LOCUS       NM_020921              10334 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens ninein (NIN), transcript variant 2, mRNA.
ACCESSION   NM_020921
VERSION     NM_020921.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10334)
  AUTHORS   Omer,S., Li,J., Yang,C.X. and Harrison,R.E.
  TITLE     Ninein promotes F-actin cup formation and inward phagosome movement
            during phagocytosis in macrophages
  JOURNAL   Mol Biol Cell 35 (3), ar26 (2024)
   PUBMED   38117588
  REMARK    GeneRIF: Ninein promotes F-actin cup formation and inward phagosome
            movement during phagocytosis in macrophages.
REFERENCE   2  (bases 1 to 10334)
  AUTHORS   Cao,Z., Ge,S., Xu,Z. and Ma,Y.Q.
  TITLE     beta3-Endonexin interacts with ninein in vascular endothelial cells
            to promote angiogenesis
  JOURNAL   Biochem Biophys Res Commun 566, 75-79 (2021)
   PUBMED   34118594
  REMARK    GeneRIF: beta3-Endonexin interacts with ninein in vascular
            endothelial cells to promote angiogenesis.
REFERENCE   3  (bases 1 to 10334)
  AUTHORS   Tong,H., Wei,Z., Yin,J., Zhang,B., Zhang,T., Deng,C., Huang,Y. and
            Zhang,N.
  TITLE     Genetic susceptibility of common polymorphisms in NIN and SIGLEC5
            to chronic periodontitis
  JOURNAL   Sci Rep 9 (1), 2088 (2019)
   PUBMED   30765789
  REMARK    GeneRIF: Genetic susceptibility of common polymorphisms in NIN and
            SIGLEC5 to chronic periodontitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10334)
  AUTHORS   Huang,N., Xia,Y., Zhang,D., Wang,S., Bao,Y., He,R., Teng,J. and
            Chen,J.
  TITLE     Hierarchical assembly of centriole subdistal appendages via
            centrosome binding proteins CCDC120 and CCDC68
  JOURNAL   Nat Commun 8, 15057 (2017)
   PUBMED   28422092
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10334)
  AUTHORS   Srivatsa,S., Parthasarathy,S., Molnar,Z. and Tarabykin,V.
  TITLE     Sip1 downstream Effector ninein controls neocortical axonal growth,
            ipsilateral branching, and microtubule growth and stability
  JOURNAL   Neuron 85 (5), 998-1012 (2015)
   PUBMED   25741725
  REMARK    GeneRIF: Ninein influences the rate of axonal growth and branching
            by affecting microtubule stability and dynamics.
REFERENCE   6  (bases 1 to 10334)
  AUTHORS   Hong,Y.R., Chen,C.H., Chuo,M.H., Liou,S.Y. and Howng,S.L.
  TITLE     Genomic organization and molecular characterization of the human
            ninein gene
  JOURNAL   Biochem Biophys Res Commun 279 (3), 989-995 (2000)
   PUBMED   11162463
REFERENCE   7  (bases 1 to 10334)
  AUTHORS   Hong,Y.R., Chen,C.H., Chang,J.H., Wang,S., Sy,W.D., Chou,C.K. and
            Howng,S.L.
  TITLE     Cloning and characterization of a novel human ninein protein that
            interacts with the glycogen synthase kinase 3beta
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 513-516 (2000)
   PUBMED   11004522
REFERENCE   8  (bases 1 to 10334)
  AUTHORS   Mack,G.J., Rees,J., Sandblom,O., Balczon,R., Fritzler,M.J. and
            Rattner,J.B.
  TITLE     Autoantibodies to a group of centrosomal proteins in human
            autoimmune sera reactive with the centrosome
  JOURNAL   Arthritis Rheum 41 (3), 551-558 (1998)
   PUBMED   9506584
REFERENCE   9  (bases 1 to 10334)
  AUTHORS   Bouckson-Castaing,V., Moudjou,M., Ferguson,D.J., Mucklow,S.,
            Belkaid,Y., Milon,G. and Crocker,P.R.
  TITLE     Molecular characterisation of ninein, a new coiled-coil protein of
            the centrosome
  JOURNAL   J Cell Sci 109 (Pt 1), 179-190 (1996)
   PUBMED   8834802
REFERENCE   10 (bases 1 to 10334)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133485.3 and AL606834.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 20, 2020 this sequence version replaced NM_020921.3.
            
            Summary: This gene encodes one of the proteins important for
            centrosomal function. This protein is important for positioning and
            anchoring the microtubules minus-ends in epithelial cells.
            Localization of this protein to the centrosome requires three
            leucine zippers in the central coiled-coil domain. Multiple
            alternatively spliced transcript variants that encode different
            isoforms have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) is the longest transcript and
            it encodes the longest isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3927129.1,
                                           SRR14038191.2646810.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000530997.7/ ENSP00000436092.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL133485.3         108105-108261       c
            158-211             AL133485.3         107563-107616       c
            212-415             AL133485.3         98973-99176         c
            416-497             AL133485.3         83836-83917         c
            498-667             AL133485.3         69811-69980         c
            668-707             AL133485.3         55864-55903         c
            708-898             AL133485.3         54048-54238         c
            899-1045            AL133485.3         50048-50194         c
            1046-1213           AL133485.3         49400-49567         c
            1214-1350           AL133485.3         48431-48567         c
            1351-1491           AL133485.3         47951-48091         c
            1492-1666           AL133485.3         47487-47661         c
            1667-1777           AL133485.3         43879-43989         c
            1778-1867           AL133485.3         43406-43495         c
            1868-2006           AL133485.3         40925-41063         c
            2007-2128           AL133485.3         38889-39010         c
            2129-2631           AL133485.3         36956-37458         c
            2632-4770           AL133485.3         33591-35729         c
            4771-4896           AL133485.3         31841-31966         c
            4897-4966           AL133485.3         31662-31731         c
            4967-5182           AL133485.3         29617-29832         c
            5183-5296           AL133485.3         25091-25204         c
            5297-5419           AL133485.3         21342-21464         c
            5420-5533           AL133485.3         20515-20628         c
            5534-5680           AL133485.3         18681-18827         c
            5681-5860           AL133485.3         16407-16586         c
            5861-5867           AL133485.3         15379-15385         c
            5868-6007           AL606834.1         1738-1877
            6008-6109           AL606834.1         4400-4501
            6110-6310           AL606834.1         10294-10494
            6311-6424           AL606834.1         13951-14064
            6425-10334          AL606834.1         16345-20254
FEATURES             Location/Qualifiers
     source          1..10334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..10334
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /note="ninein"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
     exon            1..157
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            158..211
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            212..415
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..6634
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ninein centrosomal protein; glycogen synthase kinase 3
                     beta-interacting protein; hNinein; ninein (GSK3B
                     interacting protein)"
                     /codon_start=1
                     /product="ninein isoform 2"
                     /protein_id="NP_065972.4"
                     /db_xref="CCDS:CCDS91876.1"
                     /db_xref="GeneID:51199"
                     /db_xref="HGNC:HGNC:14906"
                     /db_xref="MIM:608684"
                     /translation="MDEVEQDQHEARLKELFDSFDTTGTGSLGQEELTDLCHMLSLEE
                     VAPVLQQTLLQDNLLGRVHFDQFKEALILILSRTLSNEEHFQEPDCSLEAQPKYVRGG
                     KRYGRRSLPEFQESVEEFPEVTVIEPLDEEARPSHIPAGDCSEHWKTQRSEEYEAEGQ
                     LRFWNPDDLNASQSGSSPPQDWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQN
                     VDGEMLEEVFHNLDPDGTMSVEDFFYGLFKNGKSLTPSASTPYRQLKRHLSMQSFDES
                     GRRTTTSSAMTSTIGFRVFSCLDDGMGHASVERILDTWQEEGIENSQEILKALDFSLD
                     GNINLTELTLALENELLVTKNSIHQAALASFKAEIRHLLERVDQVVREKEKLRSDLDK
                     AEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEYKERIAALKNELRKEREQILQQAGK
                     QRLELEQEIEKAKTEENYIRDRLALSLKENSRLENELLENAEKLAEYENLTNKLQRNL
                     ENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYERQCRVLQDQVDELQSELEEYRAQGR
                     VLRLPLKNSPSEEVEANSGGIEPEHGLGSEECNPLNMSIEAELVIEQMKEQHHRDICC
                     LRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQ
                     AAVLKEAHHEATCRHEEEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFER
                     EREGLQSSAWTEEKVRGLTQELEQFHQEQLTSLVEKHTLEKEELRKELLEKHQRELQE
                     GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS
                     QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQ
                     LLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERL
                     EMEHDQERQEMMSKLLAMENIHKATCETADRERAEMSTEISRLQSKIKEMQQATSPLS
                     MLQSGCQVIGEEEVEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEI
                     SRLQQRLQKLEPGLVMSSCLDEPATEFFGNTAEQTEQFLQQNRTKQVEGVTRRHVLSD
                     LEDDEVRDLGSTGTSSVQRQEVKIEESEASVEGFSELENSEETRTESWELKNQISQLQ
                     EQLMMLCADCDRASEKKQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCL
                     QEELRMMETRYDEALENNKELTAEVFRLQDELKKMEEVTETFLSLEKSYDEVKIENEG
                     LNVLVLRLQGKIEKLQESVVQRCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVR
                     SVHHVIEECKQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTT
                     LLGFQDKHFQHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAM
                     MHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE
                     EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQEL
                     NQRLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQ
                     THIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSC
                     VDKLAKSSLLEHRIATMKQEQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSR
                     MKSDLRVTQQEKEALKQEVMSLHKQLQNAGGKSWAPEIATHPSGLHNQQKRLSWDKLD
                     HLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHLNPSGTMNP
                     TEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVKLDEQLM
                     EMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERINQHLQEELE
                     NRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAM
                     VKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNLTPAPLTSTPPLR
                     S"
     exon            416..497
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            498..667
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            668..707
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            708..898
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1045
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1213
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1350
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1491
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1666
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1777
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1867
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2006
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2128
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2631
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..4770
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            4771..4896
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..4966
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            4967..5182
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            5183..5296
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            5297..5419
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            5420..5533
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            5534..5680
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            5681..5860
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            5861..6007
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            6008..6109
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            6110..6310
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            6311..6424
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     exon            6425..10334
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10259..10264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /note="hexamer: AATAAA"
     polyA_site      10278
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /note="major polyA site"
     regulatory      10311..10316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIN"
                     /gene_synonym="SCKL7"
                     /note="hexamer: AATAAA"
     polyA_site      10334
                     /gene="NIN"
                     /gene_synonym="SCKL7"
ORIGIN      
        1 ggcccttcct ccccggcgtc cagagctccg ggtggccgcg gccgagccgg gagccgagcg
       61 cgctgggcgc ggccgtcccg ctgccgccgc caagcccgga gtgcgccagc ggccatggtt
      121 cccgcggcgg cgccgggcgc ctgagccccg ggacgcaagc gctggaggcg ggctgccggc
      181 tgtgcgggcg ctccggagag accgacagaa ggtgagcact gtgggctatg ggatggatga
      241 ggtggagcag gaccagcatg aggcccgact caaggagctg tttgacagtt ttgacacgac
      301 gggcacaggg tccctggggc aggaggaact caccgacctt tgccacatgt tgagcttgga
      361 ggaggtggcc ccagtgctgc agcagacatt acttcaggac aacctcttgg gcagggtaca
      421 ttttgaccaa tttaaagaag cattaatact catcttgtcc agaactctgt caaatgaaga
      481 acactttcaa gaaccagact gctcactaga agctcagccc aaatatgtta gaggtgggaa
      541 gcgttacgga cgaaggtcct tgcccgagtt ccaagagtcc gtggaggagt ttcctgaagt
      601 gacggtgatt gagccactgg atgaagaagc gcggccttca cacatcccag ccggtgactg
      661 cagtgagcac tggaagacgc aacgcagtga ggagtatgaa gcggaaggcc agttaaggtt
      721 ttggaaccca gatgacttga atgcttcaca gagtggatct tcccctcccc aagactggat
      781 agaagagaaa ctgcaagaag tttgtgaaga tttggggatc acccgtgatg gtcacctgaa
      841 ccggaagaag ctggtctcca tctgtgagca gtatggttta cagaatgtgg atggagagat
      901 gctcgaggaa gtattccata atcttgatcc tgacggtaca atgagtgtag aagatttttt
      961 ctatggtttg tttaaaaatg gaaaatctct tacaccatca gcatctactc catatagaca
     1021 actaaaaagg cacctttcca tgcagtcttt cgatgagagt ggacgacgta ccacaacctc
     1081 atcagcaatg acaagtacca ttggctttcg ggtcttctcc tgcctggatg atgggatggg
     1141 ccatgcatct gtggagagaa tactggacac ctggcaggaa gagggcattg agaacagcca
     1201 ggagatcctg aaggccttgg atttcagcct cgatggaaac atcaatttga cagaattaac
     1261 actggccctt gaaaatgaac ttttggttac caagaacagc attcaccagg cggctctggc
     1321 cagctttaag gctgaaatcc ggcatttgtt ggaacgagtt gatcaggtgg tcagagaaaa
     1381 agagaagcta cggtcagatc tggacaaggc cgagaagctc aagtctttaa tggcctcgga
     1441 ggtggatgat caccatgcgg ccatagagcg gcggaatgag tacaacctca ggaaactgga
     1501 tgaagagtac aaggagcgaa tagcagcctt aaaaaatgaa ctccgaaaag agagagagca
     1561 gatcctgcag caggcaggca agcagcgttt agaacttgaa caggaaattg aaaaggcaaa
     1621 aacagaagag aactatatcc gggaccgcct tgccctctct ttaaaggaaa acagtcgtct
     1681 ggaaaatgag cttctagaaa atgcagagaa gttggcagaa tatgagaatc tgacaaacaa
     1741 acttcagaga aatttggaaa atgtgttagc agaaaagttt ggtgacctcg atcctagcag
     1801 tgctgagttc ttcctgcaag aagagagact gacacagatg agaaatgaat atgagcggca
     1861 gtgcagggta ctacaagacc aagtagatga actccagtct gagctggaag aatatcgtgc
     1921 acaaggcaga gtgctcaggc ttccgttgaa gaactcaccg tcagaagaag ttgaggctaa
     1981 cagcggtggc attgagcccg aacacgggct cggttctgaa gaatgcaatc cattgaatat
     2041 gagcattgag gcagagctgg tcattgaaca gatgaaagaa caacatcaca gggacatatg
     2101 ttgcctcaga ctggagctcg aagataaagt gcgccattat gaaaagcagc tggacgaaac
     2161 cgtggtcagc tgcaagaagg cacaggagaa catgaagcaa aggcatgaga acgaaacgca
     2221 caccttagaa aaacaaataa gtgaccttaa aaatgaaatt gctgaacttc aggggcaagc
     2281 agcagtgctc aaggaggcac atcatgaggc cacttgcagg catgaggagg agaaaaaaca
     2341 actgcaagtg aagcttgagg aggaaaagac tcacctgcag gagaagctga ggctgcaaca
     2401 tgagatggag ctcaaggcta gactgacaca ggctcaagca agctttgagc gggagaggga
     2461 aggccttcag agtagcgcct ggacagaaga gaaggtgaga ggcttgactc aggaactaga
     2521 gcagtttcac caggagcagc tgacaagcct ggtggagaaa cacactcttg agaaagagga
     2581 gttaagaaaa gagctcttgg aaaagcacca aagggagctt caggagggaa gggaaaaaat
     2641 ggaaacagag tgtaatagaa gaacctctca aatagaagcc cagtttcagt ctgattgtca
     2701 gaaagtcact gagaggtgtg aaagcgctct gcaaagcctg gaggggcgct accgccaaga
     2761 gctgaaggac ctccaggaac agcagcgtga ggagaaatcc cagtgggaat ttgagaagga
     2821 cgagctcacc caggagtgtg cggaagccca ggagctgctg aaagagactc ttaagagaga
     2881 gaaaacaact tctctggtcc tgacccagga gagagagatg ctggagaaaa catacaaaga
     2941 acatttgaac agcatggtcg tcgagagaca gcagctactc caagacctgg aagacctaag
     3001 aaatgtatct gaaacccagc aaagcctgct gtctgaccag atacttgagc tgaagagcag
     3061 tcacaaaagg gaactgaggg agcgtgagga ggtcctgtgc caggcagggg cttcggagca
     3121 gctggccagc cagcggctgg aaagactaga aatggaacat gaccaggaaa ggcaggaaat
     3181 gatgtccaag cttctagcca tggagaacat tcacaaagcg acctgtgaga cagcagatcg
     3241 agaaagagcc gagatgagca cagaaatctc cagacttcag agtaaaataa aggaaatgca
     3301 gcaggcaaca tctcctctct caatgcttca gagtggttgc caggtgatag gagaggagga
     3361 ggtggaagga gatggagccc tgtccctgct tcagcaaggg gagcagctgt tggaagaaaa
     3421 tggggacgtc ctcttaagcc tgcagagagc tcatgaacag gcagtgaagg aaaatgtgaa
     3481 aatggctact gaaatttcta gattgcaaca gaggctacaa aagttagagc cagggttagt
     3541 aatgtcttct tgtttggatg agccagctac tgagtttttt ggaaatactg cggaacaaac
     3601 agagcagttt ttacagcaaa accgaacgaa gcaagtagaa ggtgtgacca ggcggcatgt
     3661 cctaagtgac ctggaagatg atgaggtccg ggacctggga agtacaggga cgagctctgt
     3721 tcagagacag gaagtcaaaa tagaggagtc tgaagcttca gtagagggtt tttctgagct
     3781 tgaaaacagt gaagagacca ggactgaatc ctgggagctg aagaatcaga ttagtcagct
     3841 tcaggaacag ctaatgatgt tatgtgcgga ctgtgatcga gcttctgaaa agaaacagga
     3901 cctacttttt gatgtttctg tgctaaaaaa gaaactgaag atgcttgaga gaatccctga
     3961 ggcttctccc aaatataagc tgttgtatga agatgtgagc cgagaaaatg actgccttca
     4021 ggaagagctg agaatgatgg agacacgcta cgatgaggca ctagaaaata acaaagaact
     4081 cactgcagag gttttcaggt tgcaggatga gctgaagaaa atggaggaag tcactgaaac
     4141 attcctcagc ctggaaaaga gttacgatga ggtcaaaata gaaaatgagg ggctgaatgt
     4201 tctggttttg agacttcaag gcaagattga gaagcttcag gaaagcgtgg tccagcggtg
     4261 tgactgctgc ttatgggaag ccagtttaga gaacctggaa atcgaacctg atggaaatat
     4321 actccagctc aatcagacac tggaagagtg tgtgcccagg gttaggagtg tacatcatgt
     4381 catagaggaa tgtaagcaag aaaaccagta ccttgagggg aacacacagc tcttggaaaa
     4441 agtaaaagca catgaaattg cctggttaca tggaacaatt cagacacatc aagaaaggcc
     4501 aagagtacag aatcaagtta tactggagga aaacactact ctcctaggct ttcaagacaa
     4561 acattttcag catcaggcca ccatagcaga gttagaactg gagaaaacaa agttacagga
     4621 gctgactagg aagttgaagg agagagtcac tattttagtt aagcaaaaag atgtactttc
     4681 tcacggagaa aaggaggaag agctgaaggc aatgatgcat gacttgcaga tcacgtgcag
     4741 tgagatgcag caaaaagttg aacttctgag atatgaatct gaaaagcttc aacaggaaaa
     4801 ttctattttg agaaatgaaa ttactacttt aaatgaagaa gatagcattt ctaacctgaa
     4861 attagggaca ttaaatggat ctcaggaaga aatgtggcaa aaaacggaaa ctgtaaaaca
     4921 agaaaatgct gcagttcaga agatggttga aaatttaaag aaacagattt cagaattaaa
     4981 aatcaaaaac caacaattgg atttggaaaa tacagaactt agccaaaaga actctcaaaa
     5041 ccaggaaaaa ctgcaagaac ttaatcaacg tctaacagaa atgctatgcc agaaggaaaa
     5101 agagccagga aacagtgcat tggaggaacg ggaacaagag aagtttaatc tgaaagaaga
     5161 actggaacgt tgtaaagtgc agtcctccac tttagtgtct tctctggagg cggagctctc
     5221 tgaagttaaa atacagaccc atattgtgca acaggaaaac caccttctca aagatgaact
     5281 ggagaaaatg aaacagctgc acagatgtcc cgatctctct gacttccagc aaaaaatctc
     5341 tagtgttcta agctacaacg aaaaactgct gaaagaaaag gaagctctga gtgaggaatt
     5401 aaatagctgt gtcgataagt tggcaaaatc aagtctttta gagcatagaa ttgcgacgat
     5461 gaagcaggaa cagaaatcct gggaacatca gagtgcgagc ttaaagtcac agctggtggc
     5521 ttctcaggaa aaggttcaga atttagaaga caccgtgcag aatgtaaacc tgcaaatgtc
     5581 ccggatgaaa tctgacctac gagtgactca gcaggaaaag gaggctttaa aacaagaagt
     5641 gatgtcttta cataagcaac ttcagaatgc tggtggcaag agctgggccc cagagatagc
     5701 tactcatcca tcagggctcc ataaccagca gaaaaggctg tcctgggaca agttggatca
     5761 tctgatgaat gaggaacagc agctgctttg gcaagagaat gagaggctcc agaccatggt
     5821 acagaacacc aaagccgaac tcacgcactc ccgggagaag gtccgtcagt tggaatccaa
     5881 tcttcttccc aagcaccaaa aacatctaaa cccatcaggt accatgaatc ccacagagca
     5941 agaaaaattg agcttaaaga gagagtgtga tcagtttcag aaagaacaat ctcctgctaa
     6001 caggaaggtc agtcagatga attcccttga acaagaatta gaaacaattc atttggaaaa
     6061 tgaaggcctg aaaaagaaac aagtaaaact ggatgagcag ctcatggaga tgcagcacct
     6121 gaggtccact gcgacgccta gcccgtcccc tcatgcttgg gatttgcagc tgctccagca
     6181 gcaagcctgt ccgatggtgc ccagggagca gtttctgcag cttcaacgcc agctgctgca
     6241 ggcagaaagg ataaaccagc acctgcagga ggaacttgaa aacaggacct ccgaaaccaa
     6301 cacaccacag ggaaaccagg aacaactggt aactgtcatg gaggaacgaa tgatagaagt
     6361 tgaacagaaa ctgaaactag tgaaaaggct tcttcaagag aaagtgaatc agctcaaaga
     6421 acaactctgc aagaacacta aggcagacgc aatggtgaag gacttgtatg ttgaaaatgc
     6481 ccagttgttg aaagctctgg aagtgactga acagcgacag aaaacagcag agaagaaaaa
     6541 ttacctcctg gaggagaaga ttgccagcct cagtaatata gttaggaatc tgacaccagc
     6601 gccattgact tctacacctc ctttgaggtc atagccaaac caaagggtac actcatattt
     6661 gtgcacttta ctgaaataga tgaacatttc agtaggttct caacttaaaa ttaagcctaa
     6721 cctaaaactg ccagcaacac aactggagtt tccatttatc ataattagtt tttctaaata
     6781 gacccttatg ggagtttgaa aataaatact cacatatttc actacttaaa ttattcccaa
     6841 gatttgaatt tattttaaaa ttttaatagc caccaagaat gtggacatat gaaaattcaa
     6901 gaacctaaaa aataccagtt ttgaatgagt ttttgtggtt ttggtttttt ttttaattat
     6961 tacaaatcta tgtgtaaaat ctagatattt gaagtttgag atctgatgag aatggttgtt
     7021 ataaacttta ttttaaaacc aaatttaggt gttcttacat atttaaatac tggaaagtca
     7081 ttataatagt tttggttctt tgaattggta gacaattagt agagtataat tggttaggag
     7141 gcagggctta ttaagtggtt attaaccgct gacatcagac aaacccaaat ctgtagaatt
     7201 ctaaccttct aacacctgtg acagtattac cactcttctt gtattataga tttagaactg
     7261 atttactcaa ttgcactctt aactaatgtt aaaagcttac ttgctttaaa cagccttttc
     7321 ttctttctct taaaagtttc atttggggag ctggtcttct aagaaacgga taaagccaca
     7381 taattaaagc agttgaacta tagggaaagc actgaacaaa ccactttgga gtaaatagct
     7441 actcttagaa aagagggata agcagaccat gtaggttttc tgtctctcaa atcttagagt
     7501 tcataaattt acttgaggtt gcctcaagaa ctcagggaac aatactgtaa actgtcttcc
     7561 tgaactactg tagggcctct ctaagaattt gaaatgtata aaccatgtga cctcatttat
     7621 ttgtcttata tatttacagc catactagaa tttttatttc tacgttttta gtaaatttaa
     7681 tattctgggg gaaaaaaggc cttgatttta gggttaaaaa cctgacttat agaagagttt
     7741 atttaatata ggtcaaaatt ttctgtgttt cttattcctt ctatacctca aatctgattc
     7801 taagaatttc ttactgtgat aatcattggc atgccacctg aggtcaagga gtgccaaata
     7861 ggactttcca ctcatgctca agatcaaaac tttatagaac agtcaacatt ttagattcgg
     7921 taaccttttt tttcttccaa ttataatctc tgctagccac ttccgccagc agttggtgga
     7981 agacttacta ggtgcagggc actttccaag ttcatcacaa caacctgctt gttttcatga
     8041 gacaataatc cgaaaagttc gctttgatat attcctggag ggccaagccc atctatttac
     8101 aaaaggtgaa cagcaaaatc aagcactgct ttatgggcag gaacacaaga gaaagcaaac
     8161 tgcccaagaa gtcatcatgt cagaaactca atctcaacaa aataatttcc atcagggaac
     8221 ttcagggttt cttgggggct tatgagtctc accggtcaac ccaggaggcc tcactacaag
     8281 agccttgaca aggcactgtt ttttgtggga ctgggagttc acactgatga agcaaacctt
     8341 tgaatttttg cacagctctt gtcagaaagc cctgagttcc ccctggataa agagttaatt
     8401 ttaatccttc cctataatta tacttcaaaa tatttgacat ctgctattat gccttcttta
     8461 gatctttctt ctgtggtgca gacatttcta gtaagtgttt gactacttgt atggcattag
     8521 ctttcacaga aaattgtttc acttaaaact gtggattggc ctaggctaag gacaaaaata
     8581 aactaagtac ctgtagtgta tttatgtgat atgtgtcaag ttactcaaag ttattgctgt
     8641 tggaactgaa caataatatt tcccagatag ctggccttag catgtgatca cggttgttgt
     8701 atttttaatt tttgtctttt acagtatgag aggtgtaggt taatttgttt atttcctata
     8761 aatttgtatt tatgtgtata taaaatgtac aatgaatgta aatatgactt tctggaaagt
     8821 ttagactaca tttagaatct ctattcaaaa tcaaaatgct gctcaaatga atttaaccaa
     8881 catctaggtg cttaatttct cattttatcc cacttatgag attgggaaaa agatcaatat
     8941 gagaaatacc atacagatac cttaaatgta tgcatttgtg caacaatttt tgagaaggtg
     9001 agtggcaatt tataatttag ttggcaattt ataatagaac ttatagcttt taaaagacct
     9061 tttaaagaca ttaaatgtaa acttaaaaat gtttagatct tgtttcaaac tttacaatag
     9121 cattcttcaa aatattaagt tatatatttt ataggcattt agttgcttat taaaagcact
     9181 gattttcaaa ctttttgatt taagaacaat tatttaagat cgtctcagaa gatgggatct
     9241 tcgtttcaag aaaagggaat caagtttgcc tttgagataa tacgttacac taagaaaagg
     9301 aaaatgtgga tagtaaaacc cacctctctc atcctattgt actctcttct gctttttaga
     9361 agcctgcact taagcttaga tttgtgaagg gagagtagaa ggggagaagt agaaccacag
     9421 tgttttattt atttttctaa aactcttact aaatccagat tttttaaact gttttaaatg
     9481 tgaattcttc ccagaaattt caatgcattg catatttagc cttcggcata tttttcatga
     9541 atagatcatg aagtcatagg cttccaaggc ataggaagag atcttgcagg tctagtattt
     9601 taataatgca ctattaccca gggcagatat tatgagaaac tgtttcttct ctaagggttt
     9661 atggcagact ttgctttttt aacatgtgag aaatgaattt tttattttgt gatttatgtg
     9721 atttcttttg ctgagtgaag gaaaggagaa attgttgcta ttgtcagcat cttaaaggta
     9781 tttccagtca aggcaaggct aagtgctttg tgatagtatt aagcaagtca tgttttgaat
     9841 ggattacctg tagtgactca ttggaatgat ataattatac aagtaatgcc aaaaaccaag
     9901 tcaaagccta attaaccaaa gcactcattt aaaaatcatc atgtttggac ctatctggac
     9961 ctctcagcac tgtaaaatag ttttggtttt gtggcatatg aatagctgtt taacaaatca
    10021 aagttagctt tttgcttctc agcttttttg ggcaatacaa gttaagttct taatggggag
    10081 acattatcat ggcatgactt aagggaacat tggtttgtga aggaaaaaca gattatctaa
    10141 agccatctct atgtttctgt tcagataaag attaatgagt tctgtgttta tatcagcttt
    10201 gtatatttca tcttagccat tctatcctag aaagatttta atgtgagctt aagatgtaaa
    10261 taaataattt tgcaaacatg ccttttgttt tctatatacc ctgacctttt aataaagttt
    10321 cagtgtattt atca
//
