LOCUS       NM_002506               1061 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens nerve growth factor (NGF), mRNA.
ACCESSION   NM_002506
VERSION     NM_002506.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Sreya,M., Tucker,D.R., Yi,J., Alotaibi,F.T., Lee,A.F., Noga,H. and
            Yong,P.J.
  TITLE     Nerve Bundle Density and Expression of NGF and IL-1beta Are
            Intra-Individually Heterogenous in Subtypes of Endometriosis
  JOURNAL   Biomolecules 14 (5), 583 (2024)
   PUBMED   38785989
  REMARK    GeneRIF: Nerve Bundle Density and Expression of NGF and IL-1beta
            Are Intra-Individually Heterogenous in Subtypes of Endometriosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Lin,C.Y., Lee,K.T., Lin,Y.Y., Tsai,C.H., Ko,C.Y., Fong,Y.C.,
            Hou,S.M., Chen,W.L., Huang,C.C. and Tang,C.H.
  TITLE     NGF facilitates ICAM-1-dependent monocyte adhesion and M1
            macrophage polarization in rheumatoid arthritis
  JOURNAL   Int Immunopharmacol 130, 111733 (2024)
   PUBMED   38387191
  REMARK    GeneRIF: NGF facilitates ICAM-1-dependent monocyte adhesion and M1
            macrophage polarization in rheumatoid arthritis.
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Zhang,T., Tong,Y., Zhu,R., Liang,Y., Zhang,J., Hu,C., He,M., Hu,Z.,
            Shen,Z., Niu,J., Zhang,J., Yu,Y., Jin,B., Lei,S., Zeng,Z., Wu,Y.,
            Cheng,Z., Xiao,Z., Guo,B., Zhao,S., Xu,G., Pan,W. and Chen,T.
  TITLE     HDAC6-dependent deacetylation of NGF dictates its ubiquitination
            and maintains primordial follicle dormancy
  JOURNAL   Theranostics 14 (6), 2345-2366 (2024)
   PUBMED   38646645
  REMARK    GeneRIF: HDAC6-dependent deacetylation of NGF dictates its
            ubiquitination and maintains primordial follicle dormancy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Promm,M., Otto,W., Gotz,S., Burger,M., Muller,K., Rubenwolf,P.,
            Neuhuber,W.L. and Rosch,W.H.
  TITLE     Innervation pattern of the unclosed detrusor muscle in classic
            bladder exstrophy: a study of patients with urothelial
            overexpression of nerve growth factor
  JOURNAL   Pediatr Surg Int 40 (1), 69 (2024)
   PUBMED   38441774
  REMARK    GeneRIF: Innervation pattern of the unclosed detrusor muscle in
            classic bladder exstrophy: a study of patients with urothelial
            overexpression of nerve growth factor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Krok,M., Wroblewska-Czajka,E., Lach-Wojnarowicz,O., Bronikowska,J.,
            Czuba,Z.P., Wylegala,E. and Dobrowolski,D.
  TITLE     Level of Secretion and the Role of the Nerve Growth Factor in
            Patients with Keratoconus before and after Collagen Fibre
            Cross-Linking Surgery
  JOURNAL   Int J Mol Sci 25 (1), 366 (2023)
   PUBMED   38203537
  REMARK    GeneRIF: Level of Secretion and the Role of the Nerve Growth Factor
            in Patients with Keratoconus before and after Collagen Fibre
            Cross-Linking Surgery.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Schon,K.R., Parker,A.P.J. and Woods,C.G.
  TITLE     Congenital Insensitivity to Pain Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29419974
REFERENCE   7  (bases 1 to 1061)
  AUTHORS   MacGrogan,D., Saint-Andre,J.P. and Dicou,E.
  TITLE     Expression of nerve growth factor and nerve growth factor receptor
            genes in human tissues and in prostatic adenocarcinoma cell lines
  JOURNAL   J Neurochem 59 (4), 1381-1391 (1992)
   PUBMED   1383421
REFERENCE   8  (bases 1 to 1061)
  AUTHORS   Hallbook,F., Ibanez,C.F. and Persson,H.
  TITLE     Evolutionary studies of the nerve growth factor family reveal a
            novel member abundantly expressed in Xenopus ovary
  JOURNAL   Neuron 6 (5), 845-858 (1991)
   PUBMED   2025430
REFERENCE   9  (bases 1 to 1061)
  AUTHORS   Borsani,G., Pizzuti,A., Rugarli,E.I., Falini,A., Silani,V.,
            Sidoli,A., Scarlato,G. and Baralle,F.E.
  TITLE     cDNA sequence of human beta-NGF
  JOURNAL   Nucleic Acids Res 18 (13), 4020 (1990)
   PUBMED   2374737
REFERENCE   10 (bases 1 to 1061)
  AUTHORS   Dracopoli,N.C. and Meisler,M.H.
  TITLE     Mapping the human amylase gene cluster on the proximal short arm of
            chromosome 1 using a highly informative (CA)n repeat
  JOURNAL   Genomics 7 (1), 97-102 (1990)
   PUBMED   1692298
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512638.5, X52599.1,
            BC032517.2, CR541855.1 and BE045524.1.
            
            On Aug 31, 2019 this sequence version replaced NM_002506.2.
            
            Summary: This gene is a member of the NGF-beta family and encodes a
            secreted protein which homodimerizes and is incorporated into a
            larger complex. This protein has nerve growth stimulating activity
            and the complex is involved in the regulation of growth and the
            differentiation of sympathetic and certain sensory neurons.
            Mutations in this gene have been associated with hereditary sensory
            and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this
            gene's expression is associated with allergic rhinitis. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032517.2, X52599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369512.3/ ENSP00000358525.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL512638.5         21937-21949         c
            14-47               X52599.1           1-34
            48-285              BC032517.2         40-277
            286-908             CR541855.1         104-726
            909-1060            BC032517.2         901-1052
            1061-1061           BE045524.1         5-5                 c
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1061
                     /gene="NGF"
                     /gene_synonym="Beta-NGF; HSAN5; NGFB"
                     /note="nerve growth factor"
                     /db_xref="GeneID:4803"
                     /db_xref="HGNC:HGNC:7808"
                     /db_xref="MIM:162030"
     exon            1..46
                     /gene="NGF"
                     /gene_synonym="Beta-NGF; HSAN5; NGFB"
                     /inference="alignment:Splign:2.1.0"
     exon            47..170
                     /gene="NGF"
                     /gene_synonym="Beta-NGF; HSAN5; NGFB"
                     /inference="alignment:Splign:2.1.0"
     exon            171..1061
                     /gene="NGF"
                     /gene_synonym="Beta-NGF; HSAN5; NGFB"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..908
                     /gene="NGF"
                     /gene_synonym="Beta-NGF; HSAN5; NGFB"
                     /note="nerve growth factor, beta subunit; beta-nerve
                     growth factor; nerve growth factor (beta polypeptide);
                     pro-nerve growth factor long"
                     /codon_start=1
                     /product="beta-nerve growth factor precursor"
                     /protein_id="NP_002497.2"
                     /db_xref="CCDS:CCDS882.1"
                     /db_xref="GeneID:4803"
                     /db_xref="HGNC:HGNC:7808"
                     /db_xref="MIM:162030"
                     /translation="MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSL
                     DTALRRARSAPAAAIAARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQD
                     LDFEVGGAAPFNRTHRSKRSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVL
                     GEVNINNSVFKQYFFETKCRDPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQA
                     AWRFIRIDTACVCVLSRKAVRRA"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NGF"
                     /gene_synonym="Beta-NGF; HSAN5; NGFB"
                     /note="hexamer: ATTAAA"
     polyA_site      1061
                     /gene="NGF"
                     /gene_synonym="Beta-NGF; HSAN5; NGFB"
                     /note="major polyA site"
ORIGIN      
        1 gctccggcac agcagagagc gctgggagcc ggaggggagc gcagcgagtt ttggccagtg
       61 gtcgtgcagt ccaaggggct ggatggcatg ctggacccaa gctcagctca gcgtccggac
      121 ccaataacag ttttaccaag ggagcagctt tctatcctgg ccacactgag gtgcatagcg
      181 taatgtccat gttgttctac actctgatca cagcttttct gatcggcata caggcggaac
      241 cacactcaga gagcaatgtc cctgcaggac acaccatccc ccaagcccac tggactaaac
      301 ttcagcattc ccttgacact gcccttcgca gagcccgcag cgccccggca gcggcgatag
      361 ctgcacgcgt ggcggggcag acccgcaaca ttactgtgga ccccaggctg tttaaaaagc
      421 ggcgactccg ttcaccccgt gtgctgttta gcacccagcc tccccgtgaa gctgcagaca
      481 ctcaggatct ggacttcgag gtcggtggtg ctgccccctt caacaggact cacaggagca
      541 agcggtcatc atcccatccc atcttccaca ggggcgaatt ctcggtgtgt gacagtgtca
      601 gcgtgtgggt tggggataag accaccgcca cagacatcaa gggcaaggag gtgatggtgt
      661 tgggagaggt gaacattaac aacagtgtat tcaaacagta cttttttgag accaagtgcc
      721 gggacccaaa tcccgttgac agcgggtgcc ggggcattga ctcaaagcac tggaactcat
      781 attgtaccac gactcacacc tttgtcaagg cgctgaccat ggatggcaag caggctgcct
      841 ggcggtttat ccggatagat acggcctgtg tgtgtgtgct cagcaggaag gctgtgagaa
      901 gagcctgacc tgccgacacg ctccctcccc ctgccccttc tacactctcc tgggcccctc
      961 cctacctcaa cctgtaaatt attttaaatt ataaggactg catggtaatt tatagtttat
     1021 acagttttaa agaatcatta tttattaaat ttttggaagc a
//
