LOCUS       NM_001377356            4131 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens NFKB inhibitor interacting Ras like 1 (NKIRAS1),
            transcript variant 7, mRNA.
ACCESSION   NM_001377356
VERSION     NM_001377356.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4131)
  AUTHORS   Postler,T.S., Wang,A., Brundu,F.G., Wang,P., Wu,Z., Butler,K.E.,
            Grinberg-Bleyer,Y., Krishnareddy,S., Lagana,S.M., Saqi,A.,
            Oeckinghaus,A., Rabadan,R. and Ghosh,S.
  TITLE     A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene
  JOURNAL   Proc Natl Acad Sci U S A 120 (46), e2312595120 (2023)
   PUBMED   37931099
  REMARK    GeneRIF: A pan-cancer analysis implicates human NKIRAS1 as a
            tumor-suppressor gene.
REFERENCE   2  (bases 1 to 4131)
  AUTHORS   Braga,E.A., Loginov,V.I., Pronina,I.V., Khodyrev,D.S., Rykov,S.V.,
            Burdennyy,A.M., Friedman,M.V., Kazubskaya,T.P., Kubatiev,A.A. and
            Kushlinskii,N.E.
  TITLE     Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated
            with loss of their methylation as well as with methylation of
            regulatory miRNA genes
  JOURNAL   Biochemistry (Mosc) 80 (4), 483-494 (2015)
   PUBMED   25869366
  REMARK    GeneRIF: It was demonstrated that elevated levels of mRNA for
            NKIRAS1 was significantly associated both with loss of methylation
            in NKIRAS1 CpG-islands and methylation in a number of miRNA genes.
REFERENCE   3  (bases 1 to 4131)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4131)
  AUTHORS   Khodyrev,D.S., Pronina,I.V., Rykov,S.V., Beresneva,E.V.,
            Fridman,M.V., Kazubskaia,T.P., Loginov,V.I. and Braga,E.A.
  TITLE     [Methylation of some miRNA genes is involved in the regulation of
            their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]
  JOURNAL   Mol Biol (Mosk) 46 (5), 773-785 (2012)
   PUBMED   23156677
  REMARK    GeneRIF: Significant correlation was found between alterations of
            methylation status of miR-34b/c, miR-193a and the expression level
            of NKIRAS1 target gene in the primary lung tumors.
REFERENCE   5  (bases 1 to 4131)
  AUTHORS   Lin,H., Wang,Y., Zhang,X., Liu,B., Zhang,W. and Cheng,J.
  TITLE     Prognostic significance of kappaB-Ras1 expression in gliomas
  JOURNAL   Med Oncol 29 (2), 1272-1279 (2012)
   PUBMED   21302000
  REMARK    GeneRIF: Low kappaB-Ras1 expression is associated with gliomas.
REFERENCE   6  (bases 1 to 4131)
  AUTHORS   Dieguez-Gonzalez,R., Akar,S., Calaza,M., Perez-Pampin,E.,
            Costas,J., Torres,M., Vicario,J.L., Velloso,M.L., Navarro,F.,
            Narvaez,J., Joven,B., Herrero-Beaumont,G., Gonzalez-Alvaro,I.,
            Fernandez-Gutierrez,B., de la Serna,A.R., Carreno,L.,
            Lopez-Longo,J., Caliz,R., Collado-Escobar,M.D., Blanco,F.J.,
            Fernandez-Lopez,C., Balsa,A., Pascual-Salcedo,D., Gomez-Reino,J.J.
            and Gonzalez,A.
  TITLE     Genetic variation in the nuclear factor kappaB pathway in relation
            to susceptibility to rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 68 (4), 579-583 (2009)
   PUBMED   18434448
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4131)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 4131)
  AUTHORS   Chen,Y., Vallee,S., Wu,J., Vu,D., Sondek,J. and Ghosh,G.
  TITLE     Inhibition of NF-kappaB activity by IkappaBbeta in association with
            kappaB-Ras
  JOURNAL   Mol Cell Biol 24 (7), 3048-3056 (2004)
   PUBMED   15024091
REFERENCE   9  (bases 1 to 4131)
  AUTHORS   Chen,Y., Wu,J. and Ghosh,G.
  TITLE     KappaB-Ras binds to the unique insert within the ankyrin repeat
            domain of IkappaBbeta and regulates cytoplasmic retention of
            IkappaBbeta x NF-kappaB complexes
  JOURNAL   J Biol Chem 278 (25), 23101-23106 (2003)
   PUBMED   12672800
REFERENCE   10 (bases 1 to 4131)
  AUTHORS   Fenwick,C., Na,S.Y., Voll,R.E., Zhong,H., Im,S.Y., Lee,J.W. and
            Ghosh,S.
  TITLE     A subclass of Ras proteins that regulate the degradation of IkappaB
  JOURNAL   Science 287 (5454), 869-873 (2000)
   PUBMED   10657303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124914.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF229839.1, CV028592.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA1965299,
                                    SAMEA1968189 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AC124914.3         61961-62167         c
            208-273             AC124914.3         59766-59831         c
            274-391             AC124914.3         56506-56623         c
            392-502             AC124914.3         55988-56098         c
            503-744             AC124914.3         45985-46226         c
            745-4131            AC124914.3         35128-38514         c
FEATURES             Location/Qualifiers
     source          1..4131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..4131
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="NFKB inhibitor interacting Ras like 1"
                     /db_xref="GeneID:28512"
                     /db_xref="HGNC:HGNC:17899"
                     /db_xref="MIM:604496"
     exon            1..207
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            208..273
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            274..391
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..502
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..987
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="isoform 1 is encoded by transcript variant 7; NFKB
                     inhibitor interacting Ras-like protein 1;
                     I-kappa-B-interacting Ras-like protein 1; kappa B-ras 1;
                     NF-kappa-B inhibitor-interacting Ras-like protein 1; kappa
                     B-Ras protein 1"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor-interacting Ras-like
                     protein 1 isoform 1"
                     /protein_id="NP_001364285.1"
                     /db_xref="CCDS:CCDS33717.1"
                     /db_xref="GeneID:28512"
                     /db_xref="HGNC:HGNC:17899"
                     /db_xref="MIM:604496"
                     /translation="MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYM
                     ASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKK
                     EIDKFKDKKEVAIVVLGNKIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEP
                     FTLLASKLSQPQSKSSFPLPGRKNKGNSNSEN"
     exon            503..744
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..4131
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      1807
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     regulatory      1989..1994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: ATTAAA"
     polyA_site      2021
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     polyA_site      2811
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
     regulatory      4102..4107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="hexamer: AATAAA"
     polyA_site      4131
                     /gene="NKIRAS1"
                     /gene_synonym="kappaB-Ras1; KBRAS1"
                     /note="major polyA site"
ORIGIN      
        1 attgtcccgc cccctgctcc gcaagattcg agcctgagcg gcctgggcgt ctcgagaggt
       61 gagagagttg gcggcgaggt ctcggcggct aagcgagcgt cggcgactgt ctctccgcga
      121 gaggaggcaa gttggggtcc aggctccaaa gccggtggcc gcgtaccgcg gtggagccgc
      181 tgtctttgag gtctgaggag agaacagttt gtccctgatg gctggcatga tggcaggccc
      241 tcagtaaatg tttggtaaat gaataaaaga atgagtctag ctctttcacc caggctggag
      301 tgaagtggtg caatctcagc tcagtgcaac ctccgccccc tgggttcaag tgattctcct
      361 gcctcagcct ccccagtagc tgggattaca gtgatatcct gagagaagat gggaaagggc
      421 tgcaaggttg tggtttgtgg attgttatct gtggggaaaa ctgcaatttt ggagcagctc
      481 ctttatggaa atcatactat tggaatggaa gattgcgaaa caatggaaga tgtatacatg
      541 gcttcagtag aaacagaccg aggagtaaaa gaacagttac atctttatga caccagaggt
      601 ctacaggaag gcgtggagct gccaaagcat tatttttcat ttgctgatgg cttcgttctt
      661 gtgtacagtg tgaataacct tgaatccttt caaagagtgg agcttctgaa gaaagaaatc
      721 gataagttca aagacaaaaa agaggtagca attgtggtat taggaaacaa aatcgacctt
      781 tctgagcaga gacaagtgga cgctgaagtg gcacagcagt gggcaaaaag tgagaaagta
      841 agactgtggg aggtgactgt tacagatcgg aaaactctga ttgaaccatt cactttatta
      901 gccagtaaac tttctcaacc ccagagcaaa tcaagctttc ctttgcctgg gaggaaaaac
      961 aaagggaact ctaattctga gaactaaaaa tcagtaattt ccacaattgt atgttgaata
     1021 gtgattgcct ttaagtgtct gtgaacatgg agtaatatta ctatttaaaa taggccattt
     1081 gtatctacct ttggtcctta ggaaaattcc taaggaagtc aattaatgca ctttagatgt
     1141 taaaagtatt tgggctaagg ttattattgc ctgatatgaa ataatatatt cttattctca
     1201 ttgtttgaaa cctgtctttg aaattagcac ctttgttatt tatgttgtac ttgtgaaaac
     1261 agtaaaatag tttggatagt tatgcaaatg cacctatgtg taacttcccc ccaaccccaa
     1321 gctgtttcgg aagatatcat aatcattctg tgtaacatta tgcaaacttc taagcccaaa
     1381 catgactttg tttttaaaaa gttcattaat ctaatgtcta ggattataaa acattttttt
     1441 gtgtctaaat tggacccaaa acattgaaca gtttggggta gtaagctaaa tttcatcttg
     1501 tggagatttt gctaaacaga ctaagaccca tgatttagct ttgctcaaat tagaatgttt
     1561 agcatgagtt gaggtaccag gtagtgttaa gtaggttcat cacgctctaa ggccgttttt
     1621 tccttagcca gacccctgtt gatagaccag atacttgagg gcaaactgtt tgctcctcct
     1681 cttgaaaatg attaggcact taaggacagt aaagctgtat tttctggaag gaagactgta
     1741 tcttctggaa tagttttcta gaaaactagt catatacaat aaaagtatca aaaatattgg
     1801 gctctaattt gatctgactt agatgtctga gtttgtgttg tttctctaaa gattttggca
     1861 agactcaagc aatgtggctg actgtaactt tattaattta aaaggtagga agtaagctac
     1921 ttagtggttt cacctgtgaa ataactattt tgactgaaat gtaaaataag ctattcaaca
     1981 aagaacatat taaaacatca agtaatttgt aacatcttaa atggaatact tttttcatga
     2041 gctctagtga agaactacta catataaaag acgatactta caaatcagct attgctgcta
     2101 cagtataatt cttcaaaatt tctcatcata aattcatttt ttggtaaaaa aaaattacca
     2161 gacactaact caccccctta cccttttccc ccggttattg aatattaatc tagcttccca
     2221 cccatgcatg ttacatagat ggacaaatgc tttcataatg atttttaaat aagtaccttc
     2281 cagtttgctt tgtttcctac taatgcaact tagtctatat tagtacaaac agttaccaat
     2341 tctttttaaa ttctgtaatg aatgtatgtg tatccagata agtttctctg aaagagacat
     2401 acagaaacag aactgctggg tcaggacatg tactgccaaa atgcccccta aggcagggta
     2461 ccaatttatc catgacggaa cccatttctc atgtacttgc tactacagca tctgcaagtc
     2521 agaaaatgct tttaaaaaga tgcagtaggg ttcgtctttg aagcctaaat ggggtagatt
     2581 atttaacctt ttctaggata cctcatctac agctgtgtaa agtacagatc ctaatatagg
     2641 taactaacta atacctacta aatatgcatt atttttagct tgttttagaa gcagatacct
     2701 atcgatttca gaagaatctg cgaatggcaa ccaaaaggca aaagaaaagt aaatgaacac
     2761 agcagtgttt attaggtggt ttttaatatt gtttattagc acagtaacaa atgcagactt
     2821 aagtagtcca caacatagaa ccaatccact gagcaactcc tattccacgc cttacagtta
     2881 gttaacagct taaggtattt cactacaggt tttcacaagt cctgattcag acctttttta
     2941 aacaaagtag attggcatat aaaataaaac gcactactca tctcttatat ggtgttttat
     3001 agccacgtgt ccattttata tatatgagat gacaatctct aaaaactctg ttaaatatca
     3061 atgttccctt ccaagaaggg aaaacaaatt ccaattttgt tttaaacaaa aagtatgtag
     3121 tcttagaggg actttacata aatggccata tgtgtaacct gtaccaaatt aagctgtttt
     3181 aaatttacag actacaagca actgaaccca aatgtctaaa tgtacattct tttctgtact
     3241 acatttcagc taatattgca gaactaatga caattttaaa agttgctatt accaattctg
     3301 tctactgtag caagatacct taagttacaa caaaatctta ggaaataaga ctgaataata
     3361 tctgttatag aaatacccta ctctttacca actcccaccc tccctgaccc cttcaaaatc
     3421 ataagcagct ctcttctgtg acagacaaat aatgtaagaa ttgtgaaacc ccaatttatg
     3481 tagcgtatct cttggtccac tgtctggcca ttctgtcatg ttctgctctg ttggtcatat
     3541 actgagtggc aatacttccc accaaggggt cggctggaag aaaagaatgt agattacttt
     3601 ggagaaagga aaagaacatt ttaaacttta gcgaatagtg acagcttggg tagatacgta
     3661 cgacaaagta tgtgtgatca aacccatctt cgaaacacca ctccaccatg ctggatattt
     3721 ttccatcaaa atttcaaaaa aacataacgt tgggggaaga gggaatgctt aggctttagt
     3781 gtactggtct gtctttatct tagttcattc catttttctc ccaacaaaca acactcaatt
     3841 ggagtttctt tactcttatg tgttaggctg agttcagtag agactggaac ggtcaaggct
     3901 tcagactgca atgaacatcc agctgtgttc atgtgaccct tagctcaatg tcaccagtta
     3961 acggcattgt gaatactgtg aagtcttcgg ggctgttgca gtgcaacact attaaccttt
     4021 acgctggtta aagagccagg ttgccaggca aaacctggac ctccaattaa gtatagtatt
     4081 tctctgaatc ttaggatctt taataaattt atatttggtt tacctagaaa a
//
