LOCUS       NM_052966               6884 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens niban apoptosis regulator 1 (NIBAN1), mRNA.
ACCESSION   NM_052966 NM_022083
VERSION     NM_052966.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6884)
  AUTHORS   Liu,G., Zhang,P., Chen,S., Chen,Z., Qiu,Y., Peng,P., Huang,W.,
            Cheng,F., Zhang,Y., Li,H., Xiao,Q., Mao,F., Wang,B., Jiang,X.,
            Wan,F., Guo,D. and Yu,X.
  TITLE     FAM129A promotes self-renewal and maintains invasive status via
            stabilizing the Notch intracellular domain in glioma stem cells
  JOURNAL   Neuro Oncol 25 (10), 1788-1801 (2023)
   PUBMED   37083136
  REMARK    GeneRIF: FAM129A promotes self-renewal and maintains invasive
            status via stabilizing the Notch intracellular domain in glioma
            stem cells.
REFERENCE   2  (bases 1 to 6884)
  AUTHORS   Cao,J.W., Cui,W.F. and Zhu,H.J.
  TITLE     The negative feedback loop FAM129A/CXCL14 aggravates the
            progression of esophageal cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 26 (12), 4220-4227 (2022)
   PUBMED   35776020
  REMARK    GeneRIF: The negative feedback loop FAM129A/CXCL14 aggravates the
            progression of esophageal cancer.
REFERENCE   3  (bases 1 to 6884)
  AUTHORS   Ayesha,M., Majid,A., Zhao,D., Greenaway,F.T., Yan,N., Liu,Q.,
            Liu,S. and Sun,M.Z.
  TITLE     MiR-4521 plays a tumor repressive role in growth and metastasis of
            hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT
            pathway via targeting FAM129A
  JOURNAL   J Adv Res 36, 147-161 (2021)
   PUBMED   35127170
  REMARK    GeneRIF: MiR-4521 plays a tumor repressive role in growth and
            metastasis of hepatocarcinoma cells by suppressing phosphorylation
            of FAK/AKT pathway via targeting FAM129A.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6884)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 6884)
  AUTHORS   Ji,H., Ding,Z., Hawke,D., Xing,D., Jiang,B.H., Mills,G.B. and Lu,Z.
  TITLE     AKT-dependent phosphorylation of Niban regulates nucleophosmin- and
            MDM2-mediated p53 stability and cell apoptosis
  JOURNAL   EMBO Rep 13 (6), 554-560 (2012)
   PUBMED   22510990
  REMARK    Erratum:[EMBO Rep. 2014 Sep;15(9):1000]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6884)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 6884)
  AUTHORS   Matsumoto,F., Fujii,H., Abe,M., Kajino,K., Kobayashi,T.,
            Matsumoto,T., Ikeda,K. and Hino,O.
  TITLE     A novel tumor marker, Niban, is expressed in subsets of thyroid
            tumors and Hashimoto's thyroiditis
  JOURNAL   Hum Pathol 37 (12), 1592-1600 (2006)
   PUBMED   16949643
  REMARK    GeneRIF: Niban expression is up-regulated in various types of
            thyroid tumors.
REFERENCE   8  (bases 1 to 6884)
  AUTHORS   Cerutti,J.M., Delcelo,R., Amadei,M.J., Nakabashi,C., Maciel,R.M.,
            Peterson,B., Shoemaker,J. and Riggins,G.J.
  TITLE     A preoperative diagnostic test that distinguishes benign from
            malignant thyroid carcinoma based on gene expression
  JOURNAL   J Clin Invest 113 (8), 1234-1242 (2004)
   PUBMED   15085203
REFERENCE   9  (bases 1 to 6884)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
REFERENCE   10 (bases 1 to 6884)
  AUTHORS   Majima,S., Kajino,K., Fukuda,T., Otsuka,F. and Hino,O.
  TITLE     A novel gene 'Niban' upregulated in renal carcinogenesis: cloning
            by the cDNA-amplified fragment length polymorphism approach
  JOURNAL   Jpn J Cancer Res 91 (9), 869-874 (2000)
   PUBMED   11011112
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF288391.1, AB050477.1 and
            AL096819.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_052966.3.
            
            Summary: This gene encodes a member of the family with sequence
            similarity 129 protein family. This gene is highly expressed in
            several cancer cells and may serve as a prognostic marker for
            certain cancers. The encoded protein may play a role in regulating
            p53-mediated apoptosis. [provided by RefSeq, Sep 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288391.1, SRR1660809.242632.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367511.4/ ENSP00000356481.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2982              AF288391.1         43-3024
            2983-3998           AB050477.1         2987-4002
            3999-6884           AL096819.17        117104-119989       c
FEATURES             Location/Qualifiers
     source          1..6884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..6884
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /note="niban apoptosis regulator 1"
                     /db_xref="GeneID:116496"
                     /db_xref="HGNC:HGNC:16784"
                     /db_xref="MIM:619294"
     exon            1..207
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..2939
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /note="cell growth-inhibiting gene 39 protein; family with
                     sequence similarity 129 member A"
                     /codon_start=1
                     /product="protein Niban 1"
                     /protein_id="NP_443198.1"
                     /db_xref="CCDS:CCDS1364.1"
                     /db_xref="GeneID:116496"
                     /db_xref="HGNC:HGNC:16784"
                     /db_xref="MIM:619294"
                     /translation="MGGSASSQLDEGKCAYIRGKTEAAIKNFSPYYSRQYSVAFCNHV
                     RTEVEQQRDLTSQFLKTKPPLAPGTILYEAELSQFSEDIKKWKERYVVVKNDYAVESY
                     ENKEAYQRGAAPKCRILPAGGKVLTSEDEYNLLSDRHFPDPLASSEKENTQPFVVLPK
                     EFPVYLWQPFFRHGYFCFHEAADQKRFSALLSDCVRHLNHDYMKQMTFEAQAFLEAVQ
                     FFRQEKGHYGSWEMITGDEIQILSNLVMEELLPTLQTDLLPKMKGKKNDRKRTWLGLL
                     EEAYTLVQHQVSEGLSALKEECRALTKGLEGTIRSDMDQIVNSKNYLIGKIKAMVAQP
                     AEKSCLESVQPFLASILEELMGPVSSGFSEVRVLFEKEVNEVSQNFQTTKDSVQLKEH
                     LDRLMNLPLHSVKMEPCYTKVNLLHERLQDLKSRFRFPHIDLVVQRTQNYMQELMENA
                     VFTFEQLLSPHLQGEASKTAVAIEKVKLRVLKQYDYDSSTIRKKIFQEALVQITLPTV
                     QKALASTCKPELQKYEQFIFADHTNMIHVENVYEEILHQILLDETLKVIKEAAILKKH
                     NLFEDNMALPSESVSSLTDLKPPTGSNQASPARRASAILPGVLGSETLSNEVFQESEE
                     EKQPEVPSSLAKGESLSLPGPSPPPDGTEQVIISRVDDPVVNPVATEDTAGLPGTCSS
                     ELEFGGTLEDEEPAQEEPEPITASGSLKALRKLLTASVEVPVDSAPVMEEDTNGESHV
                     PQENEEEEEKEPSQAAAIHPDNCEESEVSEREAQPPCPEAHGEELGGFPEVGSPASPP
                     ASGGLTEEPLGPMEGELPGEACTLTAHEGRGGKCTEEGDASQQEGCTLGSDPICLSES
                     QVSEEQEEMGGQSSAAQATASVNAEEIKVARIHECQWVVEDAPNPDVLLSHKDDVKEG
                     EGGQESFPELPSEE"
     exon            208..338
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            339..470
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            471..585
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            586..753
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            754..869
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            870..974
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1137
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1325
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1487
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1598
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1706
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1818
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..6884
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6864..6869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /note="hexamer: AATAAA"
     polyA_site      6884
                     /gene="NIBAN1"
                     /gene_synonym="C1orf24; FAM129A; GIG39; NIBAN"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcgac gcctcttgcc tcctgtctct cgcctctcga aggaagtttg ctcttaattt
       61 cagagccggg ttcgccgtcg gatcaacctc caggagctag cagcgggcgc ggaccgggca
      121 gtttccgcgc tcagcacagg cagctcgcgg tcatgggcgg ctcagcctcc agccagctgg
      181 acgagggcaa gtgcgcttac atccgaggga aaactgaggc tgccatcaaa aacttcagtc
      241 cctactacag tcgtcagtac tctgtggctt tctgcaatca cgtgcgcact gaagtagaac
      301 agcaaagaga tttaacgtca cagtttttga agaccaagcc accattggcg cctggaacta
      361 ttttgtatga agcagagcta tcacaatttt ctgaagacat aaagaagtgg aaggagagat
      421 acgttgtagt taaaaatgat tatgctgtgg agagctatga gaataaagag gcctatcaga
      481 gaggagctgc tcctaaatgt cgaattcttc cagccggtgg caaggtgtta acctcagaag
      541 atgaatataa tctgttgtct gacaggcatt tcccagaccc tcttgcctcc agtgagaagg
      601 agaacactca gccctttgtg gtcctgccca aggaattccc agtgtacctg tggcagccct
      661 tcttcagaca cggctacttc tgcttccacg aggctgctga ccagaagagg tttagtgccc
      721 tcctgagtga ctgcgtcagg catctcaatc atgattacat gaagcagatg acatttgaag
      781 cccaagcctt tttagaagct gtgcaattct tccgacagga gaagggtcac tatggttcct
      841 gggaaatgat cactggggat gaaatccaga tcctgagtaa cctggtgatg gaggagctcc
      901 tgcccactct tcagacagac ctgctgccta agatgaaggg gaagaagaat gacagaaaga
      961 ggacgtggct tggtctcctc gaggaggcct acaccctggt tcagcatcaa gtttcagaag
     1021 gattaagtgc cttgaaggag gaatgcagag ctctgacaaa gggcctggaa ggaacgatcc
     1081 gttctgacat ggatcagatt gtgaactcaa agaactattt aattggaaag atcaaagcga
     1141 tggtggccca gccggcggag aaaagctgct tggagagtgt gcagccattc ctggcatcca
     1201 tcctggagga gctcatggga ccagtgagct cgggattcag tgaagtacgt gtactctttg
     1261 agaaagaggt gaatgaagtc agccagaact tccagaccac caaagacagt gtccagctaa
     1321 aggagcatct agaccggctt atgaatcttc cgctgcattc cgtgaagatg gaaccttgtt
     1381 atactaaagt caacctgctt cacgagcgcc tgcaggatct caagagccgc ttcagattcc
     1441 cccacattga tctggtggtt cagaggacac agaactacat gcaggagcta atggagaatg
     1501 cagtgttcac ttttgagcag ttgctttccc cacatctcca aggagaggcc tccaaaactg
     1561 cagttgccat tgagaaggtt aaactccgag tcttaaagca atatgattat gacagcagca
     1621 ccatccgaaa gaagatattt caagaggcac tagttcaaat cacacttccc actgtgcaga
     1681 aggcactggc gtccacatgc aaaccagagc ttcagaaata cgagcagttc atctttgcag
     1741 atcataccaa tatgattcac gttgaaaatg tctatgagga gattttacat cagatcctgc
     1801 ttgatgaaac tctgaaagtg ataaaggaag ctgctatctt gaagaaacac aacttatttg
     1861 aagataacat ggccttgccc agtgaaagtg tgtccagctt aacagatcta aagcccccca
     1921 cagggtcaaa ccaggccagc cctgccagga gagcttctgc cattctgcca ggagttctgg
     1981 gtagtgagac cctcagtaac gaagtattcc aggagtcaga ggaagagaag cagcctgagg
     2041 tccctagctc gttggccaaa ggagaaagcc tttctctccc tgggccaagc ccacccccag
     2101 atgggactga gcaggtgatt atttcaagag tggatgaccc cgtggtgaat cctgtggcaa
     2161 cagaggacac agcaggactc ccgggcacat gctcatcaga gctggagttt ggagggaccc
     2221 ttgaggatga agaacccgcc caggaagagc cagaacccat cactgcctcg ggttctttga
     2281 aggcgctcag aaagttgctg acagcgtccg tggaagtacc agtggactct gctccagtga
     2341 tggaagaaga tacgaatggg gagagccacg ttccccaaga aaatgaagaa gaagaggaaa
     2401 aagagcccag tcaggcagct gccatccacc ccgacaactg tgaagaaagt gaagtcagcg
     2461 agagggaggc ccaacctccc tgtcccgagg cccatgggga ggagttgggg ggatttccag
     2521 aggtaggcag cccagcctct ccgccagcca gtggagggct caccgaggag cccctggggc
     2581 ccatggaggg ggagctccca ggagaggcct gcacactcac tgcccatgaa ggaagagggg
     2641 gcaagtgtac cgaggaaggg gatgcctcac agcaagaggg ctgcacctta ggttctgacc
     2701 ccatctgcct cagtgagagc caggtttctg aggaacaaga agagatggga gggcaaagca
     2761 gcgcggccca ggccacggcc agtgtgaatg cagaggagat caaggtagcc cgtattcatg
     2821 agtgtcagtg ggtggtggag gatgctccaa acccggatgt cctgctgtca cacaaagatg
     2881 acgtgaagga gggagaaggt ggtcaggaga gtttcccaga gctgccctca gaggagtgaa
     2941 agggacaatt tggctgaagt ctttctctga aaaaagccaa agggttatag gggtacactt
     3001 aggggttgca tgcaagctgt taccaaaaaa tttttaagta ttttcttaat ttgaataata
     3061 aaaccagagg aaatgcatac agggcatgag caactgaggc aaacctttgt ggacatgaat
     3121 tgttctacga tgaatttttg ctttagtatt ttaataagaa ttacaaagac aatggcatac
     3181 ttggggtgag agggagctga ggatgtctga ggagggaata gtattgcagg gaagactgag
     3241 aaaacagtag gatgacagtt ttgagtatac tctgcacttt tcaattgtgc aatcttcttg
     3301 tgcactttaa ggctttttaa ttttgtttga gaatgcaaat gtatactgta agtctacctt
     3361 tactatctac tatgcctact tcaccatctc ttaaggactc ggcatttgtc cacagtcaga
     3421 ctgcaagaga gggtaggtca tgaacagtca cccgtgctgg ctgtagcccc cacagaggca
     3481 atcatgccca atagattcaa gagaagctaa gcggaaatgg agggtggaag gtgtgatctg
     3541 tgggactgtc tgggcctgtt actcatcctg ctatcaattt cttattaatt aatcttgatg
     3601 attcttatta attaatcaca tttgcaggaa attcagatga ggcaagaaaa ttttattggc
     3661 ctgggtaaga ctgaaagcat tccaaattag gcttagactg tgcaaagggc ttagctaagt
     3721 tatcgagctt aaaacccgtc aattaaacaa acattatttg aacagttact gcatgccacg
     3781 cactgtgttg ggcttagtaa taaaaaaaag aaaagataag tgcttgttct agcataaatt
     3841 aaaaggtcca agggaattta atctggaaga gaacatatgc caatttttaa actatgacag
     3901 cttttttttt tctctttcca ttcaaatagt cctggttcat tcccagaagg gcacaaaatg
     3961 aatgaataaa taaataaatg aataaagaca aaagccaagg tgtatgctct caagttccaa
     4021 agatgttatc aaaagctgaa atcatttgtt tggtcattca gcaagctaat tgagtctctg
     4081 ttatatacca agcactgggg ataccatggc gaaaaacaac tttgttcctt cctcctagaa
     4141 cttacatttt aatggaaata gacaaaacac atcttcttaa cggatggtga cctataacca
     4201 ttaatgttga aaatggaaga gacttgcttc caaaagatta aaaggagttg ttcttttctc
     4261 cttcagaaaa ataccagatc atttcctaaa atctccagtc ccaagtatta catcgtggtt
     4321 tccctccccg actttttatt ttattttatt ctattttttt gagatggagt ctcactctgt
     4381 cgccaaggct ggagtgcagt ggtgtgatct cggctcactg caacctccgc ctcctgggtt
     4441 caggagattc tcctctgtca gcgtcccaag tagctggaat tacagccatg cggcaccatt
     4501 cccggctaat ttttgtattt ttggtagaga tgggttttca ccatgttggc caggctggtc
     4561 tcaaactcct gatttcaagc gatccaccca cctcgacttc ccaaagtgct gggattacag
     4621 cgtgagctac ctggcccctc cccaaatttt aacatcagat ctcaacatat ttgttgagaa
     4681 cttgtttaga tcatcactat cgagtaaatt tatgtcagtt ctttagagca tttgcttcac
     4741 acacagttca accatttaac cagaaattaa aatatcaccc ttttcagccc tcccatgaag
     4801 aatttctagg tcataaacat gaataatact cagtatatgt ataatatcat atttaattgt
     4861 tgcaactttt cttggcgtgt ttaaatcctc atgtctttga gggatcccac cacaggtgaa
     4921 ggaagtaaag accacttctc ccccagtctc tgctttctgc agtgctcact catatcctgg
     4981 catttagcat ggtgtgttga aattaggttt acttcttgtc tctccaagtg gctcctctct
     5041 taaaagacag aaactagggt ttagtcatca tttgtgcttc ctgctagaaa cccacagcct
     5101 tgaataatgg cttcctgcct ccttgagtca ctttaatatc cctggtgcat aggacctggc
     5161 atgcgtcagg ctgctcggga aatgtgggaa ctggacaccc agaacactgc tgtgctgggg
     5221 ctatttgggg cctgctgtca ggcagaaaga cgttttgaat tgggctttct gcccttgttg
     5281 agttttctct taagtaaagt ccaaagtcca aggggcagat ggccagatgc actgcccagt
     5341 aaggcaggaa gccaaagagg cagtgcccag ccccacaaag gctgcccgac tccctgggac
     5401 agtagtgtgg agtcccagcc caggctgacc tcacaccgga gcttcctagc ttcctttctt
     5461 tgctcaatgc agggcttctt gcaccccctg gaaagctaag agattttttt caaccctaaa
     5521 agagagtacc tttcactgca ttggatggat gaacatcagt gccctaactt tatccatcat
     5581 gtaggtcagg gaggactggg cactatttgg caggatgtac tccagaatat aatcaaagaa
     5641 ttttctgtac atatttcact aaagacaagt ttttgggctg gatgtggtag cttacaccta
     5701 taatcccagc actttgggag gctgaggtga gagggtcact tgagcccagg agttctagac
     5761 aagcctggga aacatagcaa gatctcatcc ttacaaaaaa taataatggt gtgtgcctgc
     5821 agtcctagct acttgggtgg ttgaggcagg aggattgttt gagcgaggga agttgaggct
     5881 gcagtgaact atgattttac cactgcactc cagcttgggc aacaaaatga gaccctgtct
     5941 caaaaaaaaa aaaaaagttt tctagaataa gcaggatgat tgtttaattt gaagatggaa
     6001 caggaaacta gagtgcattt aaaatactct gtcttcattt taacatgttg aatggaataa
     6061 ctgcatatca ccatgagttt gttttgcttt tcatacagac ttgtatgtgt catttgagtg
     6121 gtttccagat tggagcgagg ttattctgat ctaaatgaac agcatttttt tccttagcct
     6181 ctgtttgcca ctctgggtat ctctcctatg ggcaaagcca ttagaaatgc ataaaacctc
     6241 gagacatggt ttttggcaaa aactccatga ctttaaacta gctcttttac tactgacctt
     6301 tcacagagaa aaaatatttc ccttgaaaaa aactgggctt gtcatttttt cccttgtagc
     6361 tttaagcaga gacataagtg ccttgcatta cacatagtaa actttcttta aaaaaaaaaa
     6421 aaaaagattt tggagactac cagggtaaga ttccaacttg tccaaaagct ttctggcctt
     6481 acatatttta ttataaaaat tctcaagtct ggtaatcttc tatgtcagag ctagtgattt
     6541 caaaaggttt cacaattccc caagacaaaa gtgattttcg ttcattataa taaggttaag
     6601 tgatatgtga ttcatagcaa ttttgatgtg aagaagggaa ggacatcatt gacttaataa
     6661 tagtatcagt cggtgcaaca gttggcaaca tgtgccttca cactttacca taaagagacg
     6721 ggtttgaggg tttgccttct aaagtctgca acttcaagaa aaaaaatcga cactgtggat
     6781 tgactttccc ggtcactata taaagcaaat aaacttaaaa cactttgtaa ccatgtattt
     6841 actctgccag gtgcctatat tccaataaaa tgttcatcct tgaa
//
