LOCUS       XM_011510923            3453 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens neuronal guanine nucleotide exchange factor
            (NGEF), transcript variant X1, mRNA.
ACCESSION   XM_011510923
VERSION     XM_011510923.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011510923.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3453
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..3453
                     /gene="NGEF"
                     /gene_synonym="ARHGEF27; EPHEXIN"
                     /note="neuronal guanine nucleotide exchange factor;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 30 ESTs, 298 long SRA reads, 10
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 16 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:25791"
                     /db_xref="HGNC:HGNC:7807"
                     /db_xref="MIM:605991"
     CDS             533..2665
                     /gene="NGEF"
                     /gene_synonym="ARHGEF27; EPHEXIN"
                     /codon_start=1
                     /product="ephexin-1 isoform X1"
                     /protein_id="XP_011509225.1"
                     /db_xref="GeneID:25791"
                     /db_xref="HGNC:HGNC:7807"
                     /db_xref="MIM:605991"
                     /translation="METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQA
                     DQDIQDKEPHCHIPIKRNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPL
                     TLNIPWSRMPPCRTAMQTDPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMI
                     HPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEE
                     EEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQE
                     AMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLE
                     LEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIA
                     QLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMV
                     VKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTL
                     RTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFIL
                     RLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYV
                     AQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLK
                     ECFRVHKMDDPQRSQNKDRRKLGSRNRQ"
ORIGIN      
        1 aatgcttacc agtgaagctt ttccaggaca ggacgaagtt tttggctgtg ggctctctgg
       61 gacagagtgg agcgcctgtg gatttagccg gggacacacc atcctgctcg caggtgcctg
      121 gacaggacag gggacgaggg aggaacactc tctgaggaag cccaactcct atgagctcct
      181 ctctggcagg tgagagaatg gttttggtat tttttaaaaa aataaaatga gataaaacaa
      241 gagaaggaac agaggctacc gctaggacag gtaggaaagg agattaccac ccatccattc
      301 actgaggagg agcccccaag agaaacagca gccctggatt ccacccgagg gatcctgtct
      361 ggtctcggct tcagcactgc ccctcctggc actcagtttc accatctggg aatcaggata
      421 aggactcctt ccaggcgctc ttccattatg gctgtgggca ctcaaaccag tgaagcttgg
      481 gaaagtcatt gacctccagt cgttctgctg agaaacatct ggctctattt ccatggagac
      541 cagggaatct gaagatttgg aaaagacccg gaggaaatca gcaagtgatc aatggaacac
      601 tgataatgaa ccagccaagg tgaaacctga gttactccca gaaaaagagg agacttctca
      661 agctgaccag gatatccaag acaaagagcc tcattgccac atcccaatta agagaaattc
      721 catcttcaat cgctccataa gacgcaaaag caaagccaag gccagagaca accccgaacg
      781 gaacgccagc tgcctggcag attcacagga caatggaaaa tctgtaaatg agcccctgac
      841 cttgaatatc ccctggagca gaatgcctcc ttgcagaaca gcaatgcaga cagacccagg
      901 agcccaggaa atgagtgagt cgtcctccac cccgggaaat ggggccacgc ccgaggagtg
      961 gccggccctg gccgacagcc ccaccacgct caccgaggcc ctgcggatga tccaccccat
     1021 tcccgccgac tcctggagaa acctcattga acaaataggg ctcctgtatc aggaataccg
     1081 agataaatcg actctccaag aaatcgaaac caggaggcaa caggatgcag aaatagaaga
     1141 caataccaat gggtccccgg ccagtgagga caccccggag gaggaagaag aagaggagga
     1201 ggaggaggag ccggccagcc caccagagag gaagactctg ccccagatct gcctgctcag
     1261 taacccccac tcaaggttca acctctggca ggatcttccc gagatccgga gcagcggggt
     1321 gcttgagatc ctacagcccg aggagattaa gctgcaggag gccatgttcg agctggtcac
     1381 ttccgaggcg tcctactaca agagtctgaa cctgctcgtg tcccacttca tggagaacga
     1441 gcggataagg aagatcctgc acccgtccga ggcgcacatc ctcttctcca acgtcctgga
     1501 cgtgctggct gtcagtgagc ggttcctcct ggagctggag caccggatgg aggagaacat
     1561 cgtcatctct gacgtgtgtg acattgtgta ccgttatgcg gccgaccact tctctgtcta
     1621 catcacctac gtcagcaatc agacctacca ggagcggacc tataagcagc tgctccagga
     1681 gaaggcagct ttccgggagc tgatcgcgca gctagagctc gaccccaagt gcagggggct
     1741 gcccttctcc tccttcctca tcctgccttt ccagaggatc acacgcctca agctgttggt
     1801 ccagaacatc ctgaagaggg tagaagagag gtctgagcgg gagtgcactg ctttggatgc
     1861 tcacaaggag ctggaaatgg tggtgaaggc atgcaacgag ggcgtcagga aaatgagccg
     1921 cacggaacag atgatcagca ttcagaagaa gatggagttc aagatcaagt cggtgcccat
     1981 catctcccac tcccgctggc tgctgaagca gggtgagctg cagcagatgt caggccccaa
     2041 gacctcccgg accctgagga ccaagaagct cttccacgaa atttacctct tcctgttcaa
     2101 cgacctgctg gtgatctgcc ggcagattcc aggagacaag taccaggtat ttgactcagc
     2161 tccgcgggga ctgctgcgtg tggaggagct ggaggaccag ggccagacgc tggccaacgt
     2221 gttcatcctg cggctgctgg agaacgcaga tgaccgggag gccacctaca tgctaaaggc
     2281 gtcctctcag agtgagatga agcgttggat gacctcactg gcccccaaca ggaggaccaa
     2341 gtttgtttcg ttcacatccc ggctgctgga ctgcccccag gtccagtgcg tgcacccata
     2401 cgtggctcag cagccagacg agctgacgct ggagctcgcc gacatcctca acatcctgga
     2461 caagactgac gacgggtgga tctttggcga gcgtctgcac gaccaggaga gaggctggtt
     2521 ccccagctcc atgactgagg agatcttgaa tcccaagatc cggtcccaga acctcaagga
     2581 atgtttccgt gtccacaaga tggatgaccc tcagcgcagc cagaacaagg accgcaggaa
     2641 gctgggcagc cggaatcggc aatgaccccc acccaggggg ccagcgggag cagggcctgc
     2701 atgagacccc gacagaaggt gggggggggg gggctctggg aagcacaggc cagcacctcc
     2761 ccaggtggca ggatctggct tggggtgccc ggccctcatc cctgcccacg cagtgagtgc
     2821 tcatgtgtct tggccccttg ctcgcaaact ggataaaggg tgcccaagcc tctcctgatg
     2881 catttgtaaa caagaaggtt tcagcagtat tacaccacct ccctcatgcc tccgaggggg
     2941 tggaaggggg tgggcacact ccagggcccc ccatgcccct ggcccccagg gactggaaga
     3001 ggctcccaac ccagagtgtc cctgtgggag gcaggcagaa ggtgacaatt gacacgattt
     3061 cctgcacgcg tcctcctcta ccttggaagc agttagaatc taccaggcac agatgaggcc
     3121 gcccttgcct gacggagctt gatgagcagc ccttggtctc cggttccagg actgagagcc
     3181 cagctgcctc tgcccaccct tccccaggcc tctgccagcc tctggctgca cggtcaggcc
     3241 ctgccccatg gcaggcctgc cagagcttgg ctggggaccc ctcccgcctc tggctccctg
     3301 atgggctgga tgtaacttgt gtcttctagc cccttaagga gcccaggtgt tttaaggaat
     3361 gaattggtca ctgcatcttg tatcgattat ggttctgaga aaagcaaata tcacttttgg
     3421 ctgcattaaa agaagcatca tatataaaat aaa
//
