LOCUS       NM_001377369            4065 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens NFKB inhibitor interacting Ras like 1 (NKIRAS1),
            transcript variant 20, mRNA.
ACCESSION   NM_001377369
VERSION     NM_001377369.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4065)
  AUTHORS   Postler,T.S., Wang,A., Brundu,F.G., Wang,P., Wu,Z., Butler,K.E.,
            Grinberg-Bleyer,Y., Krishnareddy,S., Lagana,S.M., Saqi,A.,
            Oeckinghaus,A., Rabadan,R. and Ghosh,S.
  TITLE     A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 120 (46), e2312595120 (2023)
   PUBMED   37931099
  REMARK    GeneRIF: A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene.
REFERENCE   2  (bases 1 to 4065)
  AUTHORS   Braga,E.A., Loginov,V.I., Pronina,I.V., Khodyrev,D.S., Rykov,S.V.,
            Burdennyy,A.M., Friedman,M.V., Kazubskaya,T.P., Kubatiev,A.A. and
            Kushlinskii,N.E.
  TITLE     Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated
            with loss of their methylation as well as with methylation of
            regulatory miRNA genes
  JOURNAL   Biochemistry (Mosc) 80 (4), 483-494 (2015)
   PUBMED   25869366
  REMARK    GeneRIF: It was demonstrated that elevated levels of mRNA for
            NKIRAS1 was significantly associated both with loss of methylation
            in NKIRAS1 CpG-islands and methylation in a number of miRNA genes.
REFERENCE   3  (bases 1 to 4065)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4065)
  AUTHORS   Khodyrev,D.S., Pronina,I.V., Rykov,S.V., Beresneva,E.V.,
            Fridman,M.V., Kazubskaia,T.P., Loginov,V.I. and Braga,E.A.
  TITLE     [Methylation of some miRNA genes is involved in the regulation of
            their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]
  JOURNAL   Mol Biol (Mosk) 46 (5), 773-785 (2012)
   PUBMED   23156677
  REMARK    GeneRIF: Significant correlation was found between alterations of
            methylation status of miR-34b/c, miR-193a and the expression level
            of NKIRAS1 target gene in the primary lung tumors.
REFERENCE   5  (bases 1 to 4065)
  AUTHORS   Lin,H., Wang,Y., Zhang,X., Liu,B., Zhang,W. and Cheng,J.
  TITLE     Prognostic significance of kappaB-Ras1 expression in gliomas
  JOURNAL   Med Oncol 29 (2), 1272-1279 (2012)
   PUBMED   21302000
  REMARK    GeneRIF: Low kappaB-Ras1 expression is associated with gliomas.
REFERENCE   6  (bases 1 to 4065)
  AUTHORS   Dieguez-Gonzalez,R., Akar,S., Calaza,M., Perez-Pampin,E.,
            Costas,J., Torres,M., Vicario,J.L., Velloso,M.L., Navarro,F.,
            Narvaez,J., Joven,B., Herrero-Beaumont,G., Gonzalez-Alvaro,I.,
            Fernandez-Gutierrez,B., de la Serna,A.R., Carreno,L.,
            Lopez-Longo,J., Caliz,R., Collado-Escobar,M.D., Blanco,F.J.,
            Fernandez-Lopez,C., Balsa,A., Pascual-Salcedo,D., Gomez-Reino,J.J.
            and Gonzalez,A.
  TITLE     Genetic variation in the nuclear factor kappaB pathway in relation
            to susceptibility to rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 68 (4), 579-583 (2009)
   PUBMED   18434448
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4065)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 4065)
  AUTHORS   Chen,Y., Vallee,S., Wu,J., Vu,D., Sondek,J. and Ghosh,G.
  TITLE     Inhibition of NF-kappaB activity by IkappaBbeta in association with
            kappaB-Ras
  JOURNAL   Mol Cell Biol 24 (7), 3048-3056 (2004)
   PUBMED   15024091
REFERENCE   9  (bases 1 to 4065)
  AUTHORS   Chen,Y., Wu,J. and Ghosh,G.
  TITLE     KappaB-Ras binds to the unique insert within the ankyrin repeat
            domain of IkappaBbeta and regulates cytoplasmic retention of
            IkappaBbeta x NF-kappaB complexes
  JOURNAL   J Biol Chem 278 (25), 23101-23106 (2003)
   PUBMED   12672800
REFERENCE   10 (bases 1 to 4065)
  AUTHORS   Fenwick,C., Na,S.Y., Voll,R.E., Zhong,H., Im,S.Y., Lee,J.W. and
            Ghosh,S.
  TITLE     A subclass of Ras proteins that regulate the degradation of IkappaB
  JOURNAL   Science 287 (5454), 869-873 (2000)
   PUBMED   10657303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124914.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.241339.1,
                                           SRR1660809.133709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC124914.3         61961-62167         c
            208-329             AC124914.3         56506-56627         c
            330-440             AC124914.3         55988-56098         c
            441-682             AC124914.3         45985-46226         c
            683-4065            AC124914.3         35128-38510         c
FEATURES             Location/Qualifiers
     source          1..4065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..4065
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="NFKB inhibitor interacting Ras like 1"
                     /db_xref="GeneID:28512"
                     /db_xref="HGNC:HGNC:17899"
                     /db_xref="MIM:604496"
     exon            1..207
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..329
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..440
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..697
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="isoform 3 is encoded by transcript variant 20; NFKB
                     inhibitor interacting Ras-like protein 1;
                     I-kappa-B-interacting Ras-like protein 1; kappa B-ras 1;
                     NF-kappa-B inhibitor-interacting Ras-like protein 1; kappa
                     B-Ras protein 1"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor-interacting Ras-like
                     protein 1 isoform 3"
                     /protein_id="NP_001364298.1"
                     /db_xref="GeneID:28512"
                     /db_xref="HGNC:HGNC:17899"
                     /db_xref="MIM:604496"
                     /translation="MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYM
                     ASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKK
                     EIDKFKDKKEQLWY"
     exon            441..682
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..4065
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1712..1717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      1741
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      1955
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     polyA_site      2745
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     regulatory      4036..4041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      4065
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
ORIGIN      
        1 attgtcccgc cccctgctcc gcaagattcg agcctgagcg gcctgggcgt ctcgagaggt
       61 gagagagttg gcggcgaggt ctcggcggct aagcgagcgt cggcgactgt ctctccgcga
      121 gaggaggcaa gttggggtcc aggctccaaa gccggtggcc gcgtaccgcg gtggagccgc
      181 tgtctttgag gtctgaggag agaacagaca gagtctagct ctttcaccca ggctggagtg
      241 aagtggtgca atctcagctc agtgcaacct ccgccccctg ggttcaagtg attctcctgc
      301 ctcagcctcc ccagtagctg ggattacagt gatatcctga gagaagatgg gaaagggctg
      361 caaggttgtg gtttgtggat tgttatctgt ggggaaaact gcaattttgg agcagctcct
      421 ttatggaaat catactattg gaatggaaga ttgcgaaaca atggaagatg tatacatggc
      481 ttcagtagaa acagaccgag gagtaaaaga acagttacat ctttatgaca ccagaggtct
      541 acaggaaggc gtggagctgc caaagcatta tttttcattt gctgatggct tcgttcttgt
      601 gtacagtgtg aataaccttg aatcctttca aagagtggag cttctgaaga aagaaatcga
      661 taagttcaaa gacaaaaaag agcaattgtg gtattaggaa acaaaatcga cctttctgag
      721 cagagacaag tggacgctga agtggcacag cagtgggcaa aaagtgagaa agtaagactg
      781 tgggaggtga ctgttacaga tcggaaaact ctgattgaac cattcacttt attagccagt
      841 aaactttctc aaccccagag caaatcaagc tttcctttgc ctgggaggaa aaacaaaggg
      901 aactctaatt ctgagaacta aaaatcagta atttccacaa ttgtatgttg aatagtgatt
      961 gcctttaagt gtctgtgaac atggagtaat attactattt aaaataggcc atttgtatct
     1021 acctttggtc cttaggaaaa ttcctaagga agtcaattaa tgcactttag atgttaaaag
     1081 tatttgggct aaggttatta ttgcctgata tgaaataata tattcttatt ctcattgttt
     1141 gaaacctgtc tttgaaatta gcacctttgt tatttatgtt gtacttgtga aaacagtaaa
     1201 atagtttgga tagttatgca aatgcaccta tgtgtaactt ccccccaacc ccaagctgtt
     1261 tcggaagata tcataatcat tctgtgtaac attatgcaaa cttctaagcc caaacatgac
     1321 tttgttttta aaaagttcat taatctaatg tctaggatta taaaacattt ttttgtgtct
     1381 aaattggacc caaaacattg aacagtttgg ggtagtaagc taaatttcat cttgtggaga
     1441 ttttgctaaa cagactaaga cccatgattt agctttgctc aaattagaat gtttagcatg
     1501 agttgaggta ccaggtagtg ttaagtaggt tcatcacgct ctaaggccgt tttttcctta
     1561 gccagacccc tgttgataga ccagatactt gagggcaaac tgtttgctcc tcctcttgaa
     1621 aatgattagg cacttaagga cagtaaagct gtattttctg gaaggaagac tgtatcttct
     1681 ggaatagttt tctagaaaac tagtcatata caataaaagt atcaaaaata ttgggctcta
     1741 atttgatctg acttagatgt ctgagtttgt gttgtttctc taaagatttt ggcaagactc
     1801 aagcaatgtg gctgactgta actttattaa tttaaaaggt aggaagtaag ctacttagtg
     1861 gtttcacctg tgaaataact attttgactg aaatgtaaaa taagctattc aacaaagaac
     1921 atattaaaac atcaagtaat ttgtaacatc ttaaatggaa tacttttttc atgagctcta
     1981 gtgaagaact actacatata aaagacgata cttacaaatc agctattgct gctacagtat
     2041 aattcttcaa aatttctcat cataaattca ttttttggta aaaaaaaatt accagacact
     2101 aactcacccc cttacccttt tcccccggtt attgaatatt aatctagctt cccacccatg
     2161 catgttacat agatggacaa atgctttcat aatgattttt aaataagtac cttccagttt
     2221 gctttgtttc ctactaatgc aacttagtct atattagtac aaacagttac caattctttt
     2281 taaattctgt aatgaatgta tgtgtatcca gataagtttc tctgaaagag acatacagaa
     2341 acagaactgc tgggtcagga catgtactgc caaaatgccc cctaaggcag ggtaccaatt
     2401 tatccatgac ggaacccatt tctcatgtac ttgctactac agcatctgca agtcagaaaa
     2461 tgcttttaaa aagatgcagt agggttcgtc tttgaagcct aaatggggta gattatttaa
     2521 ccttttctag gatacctcat ctacagctgt gtaaagtaca gatcctaata taggtaacta
     2581 actaatacct actaaatatg cattattttt agcttgtttt agaagcagat acctatcgat
     2641 ttcagaagaa tctgcgaatg gcaaccaaaa ggcaaaagaa aagtaaatga acacagcagt
     2701 gtttattagg tggtttttaa tattgtttat tagcacagta acaaatgcag acttaagtag
     2761 tccacaacat agaaccaatc cactgagcaa ctcctattcc acgccttaca gttagttaac
     2821 agcttaaggt atttcactac aggttttcac aagtcctgat tcagaccttt tttaaacaaa
     2881 gtagattggc atataaaata aaacgcacta ctcatctctt atatggtgtt ttatagccac
     2941 gtgtccattt tatatatatg agatgacaat ctctaaaaac tctgttaaat atcaatgttc
     3001 ccttccaaga agggaaaaca aattccaatt ttgttttaaa caaaaagtat gtagtcttag
     3061 agggacttta cataaatggc catatgtgta acctgtacca aattaagctg ttttaaattt
     3121 acagactaca agcaactgaa cccaaatgtc taaatgtaca ttcttttctg tactacattt
     3181 cagctaatat tgcagaacta atgacaattt taaaagttgc tattaccaat tctgtctact
     3241 gtagcaagat accttaagtt acaacaaaat cttaggaaat aagactgaat aatatctgtt
     3301 atagaaatac cctactcttt accaactccc accctccctg accccttcaa aatcataagc
     3361 agctctcttc tgtgacagac aaataatgta agaattgtga aaccccaatt tatgtagcgt
     3421 atctcttggt ccactgtctg gccattctgt catgttctgc tctgttggtc atatactgag
     3481 tggcaatact tcccaccaag gggtcggctg gaagaaaaga atgtagatta ctttggagaa
     3541 aggaaaagaa cattttaaac tttagcgaat agtgacagct tgggtagata cgtacgacaa
     3601 agtatgtgtg atcaaaccca tcttcgaaac accactccac catgctggat atttttccat
     3661 caaaatttca aaaaaacata acgttggggg aagagggaat gcttaggctt tagtgtactg
     3721 gtctgtcttt atcttagttc attccatttt tctcccaaca aacaacactc aattggagtt
     3781 tctttactct tatgtgttag gctgagttca gtagagactg gaacggtcaa ggcttcagac
     3841 tgcaatgaac atccagctgt gttcatgtga cccttagctc aatgtcacca gttaacggca
     3901 ttgtgaatac tgtgaagtct tcggggctgt tgcagtgcaa cactattaac ctttacgctg
     3961 gttaaagagc caggttgcca ggcaaaacct ggacctccaa ttaagtatag tatttctctg
     4021 aatcttagga tctttaataa atttatattt ggtttaccta gaaaa
//
