LOCUS       NM_001033088            1340 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens neugrin, neurite outgrowth associated (NGRN),
            transcript variant 2, mRNA.
ACCESSION   NM_001033088
VERSION     NM_001033088.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Antonicka,H., Choquet,K., Lin,Z.Y., Gingras,A.C., Kleinman,C.L. and
            Shoubridge,E.A.
  TITLE     A pseudouridine synthase module is essential for mitochondrial
            protein synthesis and cell viability
  JOURNAL   EMBO Rep 18 (1), 28-38 (2017)
   PUBMED   27974379
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   Arroyo,J.D., Jourdain,A.A., Calvo,S.E., Ballarano,C.A.,
            Doench,J.G., Root,D.E. and Mootha,V.K.
  TITLE     A Genome-wide CRISPR Death Screen Identifies Genes Essential for
            Oxidative Phosphorylation
  JOURNAL   Cell Metab 24 (6), 875-885 (2016)
   PUBMED   27667664
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1340)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1340)
  AUTHORS   Ishigaki,S., Niwa,J., Yoshihara,T., Mitsuma,N., Doyu,M. and
            Sobue,G.
  TITLE     Two novel genes, human neugrin and mouse m-neugrin, are upregulated
            with neuronal differentiation in neuroblastoma cells
  JOURNAL   Biochem Biophys Res Commun 279 (2), 526-533 (2000)
   PUBMED   11118320
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091167.19.
            
            On Nov 30, 2019 this sequence version replaced NM_001033088.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.11631.1, BC096824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379095.5/ ENSP00000368389.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC091167.19        72797-73001         c
            206-316             AC091167.19        72275-72385         c
            317-1340            AC091167.19        66462-67485         c
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..1340
                     /gene="NGRN"
                     /gene_synonym="DSC92"
                     /note="neugrin, neurite outgrowth associated"
                     /db_xref="GeneID:51335"
                     /db_xref="HGNC:HGNC:18077"
                     /db_xref="MIM:616718"
     exon            1..205
                     /gene="NGRN"
                     /gene_synonym="DSC92"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..917
                     /gene="NGRN"
                     /gene_synonym="DSC92"
                     /note="neurite outgrowth associated protein; mesenchymal
                     stem cell protein DSC92; spinal cord-derived protein
                     FI58G"
                     /codon_start=1
                     /product="neugrin precursor"
                     /protein_id="NP_001028260.2"
                     /db_xref="CCDS:CCDS32329.1"
                     /db_xref="GeneID:51335"
                     /db_xref="HGNC:HGNC:18077"
                     /db_xref="MIM:616718"
                     /translation="MAVTLSLLLGGRVCAAVTRCGFATRGVAGPGPIGREPDPDSDWE
                     PEERELQEVESTLKRQKQAIRFQKIRRQMEAPGAPPRTLTWEAMEQIRYLHEEFPESW
                     SVPRLAEGFDVSTDVIRRVLKSKFLPTLEQKLKQDQKVLKKAGLAHSLQHLRGSGNTS
                     KLLPAGHSVSGSLLMPGHEASSKDPNHSTALKVIESDTHRTNTPRRRKGRNKEIQDLE
                     ESFVPVAAPLGHPRELQKYSSDSESPRGTGSGALPSGQKLEELKAEEPDNFSSKVVQR
                     GREFFDSNGNFLYRI"
     exon            206..316
                     /gene="NGRN"
                     /gene_synonym="DSC92"
                     /inference="alignment:Splign:2.1.0"
     exon            317..1340
                     /gene="NGRN"
                     /gene_synonym="DSC92"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1319..1324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NGRN"
                     /gene_synonym="DSC92"
                     /note="hexamer: AATAAA"
     polyA_site      1340
                     /gene="NGRN"
                     /gene_synonym="DSC92"
                     /note="major polyA site"
ORIGIN      
        1 gctgtttcgt agccgactgc tgaaggctgg tttgcgtcga catggcggtt accctgagtc
       61 tcttgctggg cgggcgcgtt tgcgccgccg tcactcgctg tgggttcgcg acccgggggg
      121 tggcgggccc aggccctatt ggccgggagc cggaccccga ttccgactgg gagccggagg
      181 aacgggagct gcaggaggtg gagagcaccc tgaaacgaca gaaacaagca atccgattcc
      241 agaaaattcg gaggcaaatg gaggcgcctg gtgccccgcc caggaccctg acgtgggaag
      301 ccatggagca gatacggtat ttacatgagg aatttccaga gtcctggtca gttcccaggt
      361 tggctgaagg ctttgatgtc agcactgatg tgatccgaag agttttaaaa agcaagtttt
      421 tacccacatt ggagcagaag ctgaagcagg atcaaaaagt ccttaagaaa gctgggcttg
      481 cccactcgct gcagcacctc cggggctctg gaaatacctc aaagctgctc cctgcaggcc
      541 actctgtatc aggctctttg cttatgccag ggcatgaagc ctcatctaaa gacccaaatc
      601 acagcacagc tttgaaagtg atagagtcag acactcacag gacaaataca ccaaggagaa
      661 ggaagggaag aaataaagaa atccaggacc tggaggagag ctttgtgcct gttgctgcac
      721 ccctaggtca tccaagagag ctgcagaagt actccagtga ttctgagagc cccagaggaa
      781 ctggcagtgg tgcgttgcca agtggtcaga agctggagga gttgaaggca gaggagccag
      841 ataacttcag cagcaaagta gtgcagaggg gccgagagtt ctttgacagc aacgggaact
      901 tcctgtacag aatttgagtc ggggcttggc ttatggagat gcctcgtgaa acacagctgg
      961 gcaagtatta atgtatatgg aacagcctgg atttctgcat atggataagc caccttggaa
     1021 taggaagagg tgttgagcct ggactgtggg aggaaagagc tgcgtggata gattcaaact
     1081 tcctgtggta gtgctcccag tctgacctct gtagaccttc agtactcact cttcttgctt
     1141 aggctctctg tgtgttgaaa gccatcccgt gttgcatgtg ttgttacaat tttctgtgat
     1201 acttgcaatt tatgtttgag aagaagtgaa aagtttgcct tctgacctca tttccttctt
     1261 gatcagtgaa cactaacatt ttggggacaa cttagtcaat tggttttcct tacaacaaaa
     1321 taaagtaaaa tgtagcagtc
//
