LOCUS       NM_014223               1955 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens nuclear transcription factor Y subunit gamma (NFYC),
            transcript variant 2, mRNA.
ACCESSION   NM_014223
VERSION     NM_014223.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1955)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1955)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1955)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1955)
  AUTHORS   van der Plaat,D.A., Vonk,J.M., Lahousse,L., de Jong,K., Faiz,A.,
            Nedeljkovic,I., Amin,N., van Diemen,C.C., Brusselle,G.G., Bosse,Y.,
            Brandsma,C.A., Hao,K., Pare,P.D., van Duijn,C.M., Postma,D.S. and
            Boezen,H.M.
  TITLE     Limited overlap in significant hits between genome-wide association
            studies on two airflow obstruction definitions in the same
            population
  JOURNAL   BMC Pulm Med 19 (1), 58 (2019)
   PUBMED   30845926
  REMARK    GeneRIF: The genes FABP7 and NFYC(-AS1) could play a role in
            airflow obstruction in never-smokers specifically.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1955)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1955)
  AUTHORS   Dmitrenko,V., Garifulin,O. and Kavsan,V.
  TITLE     Isolation and sequence analysis of the cDNA encoding subunit C of
            human CCAAT-binding transcription factor
  JOURNAL   Gene 197 (1-2), 161-163 (1997)
   PUBMED   9332362
REFERENCE   7  (bases 1 to 1955)
  AUTHORS   Bellorini,M., Zemzoumi,K., Farina,A., Berthelsen,J., Piaggio,G. and
            Mantovani,R.
  TITLE     Cloning and expression of human NF-YC
  JOURNAL   Gene 193 (1), 119-125 (1997)
   PUBMED   9249075
REFERENCE   8  (bases 1 to 1955)
  AUTHORS   Nakshatri,H., Bhat-Nakshatri,P. and Currie,R.A.
  TITLE     Subunit association and DNA binding activity of the heterotrimeric
            transcription factor NF-Y is regulated by cellular redox
  JOURNAL   J Biol Chem 271 (46), 28784-28791 (1996)
   PUBMED   8910521
REFERENCE   9  (bases 1 to 1955)
  AUTHORS   Sinha,S., Maity,S.N., Seldin,M.F. and de Crombrugghe,B.
  TITLE     Chromosomal assignment and tissue expression of CBF-C/NFY-C, the
            third subunit of the mammalian CCAAT-binding factor
  JOURNAL   Genomics 37 (2), 260-263 (1996)
   PUBMED   8921405
REFERENCE   10 (bases 1 to 1955)
  AUTHORS   Martinelli,R. and Heintz,N.
  TITLE     H1TF2A, the large subunit of a heterodimeric, glutamine-rich
            CCAAT-binding transcription factor involved in histone H1 cell
            cycle regulation
  JOURNAL   Mol Cell Biol 14 (12), 8322-8332 (1994)
   PUBMED   7969168
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC391720.1, BC005003.1,
            D89986.1 and AC119677.2.
            
            On Jun 2, 2019 this sequence version replaced NM_014223.4.
            
            Summary: This gene encodes one subunit of a trimeric complex
            forming a highly conserved transcription factor that binds with
            high specificity to CCAAT motifs in the promoters of a variety of
            genes. The encoded protein, subunit C, forms a tight dimer with the
            B subunit, a prerequisite for subunit A association. The resulting
            trimer binds to DNA with high specificity and affinity. Subunits B
            and C each contain a histone-like motif. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The resulting
            isoform (2) has the same N- and C- termini but lacks an internal
            segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.108153.1,
                                           SRR1803614.99351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447388.8/ ENSP00000404427.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DC391720.1         135-151
            18-1459             BC005003.1         1-1442
            1460-1525           D89986.1           1354-1419
            1526-1527           AC119677.2         6138-6139
            1528-1955           D89986.1           1420-1847
FEATURES             Location/Qualifiers
     source          1..1955
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1955
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /note="nuclear transcription factor Y subunit gamma"
                     /db_xref="GeneID:4802"
                     /db_xref="HGNC:HGNC:7806"
                     /db_xref="MIM:605344"
     exon            1..164
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            165..277
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1180
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transactivator HSM-1; histone H1 transcription factor
                     large subunit 2A; CCAAT transcription binding factor
                     subunit gamma; transcription factor NF-Y, C subunit; CCAAT
                     binding factor subunit C; transactivator HSM-1/2; CAAT box
                     DNA-binding protein subunit C; nuclear transcription
                     factor Y subunit C; nuclear transcription factor Y, gamma"
                     /codon_start=1
                     /product="nuclear transcription factor Y subunit gamma
                     isoform 2"
                     /protein_id="NP_055038.2"
                     /db_xref="CCDS:CCDS455.1"
                     /db_xref="GeneID:4802"
                     /db_xref="HGNC:HGNC:7806"
                     /db_xref="MIM:605344"
                     /translation="MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELP
                     LARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIA
                     MAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQ
                     QQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSG
                     TGQTMQVMQQIITNTGEIQQIPVQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQ
                     ITQTEVQQGQQQFSQFTDGQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTG
                     D"
     exon            278..349
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            350..463
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            464..559
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            560..733
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            734..892
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1000
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1060
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1955
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /note="hexamer: AATAAA"
     polyA_site      1955
                     /gene="NFYC"
                     /gene_synonym="CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC"
                     /note="major polyA site"
ORIGIN      
        1 gcaaacggcg tggccgccat cttgcttgtg cccccgcttc gcgcgcgctc cgttctccgt
       61 gacgcacact tccccctccc ctccgccgcg cctgggcctc tgcattgccc gactccgtag
      121 gagcgcgggg gcggctcctg ctcttcctgg actcctgagc agagttgtcg agatgtccac
      181 agaaggagga tttggtggta ctagcagcag tgatgcccag caaagcctac agtcgttctg
      241 gcctcgggtc atggaagaaa tccggaattt aacagtgaaa gacttccgag tgcaggaact
      301 cccactggct cgtattaaga agattatgaa actggatgaa gatgtgaaga tgatcagtgc
      361 agaagcgcct gtactctttg ccaaggcagc ccagattttt atcacagagt tgactcttcg
      421 agcctggatt cacacagaag ataacaagcg ccggactcta cagagaaatg atatcgccat
      481 ggcaattaca aaatttgatc agtttgattt tctcatcgat attgttccaa gagatgaact
      541 gaaacctcca aagcgtcagg aggaggtgcg ccagtctgta actcctgccg agccagtcca
      601 gtactatttc acgctggctc agcaacccac cgctgtccaa gtccagggcc agcagcaagg
      661 ccagcagacc accagctcca cgaccaccat ccagcctggg cagatcatca tcgcacagcc
      721 tcagcagggc cagaccacac ctgtgacaat gcaggttgga gaaggtcagc aggtgcagat
      781 tgtccaggct cagccacagg gtcaagccca acaggcccag agtggcactg gacagaccat
      841 gcaggtgatg cagcagatca tcactaacac aggagagatc cagcagatcc cggtgcagct
      901 gaatgccggc cagctgcagt atatccgctt agcccagcct gtatcaggca ctcaagttgt
      961 gcagggacag atccagacac ttgccaccaa tgctcaacag attacacaga cagaggtcca
     1021 gcaaggacag cagcagttca gccagttcac agatggacag cagctctacc agatccagca
     1081 agtcaccatg cctgcgggcc aggacctcgc ccagcccatg ttcatccagt cagccaacca
     1141 gccctccgac gggcaggccc cccaggtgac cggcgactga gggcctgagc tggcaaggcc
     1201 aaggacaccc aacacaattt ttgccataca gccccaggca atgggcacag ccttcctccc
     1261 cagaggaccc ggccgacctc agcgcctcct gcaggctagg acactggtgc actacacccc
     1321 atgcctgggg gccgagattc tccagcagaa agatgcaata ttttttgttt cctttttttc
     1381 catttttttc tctaaggaat caatatttca atatgttgag tgtgtgtcca atgctatgaa
     1441 attaaaatat taaataacat atttatggca ttttcttgaa gagtgtggtt gaagaaatat
     1501 ttctcctttt gtttttcttt tttttttgtt tgttactgcc acttcttttt aggagcaaat
     1561 ctccccaggg gtgtacggta tttcttgact ctgggaacag ctgctacccc caagacttgc
     1621 cacgttgttc tgccctcaga tggaattagg tgaatgtgtg tagctgcttt ttcactcgtg
     1681 gtcctctccc catcccttgc tctgacccca gagctctgtg tatttgcatc cagaggccat
     1741 ggaaacattc tttgcattta agagacagat ttattccctg tggagagtgg gtggattcat
     1801 tgccacactc ttttctccca gggacccagg aaactaggac tttgtgtgtt tgctgcccac
     1861 ctccctttta ttttttaaat gcattaaaaa ctgtgctagt ctcctttgca tggacttcaa
     1921 gctgcatgaa atgcaataaa tctcatttta gataa
//
