LOCUS       NM_025176               4991 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ninein like (NINL), transcript variant 1, mRNA.
ACCESSION   NM_025176
VERSION     NM_025176.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4991)
  AUTHORS   Ma,X.J., Shang,L., Zhang,W.M., Wang,M.R. and Zhan,Q.M.
  TITLE     Mitotic regulator Nlp interacts with XPA/ERCC1 complexes and
            regulates nucleotide excision repair (NER) in response to UV
            radiation
  JOURNAL   Cancer Lett 373 (2), 214-221 (2016)
   PUBMED   26805762
  REMARK    GeneRIF: Upon UVC radiation, Nlp interacts with XPA and ERCC1, and
            enhances their association
REFERENCE   2  (bases 1 to 4991)
  AUTHORS   Bachmann-Gagescu,R., Dona,M., Hetterschijt,L., Tonnaer,E.,
            Peters,T., de Vrieze,E., Mans,D.A., van Beersum,S.E., Phelps,I.G.,
            Arts,H.H., Keunen,J.E., Ueffing,M., Roepman,R., Boldt,K.,
            Doherty,D., Moens,C.B., Neuhauss,S.C., Kremer,H. and van Wijk,E.
  TITLE     The Ciliopathy Protein CC2D2A Associates with NINL and Functions in
            RAB8-MICAL3-Regulated Vesicle Trafficking
  JOURNAL   PLoS Genet 11 (10), e1005575 (2015)
   PUBMED   26485645
  REMARK    GeneRIF: these data support a model where CC2D2A associates with
            NINL to provide a docking point for cilia-directed cargo vesicles,
            suggesting a mechanism by which transition zone proteins can
            control the protein content of the ciliary compartment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4991)
  AUTHORS   Dona,M., Bachmann-Gagescu,R., Texier,Y., Toedt,G., Hetterschijt,L.,
            Tonnaer,E.L., Peters,T.A., van Beersum,S.E., Bergboer,J.G.,
            Horn,N., de Vrieze,E., Slijkerman,R.W., van Reeuwijk,J., Flik,G.,
            Keunen,J.E., Ueffing,M., Gibson,T.J., Roepman,R., Boldt,K.,
            Kremer,H. and van Wijk,E.
  TITLE     NINL and DZANK1 Co-function in Vesicle Transport and Are Essential
            for Photoreceptor Development in Zebrafish
  JOURNAL   PLoS Genet 11 (10), e1005574 (2015)
   PUBMED   26485514
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4991)
  AUTHORS   Zhao,W., Song,Y., Xu,B. and Zhan,Q.
  TITLE     Overexpression of centrosomal protein Nlp confers breast carcinoma
            resistance to paclitaxel
  JOURNAL   Cancer Biol Ther 13 (3), 156-163 (2012)
   PUBMED   22353935
  REMARK    GeneRIF: Breast cancer patients with high expression of Nlp were
            likely resistant to the treatment of paclitaxel.
REFERENCE   5  (bases 1 to 4991)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   6  (bases 1 to 4991)
  AUTHORS   Casenghi,M., Meraldi,P., Weinhart,U., Duncan,P.I., Korner,R. and
            Nigg,E.A.
  TITLE     Polo-like kinase 1 regulates Nlp, a centrosome protein involved in
            microtubule nucleation
  JOURNAL   Dev Cell 5 (1), 113-125 (2003)
   PUBMED   12852856
REFERENCE   7  (bases 1 to 4991)
  AUTHORS   Takahashi,M., Yamagiwa,A., Nishimura,T., Mukai,H. and Ono,Y.
  TITLE     Centrosomal proteins CG-NAP and kendrin provide microtubule
            nucleation sites by anchoring gamma-tubulin ring complex
  JOURNAL   Mol Biol Cell 13 (9), 3235-3245 (2002)
   PUBMED   12221128
REFERENCE   8  (bases 1 to 4991)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   9  (bases 1 to 4991)
  AUTHORS   Mayor,T., Stierhof,Y.D., Tanaka,K., Fry,A.M. and Nigg,E.A.
  TITLE     The centrosomal protein C-Nap1 is required for cell cycle-regulated
            centrosome cohesion
  JOURNAL   J Cell Biol 151 (4), 837-846 (2000)
   PUBMED   11076968
REFERENCE   10 (bases 1 to 4991)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA448124.1, DA871028.1, AB023197.1 and BC036380.2.
            
            On Nov 23, 2018 this sequence version replaced NM_025176.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023197.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278886.11/ ENSP00000278886.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DA448124.1         1-2
            3-14                DA871028.1         2-13
            15-4862             AB023197.1         1-4848
            4863-4876           BC036380.2         4795-4808
            4877-4991           BC036380.2         4810-4924
FEATURES             Location/Qualifiers
     source          1..4991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..4991
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /note="ninein like"
                     /db_xref="GeneID:22981"
                     /db_xref="HGNC:HGNC:29163"
                     /db_xref="MIM:609580"
     exon            1..77
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            78..268
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..4237
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ninein-like protein"
                     /codon_start=1
                     /product="ninein-like protein isoform 1"
                     /protein_id="NP_079452.3"
                     /db_xref="CCDS:CCDS33452.1"
                     /db_xref="GeneID:22981"
                     /db_xref="HGNC:HGNC:29163"
                     /db_xref="MIM:609580"
                     /translation="MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQ
                     LPVLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKY
                     VNGSKWYGRRSRPELCDAATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAES
                     TKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSE
                     QELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTR
                     VKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQE
                     GIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQ
                     VEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLL
                     RSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVV
                     EKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRND
                     ELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQ
                     VKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEEL
                     HEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAE
                     LSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQM
                     CVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGER
                     PLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGV
                     DGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQA
                     ERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLAD
                     PQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHR
                     LSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYK
                     DQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVE
                     LECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAEL
                     HRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQF
                     EKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPA
                     ALSV"
     exon            269..365
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            366..538
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            539..605
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            606..796
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            797..949
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1120
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1257
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1398
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1573
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1684
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1765
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1898
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2005
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2289
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..3336
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3441
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3511
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3670
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3784
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3931
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3932..4045
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4991
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4966..4971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /note="hexamer: AATAAA"
     polyA_site      4991
                     /gene="NINL"
                     /gene_synonym="NLP"
                     /note="major polyA site"
ORIGIN      
        1 acaaagagcg gccggcggta cgggggtggt gccgcgctcc tggccccgcg cgggcggacg
       61 gcggaggcgc ctcccagcct gctatgggat ggatgaagaa gagaaccact atgtctcgca
      121 gctcagggaa gtctacagca gctgcgacac cacggggact ggctttctgg accgccagga
      181 gctgacccag ctctgcctta agcttcacct ggagcagcag ctgcccgtcc tcctgcagac
      241 gcttctcgga aacgaccatt tcgccagggt taactttgag gaatttaagg aaggttttgt
      301 ggctgtgttg tcttcaaatg ctggtgttcg cccctcagat gaagacagta gttctttgga
      361 atcagctgcc tccagtgcca tccctccaaa gtatgtgaat ggttctaagt ggtatggccg
      421 tcggagccgg cctgagctat gtgacgctgc cacagaagcc agacgcgtgc cggagcagca
      481 aacccaggcc agcctgaaaa gtcacctctg gcgctcagcg tctctggaga gcgtggagag
      541 tcccaagtca gatgaagagg ccgagagcac taaagaagct cagaatgaat tatttgaagc
      601 acaaggacag ctgcagacct gggattctga ggactttggg agcccccaga agtcctgcag
      661 cccctccttt gacaccccag agagccagat ccggggcgtg tgggaagagc tgggggtggg
      721 cagcagcgga cacctgagcg agcaggagct ggctgtggtc tgccagagcg tcgggctcca
      781 gggactcgag aaagaggaac tcgaagacct gtttaacaaa ctggatcaag acggagacgg
      841 caaagtgagt cttgaggaat tccagcttgg cctcttcagt catgagcccg cgctacttct
      901 agagtcttcc actcgggtta aaccgagcaa ggcttggtct cattaccagg tcccagagga
      961 gagcggctgc cacaccacca caacctcatc cctcgtgtcc ctgtgctcca gcctgcgcct
     1021 cttctccagc attgacgatg gttctggctt cgcttttcct gatcaggtcc tggccatgtg
     1081 gacccaggag gggattcaga atggcaggga gatcttgcag agcctggact tcagcgtgga
     1141 cgagaaggtg aaccttctgg agctgacctg ggcccttgac aacgagctca tgacagtgga
     1201 cagtgccgtc cagcaggcag ccctggcctg ctaccaccag gagctgagct accagcaagg
     1261 gcaggtggag cagctggcaa gggagcgtga caaggcaagg caggacctgg agagggccga
     1321 gaagaggaac ctggagtttg tgaaagagat ggacgactgc cactccaccc tggagcagct
     1381 cacggagaag aaaatcaagc atctggagca ggggtaccgg gaaaggctga gcctcctgcg
     1441 gtctgaggtg gaggcggagc gagagctgtt ctgggagcag gcccacaggc agagggccgc
     1501 gctggagtgg gacgtggggc gcctgcaggc tgaggaggct ggcctccgcg agaagctgac
     1561 cctggccctg aaggaaaaca gtcgcctaca gaaggagatt gtggaagtgg tggaaaagct
     1621 ttcggattcg gagaggctgg ccctgaagct gcagaaggac ctggagtttg tgctgaagga
     1681 caagctggag ccacagagtg cagagctcct ggcccaggag gagcggttcg cagcagtcct
     1741 gaaggaatac gagctcaagt gccgggacct gcaggaccgc aacgatgagc tgcaagctga
     1801 gctggaaggc ctgtgggcgc ggctgcccaa gaaccggcac agcccctcat ggagcccgga
     1861 tgggcgcaga cggcagctcc ctggactcgg cccagcaggc atttcattcc tgggtaattc
     1921 tgctccagtg agtatagaaa cggagctgat gatggagcag gtaaaggagc attaccaaga
     1981 cctcaggacc cagctggaga ccaaggtaaa ttactacgaa agggaaattg cggcactgaa
     2041 aaggaacttt gagaaggaga ggaaggacat ggagcaggct cgcaggcgcg aggtcagcgt
     2101 gctggagggt cagaaggccg acctggagga gctccacgag aagtctcagg aggtcatctg
     2161 gggcctgcag gagcagctgc aggacacagc ccgcggcccc gagcctgagc agatgggcct
     2221 ggcaccctgc tgcacccagg cactgtgtgg cctggccctg cggcatcaca gccacctgca
     2281 gcagatcagg agagaggctg aggcggagct gagtggagag ctgtcggggc tgggagccct
     2341 gcccgctcgc agagacctga ccttggagct ggaggagccg ccgcagggac ccctgccacg
     2401 cgggagccag aggtcggagc agctggagct ggagagggca ctgaagctgc agccctgtgc
     2461 gagcgagaag cgcgcccaga tgtgcgtatc gttggccctc gaggaggagg agttggagct
     2521 tgcccgcggg aagcgagtgg acgggccctc cctggaagca gagatgcagg ccctgccgaa
     2581 agatgggctg gtggcaggaa gtggccagga gggcacacgt ggcctcctac cactgcgtcc
     2641 gggctgtggg gagcggccac tggcctggct ggccccaggt gatggcagag agtctgagga
     2701 ggcggcagga gccgggcctc gccgcaggca agcccaggac acagaagcta cgcagagccc
     2761 ggcccccgcc cctgccccgg catcccacgg cccctcagag aggtggtcac gcatgcagcc
     2821 ctgtggagtg gatggggata ttgtcccaaa ggagccagag cctttcggcg cgagcgcagc
     2881 ggggctggag cagcctggag cccgggagct gcctctgctg ggaacagaga gagacgcctc
     2941 gcaaacccag ccacggatgt gggagccacc cctgaggccg gccgcttcgt gcaggggaca
     3001 ggctgagagg ctacaggcca ttcaggaaga gcgagcacga agctggagca ggggcaccca
     3061 ggagcaggcc tcggagcagc aggcccgggc cgagggcgcc ctggagcctg ggtgtcacaa
     3121 gcacagtgtg gaggttgcca ggagagggtc cttgccatcc cacctccagc tcgcagaccc
     3181 gcagggttcc tggcaggagc agcttgctgc cccagaagag ggggagacca aaatagcgct
     3241 ggagagagag aaggatgaca tggaaaccaa acttctacat ctggaagacg tcgtccgggc
     3301 tctggagaaa catgtagatt tgagagagaa cgacagactg gagttccata gactttctga
     3361 agaaaacact ttgttgaaaa acgatctggg aagggttcgg caagagcttg aagctgcaga
     3421 aagtactcac gatgcacaga ggaaggaaat tgaggtttta aagaaagaca aggaaaaggc
     3481 ctgctctgag atggaggtgc tcaacagaca gaatcagaac tacaaggatc aattatccca
     3541 gctcaatgtc agggttcttc aactgggaca ggaggcttct acccaccagg cccaaaacga
     3601 ggagcatcgt gtgaccattc agatgttaac acagagcctg gaggaggtgg ttcgcagtgg
     3661 gcagcagcag agtgaccaaa tccaaaaact tagagttgaa cttgaatgcc tgaatcagga
     3721 acatcagagc ctgcagctgc catggtcaga gctgacccag acccttgagg aaagtcaaga
     3781 ccaggtgcag ggagctcacc tgaggctgag gcaggcccag gcccagcact tgcaggaggt
     3841 ccggctggtg ccccaggacc gtgtggccga gctgcatcgc ctgctcagcc ttcagggaga
     3901 gcaggccagg aggcgcctgg atgcacagcg ggaagaacat gagaaacagc tgaaagccac
     3961 agaagagcgg gtggaagagg cggagatgat tctgaagaat atggaaatgc tcctccaaga
     4021 gaaagtggat aagctgaagg agcagtttga aaagaacacg aagtccgacc tgctgctgaa
     4081 ggagctgtac gtggagaacg cccacctggt gagagcactt caggccaccg aggagaagca
     4141 gcgaggcgcc gagaaacaaa gccgcctctt ggaagaaaaa gttcgcgctc tcaacaaact
     4201 cgtcagtagg attgcccccg cagccctctc tgtgtaaaga cagattattt tctaggattc
     4261 attcgaaagc acatctttta aattaagcca ctgtgctgcc ttagattccg tgggtcatga
     4321 gccatgagtc ctgggacatc tgaggattgg gattctttgt tcaccccgca gatagttaat
     4381 gaatggtctg ccctgggcaa gatggaggtg ggggctgggg gaatatgcat gttgcagaag
     4441 ccggcgtttt tattagcggt cctgagtaat ttcccttggc aaaattccca gttttgccac
     4501 tctctggagc cagatcctgg gagctgtcag caaggagcag gtaagtgagc agttatggac
     4561 agcactttcc atgtggtgct tccgaccctg gctgtcagag tgaaatgtaa agtcagggct
     4621 ctgtacagtt ttgccatttc actgttctgc tttaagctta gcttattaga actcttggtg
     4681 gagggtgcgt acacacattc cagaaaaggc ttcactcgct gggaacgtca acccagcgag
     4741 aaaggagggg aagccccttc tccggggacc ttatctgtgg actcaggaat gatggtgttt
     4801 attgcaaatg cacaatcttt ttcccattga aatgtcatca cactggaaat tgtactatat
     4861 gtaaaaaaaa aaaaaagtat agttttatat ttgaaatgta tgcaaattat ggccatatgg
     4921 ctgattggaa tgtactactg taatataaaa agtcactgta tttgcaataa attcttttct
     4981 attaaaattg a
//
