LOCUS       NM_016101               2055 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens nucleolar pre-rRNA processing protein NIP7 (NIP7),
            transcript variant 1, mRNA.
ACCESSION   NM_016101
VERSION     NM_016101.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2055)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2055)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2055)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2055)
  AUTHORS   Liu,J., Li,R., Liao,X. and Jiang,W.
  TITLE     Comprehensive Bioinformatic Analysis Genes Associated to the
            Prognosis of Liposarcoma
  JOURNAL   Med Sci Monit 24, 7329-7339 (2018)
   PUBMED   30317246
  REMARK    GeneRIF: The Cox regression model revealed that only NIP7, RPL10L,
            and MCM2 exhibited significant correlation with distant
            recurrence-free survival in liposarcoma in the GSE30929 dataset,
            and the regression coefficients were -0.676, -0.703, and 0.868,
            respectively
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2055)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 2055)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 2055)
  AUTHORS   Liu,J.F., Wang,X.Q., Wang,Z.X., Chen,J.R., Jiang,T., An,X.M.,
            Chang,W.R. and Liang,D.C.
  TITLE     Crystal structure of KD93, a novel protein expressed in human
            hematopoietic stem/progenitor cells
  JOURNAL   J Struct Biol 148 (3), 370-374 (2004)
   PUBMED   15522784
  REMARK    GeneRIF: KD93 is a novel protein expressed in human hematopoietic
            stem/progenitor cells
REFERENCE   8  (bases 1 to 2055)
  AUTHORS   Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and
            Nishimoto,T.
  TITLE     A novel human nucleolar protein, Nop132, binds to the G proteins,
            RRAG A/C/D
  JOURNAL   J Biol Chem 279 (9), 8343-8350 (2004)
   PUBMED   14660641
REFERENCE   9  (bases 1 to 2055)
  AUTHORS   Chagnon,P., Michaud,J., Mitchell,G., Mercier,J., Marion,J.F.,
            Drouin,E., Rasquin-Weber,A., Hudson,T.J. and Richter,A.
  TITLE     A missense mutation (R565W) in cirhin (FLJ14728) in North American
            Indian childhood cirrhosis
  JOURNAL   Am J Hum Genet 71 (6), 1443-1449 (2002)
   PUBMED   12417987
REFERENCE   10 (bases 1 to 2055)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB453898.1, BC015941.1, DR423435.1 and AW001672.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016101.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.126114.1,
                                           SRR1660809.153249.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254940.10/ ENSP00000254940.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB453898.1         345-357
            14-1397             BC015941.1         1-1384
            1398-1973           DR423435.1         153-728
            1974-2055           AW001672.1         24-105              c
FEATURES             Location/Qualifiers
     source          1..2055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2055
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="nucleolar pre-rRNA processing protein NIP7"
                     /db_xref="GeneID:51388"
                     /db_xref="HGNC:HGNC:24328"
                     /db_xref="MIM:619204"
     exon            1..114
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..601
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="isoform 1 is encoded by transcript variant 1; 60S
                     ribosome subunit biogenesis protein NIP7 homolog; nuclear
                     import 7 homolog; NIP7, nucleolar pre-rRNA processing
                     protein"
                     /codon_start=1
                     /product="60S ribosome subunit biogenesis protein NIP7
                     homolog isoform 1"
                     /protein_id="NP_057185.1"
                     /db_xref="CCDS:CCDS10877.1"
                     /db_xref="GeneID:51388"
                     /db_xref="HGNC:HGNC:24328"
                     /db_xref="MIM:619204"
                     /translation="MRPLTEEETRVMFEKIAKYIGENLQLLVDRPDGTYCFRLHNDRV
                     YYVSEKIMKLAANISGDKLVSLGTCFGKFTKTHKFRLHVTALDYLAPYAKYKVWIKPG
                     AEQSFLYGNHVLKSGLGRITENTSQYQGVVVYSMADIPLGFGVAAKSTQDCRKVDPMA
                     IVVFHQADIGEYVRHEETLT"
     exon            115..201
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /inference="alignment:Splign:2.1.0"
     exon            202..340
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /inference="alignment:Splign:2.1.0"
     exon            341..481
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /inference="alignment:Splign:2.1.0"
     exon            482..2055
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /inference="alignment:Splign:2.1.0"
     regulatory      816..821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="hexamer: AATAGA"
     polyA_site      840
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="major polyA site"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="hexamer: AATAAA"
     polyA_site      1623
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="major polyA site"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="hexamer: AATAAA"
     polyA_site      2055
                     /gene="NIP7"
                     /gene_synonym="CGI-37; HSPC031; KD93"
                     /note="major polyA site"
ORIGIN      
        1 gacttccgtt tccagttacc aaggcacgag gatccggtgt tccaacccag ggggaaaaat
       61 gcggcctttg actgaagagg agacccgtgt catgtttgag aagatagcga aatacattgg
      121 ggagaatctt caactgctgg tggaccggcc cgatggcacc tactgtttcc gtctgcacaa
      181 cgaccgggtg tactatgtga gtgagaagat tatgaagctg gccgccaata tttccgggga
      241 caagctggtg tcgctgggga cctgctttgg aaaattcact aaaacccaca agtttcggtt
      301 gcacgtcaca gctctggatt accttgcacc ttatgccaag tataaagttt ggataaagcc
      361 tggtgcagag cagtccttcc tgtatgggaa ccatgtgttg aaatctggtc tgggtcgaat
      421 cactgaaaat acttctcagt accagggcgt ggtggtgtac tccatggcag acatcccttt
      481 gggttttggg gtggcagcca aatctacaca agactgcaga aaagtagacc ccatggcgat
      541 tgtggtattt catcaagcag acattgggga atatgtgcgg catgaagaga cgttgactta
      601 aaacgaagcc attccaagga cagacggctg tatggaaagg ccgagctttg tttcctgtgt
      661 ttgtgtggac tccaccatca tgttgaattt tgtcaacact ctggcctctt cagggacttc
      721 ttatttactg tactctctat cactgacaaa tgcaggctgg attcttatta tatacagaga
      781 tggctcaaaa atggggtttc agatctttgt gacgaaatag aatactgttt catatttgaa
      841 tcagagggct tcttgttctg agaaataggt tcaaaatcat tggaaccagg aacaagaata
      901 gcttattgtt atctgtgata acactgtttt ctaaacacaa ggattttctt ttttattaat
      961 atgcaacata gacattgcca taacagaata ataaaccaca tgtggggttt taaaaatgaa
     1021 atttggctaa taggagcaat tcagctattt ttctatacag taattggtgt gtggtataga
     1081 agaaaaacgg gttcaaaccc cacttctgcc acctaccagc tatatggcct tgaatgagtc
     1141 attcagcttt aataaggttc attttcttct gtttaaaaag acacaaaact tgaaaatcag
     1201 ctttggccat ctacctgaga attagaaagt ctgatttttg gaattagaaa tcatgattgt
     1261 aggctgggca cagtggctcg cgcctgtaat cccagcactt tgggaggcca aggcggacgg
     1321 atcacttgag gttaggagtt tgagaccagc ctggccaaca tggtgaaacc ccatctctac
     1381 taaaaaaaaa aaaaaaatta ggtgtggtga cacatggctg tggtcctagt tacttgggag
     1441 gctgaggcag gagaatggct tgaactgggg aagcagagct tgcagtgagc caagatggtg
     1501 ccattgcact ccagcctggg cgtgacagag tgagactcca tctgattgta aagcatctag
     1561 tacagtgtac agtgccttgg aaatgatagg tatggaataa atggtaatta tttttatatt
     1621 atatatatta tgtattcctg ttattaagtg tagagtttta tgagtataat ttgattttat
     1681 taccttcttt tttacaagct gttttctcag tatttttctt ggatgggatg acgctaggct
     1741 ggaaagtttt tttcatcact atgattttat aaaacaattt tttctatgaa cctttactta
     1801 cttgactgga ttggactaaa agcactgatc agaggccacg acataaaaat tcagtccctt
     1861 tgtccttccc cgtgcctccc aaagttactt taagatcctt agaatatttc tttaaatatt
     1921 ttatagacaa aaaatttaaa gactatctgt attgcaaaat taaactattt ctttaatgaa
     1981 tatattgctt attttaagtt ccaaaggtga agtctttaag aataaaacat taccaactcc
     2041 tgcttttata tgtaa
//
