LOCUS       NM_001012754            3411 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens NHL repeat containing 3 (NHLRC3), transcript variant
            1, mRNA.
ACCESSION   NM_001012754 XM_370722
VERSION     NM_001012754.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3411)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC140877.1, AL445590.4 and
            CR749318.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001012754.3.
            
            Summary: This gene encodes a protein containing NCL-1, HT2A and
            Lin-41 (NHL) family repeats. Mammalian NHL-repeat containing
            proteins may be involved in a variety of enzymatic processes,
            including protein modification through ubiquitination.
            Alternatively spliced transcript variants have been observed for
            this gene. [provided by RefSeq, Aug 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648122.1, SRR1803613.60954.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379600.8/ ENSP00000368920.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2150              BC140877.1         72-2221
            2151-2914           AL445590.4         101672-102435
            2915-3411           CR749318.1         2781-3277
FEATURES             Location/Qualifiers
     source          1..3411
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.3"
     gene            1..3411
                     /gene="NHLRC3"
                     /note="NHL repeat containing 3"
                     /db_xref="GeneID:387921"
                     /db_xref="HGNC:HGNC:33751"
     exon            1..268
                     /gene="NHLRC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..1228
                     /gene="NHLRC3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; NHL repeat-containing protein 3"
                     /codon_start=1
                     /product="NHL repeat-containing protein 3 isoform a
                     precursor"
                     /protein_id="NP_001012772.1"
                     /db_xref="CCDS:CCDS31961.1"
                     /db_xref="GeneID:387921"
                     /db_xref="HGNC:HGNC:33751"
                     /translation="MARFWVCVAGAGFFLAFLVLHSRFCGSPVLRNFTFAVSWRTEKI
                     LYRLDVGWPKHPEYFTGTTFCVAVDSLNGLVYIGQRGDNIPKILVFTEDGYFLRAWNY
                     TVDTPHGIFAASTLYEQSVWITDVGSGFFGHTVKKYSSFGDLVQVLGTPGKKGTSLNP
                     LQFDNPAELYVEDTGDIYIVDGDGGLNNRLIKLSQDFMILWLHGENGTGPAKFNIPHS
                     VTLDSAGRVWVADRGNKRIQVFDKDTGEWLGAWNNCFTEEGPSSVRFTPDGKYLIVAQ
                     LNLSRLSVVAAPPVGSIGECSVISTIQLADQVLPHLLEVDRKTGAVYVAEIGAKQVQK
                     YVPLNSYVPSFGS"
     exon            269..421
                     /gene="NHLRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            422..569
                     /gene="NHLRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            570..770
                     /gene="NHLRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            771..862
                     /gene="NHLRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..975
                     /gene="NHLRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            976..3411
                     /gene="NHLRC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NHLRC3"
                     /note="hexamer: TATAAA"
     polyA_site      1347
                     /gene="NHLRC3"
                     /note="major polyA site"
     regulatory      3341..3346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NHLRC3"
                     /note="hexamer: ATTAAA"
     polyA_site      3366
                     /gene="NHLRC3"
     regulatory      3384..3389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NHLRC3"
                     /note="hexamer: ATTAAA"
     polyA_site      3411
                     /gene="NHLRC3"
                     /note="major polyA site"
ORIGIN      
        1 attcgccctg gtctctgttc cctttcgtac tcaaagctcg tgcatccagg gaggggaaac
       61 cggagatagg gtcttcgggc cccgggcaga ccctctgtgc cgctgcaaac cgttgcagcc
      121 tgaggctgtc aggtcctccc ccagacacct gcggaccctc cctctcctgg cttcccgtct
      181 ggtcatggcg agattctggg tctgcgtagc cggtgctggc ttctttcttg catttttggt
      241 tttgcattcg cgtttttgtg gctctccagt tttgaggaac tttacttttg cagtttcctg
      301 gagaactgag aaaattcttt accggctgga tgtgggttgg cctaagcacc cagaatattt
      361 taccggaaca acattttgtg ttgcagttga ctccctcaat ggattggttt acataggtca
      421 aagaggggat aacatcccaa agatattagt gttcacagag gatggatatt tcctacgagc
      481 ctggaattat acagttgaca cacctcatgg tatatttgca gccagtactc tatatgaaca
      541 atccgtctgg atcacggatg taggaagtgg attctttggt catactgtta aaaaatacag
      601 ttcttttggt gatcttgttc aagtcttggg tactccaggc aaaaaaggca ctagtttgaa
      661 tcctttgcag tttgataacc cagcagaatt atatgtagag gacacaggag atatttacat
      721 tgtggatgga gatggaggat tgaataacag attgatcaaa ctgtcccaag atttcatgat
      781 cctttggctg catggagaaa atgggacagg gcctgctaag ttcaacatac ctcacagtgt
      841 tacacttgat tcagctggtc gggtgtgggt tgctgaccga ggaaataaaa gaatccaagt
      901 atttgataaa gacactgggg agtggttagg agcatggaat aattgtttca cagaagaggg
      961 accttcttca gtcaggttta ctcctgatgg gaagtacttg attgtggccc agctgaatct
     1021 tagcaggctc tcagtcgtag cagcaccccc agtgggaagc attggggagt gttctgtgat
     1081 cagcacaatc caactagcag atcaagtttt gccacatctc ctagaagtcg acagaaagac
     1141 tggagcagtc tatgtagcag aaattggagc aaaacaagta caaaaatatg tccctttgaa
     1201 tagctatgtt ccttcatttg gttcataatg tttctttcct gggaatattt caagtggcag
     1261 ttcagattct caattcacta agtgcttaaa aatgatgttc aagcacaaga atttattttt
     1321 ctagtataaa agatctagta tcagaaagat ttgtttttgt atcattaaga atcttatatt
     1381 ttgttgccct cttgggactt agttttattt gtaagtgcat aaggatattt taatgaaagg
     1441 aaagtaacta aaaaatgggg ttgggaagag ggactaaggt ggtaacctca ttatttgccc
     1501 tggtagactg attctccctg ggtaaaaaaa atgggaataa aaatgagctt gcatgataat
     1561 ttattaaatt tcatgtgaag aactccagac ctccagattg tgcaactaac ataaaatgag
     1621 ctgcttgaga gattgtaaat aagatgaact attgattaat ttgagtaccc acagagtgct
     1681 gtgtcttgac gacttaaaaa tgaaaaagca ggattgcctt ttgagtagct tgcagtctag
     1741 tggggagaca agcaggcaaa cagtcacaac acagcaaaag cgaccttgga gcatagtggg
     1801 acttttggag taggagtgct gcatttgact gagggaatca tggatacttc gcaggagaag
     1861 tgaatttgag ctcagacttg aaaactgagg aggagcttac caagggacaa ggaggagaaa
     1921 acaataattt ccaagtaaag aaggtataaa aagttagaag tgtactgtaa actttgatag
     1981 gcttttaggc cttttttaaa gcccaacttg gcttctgtcc attacctata agatatttaa
     2041 tgtcagtcag cctttaaatg taggaataaa atggctggca tctaagcact ttagtaaaag
     2101 aggtttttac aaataactaa ggattgtaga gcttccttct cttttttttt ctttttcttt
     2161 cttttgtttt acatgaactc aacttattcc taacatttgt ctacctcaaa gaaatttcaa
     2221 gattatttag ataacatgga tatgtgccaa atcctttgag ctgttaagat gataatttcc
     2281 tgctttcctc ctacatcttc tcctcccact ccctcctttg gtgtgaatat tggcttccca
     2341 attaagacct tttttttttt ttttccagtt tgttttagct tattataggt tttggaggaa
     2401 ctttgccatt ttgtaatctt tcaaatcatt cttcaccctt cctcacatca gcttcctgct
     2461 tttcccagtg ttttactgta aattgtgtag catatgacaa atcttgagct gactttcctc
     2521 ttcacctgtt atggctggag tattttccag acctgaaggg actcacactt gttttgatac
     2581 ttggatcaca tctccgtgag gttaggaagg taaatctacc aacaggaagc cctgtactct
     2641 gtattccaag gccattggta aatgtgttgg tgccactgat cggactgtat gaccttaaac
     2701 aagtcacctt agttttcagt gaaatgggaa tatcattgtc tcctctttca tgaatgctgt
     2761 gagaatcaga tgtgcaacag gtacagactt gccctttgaa atctatacct ctggatacat
     2821 tagaggcatt ttattaacaa aggcccttct aaatgtgcta tttatttgac aataactatc
     2881 agatttgcct taattttgtg tttatagcat ttatcaaaac gtatcctcat agactttatg
     2941 cagattaata tggtcaattg atttggataa aagaaagtaa tttcagggtt tgtttttaag
     3001 ccaggacaag aagtgcaaat gcctctttga agcaatttag gctaaactga ttttgaaatt
     3061 tcaaaatgtt ttattttact ttgttttatt aagccaggac aagaagtgca aatgcctctt
     3121 tgaagcaatt caggctaggt aaaccgattt tgccatttca aaacgtttta ttttactttg
     3181 ttttatatca gagtcttata aaacctgctg caaatatttc tgaatgtctt tgtaaaagtg
     3241 tttgttagtg tacctgtgat tatagtactt cacttttttc ctttggatta attggttaaa
     3301 tgaatgagaa atgtgttatg ttttttacta aaaagtataa attaaaattt tggaaagaaa
     3361 aggcaatatt atctggctcc ccaattaaag tttgatttta ttgtcacaaa a
//
