LOCUS       NM_020202               7233 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nitrilase family member 2 (NIT2), mRNA.
ACCESSION   NM_020202
VERSION     NM_020202.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7233)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7233)
  AUTHORS   Epova,E.Y., Shevelev,A.B., Shurubor,Y.I., Cooper,A.J.L.,
            Biryukova,Y.K., Bogdanova,E.S., Tyno,Y.Y., Lebedeva,A.A. and
            Krasnikov,B.F.
  TITLE     A novel efficient producer of human omega-amidase (Nit2) in
            Escherichia coli
  JOURNAL   Anal Biochem 632, 114332 (2021)
   PUBMED   34391728
  REMARK    GeneRIF: A novel efficient producer of human omega-amidase (Nit2)
            in Escherichia coli.
REFERENCE   3  (bases 1 to 7233)
  AUTHORS   Chen,S., Wang,Z. and Feng,C.
  TITLE     NIT2 overexpression predicts poor prognosis in tongue squamous cell
            carcinoma patients
  JOURNAL   Mol Biol Rep 47 (3), 1553-1561 (2020)
   PUBMED   31925645
  REMARK    GeneRIF: NIT2 overexpression predicts poor prognosis in tongue
            squamous cell carcinoma patients.
REFERENCE   4  (bases 1 to 7233)
  AUTHORS   Zheng,B., Chai,R. and Yu,X.
  TITLE     Downregulation of NIT2 inhibits colon cancer cell proliferation and
            induces cell cycle arrest through the caspase-3 and PARP pathways
  JOURNAL   Int J Mol Med 35 (5), 1317-1322 (2015)
   PUBMED   25738796
  REMARK    GeneRIF: Downregulation of NIT2 inhibits colon cancer cell
            proliferation and induces cell cycle arrest through the caspase-3
            and PARP pathways
REFERENCE   5  (bases 1 to 7233)
  AUTHORS   Asakura,M., Nakano,M., Hayashida,K., Fujii,H., Nakajima,M.,
            Atsuda,K., Itoh,T. and Fujiwara,R.
  TITLE     Human nitrilase-like protein does not catalyze the hydrolysis of
            vildagliptin
  JOURNAL   Drug Metab Pharmacokinet 29 (6), 463-469 (2014)
   PUBMED   25008847
  REMARK    GeneRIF: Human NIT1/2 are not involved in the metabolism of
            vildagliptin.
REFERENCE   6  (bases 1 to 7233)
  AUTHORS   Chien,C.H., Gao,Q.Z., Cooper,A.J., Lyu,J.H. and Sheu,S.Y.
  TITLE     Structural insights into the catalytic active site and activity of
            human Nit2/omega-amidase: kinetic assay and molecular dynamics
            simulation
  JOURNAL   J Biol Chem 287 (31), 25715-25726 (2012)
   PUBMED   22674578
  REMARK    GeneRIF: The activity and substrate specificity of human Nit2 was
            determined with alpha-ketoglutaramate and succinamate as
            substrates.
REFERENCE   7  (bases 1 to 7233)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 7233)
  AUTHORS   Lin,C.H., Chung,M.Y., Chen,W.B. and Chien,C.H.
  TITLE     Growth inhibitory effect of the human NIT2 gene and its allelic
            imbalance in cancers
  JOURNAL   FEBS J 274 (11), 2946-2956 (2007)
   PUBMED   17488281
  REMARK    GeneRIF: Genotype analysis in 4 types of tumor tissue showed
            allelic imbalance surrounding NIT2 locus; results show that NIT2
            plays an important role in cell growth inhibition & links to
            malignancies, suggesting Nit2 may be a potential tumor suppressor
            candidate
REFERENCE   9  (bases 1 to 7233)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 7233)
  AUTHORS   Pace,H.C., Hodawadekar,S.C., Draganescu,A., Huang,J.,
            Bieganowski,P., Pekarsky,Y., Croce,C.M. and Brenner,C.
  TITLE     Crystal structure of the worm NitFhit Rosetta Stone protein reveals
            a Nit tetramer binding two Fhit dimers
  JOURNAL   Curr Biol 10 (15), 907-917 (2000)
   PUBMED   10959838
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB466042.1, AF284574.1, BM748852.1 and AC093003.11.
            
            On Nov 22, 2018 this sequence version replaced NM_020202.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.914440.1,
                                           SRR1803614.221343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394140.9/ ENSP00000377696.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB466042.1         40-53
            15-948              AF284574.1         1-934
            949-1232            BM748852.1         208-491
            1233-7233           AC093003.11        69208-75208         c
FEATURES             Location/Qualifiers
     source          1..7233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q12.2"
     gene            1..7233
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /note="nitrilase family member 2"
                     /db_xref="GeneID:56954"
                     /db_xref="HGNC:HGNC:29878"
                     /db_xref="MIM:616769"
     exon            1..42
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..866
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /EC_number="3.5.1.3"
                     /note="Nit protein 2; nitrilase homolog 2; epididymis
                     secretory sperm binding protein Li 8a"
                     /codon_start=1
                     /product="omega-amidase NIT2"
                     /protein_id="NP_064587.1"
                     /db_xref="CCDS:CCDS33806.1"
                     /db_xref="GeneID:56954"
                     /db_xref="HGNC:HGNC:29878"
                     /db_xref="MIM:616769"
                     /translation="MTSFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPEC
                     FNSPYGAKYFPEYAEKIPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGP
                     DGTLLAKYRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAE
                     LAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRSRAVDNQVYVATASPARDDKASYVA
                     WGHSTVVNPWGEVLAKAGTEEAIVYSDIDLKKLAEIRQQIPVFRQKRSDLYAVEMKKP
                     "
     exon            43..161
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            162..282
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            283..371
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            372..465
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            466..540
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            541..619
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            620..718
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            719..774
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     exon            775..7233
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      930..935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /note="hexamer: ATTAAA"
     regulatory      942..947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /note="hexamer: AATGAA"
     polyA_site      949
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /note="major polyA site"
     polyA_site      961
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /note="hexamer: AATATA"
     polyA_site      1203
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /note="hexamer: TATAAA"
     polyA_site      2472
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
     regulatory      7204..7209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
                     /note="hexamer: AGTAAA"
     polyA_site      7233
                     /gene="NIT2"
                     /gene_synonym="HEL-S-8a"
ORIGIN      
        1 agtccgcgcc gcaggtggtg cttgtctgca gagtcatgac ctctttccgc ttggccctca
       61 tccagcttca gatttcttcc atcaaatcag ataacgtcac tcgcgcttgt agcttcatcc
      121 gggaggcagc aacgcaagga gccaaaatag tttctttgcc ggaatgcttt aattctccat
      181 atggagcgaa atattttcct gaatatgcag agaaaattcc tggtgaatcc acacagaagc
      241 tttctgaagt agcaaaggaa tgcagcatat atctcattgg aggctctatc cctgaagagg
      301 atgctgggaa attatataac acctgtgctg tgtttgggcc tgatggaact ttactagcaa
      361 agtatagaaa gatccatctg tttgacattg atgttcctgg aaaaattaca tttcaagaat
      421 ctaaaacatt gagtccgggt gatagtttct ccacatttga tactccttac tgcagagtgg
      481 gtctgggcat ctgctacgac atgcggtttg cagagcttgc acaaatctac gcacagagag
      541 gctgccagct gttggtatat ccaggagctt ttaatctgac cactggacca gcccattggg
      601 agttacttca gcgaagccgg gctgttgata atcaggtgta tgtggccaca gcctctcctg
      661 cccgggatga caaagcctcc tatgttgcct ggggacacag caccgtggtg aacccttggg
      721 gggaggttct agccaaagct ggcacagaag aagcaatcgt gtattcagac atagacctga
      781 agaagctggc tgaaatacgc cagcaaatcc ccgtttttag acagaagcga tcagacctct
      841 atgctgtgga gatgaaaaag ccctaaagtt tatgtttcta atgtgtcaca gaataggacg
      901 atatgattct acaacataat caactcccta ttaaattctt taatgaagat ttttttttta
      961 attcggcctt gtccttccta ggttctctat tgagatgaga aagcctcatt atgctgacat
     1021 tttccacgcc acattaaata gttaaaaagg atgcagcctg gagccagaga gcagaaagct
     1081 gggctggttc tgaagcttct tccatactta agttgcctcc aagcagtttg tgaaagtatc
     1141 agatcttggt atcctggtga ttgattcacc taatataaat atatttgtgt catgaacctc
     1201 ttatcccgtt gctggagttg taatctccat catctagaaa acgtggtctg gtgctattct
     1261 tttccaagca gtaccttgaa gttccatttt tggttcatga gtagctatag aacgcaaggt
     1321 gatacatctt tggtgtttgc cagagaagtt ggcagcccca cccctcctac cagcctttgc
     1381 actcttcaaa tttaaaaagg agctacttat caaccccagg cccttctggt cttagaggaa
     1441 ggactgggcc aacaaagagc accatgggag aatggcagtg gtggcattta gtgaagacaa
     1501 tttagtatga atgtctgcaa aagatttttt tgatagcgtt gagtgtctga aagtcccatt
     1561 atttttcttt tttctttttc cccagtaaca ctttctagct ccacggataa ggaatcactg
     1621 aacctagtag ttcttagaca gcttggtttg agaatccttt tgcggttaaa aattagggac
     1681 tgagccaggc gcagtagcat gcgcctgtag tcctagccac attggaggct gaggtaggag
     1741 gatcccttga gtccacaagt ttgagttcag ccagagaccc tatctcacta tatatatgta
     1801 tctcaaagac ttcaatgggt ttttgcttac atgggccagt aattgttgaa caaccagcta
     1861 tttgagaaaa agccctgatt ttgctgcttt tcatggtgta aatacttaac catggctgag
     1921 tttgagctat ctgcatgaca cctctaaaca cagagttggg aatagatgtg cacaatcagc
     1981 tctggggagc tggtgcaatc ctgccctagc acaccactgg tttaagatag atatatcata
     2041 tagatattta ccatttacca tattggaaag taaaatggag aaaaatttaa aacacaagat
     2101 acatgagcac acattccatt agctattaag gtgatggaca cggtgtccaa atgacacggt
     2161 gtcatttaac ttctggaaaa caacactgtg tactgagaac aagagaaaga caaatgactt
     2221 ttttaaatta agtttttaat ttacaattga tgcataattt tactttaaaa aaataagtgt
     2281 gcaatttggt aaactttgac atatacagct ataaaccact ccaatcaaga taacatattt
     2341 accaccccca acagtttcca tgtgctgtat tataatccct ctggctagtc ctttgtcaat
     2401 cactgataaa ttttattact atagattagc ttgcattttc taaaattata taaaaatgaa
     2461 atcatgccat tagtgctttt tctgtatgtc ttctttcact caaaatcact tggaactcaa
     2521 aattacttct ttcactcaaa atcactcaaa attacatact ctgtatgtct tctttcactc
     2581 aaaattactt ctttcatttt tagacggaag catttagacc tcaaaattac ttggagattc
     2641 atctggtatg tgcattaata attcataatt cattcctttt ttattgctga gtagtataca
     2701 atttgtttat ccatttatct gctgttggag atttgggcta tttccagatt ttggctgttg
     2761 caaaaaagca acctcacaga tccttttaaa ggatgtcagg tgctttcagg taaccctaga
     2821 ctatagtacc actgctctct atcctagcag gcacactgaa agttaaacct tgtaatagtg
     2881 cgaaatcatt ttctttttta aaaatatatt ttcttacttt tatatatttt actcaatctc
     2941 atgacagatt acattttctt ttttaaatag aaagtcttac tgtaaagccc acatctgtat
     3001 aaaaaaatga aagaatgatc tggttgatgt ggatgtgtgg aacctaggaa ccttctcttg
     3061 gattttctct tattccccaa aaaacttcat ttcctctaaa gagctgctca gaagtttgaa
     3121 aaccagtgga caagccatcc tagctgtctt gatgctagag aagcaaagac gctttacaga
     3181 gatgtagcat tcctgtaaca ggtaaggcag gtggatgcta aactttttac atttcttttt
     3241 tttttttttt tttttttgag acagagtcac gctgtcgccc aagctggagt gcagtggcat
     3301 gatcttggtt cactgcatcc tctacctcct tggttgaagc aattctcagg cctcagcctc
     3361 ctaaaagtag ctgagactac aggcacgtgc caccatgcct ggctaatttt tgtgttttta
     3421 gtagagatgg ggtttcacca tcttggccag gctggtcttg aactcctgac ctcaagtgat
     3481 ccacctgcct tagcctccca aaatgctagg attagaggcg tgagccaccg cgcccggcct
     3541 aatttttgta tttttagtag aaatggggtt tcaccatgtt ggccagtctg atctcgaact
     3601 cctggcctca agtgatccac cagccttggc ctccccaaag tgttgggatt acagacgtga
     3661 gccacggcac ccagcctttt gtttgttttt gtttttatgt atttcattaa atgaattgtc
     3721 cttttagtgg tatatcagga gatcttgcct tctggtactc ttgaaaaata tgaaaagaaa
     3781 caactgaagt aggcatctcc tataattagt atgtagcatt ttattctcag aaaatgtgtg
     3841 gtaacctggc cctggatttt acctttttgc aaagtgatat ccgaataaaa tgaacactag
     3901 attcccactt ggagtggaag aacattgcag ttgaggcctt gggtaagttt taactgccat
     3961 acccctgtac tccccgactt tctaatgaat tagacaatga tgttttattt ttgttttttg
     4021 tttttgcata atactttgaa gtctgctatc acaagttgtg aacctctatc tcttgcagtt
     4081 taggtaaggc aacacattta atgaattcac atttaagtga attcctcaca gggatgacga
     4141 cctctgttga aataggtcag gatgtgcagt ttgtggtgaa agttctactt gactttgacc
     4201 tagctgtttg aagctgagag ctaacagata ataagtgttg cactggttgc aaatgaataa
     4261 ataagtaaca ttatggggtt ttaaatgacc aaggagtaga ttgtgacatc gactgggtat
     4321 ttagggaagg actccttcct gataccaaaa gttaggtctg tgcaaagtac accaagtgga
     4381 aaaaagttta gacaagagtt taggtttcaa gataaatgtt ctgctctatt ggcactggtt
     4441 ttaagtcttt tgtgctactt tttaggcatt gctgtgtaag ttttggtggt gcgtgggtac
     4501 aatgaagcca ggagggatag aaagggaaat gatgtgtgtg ctgcaggcta aacaggggct
     4561 cttccttatg cctcataacc acctgtgtgt gacagtttca catttcctat caaattatta
     4621 tcttcattca tttctacttg tgaatgaagt tcggagacta agaaaaagcc agctgttgga
     4681 atagaaagca ctttaggata aaatggtctt gttaaaatca ccaattaaaa agttaagccc
     4741 ctgatgtaca aataactaaa acacatacat acaaagacag tgcttcttgt tcaatgattt
     4801 acttcacagc tgattcataa tcaaatgaac aagaatctgc aagaacagaa catggtgggc
     4861 agggtccagt aattccaaat gttgtcatcc tagctcttcc tgaagcatat tgaatcctcc
     4921 aagtatatcc cgttgtgcta actaggcttt aagtcttttg tctgtagatt cattctcaaa
     4981 gtttctccct cagaacaaag agcacgccat cctgtaaagt actcttcctg attttttttc
     5041 acccaatttc ttagtttctt tcaattgctt ttcagacccc ggcaggcaga ttctgccctc
     5101 atctgtccag tgacactctt ctggcagatt actaaagacc gatttgtaga cctgtccatg
     5161 tggcctctct caacaccatt ggtgtgacct tgctcatact gcctctctca ccacttaaca
     5221 ttgtccctta gatgttaaag gcccttatat taatagtttt attttagctc ctttacattt
     5281 tattttgtcc tgaggaatct cagctacatg catggtcttc aatatatgcc gataattctc
     5341 attcacatag ctctcctgtt ggcttttccc cactcgttta aaaacaacca cttcactttg
     5401 ctggactcta ccttgaatgc ctcattttca gctcacactc atgctgtgcc tttatttaga
     5461 tttgttgtgg ttgtttcccc acattctgga agctccttac ctaaatcctg tttattcctt
     5521 aatgcttagc acaatttatt actcttgttt ccatggcact acattgtact tctgttttag
     5581 agactacctt cctctgaagc atatgacagg ttcatttact atccagccca ccaaaactca
     5641 gtttttgagc tcctctatgt tcatcttttt atggctaacc ctcaccatca tgagtgctta
     5701 gtaaatgttg agttggaatg aatttattcc tacaggttgc acttgctctc tcaccaagtg
     5761 ttctggccaa ataattctgg aatgatttcc ttaccttaag ggagtctgat ctgggaagag
     5821 cctgggacgt gatgtaactt catatgctgt agagctgaat attcatttac ttaagatctt
     5881 agctccatta gaaagcagtg aaagcagtgt taattcagag gccgggtatg gtggctcacg
     5941 cctgtaatcc cagcactttg ggaggccaag atgggcagat cacttaaggt caggagttca
     6001 agaccagcct ggccaacatg gcaaaacccc atctctacta aaaatacaaa aattagccgg
     6061 gtgtggtggc acatgcctgt gatcccagct actcgggagg gtaaggcagg aggaggttac
     6121 agtgagccaa gatcacacca ctgtactcct gggcaacaga gttaaactgt atcaaaaaaa
     6181 aaatgcagta ttgatttaga gctaaggtca cctgatgctc aggccagtaa tttctccctg
     6241 catcatgctg ttgtctaagg cagacactgt aaagctctac actgctgaaa aactaagctt
     6301 gagatgcata aaagaacaca tagagatggg gagtcagttc tccatacatt ttgtgagtag
     6361 aggcattggt gttttgttcc aaactatcca atcgagaatg ttcatataat gacagctttg
     6421 gaaggtagag actatcttcc tctggatcat aggacaggtt tgtttactat ctgatacagt
     6481 caaaatagtg tttccctcta atgcgaaagt caggccagtt tgcttgtgac ctcattagat
     6541 ttgggctgtg acgcaaaccc actgcatgtg cagtatccac ctagcttgcc ctgtgtcact
     6601 cccatgggat ctgtggctca aactcatgtt gcttgctatg ttctaaataa ttaagtctgt
     6661 tgtctgaccc aggagtctca tgtcttctgc cagcattcag aaaactagtt ttcaagaagg
     6721 gtaacatctt agacctttta cagctcttga cacagagcaa tattgagaaa taaaatcagg
     6781 taaaagttat ttaatatagc agttcataat ttaggccatg gatcatctct gcagagaatc
     6841 ctaccatgct gcattcttgc tttaaacctt tcgccctcta aaacaatgcc caagagccaa
     6901 tgttagtcat ggtcttcctg tatttgctct aggtaagctg tttcatagcc ttccaggaca
     6961 acacttgcac aggttatctt taagcaccaa caaaagaaat ggagaaattt gagccatgta
     7021 tcctgagctc tgaaaggcag caatcatctt gaccccaagc atacaccatg ttcagcttcc
     7081 tccccttggc caggtaccac agctacttct atcccagtga tcagcaggcc ctccagcatg
     7141 aagacctttg agaaggatct atagctgtca actcctaata tgatttgtgc actatcacct
     7201 tgaagtaaac cagactagtt attttcatgc taa
//
