LOCUS       NM_020345               4069 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens NFKB inhibitor interacting Ras like 1 (NKIRAS1),
            transcript variant 1, mRNA.
ACCESSION   NM_020345
VERSION     NM_020345.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4069)
  AUTHORS   Postler,T.S., Wang,A., Brundu,F.G., Wang,P., Wu,Z., Butler,K.E.,
            Grinberg-Bleyer,Y., Krishnareddy,S., Lagana,S.M., Saqi,A.,
            Oeckinghaus,A., Rabadan,R. and Ghosh,S.
  TITLE     A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 120 (46), e2312595120 (2023)
   PUBMED   37931099
  REMARK    GeneRIF: A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene.
REFERENCE   2  (bases 1 to 4069)
  AUTHORS   Braga,E.A., Loginov,V.I., Pronina,I.V., Khodyrev,D.S., Rykov,S.V.,
            Burdennyy,A.M., Friedman,M.V., Kazubskaya,T.P., Kubatiev,A.A. and
            Kushlinskii,N.E.
  TITLE     Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated
            with loss of their methylation as well as with methylation of
            regulatory miRNA genes
  JOURNAL   Biochemistry (Mosc) 80 (4), 483-494 (2015)
   PUBMED   25869366
  REMARK    GeneRIF: It was demonstrated that elevated levels of mRNA for
            NKIRAS1 was significantly associated both with loss of methylation
            in NKIRAS1 CpG-islands and methylation in a number of miRNA genes.
REFERENCE   3  (bases 1 to 4069)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4069)
  AUTHORS   Khodyrev,D.S., Pronina,I.V., Rykov,S.V., Beresneva,E.V.,
            Fridman,M.V., Kazubskaia,T.P., Loginov,V.I. and Braga,E.A.
  TITLE     [Methylation of some miRNA genes is involved in the regulation of
            their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]
  JOURNAL   Mol Biol (Mosk) 46 (5), 773-785 (2012)
   PUBMED   23156677
  REMARK    GeneRIF: Significant correlation was found between alterations of
            methylation status of miR-34b/c, miR-193a and the expression level
            of NKIRAS1 target gene in the primary lung tumors.
REFERENCE   5  (bases 1 to 4069)
  AUTHORS   Lin,H., Wang,Y., Zhang,X., Liu,B., Zhang,W. and Cheng,J.
  TITLE     Prognostic significance of kappaB-Ras1 expression in gliomas
  JOURNAL   Med Oncol 29 (2), 1272-1279 (2012)
   PUBMED   21302000
  REMARK    GeneRIF: Low kappaB-Ras1 expression is associated with gliomas.
REFERENCE   6  (bases 1 to 4069)
  AUTHORS   Dieguez-Gonzalez,R., Akar,S., Calaza,M., Perez-Pampin,E.,
            Costas,J., Torres,M., Vicario,J.L., Velloso,M.L., Navarro,F.,
            Narvaez,J., Joven,B., Herrero-Beaumont,G., Gonzalez-Alvaro,I.,
            Fernandez-Gutierrez,B., de la Serna,A.R., Carreno,L.,
            Lopez-Longo,J., Caliz,R., Collado-Escobar,M.D., Blanco,F.J.,
            Fernandez-Lopez,C., Balsa,A., Pascual-Salcedo,D., Gomez-Reino,J.J.
            and Gonzalez,A.
  TITLE     Genetic variation in the nuclear factor kappaB pathway in relation
            to susceptibility to rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 68 (4), 579-583 (2009)
   PUBMED   18434448
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4069)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 4069)
  AUTHORS   Chen,Y., Vallee,S., Wu,J., Vu,D., Sondek,J. and Ghosh,G.
  TITLE     Inhibition of NF-kappaB activity by IkappaBbeta in association with
            kappaB-Ras
  JOURNAL   Mol Cell Biol 24 (7), 3048-3056 (2004)
   PUBMED   15024091
REFERENCE   9  (bases 1 to 4069)
  AUTHORS   Chen,Y., Wu,J. and Ghosh,G.
  TITLE     KappaB-Ras binds to the unique insert within the ankyrin repeat
            domain of IkappaBbeta and regulates cytoplasmic retention of
            IkappaBbeta x NF-kappaB complexes
  JOURNAL   J Biol Chem 278 (25), 23101-23106 (2003)
   PUBMED   12672800
REFERENCE   10 (bases 1 to 4069)
  AUTHORS   Fenwick,C., Na,S.Y., Voll,R.E., Zhong,H., Im,S.Y., Lee,J.W. and
            Ghosh,S.
  TITLE     A subclass of Ras proteins that regulate the degradation of IkappaB
  JOURNAL   Science 287 (5454), 869-873 (2000)
   PUBMED   10657303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG713995.1, BC012145.1 and AC124914.3.
            
            On Jan 8, 2020 this sequence version replaced NM_020345.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012145.1, AL583570.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425478.7/ ENSP00000400385.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BG713995.1         62-122
            62-1939             BC012145.1         1-1878
            1940-4069           AC124914.3         35128-37257         c
FEATURES             Location/Qualifiers
     source          1..4069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..4069
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="NFKB inhibitor interacting Ras like 1"
                     /db_xref="GeneID:28512"
                     /db_xref="HGNC:HGNC:17899"
                     /db_xref="MIM:604496"
     exon            1..207
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..329
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..440
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..925
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="isoform 1 is encoded by transcript variant 1; NFKB
                     inhibitor interacting Ras-like protein 1;
                     I-kappa-B-interacting Ras-like protein 1; kappa B-ras 1;
                     NF-kappa-B inhibitor-interacting Ras-like protein 1; kappa
                     B-Ras protein 1"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor-interacting Ras-like
                     protein 1 isoform 1"
                     /protein_id="NP_065078.1"
                     /db_xref="CCDS:CCDS33717.1"
                     /db_xref="GeneID:28512"
                     /db_xref="HGNC:HGNC:17899"
                     /db_xref="MIM:604496"
                     /translation="MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYM
                     ASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKK
                     EIDKFKDKKEVAIVVLGNKIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEP
                     FTLLASKLSQPQSKSSFPLPGRKNKGNSNSEN"
     exon            441..682
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..4069
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      1745
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     regulatory      1927..1932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      1959
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     polyA_site      2749
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     regulatory      4040..4045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      4069
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
ORIGIN      
        1 attgtcccgc cccctgctcc gcaagattcg agcctgagcg gcctgggcgt ctcgagaggt
       61 gagagagttg gcggcgaggt ctcggcggct aagcgagcgt cggcgactgt ctctccgcga
      121 gaggaggcaa gttggggtcc aggctccaaa gccggtggcc gcgtaccgcg gtggagccgc
      181 tgtctttgag gtctgaggag agaacagaca gagtctagct ctttcaccca ggctggagtg
      241 aagtggtgca atctcagctc agtgcaacct ccgccccctg ggttcaagtg attctcctgc
      301 ctcagcctcc ccagtagctg ggattacagt gatatcctga gagaagatgg gaaagggctg
      361 caaggttgtg gtttgtggat tgttatctgt ggggaaaact gcaattttgg agcagctcct
      421 ttatggaaat catactattg gaatggaaga ttgcgaaaca atggaagatg tatacatggc
      481 ttcagtagaa acagaccgag gagtaaaaga acagttacat ctttatgaca ccagaggtct
      541 acaggaaggc gtggagctgc caaagcatta tttttcattt gctgatggct tcgttcttgt
      601 gtacagtgtg aataaccttg aatcctttca aagagtggag cttctgaaga aagaaatcga
      661 taagttcaaa gacaaaaaag aggtagcaat tgtggtatta ggaaacaaaa tcgacctttc
      721 tgagcagaga caagtggacg ctgaagtggc acagcagtgg gcaaaaagtg agaaagtaag
      781 actgtgggag gtgactgtta cagatcggaa aactctgatt gaaccattca ctttattagc
      841 cagtaaactt tctcaacccc agagcaaatc aagctttcct ttgcctggga ggaaaaacaa
      901 agggaactct aattctgaga actaaaaatc agtaatttcc acaattgtat gttgaatagt
      961 gattgccttt aagtgtctgt gaacatggag taatattact atttaaaata ggccatttgt
     1021 atctaccttt ggtccttagg aaaattccta aggaagtcaa ttaatgcact ttagatgtta
     1081 aaagtatttg ggctaaggtt attattgcct gatatgaaat aatatattct tattctcatt
     1141 gtttgaaacc tgtctttgaa attagcacct ttgttattta tgttgtactt gtgaaaacag
     1201 taaaatagtt tggatagtta tgcaaatgca cctatgtgta acttcccccc aaccccaagc
     1261 tgtttcggaa gatatcataa tcattctgtg taacattatg caaacttcta agcccaaaca
     1321 tgactttgtt tttaaaaagt tcattaatct aatgtctagg attataaaac atttttttgt
     1381 gtctaaattg gacccaaaac attgaacagt ttggggtagt aagctaaatt tcatcttgtg
     1441 gagattttgc taaacagact aagacccatg atttagcttt gctcaaatta gaatgtttag
     1501 catgagttga ggtaccaggt agtgttaagt aggttcatca cgctctaagg ccgttttttc
     1561 cttagccaga cccctgttga tagaccagat acttgagggc aaactgtttg ctcctcctct
     1621 tgaaaatgat taggcactta aggacagtaa agctgtattt tctggaagga agactgtatc
     1681 ttctggaata gttttctaga aaactagtca tatacaataa aagtatcaaa aatattgggc
     1741 tctaatttga tctgacttag atgtctgagt ttgtgttgtt tctctaaaga ttttggcaag
     1801 actcaagcaa tgtggctgac tgtaacttta ttaatttaaa aggtaggaag taagctactt
     1861 agtggtttca cctgtgaaat aactattttg actgaaatgt aaaataagct attcaacaaa
     1921 gaacatatta aaacatcaag taatttgtaa catcttaaat ggaatacttt tttcatgagc
     1981 tctagtgaag aactactaca tataaaagac gatacttaca aatcagctat tgctgctaca
     2041 gtataattct tcaaaatttc tcatcataaa ttcatttttt ggtaaaaaaa aattaccaga
     2101 cactaactca cccccttacc cttttccccc ggttattgaa tattaatcta gcttcccacc
     2161 catgcatgtt acatagatgg acaaatgctt tcataatgat ttttaaataa gtaccttcca
     2221 gtttgctttg tttcctacta atgcaactta gtctatatta gtacaaacag ttaccaattc
     2281 tttttaaatt ctgtaatgaa tgtatgtgta tccagataag tttctctgaa agagacatac
     2341 agaaacagaa ctgctgggtc aggacatgta ctgccaaaat gccccctaag gcagggtacc
     2401 aatttatcca tgacggaacc catttctcat gtacttgcta ctacagcatc tgcaagtcag
     2461 aaaatgcttt taaaaagatg cagtagggtt cgtctttgaa gcctaaatgg ggtagattat
     2521 ttaacctttt ctaggatacc tcatctacag ctgtgtaaag tacagatcct aatataggta
     2581 actaactaat acctactaaa tatgcattat ttttagcttg ttttagaagc agatacctat
     2641 cgatttcaga agaatctgcg aatggcaacc aaaaggcaaa agaaaagtaa atgaacacag
     2701 cagtgtttat taggtggttt ttaatattgt ttattagcac agtaacaaat gcagacttaa
     2761 gtagtccaca acatagaacc aatccactga gcaactccta ttccacgcct tacagttagt
     2821 taacagctta aggtatttca ctacaggttt tcacaagtcc tgattcagac cttttttaaa
     2881 caaagtagat tggcatataa aataaaacgc actactcatc tcttatatgg tgttttatag
     2941 ccacgtgtcc attttatata tatgagatga caatctctaa aaactctgtt aaatatcaat
     3001 gttcccttcc aagaagggaa aacaaattcc aattttgttt taaacaaaaa gtatgtagtc
     3061 ttagagggac tttacataaa tggccatatg tgtaacctgt accaaattaa gctgttttaa
     3121 atttacagac tacaagcaac tgaacccaaa tgtctaaatg tacattcttt tctgtactac
     3181 atttcagcta atattgcaga actaatgaca attttaaaag ttgctattac caattctgtc
     3241 tactgtagca agatacctta agttacaaca aaatcttagg aaataagact gaataatatc
     3301 tgttatagaa ataccctact ctttaccaac tcccaccctc cctgacccct tcaaaatcat
     3361 aagcagctct cttctgtgac agacaaataa tgtaagaatt gtgaaacccc aatttatgta
     3421 gcgtatctct tggtccactg tctggccatt ctgtcatgtt ctgctctgtt ggtcatatac
     3481 tgagtggcaa tacttcccac caaggggtcg gctggaagaa aagaatgtag attactttgg
     3541 agaaaggaaa agaacatttt aaactttagc gaatagtgac agcttgggta gatacgtacg
     3601 acaaagtatg tgtgatcaaa cccatcttcg aaacaccact ccaccatgct ggatattttt
     3661 ccatcaaaat ttcaaaaaaa cataacgttg ggggaagagg gaatgcttag gctttagtgt
     3721 actggtctgt ctttatctta gttcattcca tttttctccc aacaaacaac actcaattgg
     3781 agtttcttta ctcttatgtg ttaggctgag ttcagtagag actggaacgg tcaaggcttc
     3841 agactgcaat gaacatccag ctgtgttcat gtgaccctta gctcaatgtc accagttaac
     3901 ggcattgtga atactgtgaa gtcttcgggg ctgttgcagt gcaacactat taacctttac
     3961 gctggttaaa gagccaggtt gccaggcaaa acctggacct ccaattaagt atagtatttc
     4021 tctgaatctt aggatcttta ataaatttat atttggttta cctagaaaa
//
