LOCUS       NM_001301159            2096 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NHL repeat containing 4 (NHLRC4), transcript variant
            1, mRNA.
ACCESSION   NM_001301159
VERSION     NM_001301159.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2096)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2096)
  AUTHORS   Martin,J., Han,C., Gordon,L.A., Terry,A., Prabhakar,S., She,X.,
            Xie,G., Hellsten,U., Chan,Y.M., Altherr,M., Couronne,O., Aerts,A.,
            Bajorek,E., Black,S., Blumer,H., Branscomb,E., Brown,N.C.,
            Bruno,W.J., Buckingham,J.M., Callen,D.F., Campbell,C.S.,
            Campbell,M.L., Campbell,E.W., Caoile,C., Challacombe,J.F.,
            Chasteen,L.A., Chertkov,O., Chi,H.C., Christensen,M., Clark,L.M.,
            Cohn,J.D., Denys,M., Detter,J.C., Dickson,M.,
            Dimitrijevic-Bussod,M., Escobar,J., Fawcett,J.J., Flowers,D.,
            Fotopulos,D., Glavina,T., Gomez,M., Gonzales,E., Goodstein,D.,
            Goodwin,L.A., Grady,D.L., Grigoriev,I., Groza,M., Hammon,N.,
            Hawkins,T., Haydu,L., Hildebrand,C.E., Huang,W., Israni,S.,
            Jett,J., Jewett,P.B., Kadner,K., Kimball,H., Kobayashi,A.,
            Krawczyk,M.C., Leyba,T., Longmire,J.L., Lopez,F., Lou,Y., Lowry,S.,
            Ludeman,T., Manohar,C.F., Mark,G.A., McMurray,K.L., Meincke,L.J.,
            Morgan,J., Moyzis,R.K., Mundt,M.O., Munk,A.C., Nandkeshwar,R.D.,
            Pitluck,S., Pollard,M., Predki,P., Parson-Quintana,B., Ramirez,L.,
            Rash,S., Retterer,J., Ricke,D.O., Robinson,D.L., Rodriguez,A.,
            Salamov,A., Saunders,E.H., Scott,D., Shough,T., Stallings,R.L.,
            Stalvey,M., Sutherland,R.D., Tapia,R., Tesmer,J.G., Thayer,N.,
            Thompson,L.S., Tice,H., Torney,D.C., Tran-Gyamfi,M., Tsai,M.,
            Ulanovsky,L.E., Ustaszewska,A., Vo,N., White,P.S., Williams,A.L.,
            Wills,P.L., Wu,J.R., Wu,K., Yang,J., Dejong,P., Bruce,D.,
            Doggett,N.A., Deaven,L., Schmutz,J., Grimwood,J., Richardson,P.,
            Rokhsar,D.S., Eichler,E.E., Gilna,P., Lucas,S.M., Myers,R.M.,
            Rubin,E.M. and Pennacchio,L.A.
  TITLE     The sequence and analysis of duplication-rich human chromosome 16
  JOURNAL   Nature 432 (7020), 988-994 (2004)
   PUBMED   15616553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA014246.1 and BC032015.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001301159.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA819929.1, DA828687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000424439.3/ ENSP00000410858.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-566               DA014246.1         1-566
            567-2096            BC032015.1         515-2044
FEATURES             Location/Qualifiers
     source          1..2096
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2096
                     /gene="NHLRC4"
                     /note="NHL repeat containing 4"
                     /db_xref="GeneID:283948"
                     /db_xref="HGNC:HGNC:26700"
     exon            1..71
                     /gene="NHLRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            72..2096
                     /gene="NHLRC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             649..1020
                     /gene="NHLRC4"
                     /codon_start=1
                     /product="NHL-repeat-containing protein 4"
                     /protein_id="NP_001288088.1"
                     /db_xref="CCDS:CCDS45366.1"
                     /db_xref="GeneID:283948"
                     /db_xref="HGNC:HGNC:26700"
                     /translation="MLGLEGPCWVGPGPDGGLAVSEEFGDVRLFGSARQPLGSLGGWT
                     GHTFGCPAGICSNSEGNVIVADEQRRQVTLFPRAGPPICLVSEGLGQPLGVACAPQGQ
                     LLVADAKDNSIKVYQGLKELA"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NHLRC4"
                     /note="hexamer: AATAAA"
     polyA_site      2096
                     /gene="NHLRC4"
                     /note="major polyA site"
ORIGIN      
        1 agttctagtt tccaacaaca gaggctgcag ccacccagcc ccgaagcagg gcccagcgag
       61 acagggccca gtggggcctt attctctctc ttgcagcccc aagcgtgacc cagctgcaga
      121 gaagctgaga cggtgattcg gactgactgg actctggcct ccaggtgtct gcacctcaca
      181 ctggacccac ctggagactc cacgggctcc cggcagctcc ggctgcttgg gtggatccgg
      241 gtgcccgcag gggctgtggg agggccccgg ggcctgcact gctcccccga tggcctgctc
      301 ttcctcacgg ccggggctgc accctgtgtc cacgtgctag atctggaggg acgccccatc
      361 tgcctcctgc cctgccgcac tccggggagc ggggccttcg ttccagagga cgtggctgtg
      421 acagcgtcag ggcttgtggt ggtcagcgat cccatccatg gggctgtcca tgcactccag
      481 cacacagccc gggaccccgg gggccactgg gtgacagtgg gcaccttcct gtctccccga
      541 gggctggctg tggatgccct caaccgcctc ctggtgacgg actacttgcc tggggctgtg
      601 cacagcttct cgttgggtcc tgcttgggag cccctggccc cagcctccat gctgggtctg
      661 gagggcccct gctgggtggg cccagggcct gatgggggcc ttgctgtgag tgaggagttt
      721 ggggatgtga ggctgtttgg cagtgcccgc caacccctgg gctccctggg gggctggacg
      781 gggcacactt tcggctgccc agcgggcatc tgctccaact cagagggcaa tgttattgtg
      841 gcagacgagc agaggcgcca ggtgaccctg tttccccggg ctgggccacc catctgcctg
      901 gtgtcagagg ggcttgggca gcccttggga gtggcctgtg caccccaggg ccagctcctg
      961 gtggctgatg ccaaggacaa ctccatcaag gtgtaccagg gcctcaagga gctggcctga
     1021 cctgaggctg ggttggagca gccctcctgt gcctgaggcc agctcccagg cccttggatc
     1081 accgcgggag gaaccctcag gatgggtgga gcctccaggc tatgggcatt gcctgcctga
     1141 tgccagcacc acctgggctg ggccctgggc ttggctcgag ttctcctgct ggtgaggctc
     1201 cggatctcag gagcagccct gagtctgctt cccaggctgc ccctgccagg cctgcagcct
     1261 ccccagccag ggctgctctc tgctgtcccc attcagtgcc ctggcccctg cattcatgcc
     1321 ccccacaccc cctcaggccc tgtgcctgga ctttggggct ggcagctgaa gccttgagat
     1381 cctgggccag ctgccggcac acagctaggc agactctccc accaggtgcc cctgcccagg
     1441 cctcctaatc gggggcagac aggcagggag ggtgtggctg ggctgggctg ggcggggcgg
     1501 cctggggcag gggtgtggcc cctaaatgtc cccaacctca gagggaccta gagtcctgag
     1561 cctccagtag cttctctggg cctggcagag gtaaggggga ggcaaccctg gagtgtctgg
     1621 aggcccatgg ctggctgaac cctggatgcc ttttcttccg cgtccccatg aatgaaagct
     1681 gtctgggcct tcattctgca gacagggaca aacagctcca tgctgtttgt cctcccagtg
     1741 cagccgtgct gggagggtct gggggagctt cctacaagga gagactcctg ctgctttgga
     1801 aaactgagaa aaaatagggg tctaaccctc tcctcccatt ttacaagtgg ggaaatgagg
     1861 cgtgaaagga gaggcgtctg ggttactccg tgggtctggg gtccagggaa gggcctgtat
     1921 gggggaggga gctgggaggg gacggtgtct ggctctaccc ctgtggggtg gggaggtggg
     1981 gctcccctgt atcacaggac atcccccctg agaggtccct catatgtctg ggtcctgtgg
     2041 gtgggggact aactgcgcaa tgtagttagg tgctcaataa acggagttgc cgctga
//
