LOCUS       NM_003634               2013 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens nipsnap homolog 1 (NIPSNAP1), transcript variant 1,
            mRNA.
ACCESSION   NM_003634
VERSION     NM_003634.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Pei,H., Dai,Y., Yu,Y., Tang,J., Cao,Z., Zhang,Y., Li,B., Nie,J.,
            Hei,T.K. and Zhou,G.
  TITLE     The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by
            Translated Peptide ATMLP Under the Control of m6 A Methylation
  JOURNAL   Adv Sci (Weinh) 10 (13), e2300314 (2023)
   PUBMED   36871154
  REMARK    GeneRIF: The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by
            Translated Peptide ATMLP Under the Control of m[6] A Methylation.
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Tu,Y.X.I., Sydor,A.M., Coyaud,E., Laurent,E.M.N., Dyer,D.,
            Mellouk,N., St-Germain,J., Vernon,R.M., Forman-Kay,J.D., Li,T.,
            Hua,R., Zhao,K., Ridgway,N.D., Kim,P.K., Raught,B. and Brumell,J.H.
  TITLE     Global Proximity Interactome of the Human Macroautophagy Pathway
  JOURNAL   Autophagy 18 (5), 1174-1186 (2022)
   PUBMED   34524948
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Princely Abudu,Y., Pankiv,S., Mathai,B.J., Hakon Lystad,A.,
            Bindesboll,C., Brenne,H.B., Yoke Wui Ng,M., Thiede,B., Yamamoto,A.,
            Mutugi Nthiga,T., Lamark,T., Esguerra,C.V., Johansen,T. and
            Simonsen,A.
  TITLE     NIPSNAP1 and NIPSNAP2 Act as 'Eat Me' Signals for Mitophagy
  JOURNAL   Dev Cell 49 (4), 509-525 (2019)
   PUBMED   30982665
  REMARK    GeneRIF: NIPSNAP1 and NIPSNAP2 have a redundant function in
            mitophagy and are predominantly expressed in different tissues.
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Okuda-Ashitaka,E., Minami,T., Tsubouchi,S., Kiyonari,H.,
            Iwamatsu,A., Noda,T., Handa,H. and Ito,S.
  TITLE     Identification of NIPSNAP1 as a nocistatin-interacting protein
            involving pain transmission
  JOURNAL   J Biol Chem 287 (13), 10403-10413 (2012)
   PUBMED   22311985
  REMARK    GeneRIF: NIPSNAP1 is an interacting molecule of NST and plays a
            crucial role in pain transmission.
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Schoeber,J.P., Topala,C.N., Lee,K.P., Lambers,T.T., Ricard,G., van
            der Kemp,A.W., Huynen,M.A., Hoenderop,J.G. and Bindels,R.J.
  TITLE     Identification of Nipsnap1 as a novel auxiliary protein inhibiting
            TRPV6 activity
  JOURNAL   Pflugers Arch 457 (1), 91-101 (2008)
   PUBMED   18392847
  REMARK    GeneRIF: This study presents the first physiological function of
            mouse Nipsnap1 as an associated protein inhibiting transient
            receptor potential vanilloid channel 6 activity that possibly
            exerts its effect directly at the plasma membrane.
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Satoh,K., Takeuchi,M., Oda,Y., Deguchi-Tawarada,M., Sakamoto,Y.,
            Matsubara,K., Nagasu,T. and Takai,Y.
  TITLE     Identification of activity-regulated proteins in the postsynaptic
            density fraction
  JOURNAL   Genes Cells 7 (2), 187-197 (2002)
   PUBMED   11895482
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Seroussi,E., Pan,H.Q., Kedra,D., Roe,B.A. and Dumanski,J.P.
  TITLE     Characterization of the human NIPSNAP1 gene from 22q12: a member of
            a novel gene family
  JOURNAL   Gene 212 (1), 13-20 (1998)
   PUBMED   9661659
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005529.7 and BC006473.1.
            
            On May 17, 2019 this sequence version replaced NM_003634.3.
            
            Summary: This gene encodes a member of the NipSnap family of
            proteins that may be involved in vesicular transport. A similar
            protein in mice inhibits the calcium channel TRPV6, and is also
            localized to the inner mitochondrial membrane where it may play a
            role in mitochondrial DNA maintenance. A pseudogene of this gene is
            located on the short arm of chromosome 17. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002371.2, SRR1803611.228575.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216121.12/ ENSP00000216121.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC005529.7         108986-109011       c
            27-2013             BC006473.1         1-1987
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..2013
                     /gene="NIPSNAP1"
                     /note="nipsnap homolog 1"
                     /db_xref="GeneID:8508"
                     /db_xref="HGNC:HGNC:7827"
                     /db_xref="MIM:603249"
     exon            1..129
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..886
                     /gene="NIPSNAP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     4-nitrophenylphosphatase domain and non-neuronal
                     SNAP25-like 1; protein NipSnap homolog 1"
                     /codon_start=1
                     /product="protein NipSnap homolog 1 isoform 1"
                     /protein_id="NP_003625.2"
                     /db_xref="CCDS:CCDS13860.1"
                     /db_xref="GeneID:8508"
                     /db_xref="HGNC:HGNC:7827"
                     /db_xref="MIM:603249"
                     /translation="MAPRLCSISVTARRLLGGPGPRAGDVASAAAARFYSKDNEGSWF
                     RSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPEYLDAYNSLTEAVLPKLHLDE
                     DYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLL
                     SRRNQLLLEFSFWNEPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAV
                     GGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMI
                     PLKISPLQ"
     exon            130..257
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..303
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..398
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..469
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..610
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..642
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..737
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..821
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..2013
                     /gene="NIPSNAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIPSNAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2013
                     /gene="NIPSNAP1"
                     /note="major polyA site"
ORIGIN      
        1 ggggccttcc tgcaaccttt gcggctccaa catggctccg cggctgtgca gcatctctgt
       61 gacggcgcgg cggctgctgg ggggcccggg gcctcgcgct ggggacgttg cgtctgcagc
      121 tgcggcgcgt ttctattcca aggacaatga aggcagctgg ttccgctccc tctttgttca
      181 caaagtggat ccccggaagg atgcccactc caccctgctg tccaagaagg aaaccagcaa
      241 cctctataag atccagtttc acaatgtaaa gcctgaatac ctggatgcct acaacagcct
      301 cacggaggct gtgctgccca agcttcacct ggatgaggac tacccatgct cactcgtggg
      361 caactggaac acgtggtatg gggagcagga ccaggcagtg cacctgtggc gattctcagg
      421 tggctaccca gccctcatgg actgcatgaa caagctcaaa aacaataagg agtacctgga
      481 gttccgaagg gagcggagcc agatgctgct gtccaggaga aaccagctgc tcctcgagtt
      541 cagcttctgg aatgagccac agcccagaat gggtcccaac atctatgagc tgaggacata
      601 caagctcaag ccaggaacca tgatcgagtg ggggaacaac tgggctcggg ccatcaagta
      661 ccggcaggag aaccaggagg cagtgggcgg cttcttctca cagataggag agctctacgt
      721 ggtgcaccat ctctgggcct ataaagacct gcagtctcgg gaggagactc gaaacgctgc
      781 ctggaggaag agaggctggg atgaaaatgt ctactataca gtccccctgg tgcgacacat
      841 ggagtctagg atcatgatcc ccttgaagat ctcgcctctg cagtgatgct gcctacacct
      901 ccacctcctt ccccttctcc ctcaggcaac cccgacagac agtggcactc ctggtcctgc
      961 tgtcttggtt ttgtcttggc tctgggagga ctctgagggg cagtgctcag ttcagacaag
     1021 ggggaactga aggctgacaa gttctgagga ttacagctct gcccaggccc tttctacttt
     1081 ccctgcctgc ctccctcccc ctgctagaag tagtttctga tttccctgaa tgaaagatag
     1141 tgatctttta ggccttcatt tatcttctaa aattcctcat ctcaaggcca ccagtcccca
     1201 gttatcaccc ttggaaatcc tctgtttagc ttagttgcac aaaaggtagt atgtccagtg
     1261 gctagaggtg gggtgggaag agaggaggcc aggccaggcc ctcaggaatt ccctggtttc
     1321 cactgggcca cccacttgct ggacagtctg agccaagtcc ctcctgctgg agaaaagcct
     1381 ggaactgcca aaacaaaaaa acaaatacaa acaaacctcg tcaccacggt caggaggagg
     1441 ttcagacatt ctgcccagag gggctgggga aagggatggg agccaggaaa gatttagggg
     1501 caggagacag acacgtaaca ggaactcgga aggtagaact tagaattcag aacttgggtt
     1561 tcaattgtag aatttggaat ctggaataca gaattgggaa gaagaacaga gatgacaaaa
     1621 gaccacttga agagaggttc ctaatactag acagatggag agtggcttgg ctgtttcccc
     1681 ctgcatattg gggttgaaaa cttaaatgtg tagttccagt ccttctatgc agagtctctc
     1741 ctgccctccc tccttcctgc aggcaaatat acaagctaga ccctgttccc tcaccctgta
     1801 tcctgtctcc cctaattgac attctatcag cccaaccctc attctgcagg gccacctggt
     1861 gtgtggaggt ggcgggaggg gtcagtgact ctgggggtct cctcagtgac ccccatacct
     1921 catcatgaac ccttgggtag cttgattctg cctaccatcc aggaaaactt gtgctggaat
     1981 tgctgatgga aacaattaaa tatttactat aaa
//
