LOCUS       NM_017595               2453 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens NFKB inhibitor interacting Ras like 2 (NKIRAS2),
            transcript variant 2, mRNA.
ACCESSION   NM_017595
VERSION     NM_017595.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Shi,J., Guo,X., Liu,C., Wang,Y., Chen,X., Wu,G., Ding,J. and
            Zhang,T.
  TITLE     Molecular insight into the potential functional role of
            pseudoenzyme GFOD1 via interaction with NKIRAS2
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (9), 1256-1266 (2024)
   PUBMED   38946427
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Tago,K., Ohta,S., Aoki-Ohmura,C., Funakoshi-Tago,M., Sashikawa,M.,
            Matsui,T., Miyamoto,Y., Wada,T., Oshio,T., Komine,M., Matsugi,J.,
            Furukawa,Y., Ohtsuki,M., Yamauchi,J. and Yanagisawa,K.
  TITLE     K15 promoter-driven enforced expression of NKIRAS exhibits tumor
            suppressive activity against the development of DMBA/TPA-induced
            skin tumors
  JOURNAL   Sci Rep 11 (1), 20658 (2021)
   PUBMED   34667224
  REMARK    GeneRIF: K15 promoter-driven enforced expression of NKIRAS exhibits
            tumor suppressive activity against the development of
            DMBA/TPA-induced skin tumors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Haemmig,S., Baumgartner,U., Gluck,A., Zbinden,S., Tschan,M.P.,
            Kappeler,A., Mariani,L., Vajtai,I. and Vassella,E.
  TITLE     miR-125b controls apoptosis and temozolomide resistance by
            targeting TNFAIP3 and NKIRAS2 in glioblastomas
  JOURNAL   Cell Death Dis 5 (6), e1279 (2014)
   PUBMED   24901050
  REMARK    GeneRIF: GBM cells overexpressing TNFAIP3 and NKIRAS2 were
            refractory to miR-125b-induced apoptosis resistance as well as TMZ
            resistance, indicating that both genes are relevant targets of
            miR-125b.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2453)
  AUTHORS   Tago,K., Funakoshi-Tago,M., Sakinawa,M., Mizuno,N. and Itoh,H.
  TITLE     KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits
            NF-kappaB activation through the suppression of transcriptional
            activation of p65/RelA
  JOURNAL   J Biol Chem 285 (40), 30622-30633 (2010)
   PUBMED   20639196
  REMARK    GeneRIF: KappaB-Ras2 is a nuclear-cytoplasmic small GTPase that
            inhibits NF-kappaB activation through the suppression of
            transcriptional activation of p65/RelA.
REFERENCE   5  (bases 1 to 2453)
  AUTHORS   Dieguez-Gonzalez,R., Akar,S., Calaza,M., Perez-Pampin,E.,
            Costas,J., Torres,M., Vicario,J.L., Velloso,M.L., Navarro,F.,
            Narvaez,J., Joven,B., Herrero-Beaumont,G., Gonzalez-Alvaro,I.,
            Fernandez-Gutierrez,B., de la Serna,A.R., Carreno,L.,
            Lopez-Longo,J., Caliz,R., Collado-Escobar,M.D., Blanco,F.J.,
            Fernandez-Lopez,C., Balsa,A., Pascual-Salcedo,D., Gomez-Reino,J.J.
            and Gonzalez,A.
  TITLE     Genetic variation in the nuclear factor kappaB pathway in relation
            to susceptibility to rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 68 (4), 579-583 (2009)
   PUBMED   18434448
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2453)
  AUTHORS   Fenwick,C., Na,S.Y., Voll,R.E., Zhong,H., Im,S.Y., Lee,J.W. and
            Ghosh,S.
  TITLE     A subclass of Ras proteins that regulate the degradation of IkappaB
  JOURNAL   Science 287 (5454), 869-873 (2000)
   PUBMED   10657303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG717103.1, BC007316.2, BC063498.1 and AC105024.8.
            
            On Nov 23, 2018 this sequence version replaced NM_017595.5.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1, and encodes isoform a. Variants 1-3 encode
            the same protein (isoform a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.971955.1,
                                           SRR1660807.38372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393885.9/ ENSP00000377463.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BG717103.1         45-71
            28-291              BC007316.2         1-264
            292-1588            BC063498.1         784-2080
            1589-2453           AC105024.8         46546-47410
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2453
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /note="NFKB inhibitor interacting Ras like 2"
                     /db_xref="GeneID:28511"
                     /db_xref="HGNC:HGNC:17898"
                     /db_xref="MIM:604497"
     exon            1..115
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            116..223
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..705
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /note="isoform a is encoded by transcript variant 2; NFKB
                     inhibitor interacting Ras-like protein 2;
                     I-kappa-B-interacting Ras-like protein 2; NF-kappa-B
                     inhibitor-interacting Ras-like protein 2; kappa B-Ras
                     protein 2"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor-interacting Ras-like
                     protein 2 isoform a"
                     /protein_id="NP_060065.2"
                     /db_xref="CCDS:CCDS11415.1"
                     /db_xref="GeneID:28511"
                     /db_xref="HGNC:HGNC:17898"
                     /db_xref="MIM:604497"
                     /translation="MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYV
                     GSIETDRGVREQVRFYDTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKK
                     EIDKSKDKKEVTIVVLGNKCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEP
                     FVYLASKMTQPQSKSAFPLSRKNKGSGSLDG"
     exon            224..465
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            466..2453
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /note="hexamer: AATAAA"
     polyA_site      2453
                     /gene="NKIRAS2"
                     /gene_synonym="kappaB-Ras2; KBRAS2"
                     /note="major polyA site"
ORIGIN      
        1 ctggaggagc ctacaccgac tctggaggaa gactggagcc tttgcggcgg cgctgcccct
       61 cccctggtcc ccgcgagctc ggagggcccg gctggtgctg cgggggcccc gggaggttga
      121 aaactaagca tggggaagag ctgcaaggtg gtcgtgtgtg gccaggcgtc tgtgggcaaa
      181 acttcaatcc tggagcagct tctgtatggg aaccatgtag tgggttcgga gatgatcgag
      241 acgcaggagg acatctacgt gggctccatt gagacagacc ggggggtgcg agagcaggtg
      301 cgtttctatg acacccgggg gctccgagat ggggccgaac tgccccgaca ctgcttctct
      361 tgcactgatg gctacgtcct ggtctatagc acagatagca gagagtcttt tcagcgtgtg
      421 gagctgctca agaaggagat tgacaaatcc aaggacaaga aggaggtcac catcgtggtc
      481 cttggcaaca agtgtgactt acaggagcag cggcgtgtag acccagatgt ggctcagcac
      541 tgggccaagt cagagaaggt gaagctgtgg gaggtgtcag tggcggaccg gcgctccctc
      601 ctggagccct ttgtctactt ggccagcaag atgacgcaac cccagagcaa gtctgccttc
      661 cccctcagcc ggaagaacaa gggcagcggc tccttggatg gctgaagagc tgccgttcct
      721 ctttcacgat cccagcccca tttcagtgtc tggggctctg gtagatgtgt tgagggcaaa
      781 gtagaggaca agctgtcttt cccagtcagc cagggagctc cccgccaggc cacgccccag
      841 ccactttgct ccctctcacc tctgggaagt gcaaatactc ttggttgaca tccccttcct
      901 cagccctccc agcctactcc ccatcccagc ttttagagga tctgctccac tgtctcctgg
      961 ggcagttgtg ggtcactgtc ccttccagct gccccagaca ggaagcagag tcaccacgca
     1021 gcagtgtccc ttcttgggtc tgagttccta ttataggtag gggccccacc ctctgggctt
     1081 cccatcagcg acacacacac acttatggca ccagcctgga ctccagaaaa agggtgtcca
     1141 ggtattgtgt gtatgcattt agttgtgcac acacaaatat gctcctatac tggcattagg
     1201 cgtctcctca tccctcaccc tgacctttct cctgtccttt tcttggctgg aagaagttgg
     1261 cctcctggga gtgtagtttt ctgttttaaa tcccccaccc ctggctgggc tcagtggctc
     1321 acccctgtaa tcccagcact ttgggaggcc aaggcgggtc gattacttga ggtcaggagt
     1381 tcacgaccag cctggccaac attgtgaaac cccatctctg ccaaaaatac aaaagttagc
     1441 cgggcgtagt ggcacatgcc tgtaatccca gctacccggg gaggctgagg caggagaatt
     1501 gcttgaactc agaaggcgga ggctgcagtg agccgagatc gtgccactgc actccagcct
     1561 ggtcaacaga gcaagactcc atctcgaaga aaaaaaaaaa aaattcccca cccctaccaa
     1621 ttgttttact tcctcttcct gctcagggag cagatgggcc tcactggttg agatggaata
     1681 gaataactgg gctatgagtc accagcccac tttgtgaccc agcaagacct ttcccctctc
     1741 tgggcatcag tttctcatct gtaagatgac cagagttgct tagatgatct cctagatcct
     1801 ttccagttct cttgatttcg taaagccaat ggcttctccc tctttaaggt gctatgccaa
     1861 ccagccctgg aggctgggat ctgccgctcc ctccagccac cagggggcag gagtgcacta
     1921 cctgctgtca gtcaccagag tggccgctca gtgcccagcc cgccagcctc gctcttggag
     1981 gctgctcttt atcctgcctg tggttttcag ctcagagctg gacttctatt tataagttac
     2041 ctgtatttat atttatatgc ccgctctcat ggtgaaggct ggacaaggtg ctcctctggc
     2101 ccctccttct tacctcagat gcctgaacag aacaaggcaa acccgtagca gcctctcagg
     2161 agctgacagg tcctctttcg gggctcagga gggtgggcac acacccagcg gcctgcagag
     2221 taagcttatt acccacaact gtgcccgctt tgtgcttcta aggtgcacac ctagcctagg
     2281 tgagacactg cagccaggca accaccgaca cacgcccctt ctcaaagcca gaggtgagtg
     2341 gggcaggtgc ccggggctgg gtgagtggaa ttaggacaca cacaggcttg ggcttcaagt
     2401 tcatttattg atgcattggt tggacacaat aaaaccacaa ttgttatcaa aaa
//
