LOCUS       NM_152864               1353 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sodium/potassium transporting ATPase interacting 4
            (NKAIN4), transcript variant 1, mRNA.
ACCESSION   NM_152864
VERSION     NM_152864.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Gorokhova,S., Bibert,S., Geering,K. and Heintz,N.
  TITLE     A novel family of transmembrane proteins interacting with beta
            subunits of the Na,K-ATPase
  JOURNAL   Hum Mol Genet 16 (20), 2394-2410 (2007)
   PUBMED   17606467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG708360.1, AK126246.1 and BM673598.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152864.3.
            
            Summary: NKAIN4 is a member of a family of mammalian proteins (see
            NKAIN1; MIM 612871) with similarity to Drosophila Nkain and
            interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330)
            (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun
            2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.567927.1, BC041812.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370316.8/ ENSP00000359340.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               BG708360.1         82-576
            496-1352            AK126246.1         496-1352
            1353-1353           BM673598.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1353
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /note="sodium/potassium transporting ATPase interacting 4"
                     /db_xref="GeneID:128414"
                     /db_xref="HGNC:HGNC:16191"
                     /db_xref="MIM:612873"
     exon            1..67
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..640
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium/potassium-transporting ATPase subunit
                     beta-1-interacting protein 4; Na(+)/K(+)-transporting
                     ATPase subunit beta-1-interacting protein 4; Na+/K+
                     transporting ATPase interacting 4"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1-interacting protein 4 isoform 1"
                     /protein_id="NP_690603.3"
                     /db_xref="CCDS:CCDS13514.1"
                     /db_xref="GeneID:128414"
                     /db_xref="HGNC:HGNC:16191"
                     /db_xref="MIM:612873"
                     /translation="MGSCSGRCALVVLCAFQLVAALERQVFDFLGYQWAPILANFVHI
                     IIVILGLFGTIQYRLRYVMVYTLWAAVWVTWNVFIICFYLEVGGLLKDSELLTFSLSR
                     HRSWWRERWPGCLHEEVPAVGLGAPHGQALVSGAGCALEPSYVEALHSCLQILIALLG
                     FVCGCQVVSVFTEEEDSFDFIGGFDPFPLYHVNEKPSSLLSKQVYLPA"
     exon            68..205
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /inference="alignment:Splign:2.1.0"
     exon            206..286
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /inference="alignment:Splign:2.1.0"
     exon            287..484
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /inference="alignment:Splign:2.1.0"
     exon            485..545
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /inference="alignment:Splign:2.1.0"
     exon            546..630
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /inference="alignment:Splign:2.1.0"
     exon            631..1353
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="NKAIN4"
                     /gene_synonym="bA261N11.2; C20orf58; FAM77A"
                     /note="major polyA site"
ORIGIN      
        1 ataggcgggc accatgggct cctgctccgg ccgctgcgcg ctcgtcgtcc tctgcgcttt
       61 tcagctggtc gccgccctgg agaggcaggt gtttgacttc ctgggctacc agtgggcgcc
      121 catcctggcc aactttgtcc acatcatcat cgtcatcctg ggactcttcg gcaccatcca
      181 gtaccggctg cgctatgtca tggtgtacac gctgtgggca gccgtctggg tcacctggaa
      241 cgtcttcatc atctgcttct acctggaagt cggtggcctc ttaaaggaca gcgagctact
      301 gaccttcagc ctctcccggc atcgctcctg gtggcgtgag cgctggccag gctgtctgca
      361 tgaggaggtg ccagcagtgg gcctcggggc cccccatggc caggccctgg tgtcaggtgc
      421 tggctgtgcc ctggagccca gctatgtgga ggccctacac agttgcctgc agatcctgat
      481 cgcgcttctg ggctttgtct gtggctgcca ggtggtcagc gtgtttacgg aggaagagga
      541 cagctttgat ttcattggtg gatttgatcc atttcctctc taccatgtca atgaaaagcc
      601 atccagtctc ttgtccaagc aggtgtactt gcctgcgtaa gtgaggaaac agctgatcct
      661 gctcctgtgg cctccagcct cagcgaccga ccagtgacaa tgacaggagc tcccaggcct
      721 tgggacgcgc ccccacccag caccccccag gcggccggca gcacctgccc tgggttctaa
      781 gtactggaca ccagccaggg cggcagggca gtgccacggc tggctgcagc gtcaagagag
      841 tttgtaattt cctttctctt aaaaaaaaaa aagaaaagaa aacatacaaa agaaaaggca
      901 aaaccccaca tgcccacctc ctctggcaac atgggggtca cagctctgcc cccaggctgt
      961 cgtctcgtcg aggagcccct ccctcaggtg cccacctggg gctgctggac cctcgggctg
     1021 caagcactgc tgctgggatg cagcctcccc aggaagtcaa tgtgaggccc gagacccctc
     1081 aagcggtgag ggcccctgtt gaacatggag ggttcctaac cccaaactcg tgccagaaga
     1141 acccccaccc cacccaggag ctgaggctga tggagcccta gggtgggggc tgggcttgac
     1201 caggaacagc agagccaggc cccaaggcat agggcagggc acatggtggt gacgagcagg
     1261 cagtactctt gtaaaggggg ctcttgggca aacagtccca aaggctcccc caggtatcat
     1321 caagttggta aataaacagg aacatggccc tca
//
