LOCUS       NM_001007531            1662 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens NFKB activating protein like (NKAPL), mRNA.
ACCESSION   NM_001007531 XM_167149
VERSION     NM_001007531.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1662)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1662)
  AUTHORS   Wu,S., Teng,M.S., Er,L.K., Hsiao,W.Y., Hsu,L.A., Yeh,C.H.,
            Lin,J.F., Lin,Y.Y., Su,C.W. and Ko,Y.L.
  TITLE     Association between NF-kappaB Pathway Gene Variants and sICAM1
            Levels in Taiwanese
  JOURNAL   PLoS One 12 (1), e0169516 (2017)
   PUBMED   28095483
  REMARK    GeneRIF: Single nucleotide polymorphism in NKAPL is associated with
            atherosclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1662)
  AUTHORS   Wang,Z., Yang,B., Liu,Y., Shugart,Y.Y., Cheng,Z., Jin,C., Yuan,J.,
            Zhu,W., Wang,G. and Zhang,F.
  TITLE     Further evidence supporting the association of NKAPL with
            schizophrenia
  JOURNAL   Neurosci Lett 605, 49-52 (2015)
   PUBMED   26297123
  REMARK    GeneRIF: further evidence for the involvement of NKAPL
            polymorphisms in the development of schizophrenia.
REFERENCE   4  (bases 1 to 1662)
  AUTHORS   Okuda,H., Kiuchi,H., Takao,T., Miyagawa,Y., Tsujimura,A.,
            Nonomura,N., Miyata,H., Okabe,M., Ikawa,M., Kawakami,Y.,
            Goshima,N., Wada,M. and Tanaka,H.
  TITLE     A novel transcriptional factor Nkapl is a germ cell-specific
            suppressor of Notch signaling and is indispensable for
            spermatogenesis
  JOURNAL   PLoS One 10 (4), e0124293 (2015)
   PUBMED   25875095
  REMARK    GeneRIF: Overexpression of NKAPL in germline stem cells
            demonstrated that Nkapl induced changes in spermatogonial stem cell
            (SSC) markers and the reduction of differentiation factors through
            the Notch signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1662)
  AUTHORS   Chen,S.F., Chao,Y.L., Shen,Y.C., Chen,C.H. and Weng,C.F.
  TITLE     Resequencing and association study of the NFKB activating
            protein-like gene (NKAPL) in schizophrenia
  JOURNAL   Schizophr Res 157 (1-3), 169-174 (2014)
   PUBMED   24972756
  REMARK    GeneRIF: Study suggested that rs1635 in the NKAPL gene appeared to
            play a role in conferring susceptibility to schizophrenia
REFERENCE   6  (bases 1 to 1662)
  AUTHORS   Xie,G., Lu,Y., Sun,Y., Zhang,S.S., Keystone,E.C., Gregersen,P.K.,
            Plenge,R.M., Amos,C.I. and Siminovitch,K.A.
  TITLE     Identification of the NF-kappaB activating protein-like locus as a
            risk locus for rheumatoid arthritis
  JOURNAL   Ann Rheum Dis 72 (7), 1249-1254 (2013)
   PUBMED   23223422
  REMARK    GeneRIF: Fine-mapping analyses identified six NKAPL locus variants
            in a single haplotype block showing association with rheumatoid
            arthritis.
REFERENCE   7  (bases 1 to 1662)
  AUTHORS   Yue,W.H., Wang,H.F., Sun,L.D., Tang,F.L., Liu,Z.H., Zhang,H.X.,
            Li,W.Q., Zhang,Y.L., Zhang,Y., Ma,C.C., Du,B., Wang,L.F., Ren,Y.Q.,
            Yang,Y.F., Hu,X.F., Wang,Y., Deng,W., Tan,L.W., Tan,Y.L., Chen,Q.,
            Xu,G.M., Yang,G.G., Zuo,X.B., Yan,H., Ruan,Y.Y., Lu,T.L., Han,X.,
            Ma,X.H., Wang,Y., Cai,L.W., Jin,C., Zhang,H.Y., Yan,J., Mi,W.F.,
            Yin,X.Y., Ma,W.B., Liu,Q., Kang,L., Sun,W., Pan,C.Y., Shuang,M.,
            Yang,F.D., Wang,C.Y., Yang,J.L., Li,K.Q., Ma,X., Li,L.J., Yu,X.,
            Li,Q.Z., Huang,X., Lv,L.X., Li,T., Zhao,G.P., Huang,W., Zhang,X.J.
            and Zhang,D.
  TITLE     Genome-wide association study identifies a susceptibility locus for
            schizophrenia in Han Chinese at 11p11.2
  JOURNAL   Nat Genet 43 (12), 1228-1231 (2011)
   PUBMED   22037552
  REMARK    GeneRIF: Genome-wide association study identifies a susceptibility
            locus for schizophrenia in Han Chinese at 11p11.2.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1662)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB471905.1, BC101681.1, AI240405.1 and BC038240.1.
            
            On May 17, 2019 this sequence version replaced NM_001007531.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC038240.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343684.4/ ENSP00000345716.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DB471905.1         1-42
            43-1267             BC101681.1         1-1225
            1268-1660           AI240405.1         1-393               c
            1661-1662           BC038240.1         1591-1592
FEATURES             Location/Qualifiers
     source          1..1662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1662
                     /gene="NKAPL"
                     /gene_synonym="bA424I5.1; C6orf194"
                     /note="NFKB activating protein like"
                     /db_xref="GeneID:222698"
                     /db_xref="HGNC:HGNC:21584"
     exon            1..1662
                     /gene="NKAPL"
                     /gene_synonym="bA424I5.1; C6orf194"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1284
                     /gene="NKAPL"
                     /gene_synonym="bA424I5.1; C6orf194"
                     /codon_start=1
                     /product="NKAP-like protein"
                     /protein_id="NP_001007532.1"
                     /db_xref="CCDS:CCDS34353.1"
                     /db_xref="GeneID:222698"
                     /db_xref="HGNC:HGNC:21584"
                     /translation="MPPVSRSSYSEDIVGSRRRRRSSSGSPPSPQSRCSSWDGCSRSH
                     SRGREGLRPPWSELDVGALYPFSRSGSRGRLPRFRNYAFASSWSTSYSGYRYHRHCYA
                     EERQSAEDYEKEESHRQRRLKERERIGELGAPEVWGPSPKFPQLDSDEHTPVEDEEEV
                     THQKSSSSDSNSEEHRKKKTSRSRNKKKRKNKSSKRKHRKYSDSDSNSESDTNSDSDD
                     DKKRVKAKKKKKKKKHKTKKKKNKKTKKESSDSSCKDSEEDLSEATWMEQPNVADTMD
                     LIGPEAPIIHTSQDEKPLKYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIGSF
                     ECSGYVMSGSRHRRMEAVRLRKENQIYSADEKRALASFNQEERRKRESKILASFREMV
                     HKKTKEKDDK"
     regulatory      1629..1634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKAPL"
                     /gene_synonym="bA424I5.1; C6orf194"
                     /note="hexamer: ATTAAA"
     regulatory      1639..1644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKAPL"
                     /gene_synonym="bA424I5.1; C6orf194"
                     /note="hexamer: ATTAAA"
     polyA_site      1649
                     /gene="NKAPL"
                     /gene_synonym="bA424I5.1; C6orf194"
     polyA_site      1662
                     /gene="NKAPL"
                     /gene_synonym="bA424I5.1; C6orf194"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcctg cgtggccgcg aatcaccagc cagcctctgg gtctgtagca accgcccagc
       61 gttgaggcgc ggctcatgcc cccagtatcc cggtccagct attccgagga catcgtgggc
      121 tctcggagaa ggcgacgcag ctcctcgggg agcccaccat ccccgcagag cagatgttcc
      181 tcttgggatg gctgttcccg ctctcactcc cgcggccgtg agggcctcag gcctccttgg
      241 agtgagttgg acgtgggcgc tctttacccc tttagtcgct ctgggtcgcg agggcggctc
      301 ccaagattcc gcaactacgc cttcgcgtcc tcctggtcga cctcgtatag tggatatcgc
      361 taccatcgtc actgctatgc agaagaacgg cagtcagcgg aagactacga gaaggaagag
      421 agccatcggc agaggaggct gaaggagaga gagaggattg gggaattggg agcgcctgaa
      481 gtgtgggggc cgtctccaaa gttccctcag ctagattctg acgaacatac cccagttgag
      541 gatgaagaag aggtaacgca tcagaaaagc agcagttcag attccaactc ggaagaacat
      601 aggaaaaaga agaccagtcg ttcaagaaac aagaaaaaaa gaaagaataa gtcgtctaaa
      661 agaaagcata ggaaatattc tgatagtgac agtaactcag agtctgacac aaattctgac
      721 tctgatgatg ataaaaagag agttaaagcc aagaagaaaa agaagaaaaa gaaacacaaa
      781 acaaagaaaa agaagaataa gaaaaccaaa aaagaatcca gtgactcaag ctgtaaagac
      841 tcagaagagg acttgtcaga agctacctgg atggagcagc caaatgtggc agatactatg
      901 gatttaatag ggccagaagc acctataata catacctctc aagatgaaaa acctttgaag
      961 tatggccatg ctttgcttcc cggtgaaggt gcagctatgg ctgagtatgt aaaagctgga
     1021 aagcgaatcc cacgaagagg tgaaattggg ttgacaagtg aagagatcgg ttcttttgaa
     1081 tgctcaggtt atgtcatgag tggtagcagg catcgcagaa tggaggctgt acgactgcgt
     1141 aaggagaacc agatctacag tgctgatgag aagagagctc ttgcatcctt taaccaagaa
     1201 gagagacgaa agagagaaag taagatttta gccagtttcc gagagatggt gcacaaaaag
     1261 acaaaagaga aagatgacaa gtaaggactt acttgttgca cagcaggaat tttaacaaca
     1321 aaaattttat gtgaccaaaa gtgttaaaag gctttacagt gctactgtac ttaccatatt
     1381 agtaagtccc tcaggaaaaa gcttcttttg agatatcttt agcagcttat tttttgttat
     1441 tttaacttta aaaagtaata tgtgcacatg gttttaaaaa tattcaacca ttataggagg
     1501 agagttagta aaaagtgaat ctttcacttt agcccctgac acctttcccc caaaaatata
     1561 tattttggtg tcttatatac agaatataca ttctgtgcat atacaagagt atatgttgca
     1621 gcataaagat taaaagctat taaagttttt tttcgctcgt ta
//
