LOCUS       NM_024522               2922 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens sodium/potassium transporting ATPase interacting 1
            (NKAIN1), mRNA.
ACCESSION   NM_024522
VERSION     NM_024522.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2922)
  AUTHORS   Wang,X., Yang,F., Sun,Z., Zhao,G., Pu,Q., Geng,C., Dong,K.,
            Zhang,X., Liu,Z. and Song,H.
  TITLE     NKAIN1, as an oncogene, promotes the proliferation and metastasis
            of breast cancer, affecting its prognosis
  JOURNAL   Mol Carcinog 63 (7), 1392-1405 (2024)
   PUBMED   38651944
  REMARK    GeneRIF: NKAIN1, as an oncogene, promotes the proliferation and
            metastasis of breast cancer, affecting its prognosis.
REFERENCE   2  (bases 1 to 2922)
  AUTHORS   Zuo,L., Wang,K., Zhang,X.Y., Krystal,J.H., Li,C.S., Zhang,F.,
            Zhang,H. and Luo,X.
  TITLE     NKAIN1-SERINC2 is a functional, replicable and genome-wide
            significant risk gene region specific for alcohol dependence in
            subjects of European descent
  JOURNAL   Drug Alcohol Depend 129 (3), 254-264 (2013)
   PUBMED   23455491
  REMARK    GeneRIF: NKAIN1-SERINC2 gene expression is associated with alcohol
            dependence in subjects of European descent.
REFERENCE   3  (bases 1 to 2922)
  AUTHORS   Gorokhova,S., Bibert,S., Geering,K. and Heintz,N.
  TITLE     A novel family of transmembrane proteins interacting with beta
            subunits of the Na,K-ATPase
  JOURNAL   Hum Mol Genet 16 (20), 2394-2410 (2007)
   PUBMED   17606467
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB499136.2, AI884789.1, AK299507.1, AK298874.1, AK022712.1 and
            AL832547.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024522.2.
            
            Summary: NKAIN1 is a member of a family of mammalian proteins with
            similarity to Drosophila Nkain and interacts with the beta subunit
            of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed
            17606467]).[supplied by OMIM, Jun 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.195151.1,
                                           SRR1803617.85303.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267762 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373736.7/ ENSP00000362841.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               DB499136.2         2-285
            285-844             AI884789.1         1-560
            845-1208            AK299507.1         517-880
            1209-1288           AK298874.1         700-779
            1289-1955           AK298874.1         781-1447
            1956-2921           AK022712.1         1528-2493
            2922-2922           AL832547.1         2187-2187
FEATURES             Location/Qualifiers
     source          1..2922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..2922
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /note="sodium/potassium transporting ATPase interacting 1"
                     /db_xref="GeneID:79570"
                     /db_xref="HGNC:HGNC:25743"
                     /db_xref="MIM:612871"
     exon            1..394
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..964
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /note="family with sequence similarity 77, member C;
                     sodium/potassium-transporting ATPase subunit
                     beta-1-interacting protein 1; Na(+)/K(+)-transporting
                     ATPase subunit beta-1-interacting protein 1; Na+/K+
                     transporting ATPase interacting 1"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1-interacting protein 1 precursor"
                     /protein_id="NP_078798.2"
                     /db_xref="CCDS:CCDS339.2"
                     /db_xref="GeneID:79570"
                     /db_xref="HGNC:HGNC:25743"
                     /db_xref="MIM:612871"
                     /translation="MGKCSGRCTLVAFCCLQLVAALERQIFDFLGYQWAPILANFLHI
                     MAVILGIFGTVQYRSRYLILYAAWLVLWVGWNAFIICFYLEVGQLSQDRDFIMTFNTS
                     LHRSWWMENGPGCLVTPVLNSRLALEDHHVISVTGCLLDYPYIEALSSALQIFLALFG
                     FVFACYVSKVFLEEEDSFDFIGGFDSYGYQAPQKTSHLQLQPLYTSG"
     exon            395..532
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /inference="alignment:Splign:2.1.0"
     exon            533..613
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /inference="alignment:Splign:2.1.0"
     exon            614..811
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /inference="alignment:Splign:2.1.0"
     exon            812..872
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /inference="alignment:Splign:2.1.0"
     exon            873..954
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /inference="alignment:Splign:2.1.0"
     exon            955..2922
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /note="hexamer: ATTAAA"
     polyA_site      2922
                     /gene="NKAIN1"
                     /gene_synonym="FAM77C"
                     /note="major polyA site"
ORIGIN      
        1 agtgctgctc tgcgctgcgc cgcgctcggg gctcgctctc cttgctccgc gctccccgcc
       61 agccgccccg gggcaggagg cgcgcctgac ggacggcccg ctagacaaag gaggcgcggc
      121 tcggcggggc cagcgcgcgg acggacggac catggactcg gagcgcgggc ggccggcccc
      181 agccttgggg accggacact cccgggcccg gccctaggcg cccggccccg ccgcccggcg
      241 cgcccagcgg ggaggacgtg gagcccgcgc ggcgcgagca ggcggcggcc gcggagcaag
      301 aagggcgccg cggcgtgcgg cccgcgcagc ccccggagcc atgggcaagt gcagcgggcg
      361 ctgcacgctg gtcgccttct gctgcctgca gctggtggct gcgctggagc ggcagatctt
      421 tgacttcctg ggctaccagt gggctcccat cctagccaac ttcctgcaca tcatggcagt
      481 catcctgggc atctttggca ccgtgcagta ccgctcccgg tacctcatcc tgtatgcagc
      541 ctggctggtg ctctgggttg gctggaatgc atttatcatc tgcttctact tggaggttgg
      601 acagctgtcc caggaccggg acttcatcat gaccttcaac acatccctgc accgctcctg
      661 gtggatggag aatgggccag gctgcctggt gacacctgtt ctgaactccc gcctggctct
      721 ggaggaccac catgtcatct ctgtcactgg ctgcctgctt gactacccct acattgaagc
      781 cctcagcagc gccctgcaga tcttcctggc actgttcggc ttcgtgttcg cctgctacgt
      841 gagcaaagtg ttcctggagg aggaggacag ctttgacttc atcggcggct ttgactccta
      901 cggataccag gcgccccaga agacgtcgca tttacagctg cagcctctgt acacgtcggg
      961 gtagcctctg ccccgcgccc accccggcgc ctcgccctgg gctgaccgca gctgccgcga
     1021 gctcgggcca aggcgcaggc gtgtccccct ggtggcccgc gcgctcactg cagcctgtgc
     1081 ccaaccccgc gtctgcatct ggagatgcgg acttggacgt ggacttggac ttggacttgg
     1141 atttgagctt ggctcttcgc agcccggact tcggaggagt ggggcggggc gggggagggg
     1201 caccacgggt tttttgtttt ttgtttgttt gtttttaatc tcagccttgg cgtgagctgg
     1261 ggccttcctc tcttctccag cctctccctt tcactcttca cccagcatcc tgcccccctg
     1321 tccaaaaaca gcaggacatc agacccatcc catcccacca cactcactca ccagctctgg
     1381 ggaaagctac tgtgaactag gagcaggatt cctgggttct aatcgcaggt ccatcactga
     1441 ctgtgacgtc tagcaaagcc cttgccctct ctgagcctcg gtttccgcac ctcaagtaat
     1501 taatccctta gcaaatggac tcttttagac ttctcattta actcaattcc ctgagctaga
     1561 ctgggattaa aattctcatt ttgcagtaca ttaaaactga ggcccagaga tgtgatttgc
     1621 ttgaggccac acagctagat ttttggtgga agtgggcctt gaacacagtg tactttctgc
     1681 agtttctgac tgtaaaaccc agtgtctgct ctctgagttc catttccaag cccccctcca
     1741 tcttggacct atgtggtctc caccatattc acacaccacc accaccactt gccaatgcct
     1801 ctcttaaagc aatataccca ttcgttctct tattgggaac tggatggatg aagccccaaa
     1861 ttcagcccca cccacagaga agccttccta cactcagcct ctgtccaccc ttggcaaatc
     1921 tttcaagctc tctcctccag gaaagtgggg ccccaactca gtcactccac ccccttccag
     1981 gtccctgagg ctggttctac tgtatcccca tcacctccac aactccactc acccctgacg
     2041 gctccatcca cctcaccagt tggaaggctt gtggtttcag agaggagcaa tgctggtcag
     2101 cgctgcccag actccagtgt ttacagatca ccagcattta caaccaatcc aatggccaga
     2161 agcctcctct aacaagccca gaaggagttc tgaaggggca gatgggggtg tgagtagtcg
     2221 gggagtcggg attgccagca ccctcaccct tccttggggg caagtagagg tgagaacact
     2281 ttccccacct ccctccacag acactcctga ggacgctgca tcccacgcac tgcctggtgc
     2341 gtccatagag agaggatcag gtctcagcat ttcatctgtg aaagaggcat ggccctgggt
     2401 tagaaaggag ggcaggagac atggaggaac tggggggcac ccagatggtg cagatggttt
     2461 gcacacctga gcctgtctgt ggtgaccatt ccgctcctct cccactaccc tccaatctat
     2521 cattccctac tctctaaggc caaaatatcc tgagcaaggc tggcaacccc accccaccat
     2581 cccaaatgca agcagccagg cccaggagtt cctctggccc ccacaggcat ggagctccca
     2641 gctggtgggt acagcttgag aggggggcag ctccctcagg ctaagctact gcccttcact
     2701 gggccagccc tgcctccagc cctcacctct ctcaccccaa ctctccccca agcccctttc
     2761 tactcaacgg gtgtagccac tggtgctttg aagccttttg tttttataag atggtttttg
     2821 caaggggacc aggttctctt ttcactggga ccttgcaagg aggggagtgc tctcctggtt
     2881 tctgtgcagg cgggttgatt aaagatggtg ttttcttctc ta
//
