LOCUS       XM_011510924            2275 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens neuronal guanine nucleotide exchange factor
            (NGEF), transcript variant X3, mRNA.
ACCESSION   XM_011510924
VERSION     XM_011510924.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011510924.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..2275
                     /gene="NGEF"
                     /gene_synonym="ARHGEF27; EPHEXIN"
                     /note="neuronal guanine nucleotide exchange factor;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 20 ESTs, 197 long SRA reads, 1 Protein, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 14 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:25791"
                     /db_xref="HGNC:HGNC:7807"
                     /db_xref="MIM:605991"
     CDS             186..1487
                     /gene="NGEF"
                     /gene_synonym="ARHGEF27; EPHEXIN"
                     /codon_start=1
                     /product="ephexin-1 isoform X3"
                     /protein_id="XP_011509226.1"
                     /db_xref="GeneID:25791"
                     /db_xref="HGNC:HGNC:7807"
                     /db_xref="MIM:605991"
                     /translation="MFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNV
                     LDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQ
                     LLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERE
                     CTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGE
                     LQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEEL
                     EDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRL
                     LDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTE
                     EILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ"
ORIGIN      
        1 ctccgacccc cgcagatgtc accctggtga cgcagctgca acaacgcatc gaaggtcaca
       61 gcatcagaga cagcagtgat ttgttaacac aggggtcggg agaagccaaa aaaacaaccc
      121 aaatcaggct ggaatgcacg gcccagaggt ccacggcgaa ccctggatca taaggagacc
      181 gtgccatgtt cgagctggtc acttccgagg cgtcctacta caagagtctg aacctgctcg
      241 tgtcccactt catggagaac gagcggataa ggaagatcct gcacccgtcc gaggcgcaca
      301 tcctcttctc caacgtcctg gacgtgctgg ctgtcagtga gcggttcctc ctggagctgg
      361 agcaccggat ggaggagaac atcgtcatct ctgacgtgtg tgacattgtg taccgttatg
      421 cggccgacca cttctctgtc tacatcacct acgtcagcaa tcagacctac caggagcgga
      481 cctataagca gctgctccag gagaaggcag ctttccggga gctgatcgcg cagctagagc
      541 tcgaccccaa gtgcaggggg ctgcccttct cctccttcct catcctgcct ttccagagga
      601 tcacacgcct caagctgttg gtccagaaca tcctgaagag ggtagaagag aggtctgagc
      661 gggagtgcac tgctttggat gctcacaagg agctggaaat ggtggtgaag gcatgcaacg
      721 agggcgtcag gaaaatgagc cgcacggaac agatgatcag cattcagaag aagatggagt
      781 tcaagatcaa gtcggtgccc atcatctccc actcccgctg gctgctgaag cagggtgagc
      841 tgcagcagat gtcaggcccc aagacctccc ggaccctgag gaccaagaag ctcttccacg
      901 aaatttacct cttcctgttc aacgacctgc tggtgatctg ccggcagatt ccaggagaca
      961 agtaccaggt atttgactca gctccgcggg gactgctgcg tgtggaggag ctggaggacc
     1021 agggccagac gctggccaac gtgttcatcc tgcggctgct ggagaacgca gatgaccggg
     1081 aggccaccta catgctaaag gcgtcctctc agagtgagat gaagcgttgg atgacctcac
     1141 tggcccccaa caggaggacc aagtttgttt cgttcacatc ccggctgctg gactgccccc
     1201 aggtccagtg cgtgcaccca tacgtggctc agcagccaga cgagctgacg ctggagctcg
     1261 ccgacatcct caacatcctg gacaagactg acgacgggtg gatctttggc gagcgtctgc
     1321 acgaccagga gagaggctgg ttccccagct ccatgactga ggagatcttg aatcccaaga
     1381 tccggtccca gaacctcaag gaatgtttcc gtgtccacaa gatggatgac cctcagcgca
     1441 gccagaacaa ggaccgcagg aagctgggca gccggaatcg gcaatgaccc ccacccaggg
     1501 ggccagcggg agcagggcct gcatgagacc ccgacagaag gtgggggggg gggggctctg
     1561 ggaagcacag gccagcacct ccccaggtgg caggatctgg cttggggtgc ccggccctca
     1621 tccctgccca cgcagtgagt gctcatgtgt cttggcccct tgctcgcaaa ctggataaag
     1681 ggtgcccaag cctctcctga tgcatttgta aacaagaagg tttcagcagt attacaccac
     1741 ctccctcatg cctccgaggg ggtggaaggg ggtgggcaca ctccagggcc ccccatgccc
     1801 ctggccccca gggactggaa gaggctccca acccagagtg tccctgtggg aggcaggcag
     1861 aaggtgacaa ttgacacgat ttcctgcacg cgtcctcctc taccttggaa gcagttagaa
     1921 tctaccaggc acagatgagg ccgcccttgc ctgacggagc ttgatgagca gcccttggtc
     1981 tccggttcca ggactgagag cccagctgcc tctgcccacc cttccccagg cctctgccag
     2041 cctctggctg cacggtcagg ccctgcccca tggcaggcct gccagagctt ggctggggac
     2101 ccctcccgcc tctggctccc tgatgggctg gatgtaactt gtgtcttcta gccccttaag
     2161 gagcccaggt gttttaagga atgaattggt cactgcatct tgtatcgatt atggttctga
     2221 gaaaagcaaa tatcactttt ggctgcatta aaagaagcat catatataaa ataaa
//
