LOCUS       NM_020888               5493 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens NHS like 3 (NHSL3), transcript variant 1, mRNA.
ACCESSION   NM_020888 XM_036299
VERSION     NM_020888.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5493)
  AUTHORS   Guo,Y., Tian,S., Li,H., Zuo,S., Yu,C. and Sun,C.
  TITLE     Transcription factor KLF9 inhibits the proliferation, invasion, and
            migration of pancreatic cancer cells by repressing KIAA1522
  JOURNAL   Asia Pac J Clin Oncol 20 (3), 423-432 (2024)
   PUBMED   38520660
  REMARK    GeneRIF: Transcription factor KLF9 inhibits the proliferation,
            invasion, and migration of pancreatic cancer cells by repressing
            KIAA1522.
REFERENCE   2  (bases 1 to 5493)
  AUTHORS   Palukuri,M.V., Patil,R.S. and Marcotte,E.M.
  TITLE     Molecular complex detection in protein interaction networks through
            reinforcement learning
  JOURNAL   BMC Bioinformatics 24 (1), 306 (2023)
   PUBMED   37532987
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5493)
  AUTHORS   Ou,M., Chu,Y., Zhang,Q., Zhao,H. and Song,Q.
  TITLE     HOXA cluster antisense RNA 2 elevates KIAA1522 expression through
            microRNA-520d-3p and insulin like growth factor 2 mRNA binding
            protein 3 to promote the growth of vascular smooth muscle cells in
            thoracic aortic aneurysm
  JOURNAL   ESC Heart Fail 9 (5), 2955-2966 (2022)
   PUBMED   35730141
  REMARK    GeneRIF: HOXA cluster antisense RNA 2 elevates KIAA1522 expression
            through microRNA-520d-3p and insulin like growth factor 2 mRNA
            binding protein 3 to promote the growth of vascular smooth muscle
            cells in thoracic aortic aneurysm.
REFERENCE   4  (bases 1 to 5493)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5493)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5493)
  AUTHORS   Wang,B., Jing,T., Jin,W., Chen,J., Wu,C., Wang,M. and Liu,Y.
  TITLE     KIAA1522 potentiates TNFalpha-NFkappaB signaling to antagonize
            platinum-based chemotherapy in lung adenocarcinoma
  JOURNAL   J Exp Clin Cancer Res 39 (1), 170 (2020)
   PUBMED   32854746
  REMARK    GeneRIF: KIAA1522 potentiates TNFalpha-NFkappaB signaling to
            antagonize platinum-based chemotherapy in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5493)
  AUTHORS   Li,Y., Wang,Y., Fan,H., Zhang,Z. and Li,N.
  TITLE     miR-125b-5p inhibits breast cancer cell proliferation, migration
            and invasion by targeting KIAA1522
  JOURNAL   Biochem Biophys Res Commun 504 (1), 277-282 (2018)
   PUBMED   30177391
  REMARK    GeneRIF: miR-125b-5p functions as a tumor suppressor and regulates
            breast cancer cell progression through targeting KIAA1522
REFERENCE   8  (bases 1 to 5493)
  AUTHORS   Liu,Y.Z., Yang,H., Cao,J., Jiang,Y.Y., Hao,J.J., Xu,X., Cai,Y. and
            Wang,M.R.
  TITLE     KIAA1522 is a novel prognostic biomarker in patients with non-small
            cell lung cancer
  JOURNAL   Sci Rep 6, 24786 (2016)
   PUBMED   27098511
  REMARK    GeneRIF: high expression of KIAA1522 can be used as an independent
            biomarker for predication of poor survival and platinum-resistance
            of NSCLC patients, and aberrant KIAA1522 might be a new target for
            the therapy of the disease.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5493)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114489.2, AI587184.1, AB040955.1 and AL713671.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020888.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401073.7/ ENSP00000383851.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC114489.2         106027-106107
            82-360              AI587184.1         28-306
            361-970             AB040955.1         162-771
            971-3387            AC114489.2         134222-136638
            3388-5493           AL713671.1         962-3067
FEATURES             Location/Qualifiers
     source          1..5493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..5493
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /note="NHS like 3"
                     /db_xref="GeneID:57648"
                     /db_xref="HGNC:HGNC:29301"
     exon            1..360
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..3410
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NHS-like protein 3"
                     /codon_start=1
                     /product="NHS-like protein 3 isoform 1"
                     /protein_id="NP_065939.2"
                     /db_xref="CCDS:CCDS41298.1"
                     /db_xref="GeneID:57648"
                     /db_xref="HGNC:HGNC:29301"
                     /translation="MAARAPPAAPAAEEPGNPGGPPRRKKSRSGASGLRRAFSWLRGK
                     RRKKKAAGAEGAEPAAPRAKKAEDKAKRAKGKGRGSAKAENDKHLSVGPGQGPGSAVD
                     EHQDNVFFPSGRPPHLEELHTQAQEGLRSLQHQEKQKLNKGGWDHGDTQSIQSSRTGP
                     DEDNISFCSQTTSYVAESSTAEDALSIRSEMIQRKGSTFRPHDSFPKSGKSGRRRRER
                     RSTVLGLPQHVQKELGLRNEREAPGTPRAPGARDAVRIPTVDGRPRGTSGMGARVSLQ
                     ALEAEAEAGAETEAMLQRHIDRVYRDDTFVGRSTGTRAPPLTRPMSLAVPGLTGGAGP
                     AEPLSPAMSISPQATYLSKLIPHAVLPPTVDVVALGRCSLRTLSRCSLHSASPASVRS
                     LGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTASNS
                     VVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLH
                     QRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGG
                     SRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGA
                     SVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNP
                     AAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPP
                     PPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVA
                     SPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLP
                     QKEPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRR
                     ALSGRASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASF
                     IFSKGSRKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPS
                     VGVPPPASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSD
                     SQKELA"
     exon            361..531
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /inference="alignment:Splign:2.1.0"
     exon            532..587
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /inference="alignment:Splign:2.1.0"
     exon            588..711
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /inference="alignment:Splign:2.1.0"
     exon            712..825
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /inference="alignment:Splign:2.1.0"
     exon            826..3387
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..5493
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5475..5480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /note="hexamer: ATTAAA"
     polyA_site      5493
                     /gene="NHSL3"
                     /gene_synonym="KIAA1522"
                     /note="major polyA site"
ORIGIN      
        1 ctccgcgccc gctcggcctc cgccgcccaa acttttctcc gggcgcgcgt ccccggcggc
       61 cgcccccggc atgggcaccg cgccgcaggg ggcctgaccc gccgcccgct ccgcccccgc
      121 ctgccatggc ggcccgcgcg ccccccgccg cacctgcggc cgaggagccg gggaacccgg
      181 gcggcccccc gcgcaggaag aagtcccgct ccggcgcgtc cggcctccgc cgcgccttca
      241 gctggctgcg gggcaagcgg cgcaagaaga aggcggcggg ggccgagggc gccgaaccgg
      301 ccgccccccg ggccaagaag gcggaggaca aggccaagag ggccaagggc aaaggccgag
      361 gctctgccaa ggctgagaat gacaaacatc taagtgtagg gcctggccag gggccagggt
      421 ctgcagtgga tgagcaccag gacaacgtct tctttcccag tgggcgaccc ccccacctgg
      481 aagagctgca cactcaggcc caggaggggc tccgctccct acaacaccaa gagaaacaga
      541 aactgaacaa gggtggctgg gaccatggag acacccagag tatccagtcc tcccggacgg
      601 ggccggatga agacaacatc tccttctgca gtcagaccac atcctacgtg gctgagagct
      661 ccacagcaga ggacgcgctc tccatccgct cggagatgat ccagcgcaaa ggctccacct
      721 tccgacccca tgactcattt cccaaatctg gaaagtcagg gcggcgtcgg cgggagcggc
      781 ggagcactgt gctgggactc ccgcagcatg tgcagaagga gcttggcctg aggaatgagc
      841 gtgaggcacc aggcacgccc cgggctcctg gtgcacggga tgccgtacgc atccccacag
      901 tggacggccg cccccgaggc acctcaggga tgggggcccg ggtgtccctg caggcgctgg
      961 aggcggaggc ggaggctggc gctgagacag aggccatgct gcagcgccac attgaccgtg
     1021 tctaccggga tgacaccttt gttggccggt ccacgggtac ccgggcccca ccattgaccc
     1081 ggcccatgtc cctagcagtg cctggattga caggaggggc agggcctgca gagcccctga
     1141 gcccggccat gtccatctcc ccccaggcca cctacctgtc gaagttgatt ccacatgctg
     1201 tgctgccgcc tacagtggac gtggtggccc taggccgctg cagcctgcgc acactaagcc
     1261 gctgcagcct gcactcggcc agcccagcct cagtccgctc gctggggcgc ttctcctccg
     1321 tctccagccc acagccccgc agccgccacc catcctcctc cagtgacacc tggagccact
     1381 ctcaatcctc cgacaccatt gtgtctgacg gttccaccct ctcctctaag ggtggctctg
     1441 agggccagcc ggagagctct acggctagca atagcgtggt accccctccc cagggaggca
     1501 gtgggagggg ctctcccagt gggggcagca ctgctgaggc ctcagacaca ctcagcattc
     1561 ggagcagtgg gcagttgtct ggccggagtg tgtccctgcg taagctgaag cggcctccac
     1621 cccctccccg ccggacccac tccctccatc agcggggctt agcagtgcct gatgggccat
     1681 tagggttgcc ccctaagcct gagcgtaagc agcagcccca gctgcctcgg ccacccacca
     1741 ctggtggctc agaaggggcg ggggcagcac cctgtccacc caacccagcc aacagctggg
     1801 tacctggctt gtctccgggt ggttcccggc gccccccacg gtccccagaa cggacacttt
     1861 cgccctccag tggatactcg agccaaagtg gtactcccac cctccctccc aagggcctgg
     1921 caggtccccc tgcttcccca ggcaaggccc agccccctaa accagagcgt gtcacgtctc
     1981 ttcgctcccc tggggcctcc gtctcctctt ccctcacgtc tttatgttcc tcctcctctg
     2041 acccagcccc ctcagaccgc tctgggccac agatattgac ccccctgggt gacaggtttg
     2101 tcatacctcc tcaccccaag gtgcctgccc ccttctcccc acctccctcc aagcccagga
     2161 gccctaaccc agctgcccct gctctagccg cccctgctgt ggttcctggg cctgtttcta
     2221 ccactgacgc cagtcctcag tcccctccca ctccccagac aaccttgact ccactgcagg
     2281 agtctcctgt catctccaaa gaccagtcac ccccaccttc cccaccccca tcttatcatc
     2341 cacccccacc acccactaag aagccagagg tggttgtgga ggcaccatct gcctcagaga
     2401 ctgctgagga gcccctccaa gatcccaact ggccccctcc cccaccccct gcccctgagg
     2461 agcaggacct gtccatggct gacttccccc caccagagga ggcttttttc tctgtggcca
     2521 gccctgagcc tgcaggccct tcaggctccc cagagcttgt cagctccccg gctgcttcgt
     2581 cctcctcagc tactgctttg cagattcagc ccccgggtag cccagaccct cctccagctc
     2641 cgccagcccc agctcctgct agttccgccc cagggcatgt ggccaagctc cctcagaagg
     2701 aaccggtggg ctgtagcaag ggtggtgggc ctcccaggga ggacgtaggt gcgcccctgg
     2761 tcacgccctc gctcctgcag atggtgcggc tgcgctccgt gggtgctcca ggaggggctc
     2821 ccaccccagc actggggcca tcggcccccc agaaaccact gcgaagggcc ctgtcagggc
     2881 gggccagccc agtgcctgcc ccctcctcag ggctccatgc tgcggtccga ctcaaggcct
     2941 gcagcctggc cgccagtgaa ggcctctcaa gtgctcagcc caacggaccg cctgaggcag
     3001 agccacggcc tccccagtcc cctgcctcaa cggccagttt catcttctcc aagggctcta
     3061 ggaagctgca gctggagcgg cccgtgtccc ctgagaccca ggctgacctc cagcggaatc
     3121 tggtggcaga actccggagc atctcagagc agcggccacc ccaggcccca aagaagtcac
     3181 ctaaggctcc cccacctgtg gcccgcaagc cgtctgtggg agtcccccca cccgcctccc
     3241 ccagttaccc tcgagctgag ccccttactg ctcctcccac caatgggctc cctcacaccc
     3301 aggacaggac taagagggag ctggcggaga atggaggtgt cctgcagctg gtgggcccag
     3361 aggagaagat gggcctcccg ggctcagact cacagaaaga gctggcctga ccaccaggca
     3421 cctcactggc actgctgacc catcccagaa acacaatctc agggacccga gcagctccaa
     3481 ggacgagagg atacagcaga cacaacctaa tagagagggc gcctgcagcc ttaacctcca
     3541 cggccttcga tacttatgca agcctggtgt tgctcctgtc ctcagagtca tcctgcgctc
     3601 atgccttttc ccgaatgggt tcacctctgg cagttgccgc ttcagtcttg gccttagcct
     3661 catcttgaag tgggtagctg gcgggagagg gtggctgcgc cccctgctgg ccctgaggct
     3721 gcagagttgg gagcaggaca cctcacctga gtttcatttt ttttcatgtc caaaccatgc
     3781 acatactata gtccagaatc aaagcacttt tgaaaagtgg ctgcatggcc atcctccagg
     3841 gcccaggaag ttgcattcca agggcctgtt tacatggcag cagaatccat ccccggcagt
     3901 cagcccatag cttgggacca gtctgtgccc tcctgcccag tccagtttac tcctcttggt
     3961 tcctgaaggt ggccaagtca ttgtgttccc acaggcttct ctaggctggg ggcaggtgtg
     4021 gggctgtgga attccaaagc acaaaaggtg cagaggggat tggccttcct gtgcctcaac
     4081 tcaccaacca ccctcctgcc ttccagttct gccaggtgct ccatgctggg gacaagtagg
     4141 agactgccag ggcccaaaga aatgggtgag cagtagagtc atctcggggc acttggcagt
     4201 gtcaagcacc tgccccttgc ctccttgacc acactggggt gggtgggccc ccagcacttc
     4261 agaggcagga gcctttgggc tgagcaagca ctgaggaggt ggatggaagg gagcatctgg
     4321 agggggggag cttccttgag cagtgggccc aggcctggcc ctccacactt cattctctga
     4381 cctttctctc tcctcatttc ggtgcatgtc ctttctgcag ctgcctttca gcacaggtgg
     4441 ttccactggg ggcagctaac gctgagtgac aaggatggga agccacaggt gcattttact
     4501 caagtcttct ctagtcaatg aggggcaccc agtgcttcta gggcaggctg ggtggtggtc
     4561 ccctaggtat cagcctctct tactgtactc tccgggaatg ttaacctttc tattttcagc
     4621 ctgtgccacc tgtctaggca agctggcttc cccattggcc cctgtgggtc cacagcagcg
     4681 tggctgcccc ccagggccac cgcttctttc ttgatcctct ttccttaaca gtgacttggg
     4741 cttgagtctg gcaaggaacc ttgcttttag cttcaccacc aaggagagag gttgacatga
     4801 cctccccgcc ccctcaccaa ggctgggaac agaggggatg tggtgagagc caggttcctc
     4861 tggccctctc cagggtgttt tccactagtc actactgtct tctccttgta gctaatcaat
     4921 caatattctt cccttgcctg tgggcagtgg agagtgctgc tgggtgtacg ctgcacctgc
     4981 ccactgagtt ggggaaagag gataatcagt gagcactgtt ctgctcagag ctcctgatct
     5041 accccacccc ctaggatcca ggactgggtc aaagctgcat gaaaccaggc cctggcagca
     5101 acctgggaat ggctggaggt gggagagaac ctgacttctc tttccctctc cctcctccaa
     5161 cattactgga actctatcct gttaggatct tctgagcttg tttccctgct gggtgggaca
     5221 gaggacaaag gagaagggag ggtctagaag aggcagccct tctttgtcct ctggggtaaa
     5281 tgagcttgac ctagagtaaa tggagagacc aaaagcctct gatttttaat ttccataaaa
     5341 tgttagaagt atatatatac atatatatat ttctttaaat ttttgagtct ttgatatgtc
     5401 taaaaatcca ttccctctgc cctgaagcct gagtgagaca catgaagaaa actgtgtttc
     5461 atttaaagat gttaattaaa tgattgaaac ttg
//
