LOCUS       NM_001042635            1108 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens neuroguidin (NGDN), transcript variant 1, mRNA.
ACCESSION   NM_001042635
VERSION     NM_001042635.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Scaturro,P., Stukalov,A., Haas,D.A., Cortese,M., Draganova,K.,
            Plaszczyca,A., Bartenschlager,R., Gotz,M. and Pichlmair,A.
  TITLE     An orthogonal proteomic survey uncovers novel Zika virus host
            factors
  JOURNAL   Nature 561 (7722), 253-257 (2018)
   PUBMED   30177828
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Sihn,C.R., Lee,Y.S., Jeong,J.S., Park,K. and Kim,S.H.
  TITLE     CANu1, a novel nucleolar protein, accumulated on centromere in
            response to DNA damage
  JOURNAL   Genes Cells 13 (8), 787-796 (2008)
   PUBMED   18547334
  REMARK    GeneRIF: Study isolated a novel human gene, to be called as CANu1,
            by the large-scale genome-wide association analysis to screen
            specific Single nucleotide polymorphisms in colon cancer.
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Jung,M.Y., Lorenz,L. and Richter,J.D.
  TITLE     Translational control by neuroguidin, a eukaryotic initiation
            factor 4E and CPEB binding protein
  JOURNAL   Mol Cell Biol 26 (11), 4277-4287 (2006)
   PUBMED   16705177
REFERENCE   10 (bases 1 to 1108)
  AUTHORS   Nousiainen,M., Sillje,H.H., Sauer,G., Nigg,E.A. and Korner,R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030817.1 and AL132855.4.
            
            On Nov 22, 2018 this sequence version replaced NM_001042635.1.
            
            Summary: Neuroguidin is an EIF4E (MIM 133440)-binding protein that
            interacts with CPEB (MIM 607342) and functions as a translational
            regulatory protein during development of the vertebrate nervous
            system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030817.1, SRR5189667.18874.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408901.8/ ENSP00000386134.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               BC030817.1         1-282
            283-295             AL132855.4         109308-109320
            296-380             AL132855.4         109570-109654
            381-433             AL132855.4         109738-109790
            434-557             AL132855.4         110041-110164
            558-726             AL132855.4         110251-110419
            727-883             AL132855.4         111212-111368
            884-941             AL132855.4         111515-111572
            942-1108            AL132855.4         112019-112185
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1108
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /note="neuroguidin"
                     /db_xref="GeneID:25983"
                     /db_xref="HGNC:HGNC:20271"
                     /db_xref="MIM:610777"
     exon            1..25
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..961
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /note="isoform 1 is encoded by transcript variant 1;
                     eukaryotic initiation factor 4E and CPEB binding protein;
                     EIF4E-binding protein; centromere accumulated nuclear
                     protein 1; neuroguidin, EIF4E binding protein"
                     /codon_start=1
                     /product="neuroguidin isoform 1"
                     /protein_id="NP_001036100.1"
                     /db_xref="CCDS:CCDS41926.1"
                     /db_xref="GeneID:25983"
                     /db_xref="HGNC:HGNC:20271"
                     /db_xref="MIM:610777"
                     /translation="MAALGVLESDLPSAVTLLKNLQEQVMAVTAQVKSLTQKVQAGAY
                     PTEKGLSFLEVKDQLLLMYLMDLTHLILDKASGGSLQGHDAVLRLVEIRTVLEKLRPL
                     DQKLKYQIDKLIKTAVTGSLSENDPLRFKPHPSNMMSKLSSEDEEEDEAEDDQSEASG
                     KKSVKGVSKKYVPPRLVPVHYDETEAEREKKRLERAKRRALSSSVIRELKEQYSDAPE
                     EIRDARHPHVTRQSQEDQHRINYEESMMVRLSVSKREKGRRKRANVMSSQLHSLTHFS
                     DISALTGGTVHLDEDQNPIKKRKKIPQKGRKKKGFRRRR"
     exon            26..85
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            86..157
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            158..295
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            296..380
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            381..433
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            434..557
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            558..726
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            727..883
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            884..941
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1108
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1085..1090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /note="hexamer: AATAAA"
     polyA_site      1108
                     /gene="NGDN"
                     /gene_synonym="C14orf120; CANu1; LCP5; lpd-2; NGD"
                     /note="major polyA site"
ORIGIN      
        1 gggctttgcg aagatggcgg cgctgggggt gctggagtcc gacctgccaa gtgccgtgac
       61 acttctgaaa aatctccagg agcaagtgat ggctgtaact gcacaagtga aatcactgac
      121 acaaaaagtt caagctggtg cctatcctac agaaaagggt ctcagcttct tggaagtgaa
      181 agaccagctg ctgctcatgt accttatgga tttgacccac ctcattctgg acaaagcctc
      241 aggaggatct cttcagggac atgatgcagt tttgagactg gtggagattc gcacggtttt
      301 ggaaaagctt cgtcccttgg accaaaagct gaagtatcaa attgacaagc tgatcaagac
      361 tgcagtgaca ggcagcctta gtgagaatga cccacttcgt tttaagcctc atcccagcaa
      421 tatgatgagc aagttgagct ctgaggatga ggaggaagat gaagcagaag atgaccagtc
      481 tgaggcttca gggaagaaat ctgtgaaggg agtgtctaag aaatatgttc ctccacgctt
      541 ggttccagta cattatgatg aaacagaagc tgagcgggag aagaagcgtc tagaacgagc
      601 caagagacgg gcattgagca gctctgtcat tcgtgaactt aaggagcagt actcagatgc
      661 tccagaggaa atccgtgatg ctcggcatcc ccatgttacc cgccagagtc aggaggacca
      721 acacaggatt aactatgagg agagcatgat ggtgcgtttg agcgtcagta agcgagagaa
      781 aggacggcga aaacgagcaa atgtcatgag ctcacaactt cattccctta cacacttcag
      841 tgacatcagt gctttgacag ggggaactgt tcatcttgat gaggatcaga atcctattaa
      901 gaagcggaag aagatacctc agaaaggtcg gaagaaaaaa ggttttcgga ggcggcggtg
      961 attatgggtg tacatatttg tatatttttt gtcatcctga gatacttcta atttcattgt
     1021 atataggtgg ttttccctgg aattcattaa ttgtttgctt tggacatgtg gaaagagcct
     1081 tactaataaa attgattttg cttatgaa
//
