LOCUS       NM_032390               1686 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens nucleolar protein interacting with the FHA domain of
            MKI67 (NIFK), mRNA.
ACCESSION   NM_032390
VERSION     NM_032390.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Tan,L., He,Y., Wu,L., Liu,S., Peng,P. and Huang,J.
  TITLE     NIFK as a potential prognostic biomarker in colorectal cancer
            correlating with immune infiltrates
  JOURNAL   Medicine (Baltimore) 102 (40), e35452 (2023)
   PUBMED   37800782
  REMARK    GeneRIF: NIFK as a potential prognostic biomarker in colorectal
            cancer correlating with immune infiltrates.
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Lin,T.C., Su,C.Y., Wu,P.Y., Lai,T.C., Pan,W.A., Jan,Y.H.,
            Chang,Y.C., Yeh,C.T., Chen,C.L., Ger,L.P., Chang,H.T., Yang,C.J.,
            Huang,M.S., Liu,Y.P., Lin,Y.F., Shyy,J.Y., Tsai,M.D. and Hsiao,M.
  TITLE     The nucleolar protein NIFK promotes cancer progression via
            CK1alpha/beta-catenin in metastasis and Ki-67-dependent cell
            proliferation
  JOURNAL   Elife 5, e11288 (2016)
   PUBMED   26984280
  REMARK    GeneRIF: NIFK is required for lung cancer progression via the
            RUNX1-dependent CK1alpha repression, which activates
            TCF4/beta-catenin signaling in metastasis and the Ki-67-dependent
            regulation in cell proliferation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Sobecki,M., Mrouj,K., Camasses,A., Parisis,N., Nicolas,E.,
            Lleres,D., Gerbe,F., Prieto,S., Krasinska,L., David,A., Eguren,M.,
            Birling,M.C., Urbach,S., Hem,S., Dejardin,J., Malumbres,M., Jay,P.,
            Dulic,V., Lafontaine,D.Lj., Feil,R. and Fisher,D.
  TITLE     The cell proliferation antigen Ki-67 organises heterochromatin
  JOURNAL   Elife 5, e13722 (2016)
   PUBMED   26949251
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Pan,W.A., Tsai,H.Y., Wang,S.C., Hsiao,M., Wu,P.Y. and Tsai,M.D.
  TITLE     The RNA recognition motif of NIFK is required for rRNA maturation
            during cell cycle progression
  JOURNAL   RNA Biol 12 (3), 255-267 (2015)
   PUBMED   25826659
  REMARK    GeneRIF: The RNA recognition motif of NIFK is required for rRNA
            maturation during cell cycle progression.
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Panteva,M.T., Salari,R., Bhattacharjee,M. and Chong,L.T.
  TITLE     Direct observations of shifts in the beta-sheet register of a
            protein-peptide complex using explicit solvent simulations
  JOURNAL   Biophys J 100 (9), L50-L52 (2011)
   PUBMED   21539773
  REMARK    GeneRIF: Potential encounter complexes of the Ki67FHA receptor and
            hNIFK peptide are misregistered states of the beta-sheet.
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Byeon,I.J., Li,H., Song,H., Gronenborn,A.M. and Tsai,M.D.
  TITLE     Sequential phosphorylation and multisite interactions characterize
            specific target recognition by the FHA domain of Ki67
  JOURNAL   Nat Struct Mol Biol 12 (11), 987-993 (2005)
   PUBMED   16244663
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Li,H., Byeon,I.J., Ju,Y. and Tsai,M.D.
  TITLE     Structure of human Ki67 FHA domain and its binding to a
            phosphoprotein fragment from hNIFK reveal unique recognition sites
            and new views to the structural basis of FHA domain functions
  JOURNAL   J Mol Biol 335 (1), 371-381 (2004)
   PUBMED   14659764
  REMARK    GeneRIF: nmr analysis of the solution structure of the FHA domain
            of human Ki67 and mapping of the binding surface for NIFK binding
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Takagi,M., Sueishi,M., Saiwaki,T., Kametaka,A. and Yoneda,Y.
  TITLE     A novel nucleolar protein, NIFK, interacts with the forkhead
            associated domain of Ki-67 antigen in mitosis
  JOURNAL   J Biol Chem 276 (27), 25386-25391 (2001)
   PUBMED   11342549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022990.1, BC024238.2 and
            BE671589.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032390.4.
            
            Summary: This gene encodes a protein that interacts with the
            forkhead-associated domain of the Ki-67 antigen. The encoded
            protein may bind RNA and may play a role in mitosis and cell cycle
            progression. Multiple pseudogenes exist on chromosomes 5, 10, 12,
            15, and 19.[provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.257496.1,
                                           SRR1660803.182395.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285814.9/ ENSP00000285814.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1130              BC022990.1         9-1138
            1131-1619           BC024238.2         1148-1636
            1620-1686           BE671589.1         17-83               c
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..1686
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="nucleolar protein interacting with the FHA domain
                     of MKI67"
                     /db_xref="GeneID:84365"
                     /db_xref="HGNC:HGNC:17838"
                     /db_xref="MIM:611970"
     exon            1..130
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..907
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="nucleolar phosphoprotein Nopp34; nucleolar protein
                     interacting with the FHA domain of pKi-67; hNIFK"
                     /codon_start=1
                     /product="MKI67 FHA domain-interacting nucleolar
                     phosphoprotein"
                     /protein_id="NP_115766.3"
                     /db_xref="CCDS:CCDS2135.1"
                     /db_xref="GeneID:84365"
                     /db_xref="HGNC:HGNC:17838"
                     /db_xref="MIM:611970"
                     /translation="MATFSGPAGPILSLNPQEDVEFQKEVAQVRKRITQRKKQEQLTP
                     GVVYVRHLPNLLDETQIFSYFSQFGTVTRFRLSRSKRTGNSKGYAFVEFESEDVAKIV
                     AETMNNYLFGERLLECHFMPPEKVHKELFKDWNIPFKQPSYPSVKRYNRNRTLTQKLR
                     MEERFKKKERLLRKKLAKKGIDYDFPSLILQKTESISKTNRQTSTKGQVLRKKKKKVS
                     GTLDTPEKTVDSQGPTPVCTPTFLERRKSQVAELNDDDKDDEIVFKQPISCVKEEIQE
                     TQTPTHSRKKRRRSSNQ"
     exon            131..268
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /inference="alignment:Splign:2.1.0"
     exon            269..377
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /inference="alignment:Splign:2.1.0"
     exon            378..589
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /inference="alignment:Splign:2.1.0"
     exon            590..649
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /inference="alignment:Splign:2.1.0"
     exon            650..718
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1686
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      936..941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="hexamer: AATATA"
     polyA_site      955
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="major polyA site"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="hexamer: ATTAAA"
     polyA_site      1587
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="major polyA site"
     regulatory      1631..1636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="hexamer: AATAAA"
     polyA_site      1656
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
                     /note="hexamer: ATTAAA"
     polyA_site      1686
                     /gene="NIFK"
                     /gene_synonym="MKI67IP; Nopp34"
ORIGIN      
        1 gtggttagcg tcggcggctt ttggcatggc gactttttct ggcccggctg ggccaatcct
       61 gtcgcttaat ccgcaggaag atgtcgagtt tcaaaaggag gtggcgcagg ttcgcaagcg
      121 cataacccag cgaaaaaaac aagaacaact tactcctgga gtagtctatg tgcgccacct
      181 acctaaccta cttgacgaaa cccagatctt ttcatatttc tcccagtttg gcactgtgac
      241 acggttcagg ctgtccagaa gtaaaaggac tggaaatagc aaaggctatg catttgtgga
      301 gtttgagtct gaggatgttg ccaaaatagt tgctgaaaca atgaacaact acctgtttgg
      361 tgaaagactc ttggagtgtc attttatgcc acctgaaaaa gtacataaag aactctttaa
      421 agactggaat attccattta agcagccatc atatccatca gtgaaacggt ataatcggaa
      481 tcggacacta acacaaaagc tacggatgga ggagcgattt aaaaagaaag aaagattact
      541 caggaagaaa ttagctaaaa aaggaattga ctatgatttt ccttctttga ttttacagaa
      601 aacggaaagt atttcaaaaa ctaatcgtca gacgtctaca aaaggccagg ttttacgtaa
      661 gaagaagaaa aaagtttcag gtactcttga cactcctgag aagactgtgg atagccaggg
      721 ccccacacca gtttgtacac caacattttt ggagaggcga aaatctcaag tggctgaact
      781 gaatgatgat gataaagatg atgaaatagt tttcaaacag cccatatcct gtgtaaaaga
      841 agaaatacaa gagactcaaa cacctacaca ttcacggaaa aaaagacgaa gaagcagcaa
      901 tcagtgattt tcaatgtatt atatttcttt tgaaaaatat aatattttta tgagagtgga
      961 ctttgtattt cactaggtac aatggaatac aacctttgac aagattttca gaggaaaaat
     1021 acactgtttg gtcaagttaa ggaaagcagt gtgtaatttt ggattgcctg cccttggctg
     1081 aaatacaggg gtgcatacca tcttgcagtg gcttggctga cattgcctct ttgtcctggc
     1141 ctctagtttt cttttgatat ttcatagctc tccttagttt actctgcctg gatagaaagt
     1201 tgaccactaa ctgcaggttt aagtactaaa ctgcagcctt ttctgtcgcc agcaattaaa
     1261 gaccaccaat cttgtttgtc catctacatg gtttgtcggg gacatttaac tcatggaggt
     1321 gctttagatt tcaacatcag atggttgaag ctggaagttt aattatatgt agagtgagaa
     1381 ggcagttcca gttttagcac agatttgttt atgtgttcag attttaatag agattcaaaa
     1441 atgactcatt tttaccaata atgttaaatt agttttggtt gtgctagcat gaattaataa
     1501 ccaccatttt ataccagtat catcagtgaa gaattgtatt tcaagattca aacaataacc
     1561 agcaattaaa cttttttcta caatgtattt gtttgcgagt aggacttggg agtcattggg
     1621 aaaaaaaaat aataaatttt ccccttcatt aacgaattca gactcattaa aaacattgcc
     1681 atcaga
//
