LOCUS       NM_005601                774 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens natural killer cell granule protein 7 (NKG7),
            transcript variant 1, mRNA.
ACCESSION   NM_005601
VERSION     NM_005601.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 774)
  AUTHORS   Ng,S.S., De Labastida Rivera,F., Yan,J., Corvino,D., Das,I.,
            Zhang,P., Kuns,R., Chauhan,S.B., Hou,J., Li,X.Y., Frame,T.C.M.,
            McEnroe,B.A., Moore,E., Na,J., Engel,J.A., Soon,M.S.F., Singh,B.,
            Kueh,A.J., Herold,M.J., Montes de Oca,M., Singh,S.S., Bunn,P.T.,
            Aguilera,A.R., Casey,M., Braun,M., Ghazanfari,N., Wani,S., Wang,Y.,
            Amante,F.H., Edwards,C.L., Haque,A., Dougall,W.C., Singh,O.P.,
            Baxter,A.G., Teng,M.W.L., Loukas,A., Daly,N.L., Cloonan,N.,
            Degli-Esposti,M.A., Uzonna,J., Heath,W.R., Bald,T., Tey,S.K.,
            Nakamura,K., Hill,G.R., Kumar,R., Sundar,S., Smyth,M.J. and
            Engwerda,C.R.
  TITLE     The NK cell granule protein NKG7 regulates cytotoxic granule
            exocytosis and inflammation
  JOURNAL   Nat Immunol 21 (10), 1205-1218 (2020)
   PUBMED   32839608
  REMARK    Erratum:[Nat Immunol. 2024 Apr;25(4):716. doi:
            10.1038/s41590-024-01770-8.. PMID: 38360937]
REFERENCE   2  (bases 1 to 774)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 774)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 774)
  AUTHORS   Medley,Q.G., Kedersha,N., O'Brien,S., Tian,Q., Schlossman,S.F.,
            Streuli,M. and Anderson,P.
  TITLE     Characterization of GMP-17, a granule membrane protein that moves
            to the plasma membrane of natural killer cells following target
            cell recognition
  JOURNAL   Proc Natl Acad Sci U S A 93 (2), 685-689 (1996)
   PUBMED   8570616
REFERENCE   5  (bases 1 to 774)
  AUTHORS   Shimane,M., Tani,K., Maruyama,K., Takahashi,S., Ozawa,K. and
            Asano,S.
  TITLE     Molecular cloning and characterization of G-CSF induced gene cDNA
  JOURNAL   Biochem Biophys Res Commun 199 (1), 26-32 (1994)
   PUBMED   7510105
REFERENCE   6  (bases 1 to 774)
  AUTHORS   Turman,M.A., Yabe,T., McSherry,C., Bach,F.H. and Houchins,J.P.
  TITLE     Characterization of a novel gene (NKG7) on human chromosome 19 that
            is expressed in natural killer cells and T cells
  JOURNAL   Hum Immunol 36 (1), 34-40 (1993)
   PUBMED   8458737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            S69115.1 and AI313472.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005601.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ052401.1, S69115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221978.10/ ENSP00000221978.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-697               S69115.1           62-758
            698-774             AI313472.1         4-80                c
FEATURES             Location/Qualifiers
     source          1..774
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..774
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /note="natural killer cell granule protein 7"
                     /db_xref="GeneID:4818"
                     /db_xref="HGNC:HGNC:7830"
                     /db_xref="MIM:606008"
     exon            1..276
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..617
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein NKG7; GIG-1 protein; G-CSF-induced gene 1 protein;
                     natural killer cell protein 7; granule membrane protein of
                     17 kDa; granule membrane protein 17; natural killer cell
                     group 7 sequence"
                     /codon_start=1
                     /product="protein NKG7 isoform 1"
                     /protein_id="NP_005592.1"
                     /db_xref="CCDS:CCDS12830.1"
                     /db_xref="GeneID:4818"
                     /db_xref="HGNC:HGNC:7830"
                     /db_xref="MIM:606008"
                     /translation="MELCRSLALLGGSLGLMFCLIALSTDFWFEAVGPTHSAHSGLWP
                     TGHGDIISGYIHVTQTFSIMAVLWALVSVSFLVLSCFPSLFPPGHGPLVSTTAAFAAA
                     ISMVVAMAVYTSERWDQPPHPQIQTFFSWSFYLGWVSAILLLCTGALSLGAHCGGPRP
                     GYETL"
     exon            277..423
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..558
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /inference="alignment:Splign:2.1.0"
     exon            559..774
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      757..762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /note="hexamer: AACAAA"
     polyA_site      774
                     /gene="NKG7"
                     /gene_synonym="GIG1; GMP-17; p15-TIA-1"
                     /note="major polyA site"
ORIGIN      
        1 ctttcttggg ctctaaggac ccaggagtct gggtgcacag cctccttctc tctgagattc
       61 aagagtctga tcagcagcct cttcctcctc caggacccag aagccctgag cttatcccca
      121 tggagctctg ccggtccctg gccctgctgg ggggctccct gggcctgatg ttctgcctga
      181 ttgctttgag caccgatttc tggtttgagg ctgtgggtcc cacccactca gctcactcgg
      241 gcctctggcc aacagggcat ggggacatca tatcaggcta catccacgtg acgcagacct
      301 tcagcattat ggctgttctg tgggccctgg tgtccgtgag cttcctggtc ctgtcctgct
      361 tcccctcact gttcccccca ggccacggcc cgcttgtctc aaccaccgca gcctttgctg
      421 cagccatctc catggtggtg gccatggcgg tgtacaccag cgagcggtgg gaccagcctc
      481 cacaccccca gatccagacc ttcttctcct ggtccttcta cctgggctgg gtctcagcta
      541 tcctcttgct ctgtacaggt gccctgagcc tgggtgctca ctgtggcggt ccccgtcctg
      601 gctatgaaac cttgtgagca gaaggcaaga gcggcaagat gagttttgag cgttgtattc
      661 caaaggcctc atctggagcc tcgggaaagt ctggtcccac atctgcccgc ccttccagcc
      721 cttccccagc ccctcctctt gtttcttcat tcattcaaca aaatttggct ggaa
//
