LOCUS       NM_001321827            3679 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens niban apoptosis regulator 3 (NIBAN3), transcript
            variant 4, mRNA.
ACCESSION   NM_001321827 XM_006722685
VERSION     NM_001321827.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3679)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3679)
  AUTHORS   Patel,S.J., Trivedi,G.L., Darie,C.C. and Clarkson,B.D.
  TITLE     The possible roles of B-cell novel protein-1 (BCNP1) in cellular
            signalling pathways and in cancer
  JOURNAL   J Cell Mol Med 21 (3), 456-466 (2017)
   PUBMED   27680505
  REMARK    GeneRIF: PI3K inhibition and p38 MAPK activation leads to reduction
            in phosphorylation of BCNP1 at serine residues.
REFERENCE   3  (bases 1 to 3679)
  AUTHORS   Boyd,R.S., Adam,P.J., Patel,S., Loader,J.A., Berry,J.,
            Redpath,N.T., Poyser,H.R., Fletcher,G.C., Burgess,N.A.,
            Stamps,A.C., Hudson,L., Smith,P., Griffiths,M., Willis,T.G.,
            Karran,E.L., Oscier,D.G., Catovsky,D., Terrett,J.A. and Dyer,M.J.
  TITLE     Proteomic analysis of the cell-surface membrane in chronic
            lymphocytic leukemia: identification of two novel proteins, BCNP1
            and MIG2B
  JOURNAL   Leukemia 17 (8), 1605-1612 (2003)
   PUBMED   12886250
  REMARK    GeneRIF: Isolation and sequencing. Prediction of transmembrane
            domains, with three alternatively spliced final exons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010618.9.
            
            On Jun 2, 2019 this sequence version replaced NM_001321827.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599164.6/ ENSP00000469225.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC010618.9         37507-37635
            130-260             AC010618.9         40995-41125
            261-386             AC010618.9         42503-42628
            387-501             AC010618.9         43827-43941
            502-669             AC010618.9         47616-47783
            670-785             AC010618.9         49390-49505
            786-890             AC010618.9         49587-49691
            891-1053            AC010618.9         49843-50005
            1054-1244           AC010618.9         50632-50822
            1245-1403           AC010618.9         52376-52534
            1404-1520           AC010618.9         53557-53673
            1521-1628           AC010618.9         53764-53871
            1629-1740           AC010618.9         56926-57037
            1741-1824           AC010618.9         59684-59767
            1825-3679           AC010618.9         62026-63880
FEATURES             Location/Qualifiers
     source          1..3679
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3679
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /note="niban apoptosis regulator 3"
                     /db_xref="GeneID:199786"
                     /db_xref="HGNC:HGNC:24130"
                     /db_xref="MIM:609967"
     exon            1..129
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1937
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /note="isoform d is encoded by transcript variant 4;
                     niban-like protein 2; B-cell novel protein 1; family with
                     sequence similarity 129 member C; protein Niban 3"
                     /codon_start=1
                     /product="protein Niban 3 isoform d"
                     /protein_id="NP_001308756.2"
                     /db_xref="CCDS:CCDS82314.1"
                     /db_xref="GeneID:199786"
                     /db_xref="HGNC:HGNC:24130"
                     /db_xref="MIM:609967"
                     /translation="MGGRPSSPLDKQQRQHLRGQVDTLLRNFLPCYRGQLAASVLRQI
                     SRELGPQEPTGSQLLRSKKLPRVREHRGPLTQLRGHPPRWQPIFCVLRGDGRLEWFSH
                     KEEYENGGHCLGSTALTGYTLLTSQREYLRLLDALCPESLGDHTQEEPDSLLEVPVSF
                     PLFLQHPFRRHLCFSAATREAQHAWRLALQGGIRLQGIVLQRSQAPAARAFLDAVRLY
                     RQHQGHFGDDDVTLGSDAEVLTAVLMREQLPALRAQTLPGLRGAGRARAWAWTELLDA
                     VHAAVLAGASAGLCAFQPEKDELLASLEKTIRPDVDQLLRQRARVAGRLRTDIRGPLE
                     SCLRREVDPQLPRVVQTLLRTVEASLEAVRTLLAQGMDRLSHRLRQSPSGTRLRREVY
                     SFGEMPWDLALMQTCYREAERSRGRLGQLAAPFGFLGMQSLVFGAQDLAQQLMADAVA
                     TFLQLADQCLTTALNCDQAAQRLERVRGRVLKKFKSDSGLAQRRFIRGWGLCIFLPFV
                     LSQLEPGCKKELPEFEGDVLAVGSQALTTEGIYEDVIRGCLLQRIDQELKKTLGANDV
                     SCTLDGCLEVPWEQEGADEETEAEREGGACPRQPDSGAQIQPLCPPPSPGTFRS"
     exon            130..260
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            261..386
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            387..501
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            502..669
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            670..785
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            786..890
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1053
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1244
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1403
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1520
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1628
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1740
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1824
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..3679
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3650..3655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /note="hexamer: AATACA"
     polyA_site      3679
                     /gene="NIBAN3"
                     /gene_synonym="BCNP1; FAM129C"
                     /note="major polyA site"
ORIGIN      
        1 aggtgcccct gagccgagga acgcaggcgg tggtcgtggg gaagggaaga ggagccccgg
       61 gagacgacag cagcatgggt gggcggcctt cgagccctct ggacaagcag cagcggcagc
      121 acctaagggg tcaggtggac accctgctga ggaacttcct gccttgctac cgtgggcagc
      181 tggcagcgtc tgtcctgcgg cagatctctc gagagctggg ccctcaggag ccgaccggaa
      241 gccagttgct acgcagcaaa aagctgcccc gagtccgtga gcaccgagga cccctgaccc
      301 agcttcgggg ccacccaccc cggtggcagc cgatcttctg tgttctgcgt ggggacggcc
      361 gcctagagtg gttcagccac aaggaggaat atgaaaacgg gggccactgc cttggctcaa
      421 cagccctgac aggatacacg ctcctgactt cccagcgaga atatctccgc cttttggatg
      481 ctctctgccc tgaatccttg ggagaccata ctcaggaaga gcctgactcc ctcttggaag
      541 tgcctgtgag cttcccgctg ttcctgcagc accccttccg ccggcacctc tgcttctctg
      601 cagccaccag ggaggcacag catgcctgga ggctggccct gcagggtggc atccggcttc
      661 agggcatagt cctgcagcga agccaggccc ctgctgcccg ggccttcctg gacgccgtcc
      721 gactctaccg gcagcaccaa ggccactttg gcgacgacga cgtgacccta ggctcagacg
      781 ccgaggtgct gaccgcggtg ctgatgcggg agcaacttcc cgcgctgcga gcccagaccc
      841 ttcctggcct gcggggggca ggccgcgccc gcgcctgggc ctggaccgag cttctagacg
      901 ccgttcacgc agctgtcctg gccggggcct ccgccgggct ctgcgccttc cagcccgaaa
      961 aggacgagct gcttgcgtcg ctggagaaga cgatccgccc ggacgtggac cagctgctgc
     1021 ggcagcgggc gcgtgtggcg gggcggctga ggacggatat caggggaccg ctcgagtcgt
     1081 gcctgcgccg ggaggtggac ccgcagctgc cccgggtcgt gcagaccctg ctgcgcaccg
     1141 tggaagcctc gctcgaggcg gtgcggaccc tcctggctca aggcatggac cgactgtccc
     1201 accgcctgcg ccagagcccc tcaggcacgc ggctgcgcag ggaggtttac tcatttgggg
     1261 agatgccgtg ggacttggcg ctgatgcaga catgctaccg tgaggccgag cggagccggg
     1321 ggcgcttggg gcagctggca gcaccgtttg gctttctggg gatgcagagc ctcgtgtttg
     1381 gggcccaaga tcttgcacag cagctcatgg ctgacgccgt ggccaccttc ctgcagctgg
     1441 ctgaccagtg tctgacgacg gccctcaact gtgaccaggc tgcccagagg ctggagagag
     1501 tcagggggcg cgtgctgaag aaattcaaat cggacagcgg gttggcgcag aggaggttca
     1561 tccgaggctg gggtctctgc atctttttac cttttgtgct gagccaactc gagccaggct
     1621 gcaaaaagga gctgcctgag ttcgaggggg atgtccttgc cgtgggcagc caggctctga
     1681 ccactgaggg catctatgag gacgtcatcc gggggtgctt gctgcagagg attgaccaag
     1741 aattgaaaaa gacccttggt gccaatgatg tatcctgcac tctggacggc tgcttggagg
     1801 tcccatggga acaggaggga gcagatgagg aaactgaggc tgagcgggaa ggaggggctt
     1861 gtcccaggca gccagactct ggtgcccaga tccagccact ctgcccaccg ccttctccag
     1921 gaacattccg gagctgaatc ttcacccaca tctatcttgt ttctattgga taaatgtcta
     1981 caagtggaat ttctgggcca aaacggatgt gccatcttta ggcttttgta acccctgcaa
     2041 cttcagaaaa ctgtaccatt ttatactcca agcagcagca tttatttgtg tattttcccc
     2101 aaggctttct ttattttaat tttttttttt tttttgagac tgagtcttgc tctgtcaccc
     2161 gggctggagt gcagtggcag gatctcggct cactgcaacc tccgcctccc gggttcaagc
     2221 gattctcctg cctcagcctc ccgagtagct gagatttcag gcacccgcca ccatgcctgg
     2281 ttaatttttg tgtttttagt agagatgggg tttcaccatg ttggccaggc tggtctcgaa
     2341 ctcctgtcct taagtgatct gcccccctca gcctcccaaa gtgctgggat tacaggtgtg
     2401 agccaccaca cgtggcctaa tttttttttt ttaaataata gagacaaggt ctcgctatgc
     2461 tgcccaggct gatctcaaac tcctggactc aagcaatcct cctgccttgg cctcccaaag
     2521 tgctaggatt ataggagtga tccactatgt ccagcctcca aatcctttct aaacactagg
     2581 acttttcatg aaaagaaaaa agctatgcca gttagacaca cacagaaatc tcatgatttt
     2641 attttgaatt tctttgacta aattgaactt acaaataagt ttattatggc caggcgtggc
     2701 agtgcacacc tgtaatccca gcactttggg aggctgaggc gggcagatca cttgagctca
     2761 ggagttcaag accagcctgg cgaacatagt gagacctcat ctctacaaaa aatacaaaat
     2821 tagcggccgg gagtggtggc tcacgcctgt catcccagca ctttgggagg ctgagacagg
     2881 tggattgctt gagccaagga gttttgaggc cagcttgggc aatgtggtga aacctgtctc
     2941 tactaaaaaa taaaataaat aaataaataa ataaataaat aaataaataa ataaaattta
     3001 aaagaagctg ggctgagatg ggagatttac ctgagcctgg gaactcaagg ctgcagtgag
     3061 tggtgattgc accactgcac tccagcctgg gtgatgggag tgagaccctg tctcaaaaaa
     3121 caaaatccaa atatgttgat tagccattta catgtttgta gttttttttt ttttaatttc
     3181 agtgaattgc ctgttcatag cttttttcta cttttcagga gtgtttgcat ttttcttatt
     3241 gatatctaat aactctttat atctgaagga tatgaacgct ttgtgataca ggttacagat
     3301 tttggggttt ttttctccgc ttgctgtgag ccttttgggt ttgtttccta gctccaaatc
     3361 ttaacttggt gtcaagtttc ctggctggga gacaagcttt taccgacttc ctctgcttgc
     3421 cagcaaagtc atctgctaac tggatattgg cagcttctct gctgtcttgc agctgcttcc
     3481 ggagtgggtt ccacagggat tcccgtgtgt tcttggttca gcttgcagag ggactttcac
     3541 actccctgga gaccgtttcc tcccattctg tctggagttt tcggcctacc ccaagacaat
     3601 gagatattcc tgacctttcc acctatttcc ctccaacccc accttccgaa atacatttgc
     3661 tcaatacatt tgcacttca
//
