LOCUS       NM_001040214            3374 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sodium/potassium transporting ATPase interacting 2
            (NKAIN2), transcript variant 1, mRNA.
ACCESSION   NM_001040214
VERSION     NM_001040214.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3374)
  AUTHORS   Zhang,G., Liu,D., Long,G., Shi,L., Qiu,H., Hu,G., Hu,G. and Liu,S.
  TITLE     Downregulation of microRNA-181d had suppressive effect on
            pancreatic cancer development through inverse regulation of KNAIN2
  JOURNAL   Tumour Biol 39 (4), 1010428317698364 (2017)
   PUBMED   28381166
  REMARK    GeneRIF: Inhibiting miR-181d may suppress pancreatic cancer
            development, possibly through the inverse regulation on NKAIN2.
REFERENCE   2  (bases 1 to 3374)
  AUTHORS   Mao,X., Luo,F., Boyd,L.K., Zhou,B., Zhang,Y., Stankiewicz,E.,
            Marzec,J., Vasiljevic,N., Yu,Y., Feng,N., Xu,J., Lorincz,A.,
            Jiang,Y., Chelala,C., Ren,G., Berney,D.M., Zhao,S.C. and Lu,Y.J.
  TITLE     NKAIN2 functions as a novel tumor suppressor in prostate cancer
  JOURNAL   Oncotarget 7 (39), 63793-63803 (2016)
   PUBMED   27588475
  REMARK    GeneRIF: NKAIN2 is a novel tumor suppressor gene whose activity is
            commonly reduced in prostate cancer
REFERENCE   3  (bases 1 to 3374)
  AUTHORS   Garner,C., Ahn,R., Ding,Y.C., Steele,L., Stoven,S., Green,P.H.,
            Fasano,A., Murray,J.A. and Neuhausen,S.L.
  TITLE     Genome-wide association study of celiac disease in North America
            confirms FRMD4B as new celiac locus
  JOURNAL   PLoS One 9 (7), e101428 (2014)
   PUBMED   24999842
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3374)
  AUTHORS   Hatemi,P.K., Medland,S.E., Klemmensen,R., Oskarsson,S., Littvay,L.,
            Dawes,C.T., Verhulst,B., McDermott,R., Norgaard,A.S.,
            Klofstad,C.A., Christensen,K., Johannesson,M., Magnusson,P.K.,
            Eaves,L.J. and Martin,N.G.
  TITLE     Genetic influences on political ideologies: twin analyses of 19
            measures of political ideologies from five democracies and
            genome-wide findings from three populations
  JOURNAL   Behav Genet 44 (3), 282-294 (2014)
   PUBMED   24569950
REFERENCE   5  (bases 1 to 3374)
  AUTHORS   Romania,P., Castellano,A., Surace,C., Citti,A., De Ioris,M.A.,
            Sirleto,P., De Mariano,M., Longo,L., Boldrini,R., Angioni,A.,
            Locatelli,F. and Fruci,D.
  TITLE     High-resolution array CGH profiling identifies Na/K transporting
            ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in
            neuroblastoma
  JOURNAL   PLoS One 8 (10), e78481 (2013)
   PUBMED   24205241
  REMARK    GeneRIF: High levels of NKAIN2 were detected in the MYCN-amplified
            NB cell lines.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3374)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3374)
  AUTHORS   Gorokhova,S., Bibert,S., Geering,K. and Heintz,N.
  TITLE     A novel family of transmembrane proteins interacting with beta
            subunits of the Na,K-ATPase
  JOURNAL   Hum Mol Genet 16 (20), 2394-2410 (2007)
   PUBMED   17606467
REFERENCE   8  (bases 1 to 3374)
  AUTHORS   Yue,Y., Stout,K., Grossmann,B., Zechner,U., Brinckmann,A.,
            White,C., Pilz,D.T. and Haaf,T.
  TITLE     Disruption of TCBA1 associated with a de novo t(1;6)(q32.2;q22.3)
            presenting in a child with developmental delay and recurrent
            infections
  JOURNAL   J Med Genet 43 (2), 143-147 (2006)
   PUBMED   15908570
  REMARK    GeneRIF: It is concluded that germline alterations of the TCBA1
            gene are associated with developmental delay and typical physical
            features.
REFERENCE   9  (bases 1 to 3374)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 3374)
  AUTHORS   Tagawa,H., Miura,I., Suzuki,R., Suzuki,H., Hosokawa,Y. and Seto,M.
  TITLE     Molecular cytogenetic analysis of the breakpoint region at 6q21-22
            in T-cell lymphoma/leukemia cell lines
  JOURNAL   Genes Chromosomes Cancer 34 (2), 175-185 (2002)
   PUBMED   11979551
  REMARK    GeneRIF: T-cell lymphoma breakpoint associated target 1 is a
            possible target gene for T-cell lineage-specific chromosome
            aberrations at 6q21.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354936.21, AK055326.1 and
            BC035062.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001040214.2.
            
            Summary: This gene encodes a transmembrane protein that interacts
            with the beta subunit of a sodium/potassium-transporting ATPase. A
            chromosomal translocation involving this gene is a cause of
            lymphoma. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.231264.1,
                                           SRR1660805.67143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368417.6/ ENSP00000357402.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AL354936.21        99812-100159
            349-1043            AK055326.1         1-695
            1044-3374           BC035062.2         829-3159
FEATURES             Location/Qualifiers
     source          1..3374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..3374
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /note="sodium/potassium transporting ATPase interacting 2"
                     /db_xref="GeneID:154215"
                     /db_xref="HGNC:HGNC:16443"
                     /db_xref="MIM:609758"
     exon            1..390
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..963
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium/potassium-transporting ATPase subunit
                     beta-1-interacting protein 2; T-cell lymphoma
                     breakpoint-associated target protein 1;
                     Na(+)/K(+)-transporting ATPase subunit beta-1-interacting
                     protein 2; Na+/K+ transporting ATPase interacting 2"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1-interacting protein 2 isoform 1"
                     /protein_id="NP_001035304.1"
                     /db_xref="CCDS:CCDS34526.1"
                     /db_xref="GeneID:154215"
                     /db_xref="HGNC:HGNC:16443"
                     /db_xref="MIM:609758"
                     /translation="MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHI
                     IIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNIS
                     MHRSWWMENGPGCTVTSVTPAPDWAPEDHRYITVSGCLLEYQYIEVAHSSLQIVLALA
                     GFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMSK"
     exon            391..528
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..609
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..810
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..871
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..953
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..3374
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3354..3359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /note="hexamer: AATAAA"
     polyA_site      3374
                     /gene="NKAIN2"
                     /gene_synonym="FAM77B; NKAIP2; TCBA; TCBA1"
                     /note="major polyA site"
ORIGIN      
        1 agatgcccga gggcgcggcg gcgctgccag gctgccgctg ctgcccctgc gggccccgag
       61 cgcgcctccg caggcggcac tgcccgcggc gcggcgtgtg caccgagcga gtgaaggtat
      121 gtgtggcggg cgcggctgga gctgccgccg ccgccgccgc cgcgccagca ggtcctaatg
      181 cctgtcactt cccaggacgc tggcagcagc agcagcccgg agcccccgag ccctcggcag
      241 gtttgcgtgt ccttccccgc gatctgattg gataaagtgg gggctcgacg gtggccgacg
      301 tgggacagtc tggctgtggc aggggtctcg gaaaccatgg gttattgcag tggcaggtgc
      361 acgcttatct ttatctgtgg catgcaactg gtttgtgtgc tggagaggca aatatttgac
      421 ttccttggat atcagtgggc acctatcctg gcaaattttg tacatattat tatcgtcatt
      481 cttggtttgt ttggaactat tcaatataga cctcgttaca taacaggata tgctgtctgg
      541 ctagtcctct gggttacgtg gaatgtgttt gttatctgct tctatttgga ggctggggac
      601 ctctcaaagg aaacagacct tatcctgact tttaatatat caatgcaccg atcttggtgg
      661 atggagaatg gaccaggatg tacggtgacg tcagtgacac ctgccccaga ctgggcccca
      721 gaagaccatc gctacatcac ggtctcaggg tgtttgctgg agtaccagta catagaagtg
      781 gctcatagtt ccctccagat tgtcctcgca ctggcaggtt tcatctacgc ctgttatgtt
      841 gtgaaatgta taactgaaga agaggacagc tttgatttca taggtggctt tgactcttat
      901 ggctatcaag ggcctcagaa gacatctcat ttacaactac agcctatgta catgtcaaaa
      961 taatacagat gacttcagta tgtcagccca tggacctttc aaagaacttt tttcgcagtg
     1021 gcctcctgca tttcatgaag agcaagaagc aactgagttt aaatacatac acgtattaac
     1081 aaaacaaatg caaagcctct acatacaaca ctgacacaca cacacacaca cacgtgagca
     1141 cgcacacacc aattccactt gacctcctct ttctaactga aacagacaaa tatgcaggac
     1201 acgcccatct tggatttcct gaaagcaggc ccctttctcc caggccttcg gaaagttcag
     1261 aaggagatgt gttgatgccc aacggttgcc ggccattgct aactcctctg cagcccagcg
     1321 ggttggcctc tgtgagctgg gaagtcatcc aaggcacatt agtttgagag ctctgtcttc
     1381 tgcactccat acatcttgac agcaccacgg ctacttaggc aatgtaattg caaaaacaaa
     1441 cgaaacatgc catgatgacc ttgtacccga agtccgaaat ggcagattgt ttgccctaaa
     1501 ggctgtaccg tacatacttg ccttaaccca cctacattgt gtgcccaaga atcccagtgc
     1561 agacagcccc aagccacttc ctttaggcta acacactgct attaattcta aatgagttca
     1621 agcctgtgtg tttcatgtca aggaacaaga ctgaatagct cagcagctcc agtgtgtctg
     1681 tataagaaaa gtgccagctg tcagcaaagt gctttaccat agagcctcca tggtggccca
     1741 aaagagacaa gtaacaataa caatatctgt catctttata attctaaaat atggtcttct
     1801 gatggggttg ggggtgggac agagtaaaac attaatctac taaactcact aatctactgg
     1861 aagcagaaag cagaaatggc ttaactcgct gattttattt attgcactct aggtgctttt
     1921 ataagtatct acaattgtct tttactaaca cagaaacagc tgtggatttc tatcaacaga
     1981 ggccaactga atatgtatta gctatgttta ctcttttata tctaattcaa attgaagact
     2041 ctacgtaggt gaactttttt ttctaacttc agtgtacaag attatttttg ggtgggtggg
     2101 gggagcaata gttaccttgg tgaaatattt gagatctttt tgtggtattt gggggatctg
     2161 ttgtgtgtta gagtgtattt caaccctcct gtattattgt ggcagaaaaa ctgtgctgtt
     2221 aacgtagttg gcaacaagat gcctttggaa acttaatagt aggtcaatgt gtttatggaa
     2281 tattctgaac tcctaggaaa ttttgttcta tattttaaag cattatttgg ttttcattag
     2341 tggaaaacat aattagctca ggcttatcag gaactcagat gagtcatatt ttttcttgga
     2401 tacacctgag acattaaact caatttttta aaactaacac accattcttt agtgcagtga
     2461 aattcaaaag ttataaattg gcatggagca agttttttct ttgatttcta tgaagtttca
     2521 gttattggat taaactactt tagaccttag cccattcgga tctacataca ccagttccat
     2581 tactgtgttt gcatggatgt ctgtaatata cacacacata tacatttgaa aatgatagag
     2641 gaacaaagag ttatcattgg aacataaact ataaaaaaag attccagcac tcatgcttga
     2701 atttcctcag tgggttgtat gtttgtccat acatacatgt ataaaataaa caattgcaaa
     2761 catgtcagtg aaacctcata tgacgctttt atagtgacat gcatgtttaa tgtatgagaa
     2821 aaatatttac caatgtattg tcctttgagt cctaaaatat aaatactata catgccagaa
     2881 actattctaa tgtgactttt aatgtgacta ttaaaaatga ggtttcactg tacattcatg
     2941 ctgtgatgcg atttcacctt atagtacatg tatatgggta cagaaaataa accctcatat
     3001 tcctgcttta agttacagcc aagttttcac caaatcacaa ctatcatcac caccaaaatt
     3061 ttaaaaaaca gtagttgact actaaaaagt aatcagtgga caggtcattt atgggatcag
     3121 taagcacagt agtgtgatta tatctgggaa aacatctaca gttgtacagc tgtatcctcc
     3181 tcaaaatccg gtgaagaatg ctatttttct aggctgagct tttgttataa acttaatatt
     3241 cagaaggcaa gggttatgat cctgatgtgt cctttttttt tgcatttgtt aattctgaat
     3301 gtatttttaa cagaatgatt tttttgactt actagtgtaa tttgcatttt aaaaataaat
     3361 ggaaaaatac ttaa
//
