LOCUS       NM_032316               3227 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens nicolin 1, tubulin polyglutamylase complex subunit
            (NICN1), mRNA.
ACCESSION   NM_032316
VERSION     NM_032316.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3227)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3227)
  AUTHORS   Hou,D., Guan,Y., Liu,J., Xiao,Z., Ouyang,Y., Yu,Y. and Chen,Z.
  TITLE     Cloning and characterization of the NPCEDRG gene promoter
  JOURNAL   Mol Cell Biochem 346 (1-2), 1-10 (2011)
   PUBMED   20821255
  REMARK    GeneRIF: results provide important clues to elucidate the
            regulation of NPCEDRG gene expression and function
REFERENCE   3  (bases 1 to 3227)
  AUTHORS   Morgan,A.R., Han,D.Y., Lam,W.J., Fraser,A.G. and Ferguson,L.R.
  TITLE     Association analysis of 3p21 with Crohn's disease in a New Zealand
            population
  JOURNAL   Hum Immunol 71 (6), 602-609 (2010)
   PUBMED   20307617
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3227)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3227)
  AUTHORS   Backofen,B., Jacob,R., Serth,K., Gossler,A., Naim,H.Y. and Leeb,T.
  TITLE     Cloning and characterization of the mammalian-specific nicolin 1
            gene (NICN1) encoding a nuclear 24 kDa protein
  JOURNAL   Eur J Biochem 269 (21), 5240-5245 (2002)
   PUBMED   12392556
REFERENCE   6  (bases 1 to 3227)
  AUTHORS   Backofen,B. and Leeb,T.
  TITLE     Genomic organization of the murine aminomethyltransferase gene
            (Amt)
  JOURNAL   DNA Seq 13 (4), 179-183 (2002)
   PUBMED   12487019
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104452.2 and BC050653.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 13, 2006 this sequence version replaced NM_032316.2.
            
            Summary: This protein encoded by this gene localizes to the nucleus
            and is expressed in numerous tissues including brain, testis,
            liver, and kidney. This refseq contains genomic sequence in its 3'
            UTR which is not supported by experimental evidence. Computer
            predictions indicate that this region of the 3' UTR contains
            hairpin-forming self-complementary sequence which is possibly
            excised after transcription. This gene has a pseudogene on
            chromosome X. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.112608.1,
                                           SRR1803617.83662.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273598.8/ ENSP00000273598.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC104452.2         138134-138169
            37-1395             BC050653.1         1-1359
            1396-3227           AC104452.2         143294-145125
FEATURES             Location/Qualifiers
     source          1..3227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3227
                     /gene="NICN1"
                     /note="nicolin 1, tubulin polyglutamylase complex subunit"
                     /db_xref="GeneID:84276"
                     /db_xref="HGNC:HGNC:18317"
                     /db_xref="MIM:611516"
     exon            1..217
                     /gene="NICN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..727
                     /gene="NICN1"
                     /note="PGs5; NPCEDRG; tubulin polyglutamylase complex
                     subunit 5; nicolin 1"
                     /codon_start=1
                     /product="nicolin-1"
                     /protein_id="NP_115692.1"
                     /db_xref="CCDS:CCDS2798.1"
                     /db_xref="GeneID:84276"
                     /db_xref="HGNC:HGNC:18317"
                     /db_xref="MIM:611516"
                     /translation="MSRVLVPCHVKGSVALQVGDVRTSQGRPGVLVIDVTFPSVAPFE
                     LQEITFKNYYTAFLSIRVRQYTSAHTPAKWVTCLRDYCLMPDPHSEEGAQEYVSLFKH
                     QMLCDMARISELRLILRQPSPLWLSFTVEELQIYQQGPKSPSVTFPKWLSHPVPCEQP
                     ALLREGLPDPSRVSSEVQQMWALTEMIRASHTSARIGRFDVDGCYDLNLLSYT"
     exon            218..394
                     /gene="NICN1"
                     /inference="alignment:Splign:2.1.0"
     exon            395..508
                     /gene="NICN1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..580
                     /gene="NICN1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..685
                     /gene="NICN1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..3227
                     /gene="NICN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2594..2599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NICN1"
                     /note="hexamer: AATAAA"
     polyA_site      2614
                     /gene="NICN1"
                     /note="major polyA site"
ORIGIN      
        1 cttgaggctc ggctgaggat gccgggaagg gctggtggtc gggggcctag agcggcggtt
       61 gcacttagtt gcggctgctg tcaccatgtc ccgcgttttg gtgccttgcc atgtgaaagg
      121 ctccgtagcc ctccaggtgg gcgacgtgcg gacctcccaa ggccggcctg gcgtgctggt
      181 catcgatgtc accttcccca gcgtcgctcc cttcgagttg caggaaatca cgtttaagaa
      241 ttactacaca gcttttttga gcatccgtgt ccgtcagtac acctcagcac acacacctgc
      301 caagtgggtg acctgcctgc gggactactg cctaatgcct gacccacaca gtgaggaggg
      361 agcccaggag tatgtatcgc tgttcaagca tcagatgctg tgtgacatgg ctagaatatc
      421 ggagctacgc ctgattctgc ggcagccatc accactgtgg ctgtctttca cagtggagga
      481 gctgcagatc tatcagcagg gaccaaagag cccctccgtg acctttccca agtggctctc
      541 ccacccagtg ccctgtgagc aacctgcact cctccgtgag ggtctcccag accccagcag
      601 ggtatcctcc gaggtgcagc agatgtgggc actgacagag atgatccggg ccagtcacac
      661 ctccgcaagg atcggccgct ttgatgtgga tggctgttat gacctgaact tgctctccta
      721 cacttgaatg gttgctccta gccaagatgt tggcctttct gtgcccaccc agacttggtt
      781 tgggccacca gaggctgaag tgtatttcct gtgcattcca agtgttgcct gcatgcctgt
      841 tctgtctggg ccacattcac agattcagga ttctcagggg cttaccgtgt tacttcagca
      901 tgagctcctg gcatgggggt gctctgtctt cgcctggctg caactcaatt cttccttcta
      961 cccaaaaaca ctccagtcag ttgtacttac tgagaatccc tgagtgccct ctgccccttc
     1021 tggcaacatg cacattcctg tcttctgcct gctccctcat gtcagtgcag ttgggctggg
     1081 ctgacctact aaaacctgct ccatgtatgg acctggaagg ccattgctgc catggcactt
     1141 gggacacttg aggaagaaac agaaacctta tttcttcctg tgtgtcccct agtggttttc
     1201 tttccatttg tgttatgcca cagagagaaa tttcctgtct gaactcttct gctgcctgcc
     1261 taggaaggaa acctgaagat ttgggcagcc tgagtctctt ggtttctgag ctggctcctg
     1321 aatatatgtt caagtgggtg tgcccatagg gcctgggcac gtgtctctag caaaaccagg
     1381 gcctgagcat aagaactggg acccttctag gcagggtgca gtggctcacg cctgtaatcc
     1441 cagcactttg ggaggcccag gcaggcggat cacctgaggt caggagttca agaccagcct
     1501 gaccaacctg gagaaacccc gtctctacta aaaatacaaa aaattagctg ggcgtggtgg
     1561 taggcacctg taatcccagc tacttgggag gctgaggcag gagaatctct tgaacccggg
     1621 aagtggaggt tgcggacctg agatcatgcc attgcactcc agcctgggca agaagagcga
     1681 aactccatct taaacaaaca aacaaaaaaa aaagaactgg gacccttctg ccatctgaca
     1741 tagcccaaag cacatctcta tcctttctcc cagttgcccc tctccttttt tgttgttttt
     1801 tttgaggttg agttttgctc ttgttgccca ggctggagtg caatagtgca atcttggcta
     1861 actgcaacct ccgcctccca ggttcaagca attctcctgc ctcagtctcc cgagtagctg
     1921 ggattacagt catgcatcac catgcctggc taattttgta tttgtagtag agatggggtt
     1981 tctccatgtt ggtcaggctg gtctcaaaca cctgacctca ggtgatctgc ctgccttggc
     2041 cttccaaagt gctgggatta caggcatgag ccaccgcgcc cgccctgccc ctttccaaga
     2101 gatatgctca gcataatgag agatcaaccg tggtggggag tgggtccaag taagggttct
     2161 cattgttgcc ttttaagagg cctaagtcct gcattaactc agtccaacca ttaagtgatg
     2221 caggctgctc ttccctcatg tgagaaaaac ctgtttccct ctggttcttc ctggctttgc
     2281 acctggtggc tattacaaag cagtactgca gtatgtcttg gacctggaaa gttggacatg
     2341 tgtgtggctc aacagttttc tcgggggagt tcagtgacct tttggtggcc accctctgtt
     2401 ctcacctgtg agttcttgca ggtggcgact tcatctgcaa ggtcacttac atagccccac
     2461 tcagctgctt cggaaagcgt gacgaagcag tagtcctcag tgtgtgtgta agtgaagagg
     2521 accttgtggt agcagggacc atgcttcatt cgtggctgtg tccccatctg agggcctggt
     2581 atgcagtaag atcaataaat acttgtggaa tgcatgactg ctggctgcct gtgtctgcct
     2641 ggtgggagag ctgtggaact aggggtccac atgaggacag actactgtgg tgctgcctac
     2701 ctgccaggct ggcccacctt ccccaccccc acttgacctt actctcttga ggtcctaaag
     2761 gtatgattca gacctttcag ccctttccag aactttgacc ctctggagac agggcggttc
     2821 tgcagggggc ggtctagccc ctagctttgt tctgggcagc ccaatcagct ctggattgcc
     2881 cgagctgccc tgaagagtca gccgaaagag ctggaggctt cttccctgtg gttgcgggtt
     2941 cctgcattct ctgctctaaa tcccagcctg cccttggggc tgcccacgcc cccttcagat
     3001 cctttgctcc ggagagagac ctgtccgagc agaggcctgg actacatctc ccggcgtgcc
     3061 tggcagtgtg gtggcctctg tgcgccgtct gcactcgttg caggcgacga tgcagagggc
     3121 tgtaagtgtg gtggcccgtc tgggctttcg cctgcaggca ttccccccgg ccttgtgtcg
     3181 tccacttagt tgcgcacagg tgggatagag ggtgctgatc ttggagg
//
