LOCUS       NM_144599               6553 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens NIPA magnesium transporter 1 (NIPA1), transcript
            variant 1, mRNA.
ACCESSION   NM_144599
VERSION     NM_144599.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6553)
  AUTHORS   Ruffo,P., De Amicis,F., La Bella,V. and Conforti,F.L.
  TITLE     Investigating Repeat Expansions in NIPA1, NOP56, and NOTCH2NLC
            Genes: A Closer Look at Amyotrophic Lateral Sclerosis Patients from
            Southern Italy
  JOURNAL   Cells 13 (8), 677 (2024)
   PUBMED   38667292
  REMARK    GeneRIF: Investigating Repeat Expansions in NIPA1, NOP56, and
            NOTCH2NLC Genes: A Closer Look at Amyotrophic Lateral Sclerosis
            Patients from Southern Italy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6553)
  AUTHORS   Jiang,M., Song,Y., Ren,M.X., He,R.C., Dong,X.H., Li,X.H., Lu,Z.F.,
            Li,S., Wu,J., Bei,Y.R., Liu,F., Long,Y., Wu,S.G., Liu,X.H.,
            Wu,L.M., Yang,H.L., McVey,D.G., Dai,X.Y., Ye,S. and Hu,Y.W.
  TITLE     LncRNA NIPA1-SO confers atherosclerotic protection by suppressing
            the transmembrane protein NIPA1
  JOURNAL   J Adv Res 54, 29-42 (2023)
   PUBMED   36736696
  REMARK    GeneRIF: LncRNA NIPA1-SO confers atherosclerotic protection by
            suppressing the transmembrane protein NIPA1.
REFERENCE   3  (bases 1 to 6553)
  AUTHORS   Fang,S.Y., Chou,Y.T., Hsu,K.C., Hsu,S.L., Yu,K.W., Tsai,Y.S.,
            Liao,Y.C., Tsai,P.C. and Lee,Y.C.
  TITLE     Clinical and genetic characterization of NIPA1 mutations in a
            Taiwanese cohort with hereditary spastic paraplegia
  JOURNAL   Ann Clin Transl Neurol 10 (3), 353-362 (2023)
   PUBMED   36607129
  REMARK    GeneRIF: Clinical and genetic characterization of NIPA1 mutations
            in a Taiwanese cohort with hereditary spastic paraplegia.
            Review article
REFERENCE   4  (bases 1 to 6553)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6553)
  AUTHORS   Corrado,L., Brunetti,M., Di Pierro,A., Barberis,M., Croce,R.,
            Bersano,E., De Marchi,F., Zuccala,M., Barizzone,N., Calvo,A.,
            Moglia,C., Mazzini,L., Chio,A. and D'Alfonso,S.
  TITLE     Analysis of the GCG repeat length in NIPA1 gene in C9orf72-mediated
            ALS in a large Italian ALS cohort
  JOURNAL   Neurol Sci 40 (12), 2537-2540 (2019)
   PUBMED   31286297
  REMARK    GeneRIF: No role of NIPA1 repeat length as a modifier of the
            C9orf72 ALS disease risk.
REFERENCE   6  (bases 1 to 6553)
  AUTHORS   Chai,J.H., Locke,D.P., Greally,J.M., Knoll,J.H., Ohta,T., Dunai,J.,
            Yavor,A., Eichler,E.E. and Nicholls,R.D.
  TITLE     Identification of four highly conserved genes between breakpoint
            hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes
            deletion region that have undergone evolutionary transposition
            mediated by flanking duplicons
  JOURNAL   Am J Hum Genet 73 (4), 898-925 (2003)
   PUBMED   14508708
  REMARK    GeneRIF: located in the genomic domain between break points 1 and 2
            on chromosome 15, of the Prader-Willi/Angelman syndromes
REFERENCE   7  (bases 1 to 6553)
  AUTHORS   Toyoda,N., Nagai,S., Terashima,Y., Motomura,K., Haino,M.,
            Hashimoto,S., Takizawa,H. and Matsushima,K.
  TITLE     Analysis of mRNA with microsomal fractionation using a SAGE-based
            DNA microarray system facilitates identification of the genes
            encoding secretory proteins
  JOURNAL   Genome Res 13 (7), 1728-1736 (2003)
   PUBMED   12805275
REFERENCE   8  (bases 1 to 6553)
  AUTHORS   Fink,J.K., Jones,S.M., Sharp,G.B., Lange,B.M., Otterud,B. and
            Leppert,M.
  TITLE     Hereditary spastic paraplegia linked to chromosome 15q: Analysis of
            candidate genes
  JOURNAL   Neurology 46 (3), 835-836 (1996)
   PUBMED   8618696
REFERENCE   9  (bases 1 to 6553)
  AUTHORS   Fink,J.K., Wu,C.T., Jones,S.M., Sharp,G.B., Lange,B.M., Lesicki,A.,
            Reinglass,T., Varvil,T., Otterud,B. and Leppert,M.
  TITLE     Autosomal dominant familial spastic paraplegia: tight linkage to
            chromosome 15q
  JOURNAL   Am J Hum Genet 56 (1), 188-192 (1995)
   PUBMED   7825577
REFERENCE   10 (bases 1 to 6553)
  AUTHORS   Hedera,P.
  TITLE     Hereditary Spastic Paraplegia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BK001020.1 and AK314073.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_144599.4.
            
            Summary: This gene encodes a magnesium transporter that associates
            with early endosomes and the cell surface in a variety of neuronal
            and epithelial cells. This protein may play a role in nervous
            system development and maintenance. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            Mutations in this gene have been associated with autosomal dominant
            spastic paraplegia 6. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK001020.1, SRR1660805.34307.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337435.9/ ENSP00000337452.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-453               BK001020.1         13-465
            454-1003            AK314073.1         427-976
            1004-6553           BK001020.1         1016-6565
FEATURES             Location/Qualifiers
     source          1..6553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q11.2"
     gene            1..6553
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /note="NIPA magnesium transporter 1"
                     /db_xref="GeneID:123606"
                     /db_xref="HGNC:HGNC:17043"
                     /db_xref="MIM:608145"
     exon            1..191
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1003
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     magnesium transporter NIPA1; spastic paraplegia 6 protein;
                     non-imprinted in Prader-Willi/Angelman syndrome region
                     protein 1; non imprinted in Prader-Willi/Angelman syndrome
                     1"
                     /codon_start=1
                     /product="magnesium transporter NIPA1 isoform 1"
                     /protein_id="NP_653200.2"
                     /db_xref="CCDS:CCDS73691.1"
                     /db_xref="GeneID:123606"
                     /db_xref="HGNC:HGNC:17043"
                     /db_xref="MIM:608145"
                     /translation="MGTAAAAAAAAAAAAAGEGARSPSPAAVSLGLGVAVVSSLVNGS
                     TFVLQKKGIVRAKRRGTSYLTDIVWWAGTIAMAVGQIGNFLAYTAVPTVLVTPLGALG
                     VPFGSILASYLLKEKLNILGKLGCLLSCAGSVVLIIHSPKSESVTTQAELEEKLTNPV
                     FVGYLCIVLLMLLLLIFWIAPAHGPTNIMVYISICSLLGSFTVPSTKGIGLAAQDILH
                     NNPSSQRALCLCLVLLAVLGCSIIVQFRYINKALECFDSSVFGAIYYVVFTTLVLLAS
                     AILFREWSNVGLVDFLGMACGFTTVSVGIVLIQVFKEFNFNLGEMNKSNMKTD"
     exon            192..239
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /inference="alignment:Splign:2.1.0"
     exon            240..330
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /inference="alignment:Splign:2.1.0"
     exon            331..491
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /inference="alignment:Splign:2.1.0"
     exon            492..6553
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6528..6533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /note="hexamer: AATAAA"
     polyA_site      6553
                     /gene="NIPA1"
                     /gene_synonym="FSP3; SLC57A1; SPG6"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcgggc ggaatgggga ctgcagctgc ggcagcggcg gcggcggcgg cggcggcggc
       61 cggggagggg gcgcgtagcc cgagccccgc cgccgtgtcg ctcggcctgg gcgtggccgt
      121 cgtgtcgagc ctggtgaacg ggtccacgtt cgtgctacag aagaagggca tcgtgcgtgc
      181 caagcggcga ggtacttcct atttaacaga cattgtgtgg tgggctggca caatcgcaat
      241 ggctgttggc cagattggaa acttcctggc ttacacggcg gtccccacgg tcctggtaac
      301 ccccctgggc gcccttggag taccgttcgg gtccatttta gcttcctatc tcctgaagga
      361 aaagctcaac atcttgggca agttggggtg cctgctaagc tgtgcaggct ccgtcgtgct
      421 gattatccac tccccaaagt ctgagagtgt gacaactcag gctgagctgg aggaaaagct
      481 gaccaatcca gtgtttgtgg gctacctgtg catcgtgctg ctcatgctgc tgctgctcat
      541 cttctggatc gcgccggccc atgggcccac caacatcatg gtctacatca gcatctgctc
      601 cttgctgggc agtttcaccg tgccttccac caagggcatc gggctggcgg cccaagacat
      661 cttgcataac aacccgtcca gtcagagagc cctctgcctg tgcctggtac tcctggccgt
      721 gctcggctgc agcatcatcg tccagttcag gtacatcaac aaggcgctgg agtgcttcga
      781 ctcctcggtg ttcggggcca tctactacgt cgtgtttacc acgctggtcc tgctggcctc
      841 agccatcctc ttccgggagt ggagcaacgt gggcctggtg gacttcttgg ggatggcctg
      901 tggattcacg accgtctccg tggggattgt ccttatacag gtgttcaaag agttcaattt
      961 caaccttggg gagatgaaca aatctaatat gaaaacagac tagattgcaa taggagcttg
     1021 gatggttcga ggaataggca ttggaggtgg tttctggccg tgattggatg tgaagtagaa
     1081 gaggtcctcg atcatggtgt tagaattgac tggatagtaa caggtggtct ggtggatagc
     1141 ggggagcatg gctcagcacc agagcagagg cccagccagc cctctgcagc ccaaacgtcc
     1201 ccaacggttg cctggcacca tctctctctg atgagacgaa tctcattttc atttccatta
     1261 acctggaagc tttcatgaat attctcttct tttaaaacat tttaacatta tttaaacaga
     1321 aaaagatggg ctctttctgg ttagttgtta catgatagca gagatatttt tacttagatt
     1381 actttgggaa tgagagattg ttgtcttgaa ctctggcact gtacagtgaa tgtgtctgta
     1441 gttgtgttag tttgcattaa gcatgtataa cattcaagta tgtcatccaa ataagaggca
     1501 tatacattga attgttttta atcctctgac aagttgactc ttcgaccccc acccccaccc
     1561 aagacatttt aatagtaaat agagagagag agaagagtta atgaacatga ggtagtgttc
     1621 cactggcagg atgacttttc aatagctcaa atcaatttca gtgcctttat cacttgaatt
     1681 attaacttaa tttgactctt aatgtgtata tgttcttaga ttagaataat gcaacttcga
     1741 gtatgcttta atatttcaat attcaagtta caaatgtata aggcagttag aaataataca
     1801 gtcacatgtc acttaatgat agggaaacat tctgagaaat gcattgtaag gtgactttat
     1861 tgtgtgaaca tcatggagtg cacttataca aacctagatg ggacacctat gacccaccca
     1921 ggccagatgg tacagcctgt tgctcctggg ccacacacct gtacagcatg tgaccgcact
     1981 gaataccgca ggcaattgta acacagtggt gagtatttgt gtttacaaac ataggaaagg
     2041 tacagtaaaa ctatggtatt acaatgttat gggaccaccg tcatgtaagt ggtatgtctt
     2101 tgacagaaac atggttacgt ggttcatgac tgtatattca ctggaagata gtcaagacta
     2161 aagacacatt agagcaaatt gaccccttta acatgtgatt attgtccaat taaagacagt
     2221 tgatttaagt agcatgaggt attattttat ttgtattcga tctgtgttac ctgggatcca
     2281 gtatcaaata tatccacatt ctttatcagc aagcattcat ggccattcag aagaaataaa
     2341 ttaggtaact tgataataag gctaagtggg agagtacctg ttcaatagct catatatcga
     2401 gtaccctgtc atacaggaac aagttaaagg acacaattga ggttaggcta gcttctacaa
     2461 attgcaatat gcagtttttg aaagattttc taacaaaaag ccaataaatg tagccatctc
     2521 cttgttgttt gcaatggcag agcatcctag agttcctcag ctaacctctc attatgtgtc
     2581 ttaaatgcaa aagagccatt aattatgcca gtatttgaat caaagaggtc attctctgtc
     2641 tatagtgttc ccatccatgt gttccaaatg ggagcatagc atgaagtgat gcacatattt
     2701 caccacggta tcatgtactt catggccagt gttttatctc agcagggaac tacgccaagt
     2761 tgaaagatgg ggttgggtaa agtagattag gtgaagtaga acataaaatt gaatagtacc
     2821 caattaaagt tcctcagtaa gaaaaaaaat gtgtttttgt aggcaaaaag aacatttcta
     2881 aagtctcaag gaatagcttc ctaaagtgtt gagtaaagag gctaaataaa atgagactag
     2941 tttaatatag agagaaaaat acctttatgg agtaaacgtg tacatgatga tcatgggttg
     3001 tcagtgattt gtgaactgag agcagcaaca acattatttt ttaaaaatct taaatcctct
     3061 caatggatgg ttaacaaatg ctcaaagtcc attactcttt ttattggctc ttgcaggttt
     3121 tgtgttttat catcagtgct tttagaaatg caggccttaa cttactgaac tgaactttct
     3181 gaaaacgtaa tgtagcagta tcaatatact tttgggcata aaaatagttt cctaggtaag
     3241 gggtgtgaga tattcaaaga atacatgtgg ctaacaagtg taatgagaaa gttcatgtgt
     3301 cacatgaaaa tgatcatgtt tgtgttgcta cagcttttgt gggaaattta gtttaaaggc
     3361 agctcttggt gtaccttagt atattttaat ccacaattat accattgata ctgagaggtg
     3421 atacccgatg atcttctcta taatattctt agagtaaaac aaaatctcaa aagtattaat
     3481 agctcttcta cccttgaagg tgactggtcc tgggacagtt agaatctttc aggtttacct
     3541 ctgttcagca gatacttcag taggatacat agcttttctt ccagtgaaac aaagttcata
     3601 tcatccattg tttttcaagc acgtgacacc agcctcaaag taaatgacat gaccagtggt
     3661 tgaacagtct aattttcaaa tttaatatag agcatataac ttctgatttg atagtattta
     3721 ttttaaaaaa ttatgttttc atcattcatt tgaaaatgaa aaagccccaa agtgagaact
     3781 ttgggggagg gcctagaaca tggatagatc tcttagtggt ctttccaaaa gtacatgtac
     3841 ttgaaatatt ttcattatca tactattctt tgaaaaaaaa gatgcttact gtatacttgt
     3901 tttcaagcat cctctaaaat caaaggtttt gatcacaata tgcagatttc tcttgataga
     3961 tacttaaata ggctatttct ctcctcttct tgggcaatgc cttgttttct cctctgaata
     4021 tttgcatttg aaaggattgc ttcctgttct gctcattgat caaaggtagg gccaattaag
     4081 gattctaacc ctaacccagc accacaaagc ccccctggag catcttcccg gctggcagga
     4141 ccatgccatc tctgtggaga aggtgctggg gagggaagtc cttccagtgc cacatggagt
     4201 gaggccctgc ccatgctggg gactttgggg aggaatttgg tattctggtg gccttgctca
     4261 gctctcattg agatcttttc ctatcagaat gttagtgaat atacttcgca gctctttgtt
     4321 cagcaataag gaatattctt tcaattcctg ctcttcaagc caatttacta cacccagttg
     4381 tctttccaga agttcatccc agcggtaata tgttggtgtt tgttcttctt tggatttcac
     4441 atctgttttc tggtagaagt gagcactgtt cacttgtgca gtcgtcttat tttccttctt
     4501 cctagatgac tcagctcttt gtaaatgttg tgctcaactt ctaggggcca gttctagact
     4561 ttggagatgc agtgtctccc aggtgtgcac ggacacctgg tccgtggaaa caggtgtgat
     4621 gggcacaggc tgctgccctt ctgtctggtc gggggattcc tcttcttcaa gctgctcagc
     4681 taacccagaa gaggggagag agtactccgg tggttcccag agcccctccc gttgtgccgc
     4741 ttcgacctga cacctgctcg atgctgactt aggcttcctg ccaccaagca ggaaactaga
     4801 aagagaacat ttcagtgtaa ggtctgttcc cgacagcatg gattagcttc cgtgttctga
     4861 agttgttctt ttcatggtgt ctgacaccga gggcgttgtt cgtccatcag gcgggattgg
     4921 atggagtctt ggtgttttgc cttctcaggg accaaaaatg tatcattgac tccttaacag
     4981 tgaccttcct cccaaggaca tatccgtgtt catttttcat aggttttact catattcata
     5041 ggtagattct gttaatgtga gttggaaaga aaagaccaat ttgtacacca gtcacaccac
     5101 aagacagttt atcatataaa atacctcaat tttttgtatt cctcatttcc acctcacaat
     5161 tgtactggtg atgaatttta agggtctgtc ctttagctta taggtgatgt ttcacatctg
     5221 gccagattct tatacctcca ttgtatactt gaaaaggttc agaattacag gaacagcagt
     5281 gagaatttgg cccactacca cgactcattt gtttcattca cattcctcac gtgcaacaac
     5341 ataattatat tttaagaaaa tgtaactttg ttacatcaaa atatgttgtc tagtaaaaag
     5401 ttgatattca gtagaacaag gatcatgtaa ataaacatct atttcacatg tacccaaaag
     5461 catttaaaaa gcagaatcca gggcccagag catgagccag ggaggaggat gtttttcttc
     5521 ttttctctat ttttccctaa attgtgcaaa cataggtgag tctcttaacc tttctgtgcc
     5581 tcagtttttc tacctctaaa ggggtgggat ggttcttcaa attgtttcta aaacaccggc
     5641 actttcagca gtgttctggt ggcctgagat gagagcaccg tgttcagaag tgcctgggag
     5701 tggcacagtg gaaactccgc ttgcacggac catggagtct gctcaggacc atgctgtagg
     5761 acacacagcc tcatgcgctg agaaagcaaa ggaagtgctg ggtgtaaagt ttgcatgatt
     5821 ccatgaagct ttagttttcc tttttttgtt ttaaaagaaa gggttttata tgttctattg
     5881 taaaatatgg aaattaaaca gggacttcag aaagccgcac agaaagatca ccttccgatg
     5941 gtgtgatgtg ctcctgacat tcggccgagg tctgtattct gaaaaagatt taatggcctg
     6001 tgaaacacgt ggattctgtt gcactggatt tgtaataaat gacgctgaac ttcctgcttc
     6061 caagcagctc aaccctgatg ctgaactgac accaggcgaa tgtcagggct cccaaaccac
     6121 tagtgccaaa gggtcatgtt gaaaagttca gaatatttat ttgtcagaat ataataattg
     6181 ccccccacct tagtattttt gcactttaca gaaatttaga tactgttttt cagtggcttg
     6241 agcgttttgc cttttcaaag gataactatt attttcttga aaatggaata taatcatgag
     6301 aggaagaaga tgtaaaaaat gtcaaatgtt gattggttgt gtaaaagttt tgtcatagac
     6361 atgtattggg gagcttccaa ttagcataca tagacacatg tgtcagtggc caagacctgc
     6421 ttatattttg ctttatagat gtagtcatag catgttgtta ttgcctcatg taaataaaaa
     6481 ggctattaag ttttccagta atatttatta atctgtatgt gttttaaaat aaaataactt
     6541 atttctagct gaa
//
