LOCUS       NM_002508               5792 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens nidogen 1 (NID1), mRNA.
ACCESSION   NM_002508
VERSION     NM_002508.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5792)
  AUTHORS   Kuan,M.I., Caruso,L.B., Zavala,A.G., Rana,P.S.J.B., O'Dowd,J.M.,
            Tempera,I. and Fortunato,E.A.
  TITLE     Human Cytomegalovirus Utilizes Multiple Viral Proteins to Regulate
            the Basement Membrane Protein Nidogen 1
  JOURNAL   J Virol 96 (20), e0133622 (2022)
   PUBMED   36218358
  REMARK    GeneRIF: Human Cytomegalovirus Utilizes Multiple Viral Proteins to
            Regulate the Basement Membrane Protein Nidogen 1.
REFERENCE   2  (bases 1 to 5792)
  AUTHORS   Khattab,A. and Torkamani,A.
  TITLE     Nidogen-1 could play a role in diabetic kidney disease development
            in type 2 diabetes: a genome-wide association meta-analysis
  JOURNAL   Hum Genomics 16 (1), 47 (2022)
   PUBMED   36271454
  REMARK    GeneRIF: Nidogen-1 could play a role in diabetic kidney disease
            development in type 2 diabetes: a genome-wide association
            meta-analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5792)
  AUTHORS   Perez-Diaz,S., Koumaiha,Z., Borok,M.J., Aurade,F., Pini,M.,
            Periou,B., Rouault,C., Baba-Amer,Y., Clement,K., Derumeaux,G.,
            Authier,F.J., Lafuste,P. and Relaix,F.
  TITLE     Obesity impairs skeletal muscle repair through NID-1 mediated
            extracellular matrix remodeling by mesenchymal progenitors
  JOURNAL   Matrix Biol 112, 90-115 (2022)
   PUBMED   35963565
  REMARK    GeneRIF: Obesity impairs skeletal muscle repair through NID-1
            mediated extracellular matrix remodeling by mesenchymal
            progenitors.
REFERENCE   4  (bases 1 to 5792)
  AUTHORS   Vaes,N., Schonkeren,S.L., Rademakers,G., Holland,A.M., Koch,A.,
            Gijbels,M.J., Keulers,T.G., de Wit,M., Moonen,L., Van der
            Meer,J.R.M., van den Boezem,E., Wolfs,T.G.A.M., Threadgill,D.W.,
            Demmers,J., Fijneman,R.J.A., Jimenez,C.R., Vanden Berghe,P.,
            Smits,K.M., Rouschop,K.M.A., Boesmans,W., Hofstra,R.M.W. and
            Melotte,V.
  TITLE     Loss of enteric neuronal Ndrg4 promotes colorectal cancer via
            increased release of Nid1 and Fbln2
  JOURNAL   EMBO Rep 22 (6), e51913 (2021)
   PUBMED   33890711
  REMARK    GeneRIF: Loss of enteric neuronal Ndrg4 promotes colorectal cancer
            via increased release of Nid1 and Fbln2.
REFERENCE   5  (bases 1 to 5792)
  AUTHORS   Zhang,B., Xu,C., Liu,J., Yang,J., Gao,Q. and Ye,F.
  TITLE     Nidogen-1 expression is associated with overall survival and
            temozolomide sensitivity in low-grade glioma patients
  JOURNAL   Aging (Albany NY) 13 (6), 9085-9107 (2021)
   PUBMED   33735110
  REMARK    GeneRIF: Nidogen-1 expression is associated with overall survival
            and temozolomide sensitivity in low-grade glioma patients.
REFERENCE   6  (bases 1 to 5792)
  AUTHORS   Stephens,R.W., Aumailley,M., Timpl,R., Reisberg,T., Tapiovaara,H.,
            Myohanen,H., Murphy-Ullrich,J. and Vaheri,A.
  TITLE     Urokinase binding to laminin-nidogen. Structural requirements and
            interactions with heparin
  JOURNAL   Eur J Biochem 207 (3), 937-942 (1992)
   PUBMED   1499567
REFERENCE   7  (bases 1 to 5792)
  AUTHORS   Wu,C. and Chung,A.E.
  TITLE     Potential role of entactin in hemostasis. Specific interaction of
            entactin with fibrinogen A alpha and B beta chains
  JOURNAL   J Biol Chem 266 (28), 18802-18807 (1991)
   PUBMED   1680863
REFERENCE   8  (bases 1 to 5792)
  AUTHORS   Aeschlimann,D. and Paulsson,M.
  TITLE     Cross-linking of laminin-nidogen complexes by tissue
            transglutaminase. A novel mechanism for basement membrane
            stabilization
  JOURNAL   J Biol Chem 266 (23), 15308-15317 (1991)
   PUBMED   1678389
REFERENCE   9  (bases 1 to 5792)
  AUTHORS   Fazio,M.J., O'Leary,J., Kahari,V.M., Chen,Y.Q., Saitta,B. and
            Uitto,J.
  TITLE     Human nidogen gene: structural and functional characterization of
            the 5'-flanking region
  JOURNAL   J Invest Dermatol 97 (2), 281-285 (1991)
   PUBMED   1906509
REFERENCE   10 (bases 1 to 5792)
  AUTHORS   Chung,A.E. and Durkin,M.E.
  TITLE     Entactin: structure and function
  JOURNAL   Am J Respir Cell Mol Biol 3 (4), 275-282 (1990)
   PUBMED   2119632
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M30269.1, AL122018.37,
            AL139161.8, CN267119.1, DA269707.1 and BQ549657.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002508.2.
            
            Summary: This gene encodes a member of the nidogen family of
            basement membrane glycoproteins. The protein interacts with several
            other components of basement membranes, and may play a role in cell
            interactions with the extracellular matrix. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M30269.1, SRR18074967.2083206.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264187.7/ ENSP00000264187.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-746               M30269.1           80-825
            747-747             AL122018.37        18132-18132         c
            748-1963            M30269.1           827-2042
            1964-1968           AL139161.8         100190-100194       c
            1969-3197           M30269.1           2048-3276
            3198-3493           CN267119.1         239-534
            3494-3754           DA269707.1         291-551
            3755-5322           AL139161.8         50567-52134         c
            5323-5792           BQ549657.1         21-490              c
FEATURES             Location/Qualifiers
     source          1..5792
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.3"
     gene            1..5792
                     /gene="NID1"
                     /gene_synonym="NID"
                     /note="nidogen 1"
                     /db_xref="GeneID:4811"
                     /db_xref="HGNC:HGNC:7821"
                     /db_xref="MIM:131390"
     exon            1..236
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..3755
                     /gene="NID1"
                     /gene_synonym="NID"
                     /note="enactin; entactin; NID-1; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="nidogen-1 precursor"
                     /protein_id="NP_002499.2"
                     /db_xref="CCDS:CCDS1608.1"
                     /db_xref="GeneID:4811"
                     /db_xref="HGNC:HGNC:7821"
                     /db_xref="MIM:131390"
                     /translation="MLASSSRIRAAWTRALLLPLLLAGPVGCLSRQELFPFGPGQGDL
                     ELEDGDDFVSPALELSGALRFYDRSDIDAVYVTTNGIIATSEPPAKESHPGLFPPTFG
                     AVAPFLADLDTTDGLGKVYYREDLSPSITQRAAECVHRGFPEISFQPSSAVVVTWESV
                     APYQGPSRDPDQKGKRNTFQAVLASSDSSSYAIFLYPEDGLQFHTTFSKKENNQVPAV
                     VAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQGVWVFEIGSPATTNGVVP
                     ADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGADTYSVPSVLSP
                     RRAATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSRQTCAN
                     NRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVP
                     IVFENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNG
                     FSITGGEFTRQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVH
                     IEPYTELYHYSTSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSR
                     PALPSTQQLSVDSVFVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTN
                     AACRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRCECVE
                     GYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGSSYTCSCLPGFSGDGQ
                     ACQDVDECQPSRCHPDAFCYNTPGSFTCQCKPGYQGDGFRCVPGEVEKTRCQHEREHI
                     LGAAGATDPQRPIPPGLFVPECDAHGHYAPTQCHGSTGYCWCVDRDGREVEGTRTRPG
                     MTPPCLSTVAPPIHQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAF
                     LHVPAKVIIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDH
                     LGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNP
                     KIETSYMDGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKA
                     LEGLQYPFAVTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQ
                     CPQGHNYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK"
     exon            237..536
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            537..763
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            764..1146
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1296
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1548
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1749
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1995
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2139
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2265
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2415
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2538
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2766
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2939
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3066
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3238
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3396
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3520
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3633
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..5792
                     /gene="NID1"
                     /gene_synonym="NID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5768..5773
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NID1"
                     /gene_synonym="NID"
                     /note="hexamer: AATAAA"
     polyA_site      5792
                     /gene="NID1"
                     /gene_synonym="NID"
                     /note="major polyA site"
ORIGIN      
        1 agttcgggaa catgttggcc tcgagcagcc ggatccgggc tgcgtggacg cgggcgctgc
       61 tgctgccgct gctgctggcg gggcctgtgg gctgcctgag ccgccaggag ctctttccct
      121 tcggccccgg acagggggac ctggagctgg aggacgggga tgacttcgtc tctcctgccc
      181 tggagctgag tggggcgctc cgcttctacg acagatccga catcgacgca gtctacgtca
      241 ccacaaatgg catcattgct acgagtgaac ccccggccaa agaatcccat cccgggctct
      301 tcccaccaac attcggtgca gtcgcccctt tcctggcgga cttggacacg accgatggcc
      361 tggggaaggt ttattatcga gaagacttat ccccctccat cactcagcga gcagcagagt
      421 gtgtccacag agggttcccg gagatctctt tccagcctag tagcgcggtg gttgtcactt
      481 gggaatccgt ggccccctac caagggccca gcagggaccc agaccagaaa ggcaagagaa
      541 acacgttcca ggctgttcta gcctcctctg attccagctc ctatgccatt ttcctttatc
      601 ctgaggatgg tctgcagttc catacgacat tctcaaagaa ggaaaacaac caagttcctg
      661 ccgtggttgc attcagtcaa ggttcagtgg gattcttatg gaagagcaac ggagcttata
      721 acatatttgc taatgacagg gaatcagttg aaaatttggc caagagtagt aactctgggc
      781 agcagggtgt ctgggtgttt gagattggga gtccagccac caccaatggc gtggtgcctg
      841 cagacgtgat cctcggaact gaagatgggg cagagtatga tgatgaggat gaagattatg
      901 acctggcgac cactcgtctg ggcctggagg atgtgggcac cacgcccttc tcctacaagg
      961 ctctgagaag gggaggtgct gacacataca gtgtgcccag cgtcctctcc ccgcgccggg
     1021 cagctaccga aaggcccctt ggacctccca cagagagaac caggtctttc cagttggcag
     1081 tggagacttt tcaccagcag caccctcagg tcatagatgt ggatgaagtt gaggaaacag
     1141 gagttgtttt cagctataac acggattccc gccagacgtg tgctaacaac agacaccagt
     1201 gctcggtgca cgcagagtgc agggactacg ccacgggctt ctgctgcagc tgtgtcgctg
     1261 gctatacggg caatggcagg caatgtgttg cagaaggttc cccccagcga gtcaatggca
     1321 aggtgaaagg aaggatcttt gtggggagca gccaggtccc cattgtcttt gagaacactg
     1381 acctccactc ttacgtagta atgaaccacg ggcgctccta cacagccatc agcaccattc
     1441 ccgagaccgt tggatattct ctgcttccac tggccccagt tggaggcatc attggatgga
     1501 tgtttgcagt ggagcaggac ggattcaaga atgggttcag catcaccggg ggtgagttca
     1561 ctcgccaggc tgaggtgacc ttcgtggggc acccgggcaa tctggtcatt aagcagcggt
     1621 tcagcggcat cgatgagcat gggcacctga ccatcgacac ggagctggag ggccgcgtgc
     1681 cgcagattcc gttcggctcc tccgtgcaca ttgagcccta cacggagctg taccactact
     1741 ccacctcagt gatcacttcc tcctccaccc gggagtacac ggtgactgag cccgagcgag
     1801 atggggcatc tccttcacgc atctacactt accagtggcg ccagaccatc accttccagg
     1861 aatgcgtcca cgatgactcc cggccagccc tgcccagcac ccagcagctc tcggtggaca
     1921 gcgtgttcgt cctgtacaac caggaggaga agatcttgcg ctatgctctc agcaactcca
     1981 ttgggcctgt gagggaaggc tcccctgatg ctcttcagaa tccctgctac atcggcactc
     2041 atgggtgtga caccaacgcg gcctgtcgcc ctggtcccag gacacagttc acctgcgagt
     2101 gctccatcgg cttccgagga gacgggcgaa cctgctatga tattgatgaa tgttcagaac
     2161 aaccctcagt gtgtgggagc cacacaatct gcaataatca cccaggaacc ttccgctgcg
     2221 agtgtgtgga gggctaccag ttttcagatg agggaacgtg tgtggctgtc gtggaccagc
     2281 gccccatcaa ctactgtgaa actggccttc ataactgcga cataccccag cgggcccagt
     2341 gtatctacac aggaggctcc tcctacacct gttcctgctt gccaggcttt tctggggatg
     2401 gccaagcctg ccaagatgta gatgaatgcc agccaagccg atgtcaccct gacgccttct
     2461 gctacaacac tccaggctct ttcacgtgcc agtgcaaacc tggttatcag ggagacggct
     2521 tccgttgcgt gcccggagag gtggagaaaa cccggtgcca gcacgagcga gaacacattc
     2581 tcggggcagc gggggcgaca gacccacagc gacccattcc tccggggctg ttcgttcctg
     2641 agtgcgatgc gcacgggcac tacgcgccca cccagtgcca cggcagcacc ggctactgct
     2701 ggtgcgtgga tcgcgacggc cgcgaggtgg agggcaccag gaccaggccc gggatgacgc
     2761 ccccgtgtct gagtacagtg gctcccccga ttcaccaagg acctgcggtg cctaccgccg
     2821 tgatcccctt gcctcctggg acccatttac tctttgccca gactgggaag attgagcgcc
     2881 tgcccctgga gggaaatacc atgaggaaga cagaagcaaa ggcgttcctt catgtcccgg
     2941 ctaaagtcat cattggactg gcctttgact gcgtggacaa gatggtttac tggacggaca
     3001 tcactgagcc ttccattggg agagctagtc tacatggtgg agagccaacc accatcatta
     3061 gacaagatct tggaagtcca gaaggtatcg ctgttgatca ccttggccgc aacatcttct
     3121 ggacagactc taacctggat cgaatagaag tggcgaagct ggacggcacg cagcgccggg
     3181 tgctctttga gactgacttg gtgaatccca gaggcattgt aacggattcc gtgagaggga
     3241 acctttactg gacagactgg aacagagata accccaagat tgaaacttcc tacatggacg
     3301 gcacgaaccg gaggatcctt gtgcaggatg acctgggctt gcccaatgga ctgaccttcg
     3361 atgcgttctc atctcagctc tgctgggtgg atgcaggcac caatcgggcg gaatgcctga
     3421 accccagtca gcccagcaga cgcaaggctc tcgaagggct ccagtatcct tttgctgtga
     3481 cgagctacgg gaagaatctg tatttcacag actggaagat gaattccgtg gttgctctcg
     3541 atcttgcaat ttccaaggag acggatgctt tccaacccca caagcagacc cggctgtatg
     3601 gcatcaccac ggccctgtct cagtgtccgc aaggccataa ctactgctca gtgaacaatg
     3661 gcggctgcac ccacctatgc ttggccaccc cagggagcag gacctgccgt tgccctgaca
     3721 acaccttggg agttgactgt atcgaacaga aatgaagaca agagtgcctt atttcctttc
     3781 caagtatttc acagcaacac tctacttgaa gcaacttggt ccagattgaa aagtgtcctc
     3841 tggctgagtg gccactaggc ccagacccag cccagcctga gccccaacaa cttttccctc
     3901 actgttcccc aaaacatgca ccctggactt ctctaataga aaagtctcca cccctacaca
     3961 aggacagaac cctccacccc tacccccaac cctcagacag acttatacac ccctgagtga
     4021 ggattacatg cccatcccag tgtcctagga ccttttccca atactagccc cccagtggtg
     4081 aacagaacct cccaaatttg agttgcaccc ttccctgtgg ccttatgagc tcagcctcgc
     4141 tttgaggtac ccaccgtcct gtcagctcct tgacctatga gccggggcct gactaggaaa
     4201 agttgggagt taaggaggaa attagcattc cttaatgttt tgttttggtg ctctgaattt
     4261 cttctttatt atagtcctat agttttactc ctcagttcct caccatcatc atcttgtcta
     4321 agacccccat tataatattc atgcgctgct ttttcatcaa aacctaccct gtcctagaga
     4381 tctatgggca tttggtggat gataatgagc agcccctccc agatagaatg tcaatatttg
     4441 agcagtagga tattggcatt tgttagttaa aggcttaaat caaaagaatg tccaatggta
     4501 ggaatttcaa ggtgtaggtc agatatttga gaatagggga tttttttgat gtgccttaaa
     4561 ttataccaaa gattactaat tattcctctt tgcccaaaat acttgcatcc aaggttctag
     4621 tctctgttgc tgtgctggtc tttagcccca ctgcttgcac tgatgtccct ccttttcacg
     4681 gagacctatc tgaggtacag gatggggctg gcaccagatg atgtcccacc acagtccctc
     4741 acctccggcc tccacatgac agaaccaatt tacactcaac catgacctca cccctccttg
     4801 gtttctccct cgatctgtgg ccctttttgg atgtattctt atctaacaac acaatccgga
     4861 aagactgaat tgaatattta tactaatggt tcatatcctt tattgctcaa tgatctaatt
     4921 aaagggatca ttgccacatt tcatgtttat atttctacaa tttgtttaga aaacatctcc
     4981 tgaccatatc agtagctcgt gttatctttt tatcaactgc ttcccagagt cctaaaacaa
     5041 tagaaatttt ggattgaaaa gttcagcata aggagtttga gtcagtaaag gatgggataa
     5101 aggagtcgag atgattcaat gaaaagtatc acaaaaaaga gattgatcaa caagagaaat
     5161 aaaaaagccc aagaggaagt ggtaggggaa ggaatttaag aacagcaata agtaaaactc
     5221 ttaagtaact ccaaaaagaa aatggtacat tttgccaaag accacttata cttgagaaca
     5281 tggaagaatt tgcctgatac tctctttggg gaaaagagtc tctcctcttt tcctcaaacc
     5341 ccagtacact cagcctctct gccccacctt ctcctgactt tgtcctcact tgcttctgca
     5401 gtacattgga acctgaattg aaagaaagtc ttccttgaat aattggagtt tgtcttgaga
     5461 ggcaaatata gccccaagaa tcacaagatt cgaggaccat gtaggtcttt tacgtagccc
     5521 aaatccataa attagtctca ctttttgtat ttatcgtttc atattaaacc ctctatatca
     5581 aatgttcatc atgattttgt atgattttta taactatttt attcatttta ttagatttat
     5641 tctaaaattt tttaatggta aattcttaaa ctgtggaaac cactgaaggt gcttattaac
     5701 tgttctccca gatttgtaca agtattggat gattccttga gtttacagct gtacaaatag
     5761 tgtggaaaat aaactttttt taaaaaagaa aa
//
