LOCUS       NM_022833               3942 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens niban apoptosis regulator 2 (NIBAN2), transcript
            variant 1, mRNA.
ACCESSION   NM_022833 XM_497077
VERSION     NM_022833.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3942)
  AUTHORS   Hahn,H., Lee,D.E., Jang,D.M., Kim,J., Lee,Y., Cheong,H., Han,B.W.
            and Kim,H.S.
  TITLE     Structural Insight on Functional Regulation of Human MINERVA
            Protein
  JOURNAL   Int J Mol Sci 21 (21), 8186 (2020)
   PUBMED   33142954
  REMARK    GeneRIF: Structural Insight on Functional Regulation of Human
            MINERVA Protein.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3942)
  AUTHORS   Cheng,K.C., Lin,R.J., Cheng,J.Y., Wang,S.H., Yu,J.C., Wu,J.C.,
            Liang,Y.J., Hsu,H.M., Yu,J. and Yu,A.L.
  TITLE     FAM129B, an antioxidative protein, reduces chemosensitivity by
            competing with Nrf2 for Keap1 binding
  JOURNAL   EBioMedicine 45, 25-38 (2019)
   PUBMED   31262713
  REMARK    GeneRIF: We have demonstrated that FAM129B in cancer promotes Nrf2
            activity by reducing its ubiquitination through competition with
            Nrf2 for Keap1 binding via its DLG and ETGE motifs. In addition,
            FAM129B reduces chemosensitivity by augmenting Nrf2 antioxidative
            signaling and confers poor prognosis in breast and lung cancer
REFERENCE   3  (bases 1 to 3942)
  AUTHORS   Ji,H., Lee,J.H., Wang,Y., Pang,Y., Zhang,T., Xia,Y., Zhong,L.,
            Lyu,J. and Lu,Z.
  TITLE     EGFR phosphorylates FAM129B to promote Ras activation
  JOURNAL   Proc Natl Acad Sci U S A 113 (3), 644-649 (2016)
   PUBMED   26721396
  REMARK    GeneRIF: activated EGFR phosphorylates the Y593 residue of the
            protein known as family with sequence similarity 129, member B
            (FAM129B), which is overexpressed in many types of human cancer.
REFERENCE   4  (bases 1 to 3942)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3942)
  AUTHORS   Chen,S., Evans,H.G. and Evans,D.R.
  TITLE     FAM129B/MINERVA, a novel adherens junction-associated protein,
            suppresses apoptosis in HeLa cells
  JOURNAL   J Biol Chem 286 (12), 10201-10209 (2011)
   PUBMED   21148485
  REMARK    GeneRIF: The rapid induction of apoptosis in FAM129B knockdown
            cells was reversed by co-transfection with recombinant FAM129B,
            indicating that its effect on apoptosis was specific.
REFERENCE   6  (bases 1 to 3942)
  AUTHORS   Zhou,Y., Zhong,Y., Wang,Y., Zhang,X., Batista,D.L., Gejman,R.,
            Ansell,P.J., Zhao,J., Weng,C. and Klibanski,A.
  TITLE     Activation of p53 by MEG3 non-coding RNA
  JOURNAL   J Biol Chem 282 (34), 24731-24742 (2007)
   PUBMED   17569660
REFERENCE   7  (bases 1 to 3942)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 3942)
  AUTHORS   Kim,J.E., Tannenbaum,S.R. and White,F.M.
  TITLE     Global phosphoproteome of HT-29 human colon adenocarcinoma cells
  JOURNAL   J Proteome Res 4 (4), 1339-1346 (2005)
   PUBMED   16083285
REFERENCE   9  (bases 1 to 3942)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   10 (bases 1 to 3942)
  AUTHORS   Zhang,X., Zhou,Y., Mehta,K.R., Danila,D.C., Scolavino,S.,
            Johnson,S.R. and Klibanski,A.
  TITLE     A pituitary-derived MEG3 isoform functions as a growth suppressor
            in tumor cells
  JOURNAL   J Clin Endocrinol Metab 88 (11), 5119-5126 (2003)
   PUBMED   14602737
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM557756.1, BX280720.1 and AL137555.1.
            
            On Nov 24, 2018 this sequence version replaced NM_022833.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF192911.1, AB210016.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373312.4/ ENSP00000362409.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                BM557756.1         16-97
            83-579              BX280720.1         1-497
            580-3942            AL137555.1         232-3594
FEATURES             Location/Qualifiers
     source          1..3942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..3942
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /note="niban apoptosis regulator 2"
                     /db_xref="GeneID:64855"
                     /db_xref="HGNC:HGNC:25282"
                     /db_xref="MIM:614045"
     exon            1..254
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2440
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /note="isoform 1 is encoded by transcript variant 1;
                     niban-like protein 1; melanoma invasion by ERK; family
                     with sequence similarity 129 member B; protein Niban 2"
                     /codon_start=1
                     /product="protein Niban 2 isoform 1"
                     /protein_id="NP_073744.2"
                     /db_xref="CCDS:CCDS35145.1"
                     /db_xref="GeneID:64855"
                     /db_xref="HGNC:HGNC:25282"
                     /db_xref="MIM:614045"
                     /translation="MGDVLSTHLDDARRQHIAEKTGKILTEFLQFYEDQYGVALFNSM
                     RHEIEGTGLPQAQLLWRKVPLDERIVFSGNLFQHQEDSKKWRNRFSLVPHNYGLVLYE
                     NKAAYERQVPPRAVINSAGYKILTSVDQYLELIGNSLPGTTAKSGSAPILKCPTQFPL
                     ILWHPYARHYYFCMMTEAEQDKWQAVLQDCIRHCNNGIPEDSKVEGPAFTDAIRMYRQ
                     SKELYGTWEMLCGNEVQILSNLVMEELGPELKAELGPRLKGKPQERQRQWIQISDAVY
                     HMVYEQAKARFEEVLSKVQQVQPAMQAVIRTDMDQIITSKEHLASKIRAFILPKAEVC
                     VRNHVQPYIPSILEALMVPTSQGFTEVRDVFFKEVTDMNLNVINEGGIDKLGEYMEKL
                     SRLAYHPLKMQSCYEKMESLRLDGLQQRFDVSSTSVFKQRAQIHMREQMDNAVYTFET
                     LLHQELGKGPTKEELCKSIQRVLERVLKKYDYDSSSVRKRFFREALLQISIPFLLKKL
                     APTCKSELPRFQELIFEDFARFILVENTYEEVVLQTVMKDILQAVKEAAVQRKHNLYR
                     DSMVMHNSDPNLHLLAEGAPIDWGEEYSNSGGGGSPSPSTPESATLSEKRRRAKQVVS
                     VVQDEEVGLPFEASPESPPPASPDGVTEIRGLLAQGLRPESPPPAGPLLNGAPAGESP
                     QPKAAPEASSPPASPLQHLLPGKAVDLGPPKPSDQETGEQVSSPSSHPALHTTTEDSA
                     GVQTEF"
     exon            255..385
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            386..514
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            515..620
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            621..788
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            789..904
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1009
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1172
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1360
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1516
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1633
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1741
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1853
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..3942
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3924..3929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /note="hexamer: AATAAA"
     polyA_site      3942
                     /gene="NIBAN2"
                     /gene_synonym="bA356B19.6; C9orf88; FAM129B; MEG-3;
                     MINERVA; OC58"
                     /note="major polyA site"
ORIGIN      
        1 aaggcggccg gctggaggga cggggcccga ccgggagcgg agccggagcg gaagccgcag
       61 ccgggcggcg ggagcggcgg gagcggcggg agcgggggaa gcagggcggg ccgggctcca
      121 tggcgccagc ggcgtccgcc tgagcagcgc gggcaacagc ggcggcgtcg gccggatcgg
      181 gccgcgacac ctcctggcca tgggggacgt gctgtccacg cacctggacg acgcccggcg
      241 ccagcacatc gcagaaaaaa ccgggaagat cctgacggag ttcctccagt tctatgaaga
      301 ccagtatggc gtggctctct tcaacagcat gcgccatgag attgagggca cggggctgcc
      361 gcaggcccag ctgctctggc gcaaggtgcc actggacgag cgcatcgtct tctcggggaa
      421 cctcttccag caccaggagg acagcaagaa gtggagaaac cgcttcagcc tcgtgcccca
      481 caactacggg ctggtgctct acgaaaacaa agcggcctat gagcggcagg tcccaccacg
      541 agccgtcatc aacagtgcag gctacaaaat cctcacgtcc gtggaccaat acctggagct
      601 cattggcaac tccttaccag ggaccacggc aaagtcgggc agtgccccca tcctcaagtg
      661 ccccacacag ttcccgctca tcctctggca tccttatgcg cgtcactact acttctgcat
      721 gatgacagaa gccgagcagg acaagtggca ggctgtgctg caggactgca tccggcactg
      781 caacaatgga atccctgagg actccaaggt agagggccct gcgttcacag atgccatccg
      841 catgtaccga cagtccaagg agctgtacgg cacctgggag atgctgtgtg ggaacgaggt
      901 gcagatcctg agcaacctgg tgatggagga gctgggccct gagctgaagg cagagctcgg
      961 cccgcggctg aaggggaaac cgcaggagcg gcagcggcag tggatccaga tctcggacgc
     1021 cgtgtaccac atggtgtacg agcaggccaa ggcgcgcttc gaggaggtgc tgtccaaggt
     1081 gcagcaggtg cagccggcca tgcaggccgt catccgaact gacatggacc aaattatcac
     1141 ctccaaggag caccttgcca gcaagatccg agccttcatc ctccccaagg cagaggtgtg
     1201 cgtgcggaac catgtccagc cctacatccc atccatcctg gaggccctga tggtccccac
     1261 cagccagggc ttcactgagg tgcgagatgt cttcttcaag gaggtcacgg acatgaacct
     1321 gaacgtcatc aacgagggcg gcattgacaa gctgggcgag tacatggaga agctgtcccg
     1381 gctggcgtac caccccctga agatgcagag ctgctatgag aagatggagt cgctgcgact
     1441 ggacgggctg cagcagcgat ttgatgtgtc cagcacgtcc gtgttcaagc agcgagccca
     1501 gatccacatg cgggagcaaa tggacaatgc cgtgtatacg ttcgagaccc tcctgcacca
     1561 ggagctgggg aaggggccca ccaaggagga gctgtgcaag tccatccagc gggtcctgga
     1621 gcgggtgctg aagaaatacg actacgacag cagctctgtg cggaagaggt tcttccggga
     1681 ggcgctgctg cagatcagca tcccgttcct gctcaagaag ctggccccta cctgcaagtc
     1741 ggagctgccc cggttccagg agctgatctt cgaggacttt gccaggttca tcctggtgga
     1801 aaacacgtac gaggaggtgg tgctgcagac cgtcatgaag gacatcctgc aggctgtgaa
     1861 ggaggccgcg gtgcagagga agcacaacct ctaccgggac agcatggtca tgcacaacag
     1921 cgaccccaac ctgcacctgc tggccgaggg cgcccccatc gactggggcg aggagtacag
     1981 caacagcggc gggggcggca gccccagccc cagcaccccg gagtcagcca ccctctcgga
     2041 aaagcgacgg cgcgccaagc aggtggtctc tgtggtccag gatgaggagg tggggctgcc
     2101 ctttgaggct agccctgagt caccaccacc tgcgtccccg gacggtgtca ctgagatccg
     2161 aggcctgctg gcccaaggtc tgcggcctga gagcccccca ccagccggcc ccctgctcaa
     2221 cggggccccc gctggggaga gtccccagcc taaggccgcc cccgaggcct cctcgccgcc
     2281 tgcctcaccc ctccagcatc tcctgcctgg aaaggctgtg gaccttgggc cccccaagcc
     2341 cagcgaccag gagactggag agcaggtgtc cagccccagc agccaccccg ccctccacac
     2401 caccaccgag gacagtgcag gggtgcagac tgagttctag gccagtgggt ccctgactgc
     2461 tgcacatggc acaggccgtt cccttccgga cccaggcagg ctcagctctg gggagggcac
     2521 cctggtctgt gccttgtggg tggaggcggg gcagggctgt gtggcaccgc cagggagcgg
     2581 gcccacctga gtcactttat tgggttcagt caacactttc ttgctccctg ttttctcttc
     2641 tgtgggatga tctcagatgc aggggctggt tttggggttt tcctgcttgt gccaagggct
     2701 ggacactgct ggggggctgg aaagcccctc ccttcctgtc cttctgtggc ctccatcccc
     2761 tcatgggtgc tgccatcctt cctggagaga gggaggtgaa agctggtgtg agcccagtgg
     2821 gttcccgccc actcacccag gagctggctg ggccaggacc gggagaggga gcactgctgc
     2881 cctcctggcc ctgctccttc cgcagttagg ggtggaccga gcctcgcttt ccccactgtt
     2941 ctggagggaa ggggaaggag ggggtcttca ggctggagcc aggctggggg tgctgggtgg
     3001 agagatgaga tttagggggt gcctcatggg gtgggcaggc ctggggtgaa atgagaaagg
     3061 cccagaacgt gcaggtctgc ggaggggaag tgtcctgagt gaaggagggg acccccatcc
     3121 tgggggatgc tgggagtgag tgagtgagat ggctgagtga gggttatggg gagcctgagg
     3181 ttttatgggc ctgtgtatcc ccttctcccg gccccagcct gcctccctcc tgcccgcctg
     3241 gcccacaggt ctccctctgg tccctgtccc tctggtggtt ggggatggag cggcagcaag
     3301 gggtgtaatg gggctgggtt ctgtcttcta caggccaccc cgaggtcctc agtggttgcc
     3361 tggggagccg gacggggctc ctgaggggta caggttgggt gggccctccc tgagggtctg
     3421 gggtcaggct ttggcctctg ctgcctctca gtcaccaagt cacctccctc tgaaaatcca
     3481 gtcccttctt tggatgtcct tgtgagtcac tctgggcctg gctgtcgtcc ctcctcagct
     3541 tcttgttcct gggacaaggg tcaagccagg atgggcccag gcctgggatc ccccacccca
     3601 ggacccccag gccccctccc ctgctgcttt gcggggggca gggcagaaat ggactccttt
     3661 tgggtccccg aggtggggtc ccctcccagc cctgcatcct ccgtgcccta gacctgctcc
     3721 ccagaggagg ggccttgacc cacaggacgt gtggtggcgc ctggcactca gggaccccca
     3781 gctgccgcag ccctggtctc tggcgcatct cttccctctt gtcccgaaga tctgcgcctc
     3841 tagtgccttt tgaggggttc ccatcatccc tccctgatat tgtattgaaa atattatgca
     3901 cactgttcat gcttctacta atcaataaac gctttattta aa
//
