LOCUS       NM_006166               3424 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens nuclear transcription factor Y subunit beta (NFYB),
            transcript variant 3, mRNA.
ACCESSION   NM_006166
VERSION     NM_006166.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Liu,P., Xing,N., Xiahou,Z., Yan,J., Lin,Z. and Zhang,J.
  TITLE     Unraveling the intricacies of glioblastoma progression and
            recurrence: insights into the role of NFYB and oxidative
            phosphorylation at the single-cell level
  JOURNAL   Front Immunol 15, 1368685 (2024)
   PUBMED   38510250
  REMARK    GeneRIF: Unraveling the intricacies of glioblastoma progression and
            recurrence: insights into the role of NFYB and oxidative
            phosphorylation at the single-cell level.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   Zhang,Y., Huang,H., Liu,P. and Xie,Y.
  TITLE     NFYB increases chemosensitivity in glioblastoma by promoting
            HDAC5-mediated transcriptional inhibition of SHMT2
  JOURNAL   J Neuropathol Exp Neurol 82 (11), 911-920 (2023)
   PUBMED   37742129
  REMARK    GeneRIF: NFYB increases chemosensitivity in glioblastoma by
            promoting HDAC5-mediated transcriptional inhibition of SHMT2.
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Feng,L., Yan,Q. and Xu,X.
  TITLE     Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1 and
            Regulate Doxorubicin Resistance in Lymphoma Cells
  JOURNAL   Mol Biotechnol 65 (6), 997-1009 (2023)
   PUBMED   36434485
  REMARK    GeneRIF: Long Non-coding RNA H19 Recruits NFYB to Activate MBTD1
            and Regulate Doxorubicin Resistance in Lymphoma Cells.
REFERENCE   4  (bases 1 to 3424)
  AUTHORS   Lu,T., Li,C., Xiang,C., Gong,Y., Peng,W., Hou,F. and Chen,C.
  TITLE     Over-expression of NFYB affects stromal cells reprogramming and
            predicts worse survival in gastric cancer patients
  JOURNAL   Aging (Albany NY) 14 (19), 7851-7865 (2022)
   PUBMED   36152055
  REMARK    GeneRIF: Over-expression of NFYB affects stromal cells
            reprogramming and predicts worse survival in gastric cancer
            patients.
REFERENCE   5  (bases 1 to 3424)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3424)
  AUTHORS   Lloberas,J., Maki,R.A. and Celada,A.
  TITLE     Repression of major histocompatibility complex I-A beta gene
            expression by dbpA and dbpB (mYB-1) proteins
  JOURNAL   Mol Cell Biol 15 (9), 5092-5099 (1995)
   PUBMED   7651426
REFERENCE   7  (bases 1 to 3424)
  AUTHORS   Chang,Z.F. and Liu,C.J.
  TITLE     Human thymidine kinase CCAAT-binding protein is NF-Y, whose A
            subunit expression is serum-dependent in human IMR-90 diploid
            fibroblasts
  JOURNAL   J Biol Chem 269 (27), 17893-17898 (1994)
   PUBMED   8027044
REFERENCE   8  (bases 1 to 3424)
  AUTHORS   Li,X.Y., Hooft van Huijsduijnen,R., Mantovani,R., Benoist,C. and
            Mathis,D.
  TITLE     Intron-exon organization of the NF-Y genes. Tissue-specific
            splicing modifies an activation domain
  JOURNAL   J Biol Chem 267 (13), 8984-8990 (1992)
   PUBMED   1577736
REFERENCE   9  (bases 1 to 3424)
  AUTHORS   Li,X.Y., Mantovani,R., Hooft van Huijsduijnen,R., Andre,I.,
            Benoist,C. and Mathis,D.
  TITLE     Evolutionary variation of the CCAAT-binding transcription factor
            NF-Y
  JOURNAL   Nucleic Acids Res 20 (5), 1087-1091 (1992)
   PUBMED   1549471
  REMARK    Erratum:[Nucleic Acids Res 1992 Apr 11;20(7):1841]
REFERENCE   10 (bases 1 to 3424)
  AUTHORS   Li,X.Y., Mattei,M.G., Zaleska-Rutczynska,Z., Hooft van
            Huijsduijnen,R., Figueroa,F., Nadeau,J., Benoist,C. and Mathis,D.
  TITLE     One subunit of the transcription factor NF-Y maps close to the
            major histocompatibility complex in murine and human chromosomes
  JOURNAL   Genomics 11 (3), 630-634 (1991)
   PUBMED   1774067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG776259.1, BC005316.1,
            BQ420877.1, CD678671.1, AU151875.1, AW576189.1, BF032637.1,
            AL042186.1 and AA479300.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006166.3.
            
            Summary: The protein encoded by this gene is one subunit of a
            trimeric complex, forming a highly conserved transcription factor
            that binds with high specificity to CCAAT motifs in the promoter
            regions in a variety of genes. This gene product, subunit B, forms
            a tight dimer with the C subunit, a prerequisite for subunit A
            association. The resulting trimer binds to DNA with high
            specificity and affinity. Subunits B and C each contain a
            histone-like motif. Observation of the histone nature of these
            subunits is supported by two types of evidence; protein sequence
            alignments and experiments with mutants. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.247352.1,
                                           SRR1803615.55114.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240055.8/ ENSP00000240055.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               BG776259.1         54-433
            381-1310            BC005316.1         382-1311
            1311-1554           BQ420877.1         534-777
            1555-1969           CD678671.1         146-560
            1970-2419           AU151875.1         1-450               c
            2420-2726           AW576189.1         20-326              c
            2727-2766           BF032637.1         279-318
            2767-2839           BF032637.1         320-392
            2840-3222           AL042186.1         37-419
            3223-3424           AA479300.1         7-208               c
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..3424
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="nuclear transcription factor Y subunit beta"
                     /db_xref="GeneID:4801"
                     /db_xref="HGNC:HGNC:7805"
                     /db_xref="MIM:189904"
     exon            1..70
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            71..155
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..773
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="isoform b is encoded by transcript variant 3;
                     CCAAT-binding transcription factor subunit A;
                     Transcription factor NF-Y, B subunit; CAAT box DNA-binding
                     protein subunit B; nuclear transcription factor Y subunit
                     B; nuclear transcription factor Y, beta"
                     /codon_start=1
                     /product="nuclear transcription factor Y subunit beta
                     isoform b"
                     /protein_id="NP_006157.1"
                     /db_xref="CCDS:CCDS9098.1"
                     /db_xref="GeneID:4801"
                     /db_xref="HGNC:HGNC:7805"
                     /db_xref="MIM:189904"
                     /translation="MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHED
                     TNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEAS
                     ERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVTATDG
                     LSEELTEEAFTNQLPAGLITTDGQQQNVMVYTTSYQQISGVQQIQFS"
     exon            156..249
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            250..380
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            381..578
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            579..660
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            661..740
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     exon            741..3424
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1164..1169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: AATAAA"
     polyA_site      1187
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="major polyA site"
     regulatory      2393..2398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: AATATA"
     polyA_site      2421
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: TATAAA"
     polyA_site      2552
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
     regulatory      2700..2705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: GATAAA"
     polyA_site      2727
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
     regulatory      3405..3410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
                     /note="hexamer: CATAAA"
     polyA_site      3424
                     /gene="NFYB"
                     /gene_synonym="CBF-A; CBF-B; HAP3; NF-YB"
ORIGIN      
        1 ccttcgcagc cattttctgt ccaaccaaac agccgattgg agacgggagc caaccagggc
       61 tgcattggag gttgaaatca caaagattag acaccttttt agataggtgt tcttcagcac
      121 cactgacaac acggttctga cagtatttca tgacaatgga tggtgacagt tctacaacag
      181 atgcttctca actaggaatc tctgcagact atattggagg aagtcattat gttatacagc
      241 ctcatgatga tactgaggac agcatgaatg atcatgaaga cacaaatggt tcaaaagaaa
      301 gtttcagaga acaagatata tatcttccaa tagcaaacgt ggctaggata atgaaaaatg
      361 ccatacctca aacgggaaag attgcaaaag atgccaaaga atgtgttcaa gaatgtgtaa
      421 gtgagttcat cagttttata acatctgaag caagtgaaag gtgccatcaa gagaaacgga
      481 aaacaatcaa tggagaagat attctctttg ctatgtctac tttaggcttt gacagttatg
      541 tggaacctct gaaattatac cttcagaaat tcagagaggc tatgaaagga gaaaagggaa
      601 ttggtggagc agtcacagct acagatggac taagtgaaga gcttacagag gaggcattta
      661 ctaaccagtt accagctggc ttaataacca cagacggtca acaacaaaat gttatggttt
      721 acacaacatc atatcaacag atttctggtg ttcagcaaat tcagttttca tgatctgaag
      781 aaatgatgga atggggagtg tagagaaatg agagtctgta tgattctgga acagagacat
      841 cagaaggaaa gactggtgaa aagatgtatc tttgtatatt aatagctgta atgtagcttc
      901 ctgatgcttg actaattgag gtgttaattc tgacttgaga atctttttca tgaatgattt
      961 taaagaaaaa tttggatttt aaaggtatta aaatattttt gttttgtacg agagtttgtt
     1021 gctctgtatg actcctgtat gcattgtata ttgcaattta ttactgtcag agatttgtag
     1081 acagtttctt attttcatat tgaatcatgt tacttttgta attcaagtaa gcggctgggt
     1141 taattcatga tgtttgccct tttaataaaa tataagggta gagttcattt tgaatgcaag
     1201 ttgcctttat tataaatttg agtttgtctt ggttatacct tgcatgataa cctagctaga
     1261 tttctagcat ttgctgtatt tattaaaatt attatttttt tggtaaaaca ttaatagttt
     1321 aagcagcatc atttttttaa aaaatgtaat tgaataagtg tgaatgcaga agcaaatatt
     1381 gtctgccctg ttaaacttgg tgcccattaa cagtgtttac actgttcatc gtgcctgtta
     1441 atgtagtttt agttactgga gcttttttaa gactagattt ggttttgagt tacattttta
     1501 agaatgtggg aatatattta agtttaatgt agtcctagtg ctcttgaaat ggtgcccctt
     1561 tcatttggta catgattttt tttcaaatca tatcttcaag tactatagta ttctcttaca
     1621 gaagaggagt tttatagtct gatggtaaat gtcttcattt taccttttta attgaaatgt
     1681 caagtttcct gttacactat ggaaaccaag aaacatcaga catcattgcg tgtacagacc
     1741 ttttgcatgg gtgagtggat gaaatggaga acagagtgag tgctgtgaac ggtgtgaaat
     1801 agaagccaac ttctagtatg ctgtcttcat ctctgcaata aactaaacgt aaataatgta
     1861 actttgtata atttagtagt atgtacttgg attgtttctt tttgaaaagt gaggatttgt
     1921 attttctcat ctattctttt tggtgttaat taacttgagg gatttctttt ttaagttttt
     1981 aatatcaaaa attgctattg tatagtttgc ctaaaaggaa gttggagtga atatcatctt
     2041 tgaaggacac tcaaatttat aaggtagaag caatttccca gatataggct gaacagaaac
     2101 atttactttg ccagaaggag cctttaggag tatatgtggg ctaatcagag gttaataatg
     2161 tcctcatctc ctactctcca tttaaaaaac aaacttcatt gtagtaaatt caaataggaa
     2221 aaaatggggg agtagttaag caaaatcaac agtcatccta ctatgttgaa agaaccaatg
     2281 ttaatatttt gataaatatc atttgtcctt ttactttgct aaatatgtat atttttataa
     2341 aaatgggctc atattgtgca taccattttg taacctgctt ttttcactta acaatatatt
     2401 gggaacatct tttccaggtc atgcatagtc ttctgcatca tttttattgg tttattattc
     2461 tgctgtatga ctcaatcata attcatttaa tcttctattg gatattttga ctatttacat
     2521 cttttcacag ttataaacag cacttcactg aatcccatgt acatccatga ctgttttctt
     2581 aaattctttg aattgctggg ttaccaaata tgcaaaattt taaggctttt gatacttcgt
     2641 tatgagtgta tttttgagat attttccact tgatccaagc agtgtgtcac tatataactg
     2701 ataaaagcac ttggtctttg attatcagat actgtctcta aaattatttt aaagattaat
     2761 atttgttcaa gtagagaatg aagataaaaa aggaatttga ggccaggtat ggggtgtctc
     2821 atgcctataa ttccagcact ttgggaggcc aaggcaggca gatcactttg aggtcaggag
     2881 tttgagacca gcctggccaa catggagaac cccccgtctc tacaaaaaat acaaaattag
     2941 cagggtgtgg tggtgcacac ctgtagtccc ttactccctg gtggctgagg cattatccct
     3001 tgaacctggg aggcagagcc taaagtgagc cgagatcgcg ccactgcact ccagcctggg
     3061 tgacacagca agactcttgt ctcaaacaaa caggaatttg agtaaatttt aaattagtat
     3121 atactacaac aaatttccaa acttcataat ttgctagtag tgctaactaa aattttacac
     3181 caggtaaaat caggtcacct tttttatgta ttgacttcat tgttggactt catactctga
     3241 tgggaaagaa aatggacatt ctgaatgtgt caggtgcata atatcctaat ttatgcttgt
     3301 cagagctggg gtctctgtct tccttggccc atgttgcatt taactgaatg tcatgttttc
     3361 tcctctggaa cttcttatgt atgcaagctc ccatgttaac ctatcataaa aatgtttttt
     3421 ataa
//
