ctcaggcaac atggagcgcc caggcctcag ggaatcccag
     3121 tccttgtccc catgccctag cttgcccctc tgtgagtagg gcaggggctg gcatttctga
     3181 ggatgacctc ggtgacctca gcaagctgct ccacccctag ggtggctcca ttctcaacgt
     3241 aatgggttag acctcgctgg cacctcagcc agctggagtg ggtggcacta acctccccca
     3301 gacaaataac tgtccacagg gtacctgcct tacgagtcac tccagggcca ctggttagtc
     3361 actgacactg aagccactgc atcagccccc tgatgaggac agggaagttg ggcagagatg
     3421 gggacataca gggcccaagc cacagccagc caggaggggt tacactaggg ctcccccact
     3481 ttccctctgg gcagagccct gggctggggg tgggtgtcac tcctctgggc agttcctgat
     3541 tcctcactgg tcaaatgttc agccacacgc tcaggccctg gggtgcctgg cccagttcca
     3601 agtgtgtgcc ggcaggggcc acaagggcca acactgaaca taccctggga tgaggctgag
     3661 ggtgtggctt ctgagccagg gccctgaggc tggtggaggg gacagccccc gaggaacctg
     3721 agagctctgc aaaggcacac accctcaggc catgggactg ggtcactgac ctcacagttc
     3781 tttagttcca aggctgggca tagcatccag gtctggctgc agcaccggag ttctctggcc
     3841 acagcaattg tcacaggtgc atgcaggtca gtgggagccc tctatgatct tccctggggc
     3901 tgggcaagca gaggtgctgt ttcccattcc tggactgact aagctggtag gatacgcctg
     3961 gacctcctgg gagctgtttc ccagcagtca gggagagctg gcctcagagg gagaaggatg
     4021 gggcctcgtg acaccgttaa gtctgtttct gtagatgtgt ggttggggtc aatatatccc
     4081 tgtagcctcc cttaagccag tttcagttgg gtttgtttct taccacctgg aatccaagct
     4141 gaaaataaat tttcactcct gttaccagga gtggggtgct gtgagagatg ctaacgtgta
     4201 gacttggctg gaggtgaggg caggactgaa gccccccatg cctcagtaag aagctgcatc
     4261 agcctggcca acatggtgaa gccctgtctc taataaaaat acaaaaagat tagctgggca
     4321 tggtggtgca tgcctgtaat cccagctact caggaggctg aggtgggagg atcacttgaa
     4381 cccgggaggt ggtggctgga gccaagatgg tgccactgca ctccagcctg ggcgacagag
     4441 caagactccg actgattaaa aaaaaaagcc gcagcctctg ttacgtggta caagctgtgg
     4501 ccaaactgtt ggtcactgta tcttcacgtg gagctgctat gagaacttgc acctgtgtaa
     4561 agccacggga ccgttgtcac gaacaaaaaa ggagcacggc tgacctgtgc gcctttccca
     4621 gcaatgagtc agggagcagg tttcccttct ccactccctt cccccatctg cccacttgat
     4681 ccgggatcct tgaggccctg gggagcaaca gagccctaag agcttcaaag gggcctgggt
     4741 ccaggaataa cttggtgaag agctgcctgc cactctgaac atccacatgt gacaataaac
     4801 atctcctgtg ttaggacatt ga
//
