LOCUS       NM_153361               2313 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NIM1 serine/threonine protein kinase (NIM1K),
            transcript variant 1, mRNA.
ACCESSION   NM_153361
VERSION     NM_153361.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2313)
  AUTHORS   Faber,S., Letteboer,S.J.F., Junger,K., Butcher,R., Tammana,T.V.S.,
            van Beersum,S.E.C., Ueffing,M., Collin,R.W.J., Liu,Q., Boldt,K. and
            Roepman,R.
  TITLE     PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to
            Primary Cilia
  JOURNAL   Cells 12 (2), 312 (2023)
   PUBMED   36672247
  REMARK    GeneRIF: PDE6D Mediates Trafficking of Prenylated Proteins NIM1K
            and UBL3 to Primary Cilia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2313)
  AUTHORS   Jaleel,M., McBride,A., Lizcano,J.M., Deak,M., Toth,R., Morrice,N.A.
            and Alessi,D.R.
  TITLE     Identification of the sucrose non-fermenting related kinase SNRK,
            as a novel LKB1 substrate
  JOURNAL   FEBS Lett 579 (6), 1417-1423 (2005)
   PUBMED   15733851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA778478.1, AC106800.2 and BC036422.2.
            
            On Nov 23, 2018 this sequence version replaced NM_153361.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036422.2, SRR1803617.62469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145544
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326035.6/ ENSP00000313572.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               DA778478.1         158-584
            428-926             AC106800.2         28636-29134         c
            927-2313            BC036422.2         927-2313
FEATURES             Location/Qualifiers
     source          1..2313
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..2313
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /note="NIM1 serine/threonine protein kinase"
                     /db_xref="GeneID:167359"
                     /db_xref="HGNC:HGNC:28646"
     exon            1..187
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..1173
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             882..2192
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase NIM1"
                     /protein_id="NP_699192.1"
                     /db_xref="CCDS:CCDS3943.1"
                     /db_xref="GeneID:167359"
                     /db_xref="HGNC:HGNC:28646"
                     /translation="MTAVYMNGGGLVNPHYARWDRRDSVESGCQTESSKEGEEGQPRQ
                     LTPFEKLTQDMSQDEKVVREITLGKRIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAI
                     KILDKTKLDQKTQRLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYAGGGELFG
                     KISTEGKLSEPESKLIFSQIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFS
                     TVSKKGEMLNTFCGSPPYAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETV
                     AKLKKSILEGTYSVPPHVSEPCHRLIRGVLQQIPTERYGIDCIMNDEWMQGVPYPTPL
                     EPFQLDPKHLSETSTLKEEENEVKSTLEHLGITEEHIRNNQGRDARSSITGVYRIILH
                     RVQRKKALESVPVMMLPDPKERDLKKGSRVYRGIRHTSKFCSIL"
     exon            1174..1442
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..2313
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2289..2294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /note="hexamer: AATAAA"
     polyA_site      2313
                     /gene="NIM1K"
                     /gene_synonym="NIM1"
                     /note="major polyA site"
ORIGIN      
        1 ggggtttgcc ctgggccgct gccggtcagg tcggccgccc ctgacagctc cgggagcctc
       61 aagcgcgaca gcggcgccct cacctcggga catccacaca ccgaccgctc ctgctccaga
      121 ggcaacaacc cagcgcgcct agcctggcgc cgtgcagcga agcccaagag ctggcctcgc
      181 cacgaaggtt gaaccagcca aattttcgag acagctcacg gcttagagga aggttcatct
      241 aaataaaggc cggctaaagt gacattgcag ggattaaatc cttctttggc tgcctgtgtg
      301 accagaaggc ttatttgcaa gtttcttctt tcctggggtc cagattatta ggtctccagc
      361 gccctgcagc ttgacagaaa gagaagcatg aaatgaaggt cagagatgag atcccgcagc
      421 agggacgtgg gggcctccca ggggcattta cgcaccagag tgcaagattc tctggccatc
      481 aagggaaata gcaaacagaa gcctttgtcc tggggcacag ccacctacca caaagcatca
      541 gactccacgt ctggccagaa agttcctgga gtcccatcag gccagtgggt atgtaacatg
      601 tgcctaattg tacagctaga gcctgcaagt tcaacgtgag ggaaggtggg aaatgtcttg
      661 agtgaggcga gcagctcctg gctgggctgg gcagactcag ctaccacgtt cactgccttc
      721 ctctcactaa agccgagagg gaggctgctc agctctcagg aaaactcttt tgaaccctgg
      781 gcacctgctg tcctcagttg gcatctccca ccctctgagc ctcttctgct cctgcacaac
      841 ctgcctcttc gctgagatgg agacgtgagc ccccgtggac gatgactgca gtgtatatga
      901 atggaggtgg cctggtgaac ccccactatg cccggtggga tcggcgcgac agtgtagaaa
      961 gtggctgtca gaccgagagt agcaaggagg gtgaggaggg acagccccgc cagctgacgc
     1021 ccttcgagaa actgacacag gacatgtccc aggatgagaa ggtggtgagg gagatcacgc
     1081 tggggaaacg gataggcttc taccgaattc gaggggaaat cggaagtgga aacttctccc
     1141 aagtgaagct tgggattcac tccctaacca aagaaaaggt ggccattaag atcctggaca
     1201 agaccaagtt agaccagaaa acccagaggc tactatcccg agaaatctcc agcatggaaa
     1261 agctgcacca tcccaacatc atccgccttt acgaagtggt ggagacccta tccaagctgc
     1321 acttggtgat ggagtatgca gggggtgggg agctcttcgg aaaaattagc actgagggga
     1381 agctctctga accagaaagc aagctcatct tctcccagat tgtgtctgcc gtgaagcaca
     1441 tgcatgaaaa ccaaattatt catagagatc tgaaagcaga aaatgtattc tataccagta
     1501 atacttgtgt gaaggtgggc gattttggat tcagcacagt aagcaaaaaa ggtgaaatgc
     1561 tgaacacttt ctgtgggtct cctccctacg ctgcgcctga actcttccgg gacgagcact
     1621 acatcggcat ttacgtggat atctgggcct tgggggtgct tttgtacttc atggtgactg
     1681 gcaccatgcc atttcgggca gaaaccgtgg ccaaactaaa aaagagcatc ctcgagggca
     1741 catacagtgt accgccgcac gtgtcagagc cctgccaccg actcatccga ggagtccttc
     1801 agcagatccc cacggagagg tacggaatcg actgcatcat gaatgatgaa tggatgcaag
     1861 gggtgccata ccctacacct ttggaacctt tccaactgga tcccaaacat ttgtcggaaa
     1921 ccagcactct caaggaagaa gaaaatgagg tcaaaagcac tttagaacat ttgggcatta
     1981 cagaagagca tattcgaaat aaccaaggga gagatgctcg cagctcaatc acaggggtct
     2041 atagaattat tttacataga gtccaaagga agaaggcttt ggaaagtgtc ccagtcatga
     2101 tgctaccaga ccctaaagaa agagacctca aaaaagggtc ccgtgtctac agagggataa
     2161 gacacacatc caaattttgc tcgattttat aaattgcact agactgcttg taactaacca
     2221 agatgattgt tgctgcttct aaattttttt caaggacaac ttgagtggag acatttttgt
     2281 aatttttaaa taaacttaaa tttgagatat gca
//
