LOCUS       NM_007361               4870 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens nidogen 2 (NID2), mRNA.
ACCESSION   NM_007361
VERSION     NM_007361.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4870)
  AUTHORS   Hao,J., Huang,C., Zhao,W., Zhao,L., Hu,X., Zhang,W., Guo,L.,
            Dou,X., Jin,T. and Hu,M.
  TITLE     Association of NID2 SNPs with Glioma Risk and Prognosis in the
            Chinese Population
  JOURNAL   Neuromolecular Med 26 (1), 27 (2024)
   PUBMED   38935278
  REMARK    GeneRIF: Association of NID2 SNPs with Glioma Risk and Prognosis in
            the Chinese Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4870)
  AUTHORS   Kiziltan,R., Cikman,O., Algul,S., Aydin,M.A. and Kemik,O.
  TITLE     Nidogen-2: A new biomarker in colon cancer patients
  JOURNAL   Ann Ital Chir 92, 88-92 (2022)
   PUBMED   34593672
  REMARK    GeneRIF: Nidogen-2: A new biomarker in colon cancer patients.
REFERENCE   3  (bases 1 to 4870)
  AUTHORS   Mao,C., Ma,Z., Jia,Y., Li,W., Xie,N., Zhao,G., Ma,B., Yu,F.,
            Sun,J., Zhou,Y., Cui,Q., Fu,Y. and Kong,W.
  TITLE     Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth
            Muscle Cells and Prevents Neointima Formation via Bridging
            Jagged1-Notch3 Signaling
  JOURNAL   Circulation 144 (15), 1244-1261 (2021)
   PUBMED   34315224
  REMARK    GeneRIF: Nidogen-2 Maintains the Contractile Phenotype of Vascular
            Smooth Muscle Cells and Prevents Neointima Formation via Bridging
            Jagged1-Notch3 Signaling.
REFERENCE   4  (bases 1 to 4870)
  AUTHORS   Shan,Z., Wang,W., Tong,Y. and Zhang,J.
  TITLE     Genome-Scale Analysis Identified NID2, SPARC, and MFAP2 as
            Prognosis Markers of Overall Survival in Gastric Cancer
  JOURNAL   Med Sci Monit 27, e929558 (2021)
   PUBMED   33758160
  REMARK    GeneRIF: Genome-Scale Analysis Identified NID2, SPARC, and MFAP2 as
            Prognosis Markers of Overall Survival in Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4870)
  AUTHORS   Liu,J., Liu,X., Zhao,S., Zheng,Y., Chen,L., Wang,J., Zhan,S.,
            Hu,S., Dong,Y., Tang,G., Lu,Y., Zhai,Y. and Cao,Z.
  TITLE     A pilot proteomic study with a prospective cohort suspected to
            develop preeclampsia
  JOURNAL   Hypertens Res 43 (11), 1319-1321 (2020)
   PUBMED   32472113
  REMARK    GeneRIF: A pilot proteomic study with a prospective cohort
            suspected to develop preeclampsia.
REFERENCE   6  (bases 1 to 4870)
  AUTHORS   Tu,H., Sasaki,T., Snellman,A., Gohring,W., Pirila,P., Timpl,R. and
            Pihlajaniemi,T.
  TITLE     The type XIII collagen ectodomain is a 150-nm rod and capable of
            binding to fibronectin, nidogen-2, perlecan, and heparin
  JOURNAL   J Biol Chem 277 (25), 23092-23099 (2002)
   PUBMED   11956183
REFERENCE   7  (bases 1 to 4870)
  AUTHORS   Sasaki,T., Gohring,W., Mann,K., Brakebusch,C., Yamada,Y.,
            Fassler,R. and Timpl,R.
  TITLE     Short arm region of laminin-5 gamma2 chain: structure, mechanism of
            processing and binding to heparin and proteins
  JOURNAL   J Mol Biol 314 (4), 751-763 (2001)
   PUBMED   11733994
  REMARK    GeneRIF: short arm region of laminin-5 gamma2 chain: structure,
            mechanism of processing and binding to heparin, nidogen-1,
            fibulin-1 and fibulin-2
REFERENCE   8  (bases 1 to 4870)
  AUTHORS   Miosge,N., Holzhausen,S., Zelent,C., Sprysch,P. and Herken,R.
  TITLE     Nidogen-1 and nidogen-2 are found in basement membranes during
            human embryonic development
  JOURNAL   Histochem J 33 (9-10), 523-530 (2001)
   PUBMED   12005023
  REMARK    GeneRIF: found to be ubiquitous component of basement membrane
            zones underneath developing epithelia of most of the major organ
            systems; may participate in cell biological functions during human
            development
REFERENCE   9  (bases 1 to 4870)
  AUTHORS   Sasaki,T., Gohring,W., Miosge,N., Abrams,W.R., Rosenbloom,J. and
            Timpl,R.
  TITLE     Tropoelastin binding to fibulins, nidogen-2 and other extracellular
            matrix proteins
  JOURNAL   FEBS Lett 460 (2), 280-284 (1999)
   PUBMED   10544250
REFERENCE   10 (bases 1 to 4870)
  AUTHORS   Kohfeldt,E., Sasaki,T., Gohring,W. and Timpl,R.
  TITLE     Nidogen-2: a new basement membrane protein with diverse binding
            properties
  JOURNAL   J Mol Biol 282 (1), 99-109 (1998)
   PUBMED   9733643
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM719690.1, AL118557.5,
            AJ223500.1 and CA413165.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007361.3.
            
            Summary: This gene encodes a member of the nidogen family of
            basement membrane proteins. This protein is a cell-adhesion protein
            that binds collagens I and IV and laminin and may be involved in
            maintaining the structure of the basement membrane.[provided by
            RefSeq, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ223500.1, AK291652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216286.10/ ENSP00000216286.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               BM719690.1         154-282             c
            130-130             AL118557.5         76226-76226         c
            131-1018            AJ223500.1         66-953
            1019-1019           AL118557.5         61431-61431         c
            1020-1422           AJ223500.1         955-1357
            1423-1423           AL118557.5         60946-60946         c
            1424-2030           AJ223500.1         1359-1965
            2031-2031           AL118557.5         48007-48007         c
            2032-2323           AJ223500.1         1967-2258
            2324-2344           AL118557.5         36965-36985         c
            2345-4869           AJ223500.1         2280-4804
            4870-4870           CA413165.1         25-25               c
FEATURES             Location/Qualifiers
     source          1..4870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..4870
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /note="nidogen 2"
                     /db_xref="GeneID:22795"
                     /db_xref="HGNC:HGNC:13389"
                     /db_xref="MIM:605399"
     exon            1..293
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..4193
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /note="osteonidogen"
                     /codon_start=1
                     /product="nidogen-2 precursor"
                     /protein_id="NP_031387.3"
                     /db_xref="CCDS:CCDS9706.1"
                     /db_xref="GeneID:22795"
                     /db_xref="HGNC:HGNC:13389"
                     /db_xref="MIM:605399"
                     /translation="MEGDRVAGRPVLSSLPVLLLLPLLMLRAAALHPDELFPHGESWG
                     DQLLQEGDDESSAVVKLANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTD
                     FPAIAPFLADIDTSHGRGRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATW
                     EQVGAYEEVKRGALPSGELNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQ
                     LQLPARVGFCRGEADDLKSEGPYFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPL
                     DNVRPAAVGDLSAAHSSVPLGRSFSHATALESDYNEDNLDYYDVNEEEAEYLPGEPEE
                     ALNGHSSIDVSFQSKVDTKPLEESSTLDPHTKEGTSLGEVGGPDLKGQVEPWDERETR
                     SPAPPEVDRDSLAPSWETPPPYPENGSIQPYPDGGPVPSEMDVPPAHPEEEIVLRSYP
                     ASGHTTPLSRGTYEVGLEDNIGSNTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGF
                     CCHCQSKFYGNGKHCLPEGAPHRVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAY
                     TAISHIPQPAAQALLPLTPIGGLFGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGE
                     ETVRITQTAEGLDPENYLSIKTNIQGQVPYVSANFTAHISPYKELYHYSDSTVTSTSS
                     RDYSLTFGAINQTWSYRIHQNITYQVCRHAPRHPSFPTTQQLNVDRVFALYNDEERVL
                     RFAVTNQIGPVKEDSDPTPGNPCYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRN
                     CVDENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHTCILITPPANPCEDGS
                     HTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTDVDECSENRCHPAATCYNTPGSF
                     SCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPL
                     QCHGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHY
                     GGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTV
                     APPMVRPTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVG
                     IDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD
                     SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDG
                     ENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFS
                     IVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTGRK"
     exon            294..599
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..832
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1134
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1494
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1644
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1890
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2091
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2322
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2466
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2595
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2739
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2859
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3093
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3315
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3485
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3615
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3616..3787
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3945
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4069
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4070..4182
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4870
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4851..4856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /note="hexamer: AATAAA"
     polyA_site      4870
                     /gene="NID2"
                     /gene_synonym="NID-2"
                     /note="major polyA site"
ORIGIN      
        1 ggagagtggg ctggaggccg gggcgggacg cgttgtgcag cgggtaagcg cacggccgag
       61 cgagcatgga gggggaccgg gtggccgggc ggccggtgct gtcgtcgtta ccagtgctac
      121 tgctgctgcc gttgctaatg ttgcgggccg cggcgctgca cccagacgag ctcttcccac
      181 acggggagtc gtggggggac cagctcctgc aggaaggcga cgacgaaagc tcagccgtgg
      241 tgaagctggc gaatcccctg cacttctacg aagcccgatt cagcaacctc tacgtgggca
      301 ccaacggcat catctccact caggacttcc ccagggaaac gcagtatgtg gactatgatt
      361 tccccaccga cttcccggcc atcgcccctt ttctggcgga catcgacacg agccacggca
      421 gaggccgagt cctgtaccga gaggacacct cccccgcagt gctgggcctg gccgcccgct
      481 atgtgcgcgc tggcttcccg cgctctgcgc gctttacccc cacccacgcc ttcctggcca
      541 cctgggagca ggtaggcgct tacgaggagg tcaagcgcgg ggcgctgccc tcgggagagc
      601 tgaacacttt ccaggcagtt ttggcatctg atgggtctga tagctacgcc ctctttcttt
      661 atcctgccaa cggcctgcag ttccttggaa cccgccccaa agagtcttac aatgtccagc
      721 ttcagcttcc agctcgggtg ggcttctgcc gaggggaggc tgatgatctg aagtcagaag
      781 gaccatattt cagcttgact agcactgaac agtctgtgaa aaatctctat caactaagca
      841 acctggggat ccctggagtg tgggctttcc atatcggcag cacttccccg ttggacaatg
      901 tcaggccagc tgcagttgga gacctttccg ctgcccactc ttctgttccc ctgggacgtt
      961 ccttcagcca tgctacagcc ctggaaagtg actataatga ggacaatttg gattactatg
     1021 atgtgaatga ggaggaagct gaataccttc cgggtgaacc agaggaggca ttgaatggcc
     1081 acagcagcat tgatgtttcc ttccaatcca aagtggatac aaagccttta gaggaatctt
     1141 ccaccttgga tcctcacacc aaagaaggaa catctctggg agaggtaggg ggcccagatt
     1201 taaaaggcca agttgagccc tgggatgaga gagagaccag aagcccagct ccaccagagg
     1261 tagacagaga ttcactggct ccttcctggg aaaccccacc accgtacccc gaaaacggaa
     1321 gcatccagcc ctacccagat ggagggccag tgccttcgga aatggatgtt cccccagctc
     1381 atcctgaaga agaaattgtt cttcgaagtt accctgcttc aggtcacact acacccttaa
     1441 gtcgagggac gtatgaggtg ggactggaag acaacatagg ttccaacacc gaggtcttca
     1501 cgtataatgc tgccaacaag gaaacctgtg aacacaacca cagacaatgc tcccggcatg
     1561 ccttctgcac ggactatgcc actggcttct gctgccactg ccaatccaag ttttatggaa
     1621 atgggaagca ctgtctgcct gaaggggcac ctcaccgagt gaatgggaaa gtgagtggcc
     1681 acctccacgt gggccataca cccgtgcact tcactgatgt ggacctgcat gcgtatatcg
     1741 tgggcaatga tggcagagcc tacacggcca tcagccacat cccacagcca gcagcccagg
     1801 ccctcctccc cctcacacca attggaggcc tgtttggctg gctctttgct ttagaaaaac
     1861 ctggctctga gaacggcttc agcctcgcag gtgctgcctt tacccatgac atggaagtta
     1921 cattctaccc gggagaggag acggttcgta tcactcaaac tgctgaggga cttgacccag
     1981 agaactacct gagcattaag accaacattc aaggccaggt gccttacgtc tcagcaaatt
     2041 tcacagccca catctctccc tacaaggagc tgtaccacta ctccgactcc actgtgacct
     2101 ctacaagttc cagagactac tctctgactt ttggtgcaat caaccaaaca tggtcctacc
     2161 gcatccacca gaacatcact taccaggtgt gcaggcacgc ccccagacac ccgtccttcc
     2221 ccaccaccca gcagctgaac gtggaccggg tctttgcctt gtataatgac gaagaaagag
     2281 tgcttagatt tgctgtgacc aatcaaattg gcccggtcaa agaggattca gaccccactc
     2341 cggggaatcc ttgctatgat gggagccaca tgtgtgacac aacagcacgg tgccatccag
     2401 ggacaggtgt agattacacc tgtgagtgcg catctgggta ccagggagat ggacggaact
     2461 gtgtggatga aaatgaatgt gcaactggct ttcatcgctg tggccccaac tctgtatgta
     2521 tcaacttgcc tggaagctac aggtgtgagt gccggagtgg ttatgagttt gcagatgacc
     2581 ggcatacttg catcttgatc accccacctg ccaacccctg tgaggatggc agtcatacct
     2641 gtgctcctgc tgggcaggcc cggtgtgttc accatggagg cagcacgttc agctgtgcct
     2701 gcctgcctgg ttatgccggc gatgggcacc agtgcactga tgtagatgaa tgctcagaaa
     2761 acagatgtca ccctgcagct acctgctaca atactcctgg ttccttctcc tgccgttgtc
     2821 aacccggata ttatggggat ggatttcagt gcatacctga ctccacctca agcctgacac
     2881 cctgtgaaca acagcagcgc catgcccagg cccagtatgc ctaccctggg gcccggttcc
     2941 acatccccca atgcgacgag cagggcaact tcctgcccct acagtgtcat ggcagcactg
     3001 gtttctgctg gtgcgtggac cctgatggtc atgaagttcc tggtacccag actccacctg
     3061 gctccacccc gcctcactgt ggaccatcac cagagcccac ccagaggccc ccgaccatct
     3121 gtgagcgctg gagggaaaac ctgctggagc actacggtgg caccccccgg gatgaccagt
     3181 acgtgcccca gtgcgatgac ctgggccact tcatccccct gcagtgccac ggaaagagcg
     3241 acttctgctg gtgtgtggac aaagatggca gagaggtgca gggcacccgc tcccagccag
     3301 gcaccacccc tgcgtgtata cccaccgtcg ctccacccat ggtccggccc acgccccggc
     3361 cagatgtgac ccctccatct gtgggcacct tcctgctcta tactcagggc cagcagattg
     3421 gctacttacc cctcaatggc accaggcttc agaaggatgc agctaagacc ctgctgtctc
     3481 tgcatggctc cataatcgtg ggaattgatt acgactgccg ggagaggatg gtgtactgga
     3541 cagatgttgc tggacggaca atcagccgtg ctggtctgga actgggagca gagcctgaga
     3601 cgatcgtgaa ttcaggtctg ataagccctg aaggacttgc catagaccac atccgcagaa
     3661 caatgtactg gacggacagt gtcctggata agatagagag cgccctgctg gatggctctg
     3721 agcgcaaggt cctcttctac acagatctgg tgaatccccg tgccatcgct gtggatccaa
     3781 tccgaggcaa cttgtactgg acagactgga atagagaagc tcctaaaatt gaaacgtcat
     3841 ctttagatgg agaaaacaga agaattctga tcaatacaga cattggattg cccaatggct
     3901 taacctttga ccctttctct aaactgctct gctgggcaga tgcaggaacc aaaaaactgg
     3961 agtgtacact acctgatgga actggacggc gtgtcattca aaacaacctc aagtacccct
     4021 tcagcatcgt aagctatgca gatcacttct accacacaga ctggaggagg gatggtgttg
     4081 tatcagtaaa taaacatagt ggccagttta ctgatgagta tctcccagaa caacgatctc
     4141 acctctacgg gataactgca gtctacccct actgcccaac aggaagaaag taagtacagt
     4201 aatgtaaagg aagacttgga gtttacaatc agaacctgga ccctaaagaa cagtgactgc
     4261 aaaggcaaag aaagtaaaaa aggaattggc cattagacgt tcctgagcat ccaagatgaa
     4321 cattttgtag tgcaaaaaga cttttgtgaa aagctgatac ctcaatcttt actactgtat
     4381 ttttaaaaat gaaggttgtt attgcaagtt taaaaaggta acagaatttt aactgttgct
     4441 tattaaagca acttcttgta aacatttatc attaatattt aaaagatcaa attcattcaa
     4501 ctaagaatta gagtttaaga ctctaaacct gatttttgcc atggattcct tctggccaag
     4561 aaattaaagc acatgtgatc aatataacaa tataatccta aaccttgaca gttggagaag
     4621 ccaatgcaga actgatggga aaggaccaat tatttatagt ttcccaacaa aagttctaag
     4681 attttttacc tctgcatcag tgcatttcta tttatatcaa aaggtgctaa aatgattcaa
     4741 tttgcatttt ctgatcctgt agtgcctcta tagaagtacc cacagaaagt aaagtatcac
     4801 atttataaat accaaagatg taacaatttt aaaattttct agattactcc aataaagtgt
     4861 tttaagtttt
//
