LOCUS       NM_021257               1778 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens neuroglobin (NGB), mRNA.
ACCESSION   NM_021257 XM_001129381 XM_001132327
VERSION     NM_021257.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Wu,F., He,J., Deng,Q., Chen,J., Peng,M., Xiao,J., Zeng,Y., Yi,L.,
            Li,Z., Tian,R. and Jiang,Z.
  TITLE     Neuroglobin inhibits pancreatic cancer proliferation and metastasis
            by targeting the GNAI1/EGFR/AKT/ERK signaling axis
  JOURNAL   Biochem Biophys Res Commun 664, 108-116 (2023)
   PUBMED   37141638
  REMARK    GeneRIF: Neuroglobin inhibits pancreatic cancer proliferation and
            metastasis by targeting the GNAI1/EGFR/AKT/ERK signaling axis.
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Zhang,L., Wang,C., Zhao,M., Li,X., Qu,H., Xu,J. and Li,D.
  TITLE     Prognostic Values Serum Cav-1 and NGB Levels in Early Neurological
            Deterioration After Intravenous Thrombolysis in Patients with Acute
            Ischemic Stroke
  JOURNAL   Clin Appl Thromb Hemost 29, 10760296231219707 (2023)
   PUBMED   38092682
  REMARK    GeneRIF: Prognostic Values Serum Cav-1 and NGB Levels in Early
            Neurological Deterioration After Intravenous Thrombolysis in
            Patients with Acute Ischemic Stroke.
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Manganelli,V., Salvatori,I., Costanzo,M., Capozzi,A., Caissutti,D.,
            Caterino,M., Valle,C., Ferri,A., Sorice,M., Ruoppolo,M.,
            Garofalo,T. and Misasi,R.
  TITLE     Overexpression of Neuroglobin Promotes Energy Metabolism and
            Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells
  JOURNAL   Cells 10 (12), 3394 (2021)
   PUBMED   34943907
  REMARK    GeneRIF: Overexpression of Neuroglobin Promotes Energy Metabolism
            and Autophagy Induction in Human Neuroblastoma SH-SY5Y Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Solar Fernandez,V., Fiocchetti,M., Cipolletti,M., Segatto,M.,
            Cercola,P., Massari,A., Ghinassi,S., Cavaliere,F. and Marino,M.
  TITLE     Neuroglobin: A New Possible Marker of Estrogen-Responsive Breast
            Cancer
  JOURNAL   Cells 10 (8), 1986 (2021)
   PUBMED   34440755
  REMARK    GeneRIF: Neuroglobin: A New Possible Marker of Estrogen-Responsive
            Breast Cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Costanzo,M., Fiocchetti,M., Ascenzi,P., Marino,M., Caterino,M. and
            Ruoppolo,M.
  TITLE     Proteomic and Bioinformatic Investigation of Altered Pathways in
            Neuroglobin-Deficient Breast Cancer Cells
  JOURNAL   Molecules 26 (8), 2397 (2021)
   PUBMED   33924212
  REMARK    GeneRIF: Proteomic and Bioinformatic Investigation of Altered
            Pathways in Neuroglobin-Deficient Breast Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Zhu,Y., Sun,Y., Jin,K. and Greenberg,D.A.
  TITLE     Hemin induces neuroglobin expression in neural cells
  JOURNAL   Blood 100 (7), 2494-2498 (2002)
   PUBMED   12239161
  REMARK    GeneRIF: Expression is induced by hemin in neural cells
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Pesce,A., Nardini,M., Dewilde,S., Ascenzi,P., Burmester,T.,
            Hankeln,T., Moens,L. and Bolognesi,M.
  TITLE     Human neuroglobin: crystals and preliminary X-ray diffraction
            analysis
  JOURNAL   Acta Crystallogr D Biol Crystallogr 58 (Pt 10 Pt 2), 1848-1850
            (2002)
   PUBMED   12351835
  REMARK    GeneRIF: an examination of the protein's structure by
            crystallization and x-ray diffraction
REFERENCE   8  (bases 1 to 1778)
  AUTHORS   Zhang,C., Wang,C., Deng,M., Li,L., Wang,H., Fan,M., Xu,W., Meng,F.,
            Qian,L. and He,F.
  TITLE     Full-length cDNA cloning of human neuroglobin and tissue expression
            of rat neuroglobin
  JOURNAL   Biochem Biophys Res Commun 290 (5), 1411-1419 (2002)
   PUBMED   11820779
  REMARK    GeneRIF: Full-length cDNA cloning and genomic organization of NGB
            have been reported.
REFERENCE   9  (bases 1 to 1778)
  AUTHORS   Dewilde,S., Kiger,L., Burmester,T., Hankeln,T., Baudin-Creuza,V.,
            Aerts,T., Marden,M.C., Caubergs,R. and Moens,L.
  TITLE     Biochemical characterization and ligand binding properties of
            neuroglobin, a novel member of the globin family
  JOURNAL   J Biol Chem 276 (42), 38949-38955 (2001)
   PUBMED   11473128
REFERENCE   10 (bases 1 to 1778)
  AUTHORS   Burmester,T., Weich,B., Reinhardt,S. and Hankeln,T.
  TITLE     A vertebrate globin expressed in the brain
  JOURNAL   Nature 407 (6803), 520-523 (2000)
   PUBMED   11029004
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007375.6.
            
            On Oct 2, 2020 this sequence version replaced NM_021257.3.
            
            Summary: This gene encodes an oxygen-binding protein that is
            distantly related to members of the globin gene family. It is
            highly conserved among other vertebrates. It is expressed in the
            central and peripheral nervous system where it may be involved in
            increasing oxygen availability and providing protection under
            hypoxic/ischemic conditions. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF422797.1, BC032509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298352.5/ ENSP00000298352.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC007375.6         153646-154003       c
            359-470             AC007375.6         152012-152123       c
            471-590             AC007375.6         151263-151382       c
            591-1778            AC007375.6         148280-149467       c
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1778
                     /gene="NGB"
                     /note="neuroglobin"
                     /db_xref="GeneID:58157"
                     /db_xref="HGNC:HGNC:14077"
                     /db_xref="MIM:605304"
     exon            1..358
                     /gene="NGB"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..725
                     /gene="NGB"
                     /note="nitrite reductase"
                     /codon_start=1
                     /product="neuroglobin"
                     /protein_id="NP_067080.1"
                     /db_xref="CCDS:CCDS9856.1"
                     /db_xref="GeneID:58157"
                     /db_xref="HGNC:HGNC:14077"
                     /db_xref="MIM:605304"
                     /translation="MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQY
                     NCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVK
                     LSSFSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWDGE"
     exon            359..470
                     /gene="NGB"
                     /inference="alignment:Splign:2.1.0"
     exon            471..590
                     /gene="NGB"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1778
                     /gene="NGB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NGB"
                     /note="hexamer: AATAAA"
     polyA_site      1778
                     /gene="NGB"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggctc tggcggctgc ggggcgcagg gcgcagcggc caagcggggt ccccggaagc
       61 acagctgggg tgtctccacc tacgactggc cgcgcgcctt ttctctcccg cgccagggaa
      121 ggagcggctg cggcccccgc cgggcggagg cacggggggc gtacgagggg cggaggggac
      181 cgcgtcgcgg aggagatggc gcggcacgtg cggtgacggc acccgagccc tgagggtccc
      241 agccccgcgc tccgcgtccc cgggacagca tggagcgccc ggagcccgag ctgatccggc
      301 agagctggcg ggcagtgagc cgcagcccgc tggagcacgg caccgtcctg tttgccaggc
      361 tgtttgccct ggagcctgac ctgctgcccc tcttccagta caactgccgc cagttctcca
      421 gcccagagga ctgtctctcc tcgcctgagt tcctggacca catcaggaag gtgatgctcg
      481 tgattgatgc tgcagtgacc aatgtggaag acctgtcctc actggaggag taccttgcca
      541 gcctgggcag gaagcaccgg gcagtgggtg tgaagctcag ctccttctcg acagtgggtg
      601 agtctctgct ctacatgctg gagaagtgtc tgggccctgc cttcacacca gccacacggg
      661 ctgcctggag ccaactctac ggggccgtag tgcaggccat gagtcgaggc tgggatggcg
      721 agtaagaggc gaccccgccc ggcagccccc atccatctgt gtctgtctgt tggcctgtat
      781 ctgttgtagc ccaggctccc caagcttccc tgcatcttgg tccttgtccc cttggccaca
      841 ctggagaggt gatggggcag ggctgggtct cagtatccta gagtccagct gcagaaggag
      901 tggcttttcc tccaggaagg ggcttctggg tgtcccctca tccccagtag cctctttctt
      961 gcgtttcttt ttaccttttt tggcactccc tctgaccccg cgatgagtgt tttggtggca
     1021 gaggtgggat gagctggaaa ggtatggagg tgggagagga tggggctctt ctgtctgtcc
     1081 tgcttcttca ggtgagtgca ggccaaggcg ggggtgagat ggctgagctt ccagcgcctt
     1141 ctgtcctgcc tgcccagtcc cttcactgct ttcctgcccc aagatggctt gcttttcaca
     1201 aataaagaga aagagcagct ttagccttct tggtggaatc ccaggcagtg ggagcagaat
     1261 cagaactgcc agggaaggga agggggacct gggtctcaat gggtctcatt tgagtctcgc
     1321 gggctgtgca gatgccctga cagagtcggt ttcctttggc ggcattccct ttccctcatt
     1381 cagcacttct gctgggaact ccctgactat tccgctgctg caggaaccca gctagctggc
     1441 caggtgggga ggggctgggg accggccagg aaggaggggt gacttcatcc cagagagacc
     1501 cgagttcccc cagcccttca tcaccaaccc gctcctgcag gagtgagtct tacctcccct
     1561 ggccctcctt tctggctcag cctgcagcga ctgtgaggcc acagctcctc agattcactg
     1621 cccgctgtgt gccagtactc aggcagctgg agagaagaga aggcagcagc agaggccccc
     1681 gccctcaccc cagccatctg cacttgtacc atttgctctg tgctgactgt ggtcctataa
     1741 attcatgaga aataaactgg ttctgtgtgc ctctctga
//
