LOCUS       NM_002507               3408 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens nerve growth factor receptor (NGFR), mRNA.
ACCESSION   NM_002507
VERSION     NM_002507.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3408)
  AUTHORS   Porter,T., Del Valle,M.M. and Kucheryavykh,L.
  TITLE     Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in
            Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic
            Population
  JOURNAL   Int J Mol Sci 25 (9), 4947 (2024)
   PUBMED   38732165
  REMARK    GeneRIF: Ethnicity-Based Variations in Focal Adhesion Kinase
            Signaling in Glioblastoma Gene Expression: A Study of the Puerto
            Rican Hispanic Population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3408)
  AUTHORS   Ludwiczak,S., Reinhard,J., Reinach,P.S., Li,A., Oronowicz,J.,
            Yousf,A., Kakkassery,V. and Mergler,S.
  TITLE     Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation
            in Etoposide-Resistant Retinoblastoma Cells
  JOURNAL   Int J Mol Sci 25 (3), 1733 (2024)
   PUBMED   38339011
  REMARK    GeneRIF: Joint CB1 and NGF Receptor Activation Suppresses TRPM8
            Activation in Etoposide-Resistant Retinoblastoma Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3408)
  AUTHORS   Myoen,S., Mochizuki,M., Shibuya-Takahashi,R., Fujimori,H.,
            Shindo,N., Yamaguchi,K., Yasuda,J., Abe,J., Imai,T., Sato,I.,
            Adachi,H., Kawamura,S., Ito,A. and Tamai,K.
  TITLE     CD271 promotes proliferation and migration in bladder cancer
  JOURNAL   Genes Cells 29 (1), 73-85 (2024)
   PUBMED   38016691
  REMARK    GeneRIF: CD271 promotes proliferation and migration in bladder
            cancer.
REFERENCE   4  (bases 1 to 3408)
  AUTHORS   Kim,Y.H., Yoon,B.A., Jo,Y.R., Nam,S.H., Kim,N.H., Kim,K.H.,
            Kim,J.K., Choi,B.O. and Park,H.T.
  TITLE     Neural cell adhesion molecule 1 is a cellular target engaged plasma
            biomarker in demyelinating Charcot-Marie-Tooth disease
  JOURNAL   Eur J Neurol 30 (6), 1745-1754 (2023)
   PUBMED   36856547
  REMARK    GeneRIF: Neural cell adhesion molecule 1 is a cellular target
            engaged plasma biomarker in demyelinating Charcot-Marie-Tooth
            disease.
REFERENCE   5  (bases 1 to 3408)
  AUTHORS   Bruno,F., Abondio,P., Montesanto,A., Luiselli,D., Bruni,A.C. and
            Maletta,R.
  TITLE     The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in
            Alzheimer's Disease
  JOURNAL   Int J Mol Sci 24 (4), 3200 (2023)
   PUBMED   36834612
  REMARK    GeneRIF: The Nerve Growth Factor Receptor (NGFR/p75[NTR]): A Major
            Player in Alzheimer's Disease.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3408)
  AUTHORS   Fantini,F. and Johansson,O.
  TITLE     Expression of growth-associated protein 43 and nerve growth factor
            receptor in human skin: a comparative immunohistochemical
            investigation
  JOURNAL   J Invest Dermatol 99 (6), 734-742 (1992)
   PUBMED   1281863
REFERENCE   7  (bases 1 to 3408)
  AUTHORS   Brodie,C. and Gelfand,E.W.
  TITLE     Functional nerve growth factor receptors on human B lymphocytes.
            Interaction with IL-2
  JOURNAL   J Immunol 148 (11), 3492-3497 (1992)
   PUBMED   1316918
REFERENCE   8  (bases 1 to 3408)
  AUTHORS   Maeda,T., Sato,O., Iwanaga,T. and Takano,Y.
  TITLE     Immunocytochemical localization of nerve growth factor receptor
            (NGFR) in human teeth
  JOURNAL   Proc Finn Dent Soc 88 Suppl 1, 557-562 (1992)
   PUBMED   1324502
REFERENCE   9  (bases 1 to 3408)
  AUTHORS   Welcher,A.A., Bitler,C.M., Radeke,M.J. and Shooter,E.M.
  TITLE     Nerve growth factor binding domain of the nerve growth factor
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (1), 159-163 (1991)
   PUBMED   1846035
REFERENCE   10 (bases 1 to 3408)
  AUTHORS   Sehgal,A., Patil,N. and Chao,M.
  TITLE     A constitutive promoter directs expression of the nerve growth
            factor receptor gene
  JOURNAL   Mol Cell Biol 8 (8), 3160-3167 (1988)
   PUBMED   2850481
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA115173.1, M14764.1,
            BQ639556.1 and CK299927.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002507.3.
            
            Summary: Nerve growth factor receptor contains an extracellular
            domain containing four 40-amino acid repeats with 6 cysteine
            residues at conserved positions followed by a serine/threonine-rich
            region, a single transmembrane domain, and a 155-amino acid
            cytoplasmic domain. The cysteine-rich region contains the nerve
            growth factor binding domain. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050309.1, M14764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000172229.8/ ENSP00000172229.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA115173.1         1-12
            13-2727             M14764.1           1-2715
            2728-3172           BQ639556.1         116-560
            3173-3408           CK299927.1         14-249              c
FEATURES             Location/Qualifiers
     source          1..3408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..3408
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /note="nerve growth factor receptor"
                     /db_xref="GeneID:4804"
                     /db_xref="HGNC:HGNC:7809"
                     /db_xref="MIM:162010"
     exon            1..191
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1409
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /note="TNFR superfamily, member 16; tumor necrosis factor
                     receptor superfamily member 16; low-affinity nerve growth
                     factor receptor; p75 ICD; NGF receptor; low affinity
                     neurotrophin receptor p75NTR; low-affinity nerve growth
                     factor receptor p75NGR; low-affinity nerve growth factor
                     receptor p75NGFR"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 16 precursor"
                     /protein_id="NP_002498.1"
                     /db_xref="CCDS:CCDS11549.1"
                     /db_xref="GeneID:4804"
                     /db_xref="HGNC:HGNC:7809"
                     /db_xref="MIM:162010"
                     /translation="MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECC
                     KACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEA
                     DDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANH
                     VDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAP
                     PEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWN
                     SCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGG
                     LYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWAT
                     QDSATLDALLAALRRIQRADLVESLCSESTATSPV"
     exon            192..333
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /inference="alignment:Splign:2.1.0"
     exon            334..693
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /inference="alignment:Splign:2.1.0"
     exon            694..946
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1107
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..3408
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /note="hexamer: ATTAAA"
     polyA_site      3408
                     /gene="NGFR"
                     /gene_synonym="CD271; Gp80-LNGFR; p75(NTR); p75NTR;
                     TNFRSF16"
                     /note="major polyA site"
ORIGIN      
        1 agagcgagcc gagccgcggc cagctccggc gggcaggggg ggcgctggag cgcagcgcag
       61 cgcagcccca tcagtccgca aagcggaccg agctggaagt cgagcgctgc cgcgggaggc
      121 gggcgatggg ggcaggtgcc accggccgcg ccatggacgg gccgcgcctg ctgctgttgc
      181 tgcttctggg ggtgtccctt ggaggtgcca aggaggcatg ccccacaggc ctgtacacac
      241 acagcggtga gtgctgcaaa gcctgcaacc tgggcgaggg tgtggcccag ccttgtggag
      301 ccaaccagac cgtgtgtgag ccctgcctgg acagcgtgac gttctccgac gtggtgagcg
      361 cgaccgagcc gtgcaagccg tgcaccgagt gcgtggggct ccagagcatg tcggcgccgt
      421 gcgtggaggc cgacgacgcc gtgtgccgct gcgcctacgg ctactaccag gatgagacga
      481 ctgggcgctg cgaggcgtgc cgcgtgtgcg aggcgggctc gggcctcgtg ttctcctgcc
      541 aggacaagca gaacaccgtg tgcgaggagt gccccgacgg cacgtattcc gacgaggcca
      601 accacgtgga cccgtgcctg ccctgcaccg tgtgcgagga caccgagcgc cagctccgcg
      661 agtgcacacg ctgggccgac gccgagtgcg aggagatccc tggccgttgg attacacggt
      721 ccacaccccc agagggctcg gacagcacag cccccagcac ccaggagcct gaggcacctc
      781 cagaacaaga cctcatagcc agcacggtgg caggtgtggt gaccacagtg atgggcagct
      841 cccagcccgt ggtgacccga ggcaccaccg acaacctcat ccctgtctat tgctccatcc
      901 tggctgctgt ggttgtgggc cttgtggcct acatagcctt caagaggtgg aacagctgca
      961 agcagaacaa gcaaggagcc aacagccggc cagtgaacca gacgccccca ccagagggag
     1021 aaaaactcca cagcgacagt ggcatctccg tggacagcca gagcctgcat gaccagcagc
     1081 cccacacgca gacagcctcg ggccaggccc tcaagggtga cggaggcctc tacagcagcc
     1141 tgcccccagc caagcgggag gaggtggaga agcttctcaa cggctctgcg ggggacacct
     1201 ggcggcacct ggcgggcgag ctgggctacc agcccgagca catagactcc tttacccatg
     1261 aggcctgccc cgttcgcgcc ctgcttgcaa gctgggccac ccaggacagc gccacactgg
     1321 acgccctcct ggccgccctg cgccgcatcc agcgagccga cctcgtggag agtctgtgca
     1381 gtgagtccac tgccacatcc ccggtgtgag cccaaccggg gagcccccgc cccgccccac
     1441 attccgacaa ccgatgctcc agccaacccc tgtggagccc gcacccccac cctttggggg
     1501 gggcccgcct ggcagaactg agctcctctg ggcaggacct cagagtccag gccccaaaac
     1561 cacagccctg tcagtgcagc ccgtgtggcc ccttcacttc tgaccacact tcctgtccag
     1621 agagagaagt gcccctgctg cctccccaac cctgcccctg ccccgtcacc atctcaggcc
     1681 acctgccccc ttctcccaca ctgctaggtg ggccagcccc tcccaccaca gcaggtgtca
     1741 tatatggggg gccaacacca gggatggtac tagggggaag tgacaaggcc ccagagactc
     1801 agagggagga atcgaggaac cagagccatg gactctacac tgtgaacttg gggaacaagg
     1861 gtggcatccc agtggcctca accctccctc agcccctctt gccccccacc ccagcctaag
     1921 atgaagagga tcggaggctt gtcagagctg ggaggggttt tcgaagctca gcccaccccc
     1981 ctcattttgg atataggtca gtgaggccca gggagaggcc atgattcgcc caaagccaga
     2041 cagcaacggg gaggccaagt gcaggctggc accgccttct ctaaatgagg ggcctcaggt
     2101 ttgcctgagg gcgaggggag ggtggcaggt gaccttctgg gaaatggctt gaagccaagt
     2161 cagctttgcc ttccacgctg tctccagacc cccacccctt ccccactgcc tgcccacccg
     2221 tggagatggg atgcttgcct agggcctggt ccatgatgga gtcaggtttg gggttcgtgg
     2281 aaagggtgct gcttccctct gcctgtccct ctcaggcatg cctgtgtgac atcagtggca
     2341 tggctccagt ctgctgccct ccatcccgac atggacccgg agctaacact ggcccctaga
     2401 atcagcctag gggtcaggga ccaaggaccc ctcaccttgc aacacacaga cacacgcaca
     2461 cacacacaca ggaggagaaa tctcactttt ctccatgagt tttttctctt gggctgagac
     2521 tggatactgc ccggggcagc tgccagagaa gcatcggagg gaattgaggt ctgctcggcc
     2581 gtcttcactc gcccccgggt ttggcgggcc aaggactgcc gaccgaggct ggagctggcg
     2641 tctgtcttca agggcttaca cgtggaggaa tgctccccca tcctcccctt ccctgcaaac
     2701 atggggttgg ctgggcccag aaggttgtga tgaagaaaag tgggccagtg tgggaatgcg
     2761 gcaagaagga attgacttcg actgtgacct gtggggattt ctcccagctc tagacaaccc
     2821 tgcaaaggac tgttttttcc tgagcttggc cagaaggggg ccatgaggcc tcagtggact
     2881 ttccaccccc tccctggcct gttctgtttt gcctgaagtt ggagtgagtg tggctcccct
     2941 ctatttagca tgacaagccc caggcaggct gtgcgctgac aaccaccgct ccccagccca
     3001 gggttccccc agccctgtgg aagggactag gagcactgta gtaaatggca attctttgac
     3061 ctcaacctgt gatgagggga ggaaactcac ctgctggccc ctcacctggg cacctgggga
     3121 gtgggacaga gtctgggtgt atttattttc ctccccagca ggtggggagg gggtttgggg
     3181 gcttgcaagt atgttttagc atgtgtttgg ttctggggcc cctttttact ccccttgagc
     3241 tgagatggaa cccttttggc ccccgagctg ggggccatga gctccagacc cccagcaacc
     3301 ctcctatcac ctcccctcct tgcctcctgt gtaatcattt cttgggccct cctgaaactt
     3361 acacacaaaa cgttaagtga tgaacattaa atagcaaaga aagaaaaa
//
